Clonidine hydrochloride (BioDeep_00000399070)
natural product
代谢物信息卡片
Clonidine hydrochloride (Catapres) [largely precursor]
化学式: C9H10Cl3N3 (264.994027)
中文名称: 盐酸可乐定
谱图信息:
最多检出来源 Escherichia coli(natural_products) 92.31%
分子结构信息
SMILES: C1(=CC=C(C(=C1Cl)NC2NCCN=2)Cl).Cl
InChI: 1H
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:3758
- KEGGdrug: D81843
- KEGGdrug: D00604
- PubChem: 20179
- ChEMBL: CHEMBL1705
- MeSH: Clonidine
- CAS: 4205-91-8
- MoNA: CCMSLIB00000078473
- medchemexpress: HY-B0409A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xingyu Su, Fan Lu, Yihua Chen, Miao Wang, Guoqing Tang, Wan Lin, Yingwen Liu, Huadong Wang, Haiyan Yin, Yiyang Wang. α2-Adrenoreceptor antagonist ameliorates sepsis-associated pulmonary fibrosis by suppressing norepinephrine-mediated fibroblast differentiation via inhibiting PKC activation.
Shock (Augusta, Ga.).
2023 Oct; ?(?):. doi:
10.1097/shk.0000000000002240. [PMID: 37878498] - Jing Chen, Juan Zhang, Dan-Dan Yang, Zi-Cheng Li, Bo Zhao, Yue Chen, Zhi He. Clonidine ameliorates cerebral ischemia-reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor.
Metabolic brain disease.
2022 08; 37(6):1829-1841. doi:
10.1007/s11011-022-01028-y. [PMID: 35727521] - Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y Bois, Masoud Jamei. Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Drug metabolism and disposition: the biological fate of chemicals.
2022 07; 50(7):957-967. doi:
10.1124/dmd.121.000818. [PMID: 35504655] - Hanna Remde, Christina Pamporaki, Marcus Quinkler, Svenja Nölting, Aleksander Prejbisz, Henri J L M Timmers, Jimmy Masjkur, Carmina T Fuss, Martin Fassnacht, Graeme Eisenhofer, Timo Deutschbein. Improved Diagnostic Accuracy of Clonidine Suppression Testing Using an Age-Related Cutoff for Plasma Normetanephrine.
Hypertension (Dallas, Tex. : 1979).
2022 06; 79(6):1257-1264. doi:
10.1161/hypertensionaha.122.19019. [PMID: 35378989] - Jonathan Hanna, Lama Ghazi, Yu Yamamoto, Michael Simonov, Tayyab Shah, Francis P Wilson, Aldo J Peixoto. Excessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension.
American journal of hypertension.
2022 05; 35(5):433-440. doi:
10.1093/ajh/hpac004. [PMID: 35038322] - Theodoros V Giannouchos, Ainhoa Gómez-Lumbreras, Daniel C Malone. Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S.
The American journal of emergency medicine.
2022 05; 55(?):147-151. doi:
10.1016/j.ajem.2022.03.008. [PMID: 35325788] - Dan Longrois, Fabrice Petitjeans, Olivier Simonet, Marc de Kock, Marc Belliveau, Cyrille Pichot, Thomas Lieutaud, Marco Ghignone, Luc Quintin. How should dexmedetomidine and clonidine be prescribed in the critical care setting?.
Revista Brasileira de terapia intensiva.
2022; 33(4):600-615. doi:
10.5935/0103-507x.20210087. [PMID: 35081245] - Constance Guille, Courtney King, Viswanathan Ramakrishnan, Nathaniel Baker, Bernadette Cortese, Lisa Nunn, Taylor Rogers, Aimee McRae-Clark, Kathleen Brady. The impact of lofexidine on stress-related opioid craving and relapse: Design and methodology of a randomized clinical trial.
Contemporary clinical trials.
