Mitoxantrone hydrochloride (BioDeep_00000399074)
natural product
代谢物信息卡片
Mitoxantrone (dihydrochloride)
化学式: C22H30Cl2N4O6 (516.15423)
中文名称: 米托蒽醌二盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC(=C2C(=C1O)C(C3=C(C2=O)C(=CC=C3NCCNCCO)NCCNCCO)=O)O).Cl.Cl
InChI: 2*1H
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:50727
- KEGGdrug: D02166
- PubChem: 51082
- ChEMBL: CHEMBL1417019
- MeSH: Mitoxantrone
- CAS: 70476-82-3
- CAS: 70476-82-3, 65271-80-9 (free base), 70711-41-0 (diacetate)
- MoNA: CCMSLIB00000078486
- MoNA: CCMSLIB00000078485
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ana Dias-Carvalho, Ana Margarida-Araújo, Ana Reis-Mendes, Catarina Oliveira Sequeira, Sofia Azeredo Pereira, Paula Guedes de Pinho, Félix Carvalho, Susana Isabel Sá, Eduarda Fernandes, Vera Marisa Costa. A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study.
International journal of molecular sciences.
2023 Aug; 24(17):. doi:
10.3390/ijms241713126. [PMID: 37685929] - Andreia Granja, Rita Lima-Sousa, Cátia G Alves, Duarte de Melo-Diogo, Cláudia Nunes, Célia T Sousa, Ilídio J Correia, Salette Reis. Multifunctional targeted solid lipid nanoparticles for combined photothermal therapy and chemotherapy of breast cancer.
Biomaterials advances.
2023 Aug; 151(?):213443. doi:
10.1016/j.bioadv.2023.213443. [PMID: 37146526] - Mengting Jia, Yang Xiao, Caiyong Zhang, Tianyu Jiang, Yuxin Huang, Jiayi Gao, Yixing Li, Lei Zhou. Mitoxantrone alleviates hepatic steatosis induced by high-fat diet in broilers.
Biochemical and biophysical research communications.
2022 10; 627(?):52-59. doi:
10.1016/j.bbrc.2022.08.042. [PMID: 36007336] - Andreia Granja, Cláudia Nunes, Célia T Sousa, Salette Reis. Folate receptor-mediated delivery of mitoxantrone-loaded solid lipid nanoparticles to breast cancer cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113525. doi:
10.1016/j.biopha.2022.113525. [PMID: 36049314] - Hao-Hua Deng, Hui-Jing Yang, Kai-Yuan Huang, Yi-Jing Zheng, Ying-Ying Xu, Hua-Ping Peng, Yin-Huan Liu, Wei Chen, Guo-Lin Hong. Antenna effect of pyridoxal phosphate on the fluorescence of mitoxantrone-silicon nanoparticles and its application in alkaline phosphatase assay.
Analytical and bioanalytical chemistry.
2022 Jul; 414(17):4877-4884. doi:
10.1007/s00216-022-04110-7. [PMID: 35576012] - Zhiwang Zhang, Zupeng Luo, Lin Yu, Yang Xiao, Siqi Liu, Zhier ALuo, Zeqiang Ma, Liang Huang, Lianggui Xiao, Mengting Jia, Ziyi Song, Haojie Zhang, Yixing Li, Lei Zhou. Ruthenium 360 and mitoxantrone inhibit mitochondrial calcium uniporter channel to prevent liver steatosis induced by high-fat diet.
British journal of pharmacology.
2022 06; 179(11):2678-2696. doi:
10.1111/bph.15767. [PMID: 34862596] - Qi Zhang, Peter Radvak, Juhyung Lee, Yue Xu, Vivian Cao-Dao, Miao Xu, Wei Zheng, Catherine Z Chen, Hang Xie, Yihong Ye. Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection.
Scientific reports.
2022 04; 12(1):6294. doi:
10.1038/s41598-022-10293-x. [PMID: 35440680] - Xuan Yu, Meng Wang, Huimin Wang, Xiaoliang Ren, Miaomiao Jiang, Yan Zhu, Deqin Zhang. An application of p-sulfonatocalix[6]arenes to attenuate cardiotoxicity of mitoxantrone in vitro: preparation, characterization and evaluation.
The Journal of pharmacy and pharmacology.
2022 Jan; 74(1):41-56. doi:
10.1093/jpp/rgab154. [PMID: 34986225] - P M Emeka, H I M Ibrahim, I A Alhaider, M A Morsy, M E Mohamed. Subchronic administration of mitoxantrone and the influence of enzyme inhibitors on its induced cardiotoxicity in mice: role of NRF-2/CYP2E1.
European review for medical and pharmacological sciences.
2021 Dec; 25(24):7806-7822. doi:
10.26355/eurrev_202112_27627. [PMID: 34982442] - Martyna Lis, Natalia Niedziela, Maria Nowak-Kiczmer, Katarzyna Kubicka-Bączyk, Monika Adamczyk-Sowa. Calcium-phosphate homeostasis in secondary progressive multiple sclerosis patients during mitoxantrone therapy.
Neurological research.
2021 Dec; 43(12):1050-1055. doi:
10.1080/01616412.2021.1949683. [PMID: 34240684] - Kiran Bharat Lokhande, Sayali Doiphode, Renu Vyas, K Venkateswara Swamy. Molecular docking and simulation studies on SARS-CoV-2 Mpro reveals Mitoxantrone, Leucovorin, Birinapant, and Dynasore as potent drugs against COVID-19.
