Sotalol hydrochloride (BioDeep_00000399080)

   

natural product


代谢物信息卡片


Sotalol hydrochloride

化学式: C12H21ClN2O3S (308.0961)
中文名称: 盐酸索他洛尔
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(=CC=C(C=C1)NS(C)(=O)=O)C(CNC(C)C)O.Cl
InChI: 1H

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
C93038 - Cation Channel Blocker

同义名列表

2 个代谢物同义名

Sotalol hydrochloride; Sotalol (Betapace)



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Christian Funck-Brentano, Joe-Elie Salem. Influence of baseline QTc on sotalol-induced prolongation of ventricular repolarization in men and women. British journal of clinical pharmacology. 2022 07; 88(7):3510-3515. doi: 10.1111/bcp.15188. [PMID: 34921433]
  • Yuefei Ruan, Hongwen Sun, Yichun Lu, Yanwei Zhang, Jiayao Xu, Hongkai Zhu, Yuhe He. Evaluating phospholipid- and protein-water partitioning of two groups of chemicals of emerging concern: Diastereo- and enantioselectivity. Journal of hazardous materials. 2022 05; 430(?):128499. doi: 10.1016/j.jhazmat.2022.128499. [PMID: 35739679]
  • Lei Xu, Weiqi Meng, Jing Lu, Fengjuan Cui, Lidi Gao, Lin Chen, Yang Xin. Hyphenation of field-amplified sample injection and transient isotachophoresis in CE for the determination of sotalol and metoprolol in human urine samples. Journal of separation science. 2020 Jun; 43(11):2193-2200. doi: 10.1002/jssc.201901165. [PMID: 32068343]
  • Jessica L Jacobson, John C Somberg, Hoang H Nguyen. Intravenous Sotalol for the Treatment of Ventricular Dysrhythmias in an Infant on Extracorporeal Membrane Oxygenation. Pediatric cardiology. 2020 Feb; 41(2):418-422. doi: 10.1007/s00246-019-02225-w. [PMID: 31664485]
  • Yunlu Liu, Lin Wang, Feng Wan, Na Yang. Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs. Drug design, development and therapy. 2020; 14(?):4263-4276. doi: 10.2147/dddt.s268113. [PMID: 33116414]
  • Elyes Dahmane, Kathy Tang, Jogarao V S Gobburu, T Joseph Mattingly, Brent N Reed, Vincent Y See, Joshuha Ayres, Vijay Ivaturi. Clinical Pharmacology-Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy. Clinical and translational science. 2019 11; 12(6):648-656. doi: 10.1111/cts.12670. [PMID: 31328888]
  • Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121793. doi: 10.1016/j.jchromb.2019.121793. [PMID: 31629310]
  • Kenta Watanabe, Tadashi Tsubouchi, Toru Yamada, Eiichi Hinoi, Izuru Miyawaki. Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors. The Journal of toxicological sciences. 2019; 44(7):441-457. doi: 10.2131/jts.44.441. [PMID: 31270301]
  • Joe-Elie Salem, Pauline Dureau, Anne Bachelot, Marine Germain, Pascal Voiriot, Bruno Lebourgeois, David-Alexandre Trégouët, Jean-Sébastien Hulot, Christian Funck-Brentano. Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women. JAMA cardiology. 2018 09; 3(9):877-882. doi: 10.1001/jamacardio.2018.2251. [PMID: 30073300]
  • Saeedeh Ansari, Saeed Masoum. A multi-walled carbon nanotube-based magnetic molecularly imprinted polymer as a highly selective sorbent for ultrasonic-assisted dispersive solid-phase microextraction of sotalol in biological fluids. The Analyst. 2018 Jun; 143(12):2862-2875. doi: 10.1039/c7an02077e. [PMID: 29790490]
  • B Broux, D De Clercq, A Decloedt, L Vera, M Devreese, R Gehring, S Croubels, G van Loon. Pharmacokinetics and electrophysiological effects of sotalol hydrochloride in horses. Equine veterinary journal. 2018 May; 50(3):377-383. doi: 10.1111/evj.12765. [PMID: 29023952]
  • Sonia Goineau, Vincent Castagné. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers. Journal of pharmacological and toxicological methods. 2018 Mar; 90(?):58-66. doi: 10.1016/j.vascn.2017.12.003. [PMID: 29274391]
