Maprotiline Hydrochloride (BioDeep_00000399081)
natural product
代谢物信息卡片
Maprotiline Hydrochloride
化学式: C20H24ClN (313.15971740000003)
中文名称: 马替普林盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=C2C(=C1)C3(C4=C(C2CC3)C=CC=C4)CCCNC).Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:6691
- KEGGdrug: D00818
- PubChem: 71478
- ChEMBL: CHEMBL1200427
- ChEMBL: CHEMBL1237135
- MeSH: Maprotiline
- CAS: 10347-81-6
- MoNA: CCMSLIB00000078501
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ute Krügel, Isabelle Straub, Holger Beckmann, Michael Schaefer. Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
Pain.
2017 05; 158(5):856-867. doi:
10.1097/j.pain.0000000000000846. [PMID: 28106668] - Guoxun Zheng, Weiwei Xue, Panpan Wang, Fengyuan Yang, Bo Li, Xiaofeng Li, Yinghong Li, Xiaojun Yao, Feng Zhu. Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study.
Scientific reports.
2016 05; 6(?):26883. doi:
10.1038/srep26883. [PMID: 27230580] - Y M McNamara, S A Bright, A J Byrne, S M Cloonan, T McCabe, D C Williams, M J Meegan. Synthesis and antiproliferative action of a novel series of maprotiline analogues.
European journal of medicinal chemistry.
2014 Jan; 71(?):333-53. doi:
10.1016/j.ejmech.2013.10.076. [PMID: 24333581] - Lynette Hui-Wen Lee, Chay-Hoon Tan, Guanghou Shui, Markus R Wenk, Wei-Yi Ong. Role of prefrontal cortical calcium independent phospholipase A₂ in antidepressant-like effect of maprotiline.
The international journal of neuropsychopharmacology.
2012 Sep; 15(8):1087-98. doi:
10.1017/s1461145711001234. [PMID: 21835087] - Suzanne M Cloonan, Aleksandra Drozgowska, Darren Fayne, D Clive Williams. The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters.
Leukemia & lymphoma.
2010 Mar; 51(3):523-39. doi:
10.3109/10428190903552112. [PMID: 20141432] - Marwa A Aboukhatwa, Ashiwel S Undieh. Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition.
BMC neuroscience.
2010 Jan; 11(?):10. doi:
10.1186/1471-2202-11-10. [PMID: 20105322] - Lynette Hui-Wen Lee, Guanghou Shui, Akhlaq A Farooqui, Markus R Wenk, Chay-Hoon Tan, Wei-Yi Ong. Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids?.
The international journal of neuropsychopharmacology.
2009 Aug; 12(7):953-64. doi:
10.1017/s146114570900995x. [PMID: 19203412] - J E Warnick, C J Huang, E O Acevedo, K J Sufka. Modelling the anxiety-depression continuum in chicks.
Journal of psychopharmacology (Oxford, England).
2009 Mar; 23(2):143-56. doi:
10.1177/0269881108089805. [PMID: 18515452] - Natasa Spasojevic, Ljubica Gavrilovic, Ivan Kovacevic, Sladjana Dronjak. Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats.
Autonomic neuroscience : basic & clinical.
2009 Jan; 145(1-2):104-7. doi:
10.1016/j.autneu.2008.11.002. [PMID: 19083273] - Murat Pinar, Murat Gulsun, Ilker Tasci, Ahmet Erdil, Erol Bolu, Cengizhan Acikel, Ali Doruk. Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Jan; 32(1):135-9. doi:
10.1016/j.pnpbp.2007.07.028. [PMID: 17825464] - Sladjana Dronjak, Natasa Spasojevic, Ljubica Gavrilovic, Vladislav Varagic. Effects of noradrenaline and serotonin reuptake inhibitors on pituitary-adrenocortical and sympatho-adrenomedullar system of adult rats.
Neuro endocrinology letters.
2007 Oct; 28(5):614-20. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2006 Mar; 26(3):212-4. doi:
". [PMID: 16613263] - Kuo-Shyan Lin, Yu-Shin Ding. Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons.
Bioorganic & medicinal chemistry.
2005 Aug; 13(15):4658-66. doi:
10.1016/j.bmc.2005.04.062. [PMID: 15914010] - Yu-Shin Ding, Kuo-Shyan Lin, Jean Logan, Helene Benveniste, Pauline Carter. Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine.
Journal of neurochemistry.
2005 Jul; 94(2):337-51. doi:
10.1111/j.1471-4159.2005.03202.x. [PMID: 15998285] - G M Murav'eva. [Detection of maprotiline and proserine in forensic medical examination of cadaver].
Sudebno-meditsinskaia ekspertiza.
2005 Mar; 48(2):42-3. doi:
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Archives of toxicology.
2004 Aug; 78(8):453-9. doi:
10.1007/s00204-004-0564-1. [PMID: 15057508] - Zhen-ming Shen, Mei-lan Zhu, An-quan Zhao. [Comparative observation on efficacy of jieyu pill and maprotiline in treating depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 May; 24(5):415-7. doi:
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Brain research.
2003 Feb; 964(1):83-90. doi:
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Synapse (New York, N.Y.).