Journal of biomolecular structure & dynamics.
2021 11; 39(18):7294-7305. doi:
10.1080/07391102.2020.1805019. [PMID: 32815481] - Andreia Granja, Rita Lima-Sousa, Cátia G Alves, Duarte de Melo-Diogo, Marina Pinheiro, Célia T Sousa, Ilídio J Correia, Salette Reis. Mitoxantrone-loaded lipid nanoparticles for breast cancer therapy - Quality-by-design approach and efficacy assessment in 2D and 3D in vitro cancer models.
International journal of pharmaceutics.
2021 Sep; 607(?):121044. doi:
10.1016/j.ijpharm.2021.121044. [PMID: 34450227] - Asvelt J Nduwumwami, Jeremy A Hengst, Jong K Yun. Sphingosine Kinase Inhibition Enhances Dimerization of Calreticulin at the Cell Surface in Mitoxantrone-Induced Immunogenic Cell Death.
The Journal of pharmacology and experimental therapeutics.
2021 09; 378(3):300-310. doi:
10.1124/jpet.121.000629. [PMID: 34158403] - Zhiwang Zhang, Siqi Liu, Yilin Qi, Zhier Aluo, Lifang Zhang, Lin Yu, Qiang Li, Zupeng Luo, Zheng Sun, Lei Zhou, Yixing Li. Calcium supplementation relieves high-fat diet-induced liver steatosis by reducing energy metabolism and promoting lipolysis.
The Journal of nutritional biochemistry.
2021 08; 94(?):108645. doi:
10.1016/j.jnutbio.2021.108645. [PMID: 33838230] - Anthony T Reder, Diego Centonze, Maria L Naylor, Anjali Nagpal, Rajani Rajbhandari, Arman Altincatal, Michelle Kim, Aaron Berdofe, Maha Radhakrishnan, Eunice Jung, Alfred W Sandrock, Karen Smirnakis, Catrinel Popescu, Carl de Moor. COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies.
CNS drugs.
2021 03; 35(3):317-330. doi:
10.1007/s40263-021-00804-1. [PMID: 33743151] - Rong Yang, Zhenxing Chen, Fuda Xie, Mingxiang Xie, Na Liu, Ziren Su, Jiangyong Gu, Ruizhi Zhao. (+/-)-Borneol Reverses Mitoxantrone Resistance against P-Glycoprotein.
Journal of chemical information and modeling.
2021 01; 61(1):252-262. doi:
10.1021/acs.jcim.0c00892. [PMID: 33378196] - Sameer Salunkhe, Saket V Mishra, Atanu Ghorai, Aarti Hole, Pratik Chandrani, Amit Dutt, Murali Chilakapati, Shilpee Dutt. Metabolic rewiring in drug resistant cells exhibit higher OXPHOS and fatty acids as preferred major source to cellular energetics.
Biochimica et biophysica acta. Bioenergetics.
2020 12; 1861(12):148300. doi:
10.1016/j.bbabio.2020.148300. [PMID: 32858000] - Kuo-Ching Mei, Yu-Pei Liao, Jinhong Jiang, Michelle Chiang, Mercedeh Khazaieli, Xiangsheng Liu, Xiang Wang, Qi Liu, Chong Hyun Chang, Xiao Zhang, Juan Li, Ying Ji, Brenda Melano, Donatello Telesca, Tian Xia, Huan Meng, Andre E Nel. Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.
ACS nano.
2020 10; 14(10):13343-13366. doi:
10.1021/acsnano.0c05194. [PMID: 32940463] - Kirk E Cahill, Yasmin H Karimi, Theodore G Karrison, Nitin Jain, Margaret Green, Howard Weiner, Noreen Fulton, Sabah Kadri, Lucy A Godley, Andrew S Artz, Hongtao Liu, Michael J Thirman, Michelle M Le Beau, Megan E McNerney, Jeremy Segal, Richard A Larson, Wendy Stock, Olatoyosi Odenike. A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia.
Blood advances.
2020 02; 4(4):599-606. doi:
10.1182/bloodadvances.2019000795. [PMID: 32074275] - Parth Kapoor, Deborah A Briggs, Megan H Cox, Ian D Kerr. Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis.
International journal of molecular sciences.
2020 Jan; 21(3):. doi:
10.3390/ijms21030759. [PMID: 31979415] - Abbas A Ridha, Soheila Kashanian, Abbas H Azandaryani, Ronak Rafipour, Elahe Mahdavian. New Folate-Modified Human Serum Albumin Conjugated to Cationic Lipid Carriers for Dual Targeting of Mitoxantrone against Breast Cancer.
Current pharmaceutical biotechnology.
2020; 21(4):305-315. doi:
10.2174/1389201020666191114113022. [PMID: 31729941] - Wenji Zhang, Yang Yang, Zizheng Dong, Zhi Shi, Jian-Ting Zhang. Single-nucleotide polymorphisms in a short basic motif in the ABC transporter ABCG2 disable its trafficking out of endoplasmic reticulum and reduce cell resistance to anticancer drugs.
The Journal of biological chemistry.
2019 12; 294(52):20222-20232. doi:
10.1074/jbc.ra119.008347. [PMID: 31719146] - Xiaoqing Fan, Jie Bai, Shengyu Zhao, Minwan Hu, Yanhong Sun, Baolian Wang, Ming Ji, Jing Jin, Xiaojian Wang, Jinping Hu, Yan Li. Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship.