  • Mariusz Stolarczyk, Anna Apola, Anna Malanka, Anna Kwiecien, Edyta Wrona, Wlodzimierz Opoka. DETERMINATION OF SOTALOL, OXPRENOLOL AND LABETALOL IN BINARY MIXTURES AND IN SPIKED HUMAN SERUM BY DERIVATIVE SPECTROPHOTOMETRIC METHOD. Acta poloniae pharmaceutica. 2017 Jan; 74(1):93-102. doi: . [PMID: 29474765]
  • Chuixiu Huang, Knut Fredrik Seip, Astrid Gjelstad, Stig Pedersen-Bjergaard. Electromembrane extraction of polar basic drugs from plasma with pure bis(2-ethylhexyl) phosphite as supported liquid membrane. Analytica chimica acta. 2016 Aug; 934(?):80-7. doi: 10.1016/j.aca.2016.06.002. [PMID: 27506347]
  • Ester Alves, Nikolay Lukoyanov, Paula Serrão, Daniel Moura, Mónica Moreira-Rodrigues. Epinephrine increases contextual learning through activation of peripheral β2-adrenoceptors. Psychopharmacology. 2016 06; 233(11):2099-2108. doi: 10.1007/s00213-016-4254-5. [PMID: 26935825]
  • Dingxin Qin, George Leef, Mian Bilal Alam, Rohit Rattan, Mohamad Bilal Munir, Divyang Patel, Furqan Khattak, Evan Adelstein, Sandeep K Jain, Samir Saba. Comparative effectiveness of antiarrhythmic drugs for rhythm control of atrial fibrillation. Journal of cardiology. 2016 May; 67(5):471-6. doi: 10.1016/j.jjcc.2015.07.001. [PMID: 26233885]
  • Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama. Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model. Cardiovascular toxicology. 2016 Apr; 16(2):138-46. doi: 10.1007/s12012-015-9322-2. [PMID: 25822712]
  • B Broux, D De Clercq, A Decloedt, S De Baere, M Devreese, N Van Der Vekens, S Ven, S Croubels, G van Loon. Pharmacokinetics of intravenously and orally administered sotalol hydrochloride in horses and effects on surface electrocardiogram and left ventricular systolic function. Veterinary journal (London, England : 1997). 2016 Feb; 208(?):60-4. doi: 10.1016/j.tvjl.2015.09.021. [PMID: 26670333]
  • Zhiping Feng, Siyuan Yu, Wei Liu, Li Yang, Yang Liu, Suodi Zhai, Fang Wang, Xianhua Zhang. A simple and sensitive LC-MS/MS method for the determination of sotalol in rat plasma. Biomedical chromatography : BMC. 2015 Aug; 29(8):1167-72. doi: 10.1002/bmc.3403. [PMID: 25582386]
  • Ryan M Fryer, Khing Jow Ng, Liguo Chi, Xidong Jin, Glenn A Reinhart. Long-term stability, reproducibility, and statistical sensitivity of a telemetry-instrumented dog model: A 27-month longitudinal assessment. Journal of pharmacological and toxicological methods. 2015 Jul; 74(?):26-32. doi: 10.1016/j.vascn.2015.04.007. [PMID: 25946685]
  • M W Rivolta, L T Mainardi, R Sassi. Quantification of ventricular repolarization heterogeneity during moxifloxacin or sotalol administration using [Formula: see text]-index. Physiological measurement. 2015 Apr; 36(4):803-11. doi: 10.1088/0967-3334/36/4/803. [PMID: 25798997]
  • Borje Darpo, Dilip R Karnad, Fabio Badilini, Jeff Florian, Christine E Garnett, Snehal Kothari, Gopi Krishna Panicker, Nenad Sarapa. Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol. British journal of clinical pharmacology. 2014 Mar; 77(3):522-31. doi: 10.1111/bcp.12201. [PMID: 23819796]
  • Feras Khalil, Stephanie Läer. Physiologically based pharmacokinetic models in the prediction of oral drug exposure over the entire pediatric age range-sotalol as a model drug. The AAPS journal. 2014 Mar; 16(2):226-39. doi: 10.1208/s12248-013-9555-6. [PMID: 24399240]
  • Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):581-94. doi: 10.1093/toxsci/kft205. [PMID: 24052561]
  • Tristan Juvet, Venkata C Gourineni, Sandeep Ravi, Stuart W Zarich. Life-threatening hyperkalemia: a potentially lethal drug combination. Connecticut medicine. 2013 Sep; 77(8):491-3. doi: NULL. [PMID: 24156179]