2003 Feb; 47(2):123-33. doi:
10.1002/syn.10155. [PMID: 12454950] - R Waschgler, M R Hubmann, A Conca, W Moll, P König. Simultaneous quantification of citalopram, clozapine, fluoxetine, norfluoxetine, maprotiline, desmethylmaprotiline and trazodone in human serum by HPLC analysis.
International journal of clinical pharmacology and therapeutics.
2002 Dec; 40(12):554-9. doi:
10.5414/cpp40554. [PMID: 12503813] - Cui Han, Xue-wu Li, He-chun Luo. [Comparative study of electro-acupuncture and maprotiline in treating depression].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2002 Jul; 22(7):512-4, 521. doi:
". [PMID: 12592685] - Lars Brachtendorf, Alexander Jetter, K Tobias Beckurts, Arnulf H Hölscher, Uwe Fuhr. Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Pharmacology & toxicology.
2002 Mar; 90(3):144-9. doi:
10.1034/j.1600-0773.2002.900306.x. [PMID: 12071336] - Claus Normann, Klaus Lieb, Jörg Walden. Increased plasma concentration of maprotiline by coadministration of risperidone.
Journal of clinical psychopharmacology.
2002 Feb; 22(1):92-4. doi:
10.1097/00004714-200202000-00016. [PMID: 11799350] - M Cakrt, T Buzinkaiová, J Polonský, V Korínková. Spectrofluorimetric and isotachophoretic determination of maprotiline in human blood serum.
Electrophoresis.
2000 Aug; 21(14):2834-8. doi:
10.1002/1522-2683(20000801)21:14<2834::aid-elps2834>3.0.co;2-c. [PMID: 11001290] - A Ozkul, A Oztunç. Determination of maprotiline hydrochloride in tablets by ion-pair extraction using bromthymol blue.
Die Pharmazie.
2000 Apr; 55(4):321-2. doi:
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European journal of pharmacology.
1999 Oct; 382(3):211-5. doi:
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Epilepsia.
1999; 40 Suppl 10(?):S48-56. doi:
10.1111/j.1528-1157.1999.tb00885.x. [PMID: 10609604] - I Fukunishi, T Kitaoka, T Shirai, S Watanabe. Cardiac arrest caused by maprotiline in an elderly hemodialysis patient.
Nephron.
1998; 78(2):225. doi:
10.1159/000044917. [PMID: 9496744] - M Vrethem, J Boivie, H Arnqvist, H Holmgren, T Lindström, L H Thorell. A comparison a amitriptyline and maprotiline in the treatment of painful polyneuropathy in diabetics and nondiabetics.
The Clinical journal of pain.
1997 Dec; 13(4):313-23. doi:
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1997 Oct; 700(1-2):183-9. doi:
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Neuroscience research.
1997 Sep; 29(1):87-91. doi:
10.1016/s0168-0102(97)00072-2. [PMID: 9293496] - F König, M Wolfersdorf, M Löble, S Wössner, B Hauger. Trimipramine and maprotiline plasma levels during combined treatment with moclobemide in therapy-resistant depression.
Pharmacopsychiatry.
1997 Jul; 30(4):125-7. doi:
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Biological psychiatry.
1997 Apr; 41(7):774-81. doi:
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The American journal of cardiology.
1997 Jan; 79(2):242-5. doi:
10.1016/s0002-9149(96)00727-8. [PMID: 9193039] - S V Vormfelde, A Bitsch, I Meineke, U M Gundert-Remy, C H Gleiter. Non-response to maprotiline caused by ultra-rapid metabolism that is different from CYP2D6?.
European journal of clinical pharmacology.
1997; 52(5):387-90. doi:
10.1007/s002280050306. [PMID: 9272409] - M el-Dakhakhny, H A Abdel el-Latif, H P Ammon. Different effects of the antidepressant drugs imipramine, maprotiline and bupropion on insulin secretion from mouse pancreatic islets.
Arzneimittel-Forschung.
1996 Jul; 46(7):667-9. doi:
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Journal of chromatography. B, Biomedical applications.
1995 Jul; 669(2):390-6. doi:
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The Journal of pharmacology and experimental therapeutics.
1995 Apr; 273(1):128-37. doi:
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European archives of psychiatry and clinical neuroscience.
1995; 246(1):1-6. doi:
10.1007/bf02191808. [PMID: 8773212] - H Lefebvre, C Noblet, N Moore, L M Wolf. Pseudo-phaeochromocytoma after multiple drug interactions involving the selective monoamine oxidase inhibitor selegiline.
Clinical endocrinology.
1995 Jan; 42(1):95-8; discussion 98. doi:
10.1111/j.1365-2265.1995.tb02604.x. [PMID: 7889639] - G Harrer, W D Hübner, H Podzuweit. Effectiveness and tolerance of the hypericum extract LI 160 compared to maprotiline: a multicenter double-blind study.
Journal of geriatric psychiatry and neurology.
1994 Oct; 7 Suppl 1(?):S24-8. doi:
10.1177/089198879400700108. [PMID: 7857503] - D Johnson, H Ksciuk, H Woelk, E Sauerwein-Giese, A Frauendorf. Effects of hypericum extract LI 160 compared with maprotiline on resting EEG and evoked potentials in 24 volunteers.