Toxicology in vitro : an international journal published in association with BIBRA.
2019 Dec; 61(?):104642. doi:
10.1016/j.tiv.2019.104642. [PMID: 31493543] - Lili Dong, Shengqiang Shen, Wei Chen, Dongdong Xu, Qing Yang, Huizhe Lu, Jianjun Zhang. Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation.
Journal of chemical information and modeling.
2019 10; 59(10):4374-4382. doi:
10.1021/acs.jcim.9b00479. [PMID: 31487462] - Mandeep Atwal, Rebecca L Swan, Chloe Rowe, Ka C Lee, David C Lee, Lyle Armstrong, Ian G Cowell, Caroline A Austin. Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations.
Molecular pharmacology.
2019 10; 96(4):475-484. doi:
10.1124/mol.119.117259. [PMID: 31399497] - Zhen Li, Jialong Fan, Chunyi Tong, Hongyan Zhou, Wenmiao Wang, Bin Li, Bin Liu, Wei Wang. A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy.
Nanomedicine (London, England).
2019 08; 14(15):2011-2025. doi:
10.2217/nnm-2018-0378. [PMID: 31355696] - Meghan Kirsch, Chick Weisse, Allyson Berent, Craig Clifford, Nicole Leibman, Luke Wittenburg, Stephen B Solomon, Kenneth Lamb. Pilot study comparing serum chemotherapy levels after intra-arterial and intravenous administration in dogs with naturally occurring urinary tract tumors.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2019 Jul; 83(3):187-196. doi:
. [PMID: 31308591] - Su-Fern Tan, Wendy Dunton, Xin Liu, Todd E Fox, Samy A F Morad, Dhimant Desai, Kenichiro Doi, Mark R Conaway, Shantu Amin, David F Claxton, Hong-Gang Wang, Mark Kester, Myles C Cabot, David J Feith, Thomas P Loughran. Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation.
Journal of lipid research.
2019 06; 60(6):1078-1086. doi:
10.1194/jlr.m091876. [PMID: 30962310] - Ana Paula Pereira da Rosa, Rodrigo Pereira Cavalcante, Débora Antonio da Silva, Lucas de Melo da Silva, Thalita Ferreira da Silva, Fábio Gozzi, Enda McGlynn, Anita Brady-Boyd, Gleison Antônio Casagrande, Heberton Wender, Silvio César de Oliveira, Amilcar Machulek Junior. H2O2-assisted photoelectrocatalytic degradation of Mitoxantrone using CuO nanostructured films: Identification of by-products and toxicity.
The Science of the total environment.
2019 Feb; 651(Pt 2):2845-2856. doi:
10.1016/j.scitotenv.2018.10.173. [PMID: 30463137] - Yandan Yao, Phei Er Saw, Yan Nie, Ping-Pui Wong, Linjia Jiang, Xiaojing Ye, Jun Chen, Tao Ding, Liang Xu, Herui Yao, Hai Hu, Xiaoding Xu. Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy.
Journal of materials chemistry. B.
2019 01; 7(4):576-585. doi:
10.1039/c8tb02600a. [PMID: 32254791] - Ikumi Washio, Takeo Nakanishi, Naoki Ishiguro, Bojan Bister, Ikumi Tamai. Effect of endogenous multidrug resistance 1 and P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines.
Biopharmaceutics & drug disposition.
2019 Jan; 40(1):32-43. doi:
10.1002/bdd.2167. [PMID: 30556139] - Jiajia Wang, Sajid Asghar, Xin Jin, Zhipeng Chen, Lin Huang, Qineng Ping, Li Zong, Yanyu Xiao. Mitoxantrone-loaded chitosan/hyaluronate polyelectrolyte nanoparticles decorated with amphiphilic PEG derivates for long-circulating effect.
Colloids and surfaces. B, Biointerfaces.
2018 Nov; 171(?):468-477. doi:
10.1016/j.colsurfb.2018.07.060. [PMID: 30077147] - Richard D Lin, Nicole F Steinmetz. Tobacco mosaic virus delivery of mitoxantrone for cancer therapy.
Nanoscale.
2018 Aug; 10(34):16307-16313. doi:
10.1039/c8nr04142c. [PMID: 30129956] - Lucillia Bezu, Allan Sauvat, Juliette Humeau, Lígia C Gomes-da-Silva, Kristina Iribarren, Sabrina Forveille, Pauline Garcia, Liwei Zhao, Peng Liu, Laurence Zitvogel, Laura Senovilla, Oliver Kepp, Guido Kroemer. eIF2α phosphorylation is pathognomonic for immunogenic cell death.
Cell death and differentiation.
2018 08; 25(8):1375-1393. doi:
10.1038/s41418-017-0044-9. [PMID: 29358668] - Marielle Margier, Caroline Buffière, Pascale Goupy, Didier Remond, Charlotte Halimi, Catherine Caris-Veyrat, Patrick Borel, Emmanuelle Reboul. Opposite Effects of the Spinach Food Matrix on Lutein Bioaccessibility and Intestinal Uptake Lead to Unchanged Bioavailability Compared to Pure Lutein.
Molecular nutrition & food research.
2018 06; 62(11):e1800185. doi:
10.1002/mnfr.201800185. [PMID: 29667316] - Hong-Hu Zhu, Zhi-Ping Guo, Jin-Song Jia, Qian Jiang, Hao Jiang, Xiao-Jun Huang. The impact of oral arsenic and all-trans-retinoic acid on coagulopathy in acute promyelocytic leukemia.