  • Daniel M DeLillo, Sophy A Jesty, Marcy J Souza. Episodic syncope caused by ventricular flutter in a tiger (Panthera tigris). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2013 Jun; 44(2):500-4. doi: 10.1638/2012-0203.1. [PMID: 23805576]
  • Ali A Ensafi, Ali R Allafchian, B Rezaei, R Mohammadzadeh. Characterization of carbon nanotubes decorated with NiFe2O4 magnetic nanoparticles as a novel electrochemical sensor: application for highly selective determination of sotalol using voltammetry. Materials science & engineering. C, Materials for biological applications. 2013 Jan; 33(1):202-8. doi: 10.1016/j.msec.2012.08.031. [PMID: 25428063]
  • Jeonghyeon Park, Keumhan Noh, Hae Won Lee, Mi-sun Lim, Sook Jin Seong, Jeong Ju Seo, Eun-Jung Kim, Wonku Kang, Young-Ran Yoon. Pharmacometabolomic approach to predict QT prolongation in guinea pigs. PloS one. 2013; 8(4):e60556. doi: 10.1371/journal.pone.0060556. [PMID: 23593245]
  • Wei Liu, Hideaki Okochi, Leslie Z Benet, Suo-Di Zhai. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Pharmaceutical research. 2012 Jul; 29(7):1768-74. doi: 10.1007/s11095-012-0699-3. [PMID: 22350803]
  • John C Somberg, Richard A Preston, Vasant Ranade, Ivana Cvetanovic, Janos Molnar. Gender differences in cardiac repolarization following intravenous sotalol administration. Journal of cardiovascular pharmacology and therapeutics. 2012 Mar; 17(1):86-92. doi: 10.1177/1074248411406505. [PMID: 21527783]
  • Li Zhang, Xiaoli Su, Chenggong Zhang, Li Ouyang, Qingji Xie, Ming Ma, Shouzhuo Yao. Extraction and preconcentration of beta-blockers in human urine for analysis with high performance liquid chromatography by means of carrier-mediated liquid phase microextraction. Talanta. 2010 Aug; 82(3):984-92. doi: 10.1016/j.talanta.2010.06.003. [PMID: 20678656]
  • Anna R M Gelzer, Marc S Kraus, Mark Rishniw, Shari A Hemsley, N Sydney Moïse. Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 2010 Aug; 12(2):93-106. doi: 10.1016/j.jvc.2010.06.001. [PMID: 20663731]
  • John C Somberg, Richard A Preston, Vasant Ranade, Janos Molnar. Developing a safe intravenous sotalol dosing regimen. American journal of therapeutics. 2010 Jul; 17(4):365-72. doi: 10.1097/mjt.0b013e3181ea3184. [PMID: 20562595]
  • Christopher Keating, Vicente Martinez, Lorna Ewart, Stephen Gibbons, Luke Grundy, Jean-Pierre Valentin, David Grundy. The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions. Toxicology and applied pharmacology. 2010 Jun; 245(3):299-309. doi: 10.1016/j.taap.2010.03.014. [PMID: 20350559]
  • Lihui Zheng, Lan Zhang, Ping Tong, Xinyu Zheng, Yuwu Chi, Guonan Chen. Highly sensitive transient isotachophoresis sample stacking coupling with capillary electrophoresis-amperometric detection for analysis of doping substances. Talanta. 2010 Jun; 81(4-5):1288-94. doi: 10.1016/j.talanta.2010.02.023. [PMID: 20441897]
  • Stefan R Braam, Leon Tertoolen, Anja van de Stolpe, Thomas Meyer, Robert Passier, Christine L Mummery. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem cell research. 2010 Mar; 4(2):107-16. doi: 10.1016/j.scr.2009.11.004. [PMID: 20034863]
  • Verena C Mulder, Heleen M H Oudemans-Van Straaten, Durk F Zandstra, Eric J F Franssen. Massive ingestion of cardiac drugs: toxicokinetic aspects of digoxin and sotalol during hemofiltration. Clinical toxicology (Philadelphia, Pa.). 2010 Mar; 48(3):218-21. doi: 10.3109/15563650903544132. [PMID: 20136482]
  • John C Somberg, Richard A Preston, Vasant Ranade, Janos Molnar. QT prolongation and serum sotalol concentration are highly correlated following intravenous and oral sotalol. Cardiology. 2010; 116(3):219-25. doi: 10.1159/000316050. [PMID: 20693799]
  • Vincent Michiels, Hielko Miljoen, Christiaan Vrints. Gastroenteritis with severe consequences: a case of sotalol-induced torsades de pointes. Acta cardiologica. 2009 Dec; 64(6):839-42. doi: 10.2143/ac.64.6.2044756. [PMID: 20128168]