Journal of geriatric psychiatry and neurology.
1994 Oct; 7 Suppl 1(?):S44-6. doi:
10.1177/089198879400700112. [PMID: 7857508] - H J Kuss, S Sirch, D Y Zhao. Assay for maprotiline in human serum with improved sensitivity and selectivity.
Journal of chromatography. B, Biomedical applications.
1994 Jun; 656(1):245-9. doi:
10.1016/0378-4347(94)00071-9. [PMID: 7952036] - L Firkusny, C H Gleiter. Maprotiline metabolism appears to co-segregate with the genetically-determined CYP2D6 polymorphic hydroxylation of debrisoquine.
British journal of clinical pharmacology.
1994 Apr; 37(4):383-8. doi:
10.1111/j.1365-2125.1994.tb04293.x. [PMID: 8018460] - B Szabo, T Auberle, K Starke. Inhibition of uptake 1 by (+)-oxaprotiline reveals a differential central regulation of noradrenaline and adrenaline release.
Naunyn-Schmiedeberg's archives of pharmacology.
1993 Sep; 348(3):249-57. doi:
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Journal of chromatography.
1993 Jun; 615(2):237-42. doi:
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Synapse (New York, N.Y.).
1993 Apr; 13(4):295-309. doi:
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European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
1993 Mar; 3(1):13-21. doi:
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The Journal of clinical psychiatry.
1993 Feb; 54 Suppl(?):16-22. doi:
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Journal of affective disorders.
1993 Feb; 27(2):123-9. doi:
10.1016/0165-0327(93)90085-x. [PMID: 8382710] - K Miyake, H Fukuchi, T Kitaura, M Kimura, Y Kimura. Pharmacokinetic analysis of maprotiline and its demethylated metabolite in serum and brain of rats after acute and chronic oral administration of maprotiline.
Journal of pharmaceutical sciences.
1992 Oct; 81(10):1032-7. doi:
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Archiv fur Kriminologie.
1992 Sep; 190(3-4):82-7. doi:
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Ceskoslovenska psychiatrie.
1992 Jun; 88(2):97-105. doi:
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Biopharmaceutics & drug disposition.
1992 Mar; 13(2):83-93. doi:
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Psychological medicine.
1992 Feb; 22(1):61-7. doi:
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Journal of pharmaceutical sciences.
1991 Dec; 80(12):1114-8. doi:
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Biological mass spectrometry.
1991 Nov; 20(11):709-16. doi:
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European journal of pharmacology.
1991 Jul; 199(3):325-34. doi:
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Japanese journal of medicine.
1991 Jul; 30(4):387-91. doi:
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Journal of neural transmission. General section.
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1991; 34(?):11-7. doi:
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Annals of clinical biochemistry.
1990 Sep; 27 ( Pt 5)(?):478-81. doi:
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Journal of neural transmission. Supplementum.
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Clinical pharmacy.
1990 Jan; 9(1):45-9. doi:
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Therapie.
1989 Jul; 44(4):257-61. doi:
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Journal de toxicologie clinique et experimentale.
1989 Jul; 9(4):291-3. doi:
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Clinical chemistry.
1989 Mar; 35(3):453-6. doi:
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The Journal of clinical psychiatry.
1989 Feb; 50(2):60-3. doi:
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Journal of neural transmission. Supplementum.
1989; 28(?):45-52. doi:
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Journal of pharmaceutical and biomedical analysis.
1989; 7(12):1897-901. doi:
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Molecular immunology.
1988 Dec; 25(12):1299-308. doi:
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Journal of chromatography.
1988 Nov; 432(?):334-9. doi:
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1988 Oct; 26(10):495-9. doi:
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1988 Jul; 3(3):205-14. doi:
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The American journal of emergency medicine.
1988 May; 6(3):247-9. doi:
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1988 Feb; 38(2):292-6. doi:
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1987 Oct; 37(10):1179-81. doi:
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Revue d'electroencephalographie et de neurophysiologie clinique.
1987 Sep; 17(3):279-87. doi:
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International clinical psychopharmacology.
1987 Jul; 2(3):239-53. doi:
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The Japanese journal of psychiatry and neurology.
1987 Jun; 41(2):247-54. doi:
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The Japanese journal of psychiatry and neurology.
1987 Jun; 41(2):255-60. doi:
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1987; 89(1):22-42. doi:
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1987; 5(2):151-71. doi:
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Asia-Oceania journal of obstetrics and gynaecology.
1986 Dec; 12(4):517-21. doi:
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1986 Sep; 19(5):362-4. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1986 Aug; 16(8):743-52. doi:
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1986 Jun; 5(6):471-80. doi:
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The Japanese journal of psychiatry and neurology.
1986 Mar; 40(1):47-56. doi:
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Acta psychiatrica Scandinavica.
1986 Feb; 73(2):133-8. doi:
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1986; 15(2):62-7. doi:
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1986; 66(1):47-58. doi:
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1986; 19 Suppl 2(?):79-84. doi:
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