Leukemia research.
2018 02; 65(?):14-19. doi:
10.1016/j.leukres.2017.11.009. [PMID: 29232592] - Linhua Zhang, Yanqing Ren, Yong Wang, Yingna He, Wei Feng, Cunxian Song. Pharmacokinetics, distribution and anti-tumor efficacy of liposomal mitoxantrone modified with a luteinizing hormone-releasing hormone receptor-specific peptide.
International journal of nanomedicine.
2018; 13(?):1097-1105. doi:
10.2147/ijn.s150512. [PMID: 29520138] - Hema Masarapu, Bindi K Patel, Paul L Chariou, He Hu, Neetu M Gulati, Bradley L Carpenter, Reza A Ghiladi, Sourabh Shukla, Nicole F Steinmetz. Physalis Mottle Virus-Like Particles as Nanocarriers for Imaging Reagents and Drugs.
Biomacromolecules.
2017 Dec; 18(12):4141-4153. doi:
10.1021/acs.biomac.7b01196. [PMID: 29144726] - Hiroshi Kaneko, Takehide Katoh, Ikuo Hirano, Atsushi Hasegawa, Tadayuki Tsujita, Masayuki Yamamoto, Ritsuko Shimizu. Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings.
Genes to cells : devoted to molecular & cellular mechanisms.
2017 Nov; 22(11):939-952. doi:
10.1111/gtc.12537. [PMID: 29044949] - Yuxuan Xin, Qi Qi, Zhenmin Mao, Xiaoping Zhan. PLGA nanoparticles introduction into mitoxantrone-loaded ultrasound-responsive liposomes: In vitro and in vivo investigations.
International journal of pharmaceutics.
2017 Aug; 528(1-2):47-54. doi:
10.1016/j.ijpharm.2017.05.059. [PMID: 28559216] - Adam Osowski, Adam Kasparek, Zbigniew Wieczorek, Ryszard Amarowicz, Mariusz Szabelski. Evaluation of the characteristics of some plant polyphenols as molecules intercepting mitoxantrone.
Food chemistry.
2017 Jul; 227(?):142-148. doi:
10.1016/j.foodchem.2017.01.083. [PMID: 28274414] - Carl LaCerte, Vijay Ivaturi, Joga Gobburu, Jacqueline M Greer, L Austin Doyle, John J Wright, Judith E Karp, Michelle A Rudek. Exposure-Response Analysis of Alvocidib (Flavopiridol) Treatment by Bolus or Hybrid Administration in Newly Diagnosed or Relapsed/Refractory Acute Leukemia Patients.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2017 Jul; 23(14):3592-3600. doi:
10.1158/1078-0432.ccr-16-2629. [PMID: 28174232] - Masafumi Ikeda, Takuji Okusaka, Yozo Sato, Junji Furuse, Shuichi Mitsunaga, Hideki Ueno, Chigusa Morizane, Yoshitaka Inaba, Tatsushi Kobayashi, Yasuaki Arai. A Phase I/II trial of continuous hepatic intra-arterial infusion of 5-fluorouracil, mitoxantrone and cisplatin for advanced hepatocellular carcinoma.
Japanese journal of clinical oncology.
2017 Jun; 47(6):512-519. doi:
10.1093/jjco/hyx038. [PMID: 28334948] - Jacqueline Calvano, William Achanzar, Bethanne Murphy, Janet DiPiero, Clifford Hixson, Cecilia Parrula, Holly Burr, Raja Mangipudy, Mark Tirmenstein. Evaluation of microRNAs-208 and 133a/b as differential biomarkers of acute cardiac and skeletal muscle toxicity in rats.
Toxicology and applied pharmacology.
2016 Dec; 312(?):53-60. doi:
10.1016/j.taap.2015.11.015. [PMID: 26627004] - Joanna Laskowska, Joanna Lewandowska-Bieniek, Joanna Szczepanek, Jan Styczyński, Andrzej Tretyn. Genomic and transcriptomic profiles and in vitro resistance to mitoxantrone and idarubicin in pediatric acute leukemias.
The journal of gene medicine.
2016 Aug; 18(8):165-79. doi:
10.1002/jgm.2889. [PMID: 27280600] - Guixia Ling, Tianhong Zhang, Peng Zhang, Jin Sun, Zhonggui He. Nanostructured lipid-carrageenan hybrid carriers (NLCCs) for controlled delivery of mitoxantrone hydrochloride to enhance anticancer activity bypassing the BCRP-mediated efflux.
Drug development and industrial pharmacy.
2016 Aug; 42(8):1351-9. doi:
10.3109/03639045.2015.1135937. [PMID: 26754913] - Vered Heleg-Shabtai, Ruth Aizen, Etery Sharon, Yang Sung Sohn, Alexander Trifonov, Natalie Enkin, Lina Freage, Rachel Nechushtai, Itamar Willner. Gossypol-Capped Mitoxantrone-Loaded Mesoporous SiO2 NPs for the Cooperative Controlled Release of Two Anti-Cancer Drugs.
ACS applied materials & interfaces.