  • Joel Xue, Weihua Gao, Yao Chen, Xiaodong Han. Identify drug-induced T wave morphology changes by a cell-to-electrocardiogram model and validation with clinical trial data. Journal of electrocardiology. 2009 Nov; 42(6):534-42. doi: 10.1016/j.jelectrocard.2009.07.010. [PMID: 19700171]
  • Robert W Bolderman, J J Rob Hermans, Leonard M Rademakers, Tim S Jansen, Sander Verheule, Frederik H van der Veen, Jos G Maessen. Intrapericardial delivery of amiodarone and sotalol: atrial transmural drug distribution and electrophysiological effects. Journal of cardiovascular pharmacology. 2009 Oct; 54(4):355-63. doi: 10.1097/fjc.0b013e3181bad042. [PMID: 19701096]
  • Irena Baranowska, Andrzej Wilczek. Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2009 Jun; 25(6):769-72. doi: 10.2116/analsci.25.769. [PMID: 19531885]
  • A Srivastava, M Ahmed Khan, J Watkiss. Post induction arrhythmia in a renal patient: an unexpected risk factor. Anaesthesia. 2009 Apr; 64(4):439-43. doi: 10.1111/j.1365-2044.2008.05783.x. [PMID: 19317712]
  • Tomomichi Ishizaka, Yu Yoshimatsu, Minori Ozawa, Tomofumi Kimotsuki, Wataru Takasaki, Sunao Manabe, Mitsuya Yasuda. Evaluation of drug-induced QT prolongation in a halothane-anesthetized monkey model: effects of sotalol. Journal of pharmacological and toxicological methods. 2009 Mar; 59(2):86-93. doi: 10.1016/j.vascn.2009.01.002. [PMID: 19367688]
  • N A Mazur, F M Khezheva. [Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension]. Kardiologiia. 2009; 49(2):27-31. doi: NULL. [PMID: 19254213]
  • Claus Graff, Mads P Andersen, Joel Q Xue, Thomas B Hardahl, Jørgen K Kanters, Egon Toft, Michael Christiansen, Henrik K Jensen, Johannes J Struijk. Identifying drug-induced repolarization abnormalities from distinct ECG patterns in congenital long QT syndrome: a study of sotalol effects on T-wave morphology. Drug safety. 2009; 32(7):599-611. doi: 10.2165/00002018-200932070-00006. [PMID: 19530746]
  • Jean-Philippe Couderc, Meijian Zhou, Nenad Sarapa, Wojciech Zareba. Investigating the effect of sotalol on the repolarization intervals in healthy young individuals. Journal of electrocardiology. 2008 Nov; 41(6):595-602. doi: 10.1016/j.jelectrocard.2008.06.013. [PMID: 18801493]
  • Jens Mortensen, Uffe Holst, Jørn Skibsted Jakobsen, Frederik Andreasen. Endoluminal norepinephrine inhibits smooth muscle activity of the pig pyeloureter by stimulation of beta-adrenoceptors without side effects. Basic & clinical pharmacology & toxicology. 2008 Nov; 103(5):455-60. doi: 10.1111/j.1742-7843.2008.00297.x. [PMID: 18713234]
  • Courtney J Collins, Alfonso Berduque, Damien W M Arrigan. Electrochemically modulated liquid-liquid extraction of ionized drugs under physiological conditions. Analytical chemistry. 2008 Nov; 80(21):8102-8. doi: 10.1021/ac800646b. [PMID: 18841995]
  • Mitsuyasu Tabo, Toshiko Hara, Sachiko Sone, Nobuyuki Shishido, Shino Kuramoto, Kounosuke Nakano, Hideko Onodera, Kazuya Kimura, Kazuko Kobayashi. Prediction of drug-induced QT interval prolongation in telemetered common marmosets. The Journal of toxicological sciences. 2008 Aug; 33(3):315-25. doi: 10.2131/jts.33.315. [PMID: 18670163]
  • J J Lynch, A W Wilson, L E Hernandez, R A Nelson, K C Marsh, B F Cox, S W Mittelstadt. Dose-response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys. British journal of pharmacology. 2008 Aug; 154(7):1439-45. doi: 10.1038/bjp.2008.206. [PMID: 18516073]
  • Mieko Yorimitsu, Shoshiro Okada, Naoko Yamaguchi-Shima, Takahiro Shimizu, Junichi Arai, Kunihiko Yokotani. Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats. Life sciences. 2008 Feb; 82(9-10):487-94. doi: 10.1016/j.lfs.2007.12.006. [PMID: 18201726]