2016 Jun; 8(23):14414-22. doi:
10.1021/acsami.6b03865. [PMID: 27186957] - Jan Zaloga, Marina Pöttler, Gerd Leitinger, Ralf P Friedrich, Gunter Almer, Stefan Lyer, Eva Baum, Rainer Tietze, Ralph Heimke-Brinck, Harald Mangge, Frank Dörje, Geoffrey Lee, Christoph Alexiou. Pharmaceutical formulation of HSA hybrid coated iron oxide nanoparticles for magnetic drug targeting.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2016 Apr; 101(?):152-62. doi:
10.1016/j.ejpb.2016.01.017. [PMID: 26854862] - M Adamczyk-Sowa, P Sowa, J Adamczyk, N Niedziela, H Misiolek, M Owczarek, K Zwirska-Korczala. Effect of melatonin supplementation on plasma lipid hydroperoxides, homocysteine concentration and chronic fatigue syndrome in multiple sclerosis patients treated with interferons-beta and mitoxantrone.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2016 Apr; 67(2):235-42. doi:
NULL. [PMID: 27226183] - Tingting Hu, Hua Cao, Chengli Yang, Lijing Zhang, Xiaohua Jiang, Xiang Gao, Fan Yang, Gu He, Xiangrong Song, Aiping Tong, Gang Guo, Changyang Gong, Rui Li, Xiaoning Zhang, Xinchun Wang, Yu Zheng. LHD-Modified Mechanism-Based Liposome Coencapsulation of Mitoxantrone and Prednisolone Using Novel Lipid Bilayer Fusion for Tissue-Specific Colocalization and Synergistic Antitumor Effects.
ACS applied materials & interfaces.
2016 Mar; 8(10):6586-601. doi:
10.1021/acsami.5b10598. [PMID: 26907854] - Kevin A Carter, Sophie Wang, Jumin Geng, Dandan Luo, Shuai Shao, Jonathan F Lovell. Metal Chelation Modulates Phototherapeutic Properties of Mitoxantrone-Loaded Porphyrin-Phospholipid Liposomes.
Molecular pharmaceutics.
2016 Feb; 13(2):420-7. doi:
10.1021/acs.molpharmaceut.5b00653. [PMID: 26691879] - King Leung Fung, Khyati Kapoor, Jessica N Pixley, Darrell J Talbert, Alexandra D T Kwit, Suresh V Ambudkar, Michael M Gottesman. Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers.
Drug metabolism and disposition: the biological fate of chemicals.
2016 Feb; 44(2):180-8. doi:
10.1124/dmd.115.066506. [PMID: 26622052] - J A Otero, V Miguel, L González-Lobato, R García-Villalba, J C Espín, J G Prieto, G Merino, A I Álvarez. Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid.
Animal : an international journal of animal bioscience.
2016 Feb; 10(2):238-47. doi:
10.1017/s1751731115002141. [PMID: 26510964] - Chabita Saha, Agrima Kaushik, Asmita Das, Sandip Pal, Debashis Majumder. Anthracycline Drugs on Modified Surface of Quercetin-Loaded Polymer Nanoparticles: A Dual Drug Delivery Model for Cancer Treatment.
PloS one.
2016; 11(5):e0155710. doi:
10.1371/journal.pone.0155710. [PMID: 27196562] - Guixia Ling, Tianhong Zhang, Peng Zhang, Jin Sun, Zhonggui He. Synergistic and complete reversal of the multidrug resistance of mitoxantrone hydrochloride by three-in-one multifunctional lipid-sodium glycocholate nanocarriers based on simultaneous BCRP and Bcl-2 inhibition.
International journal of nanomedicine.
2016 ; 11(?):4077-91. doi:
10.2147/ijn.s95767. [PMID: 27601896] - Żanna Pastuszak, Kazimierz Tomczykiewicz, Renata Piusińska-Macoch, Adam Stępień. Cardiac effects of mitoxanthrone therapy in patients with multiple sclerosis.
Kardiologia polska.
2016; 74(4):380-4. doi:
10.5603/kp.a2015.0195. [PMID: 26412472] - Marcin Luty, Edyta Kwiecień, Magdalena Firlej, Anna Łabędź-Masłowska, Milena Paw, Zbigniew Madeja, Jarosław Czyż. Curcumin augments the cytostatic and anti-invasive effects of mitoxantrone on carcinosarcoma cells in vitro.
Acta biochimica Polonica.
2016; 63(3):397-401. doi:
10.18388/abp.2016_1314. [PMID: 27390785] - Ning Song, Ming Zhao, Yuji Wang, Xi Hu, Jianhui Wu, Xueyun Jiang, Shan Li, Chunying Cui, Shiqi Peng. Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT.
Drug design, development and therapy.
2016; 10(?):2701-11. doi:
10.2147/dddt.s113804. [PMID: 27621591] - Iwona Cicha, Laura Scheffler, Astrid Ebenau, Stefan Lyer, Christoph Alexiou, Margarete Goppelt-Struebe. Mitoxantrone-loaded superparamagnetic iron oxide nanoparticles as drug carriers for cancer therapy: Uptake and toxicity in primary human tubular epithelial cells.
Nanotoxicology.
2016; 10(5):557-66. doi:
10.3109/17435390.2015.1095364. [PMID: 26468004] - Linda Koutova, Monika Sterbova, Eva Pazourkova, Sarka Pospisilova, Iveta Svobodova, Ales Horinek, Daniel Lysak, Marie Korabecna. The impact of standard chemotherapy on miRNA signature in plasma in AML patients.
Leukemia research.
2015 Dec; 39(12):1389-95. doi:
10.1016/j.leukres.2015.08.009. [PMID: 26340914] - José Carlos Jaime-Pérez, Xitlaly Judith González-Leal, Mónica Andrea Pinzón-Uresti, Andrés Gómez-De León, Olga G Cantú-Rodríguez, Homero Gutiérrez-Aguirre, David Gómez-Almaguer. Is There Still a Role for Low-Dose All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia in the Arsenic Trioxide Era?.
Clinical lymphoma, myeloma & leukemia.
2015 Dec; 15(12):816-9. doi:
10.1016/j.clml.2015.09.002. [PMID: 26500134] - N Anghel, C Cotoraci, A Ivan, M Suciu, H Herman, C Balta, L Nicolescu, T Olariu, Z Galajda, A Ardelean, A Hermenean. Chrysin attenuates cardiomyocyte apoptosis and loss of intermediate filaments in a mouse model of mitoxantrone cardiotoxicity.
Histology and histopathology.
2015 Dec; 30(12):1465-75. doi:
10.14670/hh-11-641. [PMID: 26112963] - Verónica Miguel, Jon A Otero, Borja Barrera, Idania Rodeiro, Julio G Prieto, Gracia Merino, Ana I Álvarez. ABCG2/BCRP interaction with the sea grass Thalassia testudinum.
Drug metabolism and personalized therapy.
2015 Dec; 30(4):251-6. doi:
10.1515/dmpt-2015-0013. [PMID: 26444365] - Zhi Li, Fei-long Zhang, Li-li Pan, Xia-li Zhu, Zhen-zhong Zhang. Preparation and characterization of injectable Mitoxantrone poly (lactic acid)/fullerene implants for in vivo chemo-photodynamic therapy.
Journal of photochemistry and photobiology. B, Biology.
2015 Aug; 149(?):51-7. doi:
10.1016/j.jphotobiol.2015.05.018. [PMID: 26046749] - Lília R Cordeiro Pedrosa, Olaf van Tellingen, Thomas Soullié, Ann L Seynhaeve, Alexander M M Eggermont, Timo L M Ten Hagen, Marcel Verheij, Gerben A Koning. Plasma membrane targeting by short chain sphingolipids inserted in liposomes improves anti-tumor activity of mitoxantrone in an orthotopic breast carcinoma xenograft model.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2015 Aug; 94(?):207-19. doi:
10.1016/j.ejpb.2015.05.003. [PMID: 25982691] - C C Wen, S W Yee, X Liang, T J Hoffmann, M N Kvale, Y Banda, E Jorgenson, C Schaefer, N Risch, K M Giacomini. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
Clinical pharmacology and therapeutics.
2015 May; 97(5):518-25. doi:
10.1002/cpt.89. [PMID: 25676789] - José Luís Dores-Sousa, José Alberto Duarte, Vítor Seabra, Maria de Lourdes Bastos, Félix Carvalho, Vera Marisa Costa. The age factor for mitoxantrone's cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury.
Toxicology.
2015 Mar; 329(?):106-19. doi:
10.1016/j.tox.2015.01.006. [PMID: 25582955] - Jingyuan Zhao, Xueqin Song, Xiaoqing Ai, Xiaojing Gu, Guangbiao Huang, Xue Li, Lijuan Pang, Minli Ding, Shuang Ding, Luxian Lv. Adjunctive Aripiprazole Treatment for Risperidone-Induced Hyperprolactinemia: An 8-Week Randomized, Open-Label, Comparative Clinical Trial.
PloS one.
2015; 10(10):e0139717. doi:
10.1371/journal.pone.0139717. [PMID: 26448615] - Giovanna Vitaliti, Omidreza Tabatabaie, Nassim Matin, Caterina Ledda, Piero Pavone, Riccardo Lubrano, Agostino Serra, Paola Di Mauro, Salvatore Cocuzza, Raffaele Falsaperla. The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data.
Human vaccines & immunotherapeutics.
2015; 11(12):2749-63. doi:
10.1080/21645515.2015.1061161. [PMID: 26266339] - Kee W Tan, Janine Cooney, Dwayne Jensen, Yan Li, James W Paxton, Nigel P Birch, Arjan Scheepens. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2).
Molecular nutrition & food research.
2014 Nov; 58(11):2099-110. doi:
10.1002/mnfr.201400288. [PMID: 25044854] - Jianliang Yang, Yuankai Shi, Chunlei Li, Lin Gui, Xi Zhao, Peng Liu, Xiaohong Han, Yuanyuan Song, Ning Li, Ping Du, Shuxiang Zhang. Phase I clinical trial of pegylated liposomal mitoxantrone plm60-s: pharmacokinetics, toxicity and preliminary efficacy.
Cancer chemotherapy and pharmacology.
2014 Sep; 74(3):637-46. doi:
10.1007/s00280-014-2523-8. [PMID: 25034977] - M Adamczyk-Sowa, K Pierzchala, P Sowa, R Polaniak, M Kukla, M Hartel. Influence of melatonin supplementation on serum antioxidative properties and impact of the quality of life in multiple sclerosis patients.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2014 Aug; 65(4):543-50. doi:
NULL. [PMID: 25179086] - Hong Zhao, Zbigniew Darzynkiewicz. Attenuation of replication stress-induced premature cellular senescence to assess anti-aging modalities.
Current protocols in cytometry.