  • M Stockburger, L Gerhardt, S Helms, M Schlegl, C Butter. Bifocal versus unifocal right atrial pacing under plasma level controlled sotalol to prevent atrial fibrillation in patients with symptomatic sinus bradycardia and paroxysmal atrial fibrillation. Herzschrittmachertherapie & Elektrophysiologie. 2007 Dec; 18(4):250-8. doi: 10.1007/s00399-007-0582-9. [PMID: 18084799]
  • Anthony A Fossa, Todd Wisialowski, Kimberly Crimin, Eric Wolfgang, Jean-Philippe Couderc, Martin Hinterseer, Stefan Kaab, Wojciech Zareba, Fabio Badilini, Nenad Sarapa. Analyses of dynamic beat-to-beat QT-TQ interval (ECG restitution) changes in humans under normal sinus rhythm and prior to an event of torsades de pointes during QT prolongation caused by sotalol. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2007 Oct; 12(4):338-48. doi: 10.1111/j.1542-474x.2007.00183.x. [PMID: 17970959]
  • Herbert M Himmel. Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential. Journal of pharmacological and toxicological methods. 2007 Sep; 56(2):145-58. doi: 10.1016/j.vascn.2007.04.004. [PMID: 17590357]
  • James T Limberis, Jeff S McDermott, Heinz J Salmen, Zhi Su, Ann Mikhail, Jonathon R Green, Bryan F Cox, Gary A Gintant, Ruth L Martin. The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol. Journal of pharmacological and toxicological methods. 2007 Jul; 56(1):11-7. doi: 10.1016/j.vascn.2007.01.001. [PMID: 17350293]
  • Shuijun Li, Gangyi Liu, Jingying Jia, Yun Liu, Cheng Pan, Chen Yu, Yongbao Cai, Jianying Ren. Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Mar; 847(2):174-81. doi: 10.1016/j.jchromb.2006.10.013. [PMID: 17113839]
  • S G Kanorskiĭ, V V Bodrikova, Iu S Kanorskaia. [Influence of perindopril, rosuvastatin, or omega-3 polyunsaturated fatty acids on efficacy of antirecurrence therapy with sotalol in patients with persistent atrial fibrillation]. Kardiologiia. 2007; 47(12):39-44. doi: . [PMID: 18260977]
  • Thomas Vormberge, Michael Hoffmann, Herbert Himmel. Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve. Journal of pharmacological and toxicological methods. 2006 Sep; 54(2):130-40. doi: 10.1016/j.vascn.2006.03.011. [PMID: 16757186]
  • A Zarghi, S M Foroutan, A Shafaati, A Khoddam. Development an ion-pair liquid chromatographic method for determination of sotalol in plasma using a monolithic column. Journal of pharmaceutical and biomedical analysis. 2006 Jun; 41(4):1433-7. doi: 10.1016/j.jpba.2006.03.007. [PMID: 16682163]
  • Fátima da Silva Leite, Valéria Adriana Pereira, Célia Etsuco Omosako, Maria José Carvalho Carmona, José Otávio Costa Auler, Silvia Regina Cavani Jorge Santos. A micromethod for the quantification of atenolol in plasma using high-performance liquid chromatography with fluorescence detection: therapeutic drug monitoring of two patients with severe coronary insufficiency before cardiac surgery. Therapeutic drug monitoring. 2006 Apr; 28(2):237-44. doi: 10.1097/01.ftd.0000198647.39751.f5. [PMID: 16628137]
  • Josep Rotllant, Neil M Ruane, Maria T Dinis, Adelino V M Canario, Deborah M Power. Intra-adrenal interactions in fish: catecholamine stimulated cortisol release in sea bass (Dicentrarchus labrax L.). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2006 Mar; 143(3):375-81. doi: 10.1016/j.cbpa.2005.12.027. [PMID: 16443381]
  • Jan-Peer Elshoff, Stephanie Läer. Development of an intravenous microdialysis method for pharmacokinetic investigations in humans. Journal of pharmacological and toxicological methods. 2005 Sep; 52(2):251-9. doi: 10.1016/j.vascn.2005.01.001. [PMID: 16125623]
  • Jean-Louis Démolis, Soraya Strabach, Françoise Vacheron, Christian Funck-Brentano. Assessment of the effect of a single oral dose of telithromycin on sotalol-induced qt interval prolongation in healthy women. British journal of clinical pharmacology. 2005 Aug; 60(2):120-7. doi: 10.1111/j.1365-2125.2005.02395.x. [PMID: 16042664]
  • Tung Si Ho, Jan Leon Egge Reubsaet, Hanne Sofie Anthonsen, Stig Pedersen-Bjergaard, Knut Einar Rasmussen. Liquid-phase microextraction based on carrier mediated transport combined with liquid chromatography-mass spectrometry. New concept for the determination of polar drugs in a single drop of human plasma. Journal of chromatography. A. 2005 Apr; 1072(1):29-36. doi: 10.1016/j.chroma.2004.11.078. [PMID: 15881456]
  • Hiroshi Sawada, Kenji Takami, Satoru Asahi. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Feb; 83(2):282-92. doi: 10.1093/toxsci/kfh264. [PMID: 15342952]
  • Mayumi Kano, Tohru Toyoshi, Sakae Iwasaki, Masami Kato, Masayoshi Shimizu, Takao Ota. QT PRODACT: usability of miniature pigs in safety pharmacology studies: assessment for drug-induced QT interval prolongation. Journal of pharmacological sciences. 2005; 99(5):501-11. doi: 10.1254/jphs.qt-c13. [PMID: 16493190]
  • Christian Wolpert, Rainer Schimpf, Carla Giustetto, Charles Antzelevitch, Jonathan Cordeiro, Robert Dumaine, Ramon Brugada, Kui Hong, Urs Bauersfeld, Fiorenzo Gaita, Martin Borggrefe. Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. Journal of cardiovascular electrophysiology. 2005 Jan; 16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x. [PMID: 15673388]
  • Aryan N Mooss, Richard L Wurdeman, Jeffrey T Sugimoto, Kathleen A Packard, Daniel E Hilleman, Thomas L Lenz, Karen S Rovang, Joseph M Arcidi, Syed M Mohiuddin. Amiodarone versus sotalol for the treatment of atrial fibrillation after open heart surgery: the Reduction in Postoperative Cardiovascular Arrhythmic Events (REDUCE) trial. American heart journal. 2004 Oct; 148(4):641-8. doi: 10.1016/j.ahj.2004.04.031. [PMID: 15459595]
  • Thomas J van Brakel, J J Rob Hermans, Ben J Janssen, Helma van Essen, Nicole Botterhuis, Jos F M Smits, Jos G Maessen. Intrapericardial delivery enhances cardiac effects of sotalol and atenolol. Journal of cardiovascular pharmacology. 2004 Jul; 44(1):50-6. doi: 10.1097/00005344-200407000-00007. [PMID: 15175557]
  • Tetsuya Saita, Hiroshi Fujito, Yukitaka Nakano, Masato Mori. Establishment of an enzyme-linked immunosorbent assay for measurement of sotalol. Biological & pharmaceutical bulletin. 2004 Jan; 27(1):94-6. doi: 10.1248/bpb.27.94. [PMID: 14709906]
  • Nancy M Allen LaPointe, Anita Chen, Bradley Hammill, Elizabeth DeLong, Judith M Kramer, Robert M Califf. Evaluation of the dofetilide risk-management program. American heart journal. 2003 Nov; 146(5):894-901. doi: 10.1016/s0002-8703(03)00409-5. [PMID: 14597941]
  • Elena Badaloni, Ilaria D'Acquarica, Francesco Gasparrini, Silvana Lalli, Domenico Misiti, Franco Pazzucconi, Cesare R Sirtori. Enantioselective liquid chromatographic-electrospray mass spectrometric assay of beta-adrenergic blockers: application to a pharmacokinetic study of sotalol in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Oct; 796(1):45-54. doi: 10.1016/j.jchromb.2003.07.001. [PMID: 14552815]
  • Martijn A Oudijk, Jopje M Ruskamp, F F Tessa Ververs, E Barbara Ambachtsheer, Philip Stoutenbeek, Gerard H A Visser, Erik J Meijboom. Treatment of fetal tachycardia with sotalol: transplacental pharmacokinetics and pharmacodynamics. Journal of the American College of Cardiology. 2003 Aug; 42(4):765-70. doi: 10.1016/s0735-1097(03)00779-4. [PMID: 12932617]