2014 Jul; 69(?):9.47.1-9.47.10. doi:
10.1002/0471142956.cy0947s69. [PMID: 24984966] - Saeed Ghanbarzadeh, Sanam Arami, Zhaleh Pourmoazzen, Javad Ghasemian-Yadegari, Arash Khorrami. Plasma stable, pH-sensitive fusogenic polymer-modified liposomes: A promising carrier for mitoxantrone.
Journal of biomaterials applications.
2014 07; 29(1):81-92. doi:
10.1177/0885328213515288. [PMID: 24336315] - Friedemann Schad, Jan Atxner, Dirk Buchwald, Antje Happe, Stephan Popp, Matthias Kröz, Harald Matthes. Intratumoral Mistletoe (Viscum album L) Therapy in Patients With Unresectable Pancreas Carcinoma: A Retrospective Analysis.
Integrative cancer therapies.
2014 Jul; 13(4):332-40. doi:
10.1177/1534735413513637. [PMID: 24363283] - Ludmilla Le Berre, Gaëlle Tilly, Jacques Dantal. Is there B cell involvement in a rat model of spontaneous idiopathic nephrotic syndrome treated with LF15-0195?.
Journal of nephrology.
2014 Jun; 27(3):265-73. doi:
10.1007/s40620-014-0081-0. [PMID: 24664644] - Verónica Miguel, Jon Andoni Otero, Rocío García-Villalba, Francisco Tomás-Barberán, Juan Carlos Espín, Gracia Merino, Ana I Álvarez. Role of ABCG2 in transport of the mammalian lignan enterolactone and its secretion into milk in Abcg2 knockout mice.
Drug metabolism and disposition: the biological fate of chemicals.
2014 May; 42(5):943-6. doi:
10.1124/dmd.113.055970. [PMID: 24568887] - Luciana G Rossato, Vera M Costa, Eliane Dallegrave, Marcelo Arbo, Ricardo J Dinis-Oliveira, Alice Santos-Silva, José A Duarte, Maria de Lourdes Bastos, Carlos Palmeira, Fernando Remião. Cumulative mitoxantrone-induced haematological and hepatic adverse effects in a subchronic in vivo study.
Basic & clinical pharmacology & toxicology.
2014 Mar; 114(3):254-62. doi:
10.1111/bcpt.12143. [PMID: 24119282] - Luciana Grazziotin Rossato, Vera Marisa Costa, Eliane Dallegrave, Marcelo Arbo, Renata Silva, Rita Ferreira, Francisco Amado, Ricardo Jorge Dinis-Oliveira, José Alberto Duarte, Maria de Lourdes Bastos, Carlos Palmeira, Fernando Remião. Mitochondrial cumulative damage induced by mitoxantrone: late onset cardiac energetic impairment.
Cardiovascular toxicology.
2014 Mar; 14(1):30-40. doi:
10.1007/s12012-013-9230-2. [PMID: 24096626] - Wei Tian, Lan Zhang, Na Wei, Chan Li, Bei-Bei Ni, Xi Zhao, Chun-Lei Li. [Repeated injection of mitoxantrone containing thermosensitive liposomes in rat induced ABC phenomenon].
Yao xue xue bao = Acta pharmaceutica Sinica.
2014 Feb; 49(2):256-9. doi:
NULL. [PMID: 24761619] - Hui-Qin Guo, Guan-Nan Zhang, Yi-Jun Wang, Yun-Kai Zhang, Kamlesh Sodani, Tanaji T Talele, Charles R Ashby, Zhe-Sheng Chen. β-Elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter.
Oncology reports.
2014 Feb; 31(2):858-66. doi:
10.3892/or.2013.2870. [PMID: 24284783] - Izabela Sadowska-Bartosz, Monika Adamczyk-Sowa, Agnieszka Gajewska, Grzegorz Bartosz. Oxidative modification of blood serum proteins in multiple sclerosis after interferon or mitoxantrone treatment.
Journal of neuroimmunology.
2014 Jan; 266(1-2):67-74. doi:
10.1016/j.jneuroim.2013.11.005. [PMID: 24290230] - Kee W Tan, Daniel P Killeen, Yan Li, James W Paxton, Nigel P Birch, Arjan Scheepens. Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2).
European journal of pharmacology.
2014 Jan; 723(?):346-52. doi:
10.1016/j.ejphar.2013.11.005. [PMID: 24269959] - Ulrike Weissenstein, Matthias Kunz, Konrad Urech, Stephan Baumgartner. Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro.
BMC complementary and alternative medicine.
2014 Jan; 14(?):6. doi:
10.1186/1472-6882-14-6. [PMID: 24397864] - Chunlei Li, Xi Zhao, Chenxin Deng, Caixia Wang, Na Wei, Jingxia Cui. Pegylated liposomal mitoxantrone is more therapeutically active than mitoxantrone in L1210 ascitic tumor and exhibits dose-dependent activity saturation effect.
International journal of pharmaceutics.
2014 Jan; 460(1-2):165-72. doi:
10.1016/j.ijpharm.2013.10.023. [PMID: 24148664] - Jan Zaloga, Christina Janko, Johannes Nowak, Jasmin Matuszak, Sabine Knaup, Dietmar Eberbeck, Rainer Tietze, Harald Unterweger, Ralf P Friedrich, Stephan Duerr, Ralph Heimke-Brinck, Eva Baum, Iwona Cicha, Frank Dörje, Stefan Odenbach, Stefan Lyer, Geoffrey Lee, Christoph Alexiou. Development of a lauric acid/albumin hybrid iron oxide nanoparticle system with improved biocompatibility.