  • O Rbeida, B Christiaens, P Chiap, Ph Hubert, D Lubda, K-S Boos, J Crommen. Fully automated LC method for the determination of sotalol in human plasma using restricted access material with cation exchange properties for sample clean-up. Journal of pharmaceutical and biomedical analysis. 2003 Aug; 32(4-5):829-38. doi: 10.1016/s0731-7085(03)00186-9. [PMID: 12899969]
  • Weeranuj Yamreudeewong, Michael DeBisschop, Linda G Martin, Dennis L Lower. Potentially significant drug interactions of class III antiarrhythmic drugs. Drug safety. 2003; 26(6):421-38. doi: 10.2165/00002018-200326060-00004. [PMID: 12688833]
  • Michael Schlauch, Katrin Fulde, August W Frahm. Enantioselective determination of (R)- and (S)-sotalol in human plasma by on-line coupling of a restricted-access material precolumn to a cellobiohydrolase I-based chiral stationary phase. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Aug; 775(2):197-207. doi: 10.1016/s1570-0232(02)00287-8. [PMID: 12113986]
  • Shoshiro Okada, Yoshinori Murakami, Kunihiko Yokotani. Centrally applied nitric oxide donor elevates plasma corticosterone by activation of the hypothalamic noradrenergic neurons in rats. Brain research. 2002 Jun; 939(1-2):26-33. doi: 10.1016/s0006-8993(02)02540-4. [PMID: 12020848]
  • J Shi, T M Ludden, A P Melikian, M R Gastonguay, P H Hinderling. Population pharmacokinetics and pharmacodynamics of sotalol in pediatric patients with supraventricular or ventricular tachyarrhythmia. Journal of pharmacokinetics and pharmacodynamics. 2001 Dec; 28(6):555-75. doi: 10.1023/a:1014412521191. [PMID: 11999292]
  • S S Chugh, S B Johnson, D L Packer. Amplified effects of d,l-sotalol in canine dilated cardiomyopathy. Pacing and clinical electrophysiology : PACE. 2001 Dec; 24(12):1783-8. doi: 10.1046/j.1460-9592.2001.01783.x. [PMID: 11817813]
  • L C da Cunha, F A Gondim, A A de Paola, I C Barros, S R Santos. An improved HPLC-fluorescence stereoselective method for analysis of (+)-S- and (-)-R-sotalol enantiomers in plasma sample. Bollettino chimico farmaceutico. 2001 Nov; 140(6):448-54. doi: NULL. [PMID: 11822237]
  • G A Gintant, J T Limberis, J S McDermott, C D Wegner, B F Cox. The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis. Journal of cardiovascular pharmacology. 2001 May; 37(5):607-18. doi: 10.1097/00005344-200105000-00012. [PMID: 11336111]
  • K M Kulmatycki, K Abouchehade, S Sattari, F Jamali. Drug-disease interactions: reduced beta-adrenergic and potassium channel antagonist activities of sotalol in the presence of acute and chronic inflammatory conditions in the rat. British journal of pharmacology. 2001 May; 133(2):286-94. doi: 10.1038/sj.bjp.0704067. [PMID: 11350865]
  • S Läer, I Wauer, H Scholz. Small blood volumes from children for quantitative sotalol determination using high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2001 Apr; 753(2):421-5. doi: 10.1016/s0378-4347(00)00562-4. [PMID: 11334359]
  • J P Saul, B Ross, M S Schaffer, L Beerman, A P Melikian, J Shi, J Williams, J T Barbey, J Jin, P H Hinderling. Pharmacokinetics and pharmacodynamics of sotalol in a pediatric population with supraventricular and ventricular tachyarrhythmia. Clinical pharmacology and therapeutics. 2001 Mar; 69(3):145-57. doi: 10.1067/mcp.2001.113795. [PMID: 11240979]
  • P Chiap, A Ceccato, B Miralles Buraglia, B Boulanger, P Hubert, J Crommen. Development and validation of an automated method for the liquid chromatographic determination of sotalol in plasma using dialysis and trace enrichment on a cation-exchange pre-column as on-line sample preparation. Journal of pharmaceutical and biomedical analysis. 2001 Mar; 24(5-6):801-14. doi: 10.1016/s0731-7085(00)00547-1. [PMID: 11248472]
  • J P Saul, M S Schaffer, P P Karpawich, C C Erickson, M R Epstein, A P Melikian, J Shi, A H Karara, B Cai, P H Hinderling. Single-dose pharmacokinetics of sotalol in a pediatric population with supraventricular and/or ventricular tachyarrhythmia. Journal of clinical pharmacology. 2001 Jan; 41(1):35-43. doi: 10.1177/00912700122009818. [PMID: 11144992]
  • S A Doggrell, L Brown. D-Sotalol: death by the SWORD or deserving of further consideration for clinical use?. Expert opinion on investigational drugs. 2000 Jul; 9(7):1625-34. doi: 10.1517/13543784.9.7.1625. [PMID: 11060766]
  • S R Santos, O Papini, C E Omosako, M D Pereira, T B Quintavalle, M F Riccio, A Kurata, V A Pereira, G Di-Pietro, O E Della-Paschoa, M Danhof, P L Da-Luz. A simple HPLC-fluorescence method for the measurement of R,S-sotalol in the plasma of patients with life-threatening cardiac arrhythmias. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2000 Feb; 33(2):199-204. doi: 10.1590/s0100-879x2000000200006. [PMID: 10657059]
  • L Oleksowicz, P Escott, G C Leichman, E Spangenthal. Sustained ventricular tachycardia and its successful prophylaxis during high-dose bolus interleukin-2 therapy for metastatic renal cell carcinoma. American journal of clinical oncology. 2000 Feb; 23(1):34-6. doi: 10.1097/00000421-200002000-00009. [PMID: 10683072]
  • M Silomon, F Bach, S Juckenhöfel, T Claus, G Molter. [Bioavailability of sotalol in short bowel syndrome]. Medizinische Klinik (Munich, Germany : 1983). 1999 Nov; 94(11):638-41. doi: 10.1007/bf03045005. [PMID: 10603736]
  • J Merot, F Charpentier, J M Poirier, G Coutris, J Weissenburger. Effects of chronic treatment by amiodarone on transmural heterogeneity of canine ventricular repolarization in vivo: interactions with acute sotalol. Cardiovascular research. 1999 Nov; 44(2):303-14. doi: 10.1016/s0008-6363(99)00232-1. [PMID: 10690307]
  • J T Barbey, M E Sale, R L Woosley, J Shi, A P Melikian, P H Hinderling. Pharmacokinetic, pharmacodynamic, and safety evaluation of an accelerated dose titration regimen of sotalol in healthy middle-aged subjects. Clinical pharmacology and therapeutics. 1999 Jul; 66(1):91-9. doi: 10.1016/s0009-9236(99)70058-5. [PMID: 10430114]
  • M Kirjavainen, A Urtti, R Valjakka-Koskela, J Kiesvaara, J Mönkkönen. Liposome-skin interactions and their effects on the skin permeation of drugs. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 1999 Mar; 7(4):279-86. doi: 10.1016/s0928-0987(98)00037-2. [PMID: 9971910]
  • M Patten, H P Koch, F Sonntag, B Lüderitz, T Meinertz. [Medicamentous prevention of symptomatic paroxysmal atrial fibrillation/flutter onset. Goals and design of the SOPAT Study. Executive committee of the investigators representing trial physicians]. Zeitschrift fur Kardiologie. 1999 Mar; 88(3):185-94. doi: 10.1007/s003920050275. [PMID: 10355069]
  • M H Lehmann, S Hardy, D Archibald, D J MacNeil. JTc prolongation with d,l-sotalol in women versus men. The American journal of cardiology. 1999 Feb; 83(3):354-9. doi: 10.1016/s0002-9149(98)00868-6. [PMID: 10072223]
  • J Bathen, S Madsen. [Sotalol--atrial fibrillation, reduced renal function and sudden death]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 1998 Oct; 118(26):4086-7. doi: NULL. [PMID: 9844513]
  • K J Ascah, G A Rock, P S Wells. Interaction between fenofibrate and warfarin. The Annals of pharmacotherapy. 1998 Jul; 32(7-8):765-8. doi: 10.1345/aph.17310. [PMID: 9681093]
  • J Reisinger, E Gatterer, G Heinze, K Wiesinger, E Zeindlhofer, M Gattermeier, G Poelzl, H Kratzer, A Ebner, W Hohenwallner, K Lenz, J Slany, P Kuhn. Prospective comparison of flecainide versus sotalol for immediate cardioversion of atrial fibrillation. The American journal of cardiology. 1998 Jun; 81(12):1450-4. doi: 10.1016/s0002-9149(98)00223-9. [PMID: 9645896]