International journal of nanomedicine.
2014; 9(?):4847-66. doi:
10.2147/ijn.s68539. [PMID: 25364244] - Mateusz Legut, Dominik Lipka, Nina Filipczak, Adriana Piwoni, Arkadiusz Kozubek, Jerzy Gubernator. Anacardic acid enhances the anticancer activity of liposomal mitoxantrone towards melanoma cell lines - in vitro studies.
International journal of nanomedicine.
2014; 9(?):653-68. doi:
10.2147/ijn.s54911. [PMID: 24489469] - Aleksandra Podlecka-Piętowska, Janusz Kochanowski, Beata Zakrzewska-Pniewska, Grzegorz Opolski, Hubert Kwieciński, Anna Maria Kamińska. The N-terminal pro-brain natriuretic peptide as a marker of mitoxantrone-induced cardiotoxicity in multiple sclerosis patients.
Neurologia i neurochirurgia polska.
2014; 48(2):111-5. doi:
10.1016/j.pjnns.2013.12.005. [PMID: 24821636] - A Q Sukkurwala, I Martins, Y Wang, F Schlemmer, C Ruckenstuhl, M Durchschlag, M Michaud, L Senovilla, A Sistigu, Y Ma, E Vacchelli, E Sulpice, X Gidrol, L Zitvogel, F Madeo, L Galluzzi, O Kepp, G Kroemer. Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8.
Cell death and differentiation.
2014 Jan; 21(1):59-68. doi:
10.1038/cdd.2013.73. [PMID: 23787997] - Goundla Srinivas, Ram V Mohan, Ajit D Kelkar. Polymer micelle assisted transport and delivery of model hydrophilic components inside a biological lipid vesicle: a coarse-grain simulation study.
The journal of physical chemistry. B.
2013 Oct; 117(40):12095-104. doi:
10.1021/jp405381k. [PMID: 23952604] - Joshua Bakhsheshian, Matthew D Hall, Robert W Robey, Michelle A Herrmann, Jin-Qiu Chen, Susan E Bates, Michael M Gottesman. Overlapping substrate and inhibitor specificity of human and murine ABCG2.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Oct; 41(10):1805-12. doi:
10.1124/dmd.113.053140. [PMID: 23868912] - Hong Zhao, H Dorota Halicka, Jiangwei Li, Zbigniew Darzynkiewicz. Berberine suppresses gero-conversion from cell cycle arrest to senescence.
Aging.
2013 Aug; 5(8):623-36. doi:
10.18632/aging.100593. [PMID: 23974852] - Krupa J Patel, Olivier Trédan, Ian F Tannock. Distribution of the anticancer drugs doxorubicin, mitoxantrone and topotecan in tumors and normal tissues.
Cancer chemotherapy and pharmacology.
2013 Jul; 72(1):127-38. doi:
10.1007/s00280-013-2176-z. [PMID: 23680920] - Yongping Shi, Zhigui Su, Sai Li, Yinan Chen, Xi Chen, Yanyu Xiao, Minjie Sun, Qineng Ping, Li Zong. Multistep targeted nano drug delivery system aiming at leukemic stem cells and minimal residual disease.
Molecular pharmaceutics.
2013 Jun; 10(6):2479-89. doi:
10.1021/mp4001266. [PMID: 23646913] - A Jamroz-Wisniewska, J Beltowski, Z Stelmasiak, H Bartosik-Psujek. Paraoxonase 1 activity in multiple sclerosis patients during mitoxantrone therapy.
Acta neurologica Scandinavica.
2013 Jun; 127(6):e33-6. doi:
10.1111/ane.12000. [PMID: 22881373] - Antonio González-Sarrías, Verónica Miguel, Gracia Merino, Ricardo Lucas, Juan C Morales, Francisco Tomás-Barberán, Ana I Alvarez, Juan C Espín. The gut microbiota ellagic acid-derived metabolite urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein (ABCG2/BCRP).
Journal of agricultural and food chemistry.
2013 May; 61(18):4352-9. doi:
10.1021/jf4007505. [PMID: 23586460] - Han Chen, Tong Zhang, Zhimin Zhou, Man Guan, Jingjie Wang, Lingrong Liu, Qiqing Zhang. Enhanced uptake and cytotoxity of folate-conjugated mitoxantrone-loaded micelles via receptor up-regulation by dexamethasone.
International journal of pharmaceutics.
2013 May; 448(1):142-9. doi:
10.1016/j.ijpharm.2013.03.032. [PMID: 23538095] - Paulina Koczurkiewicz, Irma Podolak, Katarzyna Anna Wójcik, Agnieszka Galanty, Zbigniew Madeja, Marta Michalik, Jarosław Czyż. Lclet 4 enhances pro-apoptotic and anti-invasive effects of mitoxantrone on human prostate cancer cells - in vitro study.
Acta biochimica Polonica.
2013; 60(3):331-8. doi:
10.18388/abp.2013_1989. [PMID: 23869350] - Ye Tian, Bo-Xuan Qu, Yan Yao, Su Zeng. [Establishment of BCRP expressed pig kidney cell line LLC-PK1/BCRP and its biological profile].
Yao xue xue bao = Acta pharmaceutica Sinica.
2012 Dec; 47(12):1599-604. doi:
NULL. [PMID: 23460964]