2021 12; 111(?):106616. doi:
10.1016/j.cct.2021.106616. [PMID: 34737091] - Leonna Dsouza, Pinal Chaudhari, Bheemisetty Brahmam, Shaila A Lewis. Derma roller mediated transdermal delivery of tizanidine invasomes for the management of skeletal muscle spasms.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Oct; 165(?):105920. doi:
10.1016/j.ejps.2021.105920. [PMID: 34192586] - Michael J Brucculeri, Juan Garcia. Potassium wasting nephropathy in the setting of tizanidine overdose: a case report.
Journal of medical case reports.
2021 May; 15(1):250. doi:
10.1186/s13256-021-02811-8. [PMID: 33931107] - Marcelo Daniel Sciorra, Elisa Fantino, Cecilia Eugenia María Grossi, Rita María Ulloa. Characterization of two group III potato CDPKs, StCDPK22 and StCDPK24, that contain three EF-Hand motifs in their CLDs.
Plant physiology and biochemistry : PPB.
2021 May; 162(?):716-729. doi:
10.1016/j.plaphy.2021.03.008. [PMID: 33799183] - Hongfei Liu, Xiaoya Xie, Chao Chen, Caleb Kesse Firempong, Yingshu Feng, Limin Zhao, Xuezhi Yin. Preparation and in vitro/in vivo evaluation of a clonidine hydrochloride drug-resin suspension as a sustained-release formulation.
Drug development and industrial pharmacy.
2021 Mar; 47(3):394-402. doi:
10.1080/03639045.2021.1890110. [PMID: 33615926] - Seo-Yeon Yoon, Dae-Hyun Roh, Ji-Hee Yeo, Jiwan Woo, Se Hee Han, Key-Sun Kim. Analgesic Efficacy of α2 Adrenergic Receptor Agonists Depends on the Chronic State of Neuropathic Pain: Role of Regulator of G Protein Signaling 4.
Neuroscience.
2021 02; 455(?):177-194. doi:
10.1016/j.neuroscience.2020.12.021. [PMID: 33359660] - Sanjiv K Hyoju, Olga Zaborina, Harry van Goor. SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol).
Medical hypotheses.
2020 Nov; 144(?):110039. doi:
10.1016/j.mehy.2020.110039. [PMID: 32758881] - Tiran Golani, Boris Fishman, Yehonatan Sharabi, Yael Olswang-Kutz, Avshalom Leibowitz, Ehud Grossman, Gadi Shlomai. The association between systolic blood pressure reduction during clonidine suppression testing and the decrease in plasma catecholamines and metanephrines.
Journal of clinical hypertension (Greenwich, Conn.).
2020 10; 22(10):1924-1931. doi:
10.1111/jch.14014. [PMID: 32882089] - Fabrice Petitjeans, Jean-Yves Martinez, Marc Danguy des Déserts, Sandrine Leroy, Luc Quintin, Jacques Escarment. A Centrally Acting Antihypertensive, Clonidine, Sedates Patients Presenting With Acute Respiratory Distress Syndrome Evoked by Severe Acute Respiratory Syndrome-Coronavirus 2.
Critical care medicine.
2020 10; 48(10):e991-e993. doi:
10.1097/ccm.0000000000004503. [PMID: 32618691] - Tyler J Loftus, Kolenkode B Kannan, Juan C Mira, Scott C Brakenridge, Philip A Efron, Alicia M Mohr. Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
Shock (Augusta, Ga.).
2020 10; 54(4):482-487. doi:
10.1097/shk.0000000000001506. [PMID: 31904616] - Saskia Floerl, Annett Kuehne, Yohannes Hagos. Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
International journal of molecular sciences.
2020 Sep; 21(18):. doi:
10.3390/ijms21186871. [PMID: 32961667] - Haitham AlRabiah, Sabry M Attia, Nasser S Al-Shakliah, Gamal A E Mostafa. Development and Validation of an HPLC-UV Detection Assay for the Determination of Clonidine in Mouse Plasma and Its Application to a Pharmacokinetic Study.
Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184109. [PMID: 32911847] - Michael E Cloesmeijer, Huub L A van den Oever, Ron A A Mathôt, Marieke Zeeman, Arriette Kruisdijk-Gerritsen, Carmen M A Bles, Polina Nassikovker, Arthur R de Meijer, Fred L van Steveninck, Maurits E L Arbouw. Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics.
British journal of clinical pharmacology.
2020 08; 86(8):1620-1631. doi:
10.1111/bcp.14273. [PMID: 32150285] - Abbu Stephanie, Curtis D Caldwell, Debbie Fraser, Rachel Joseph, Heather D Goodall, Jody Ridky, Kathryn Rudd, Lori Williams. Academy News.
Neonatal network : NN.
2020 08; 39(5):306-311. doi:
10.1891/0730-0832.39.5.306. [PMID: 32879048] - Bhuvanenthiran Mutharani, Palraj Ranganathan, Tse-Wei Chen, Shen-Ming Chen, Jeyaraj Vinoth Kumar. Thermoreversible Switchlike Electrocatalytic Reduction of Tizanidine Based on a Graphene Oxide Tethered Stimuli-Responsive Smart Surface Supported Pd Catalyst.
Analytical chemistry.
2020 07; 92(13):8965-8973. doi:
10.1021/acs.analchem.0c00958. [PMID: 32436691] - Weijiang Zhang, Christine McIntyre, Todd Riehl, Harper Forbes, Enric Bertran, Hye Jin Choi, Dae Ho Lee, Jeeyun Lee. Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine (a CYP1A2 Substrate) in Patients With BRAFV600 Mutation-Positive Malignancies.
Clinical pharmacology in drug development.
2020 07; 9(5):651-658. doi:
10.1002/cpdd.788. [PMID: 32311241] - Huub L A van den Oever, Marieke Zeeman, Polina Nassikovker, Carmen Bles, Fred A L van Steveninck, Arthur R de Meijer, Arriette Kruisdijk-Gerritsen, Maurits Arbouw. In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients.
Blood purification.
2020; 49(5):622-626. doi:
10.1159/000505610. [PMID: 31962323] - Michael Doumas, Konstantinos P Imprialos, Manolis S Kallistratos, Athanasios J Manolis. Recent advances in understanding and managing resistant/refractory hypertension.
F1000Research.
2020; 9(?):. doi:
10.12688/f1000research.21669.1. [PMID: 32201574] - Hetal Thakkar, Kartik Pandya, Brijesh Patel. Microneedle-Mediated Transdermal Delivery of Tizanidine Hydrochloride.
Methods in molecular biology (Clifton, N.J.).
2020; 2059(?):239-258. doi:
10.1007/978-1-4939-9798-5_13. [PMID: 31435926] - Xuan Zou, Yang Wang, Yuheng Wang, Junting Yang, Huishu Guo, Zhengxu Cai. Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine.
Drug design, development and therapy.
2020; 14(?):5623-5632. doi:
10.2147/dddt.s260703. [PMID: 33376306] - Gretchen Hermes, Scott M Hyman, Nia Fogelman, Thomas R Kosten, Rajita Sinha. Lofexidine in Combination With Oral Naltrexone for Opioid Use Disorder Relapse Prevention: A Pilot Randomized, Double-Blind, Placebo-Controlled Study.
The American journal on addictions.
2019 11; 28(6):480-488. doi:
10.1111/ajad.12942. [PMID: 31448846] - John C Hayden, Maddlie Bardol, Dermot R Doherty, Ian Dawkins, Martina Healy, Cormac V Breatnach, Paul J Gallagher, Gráinne Cousins, Joseph F Standing. Optimizing clonidine dosage for sedation in mechanically ventilated children: A pharmacokinetic simulation study.
Paediatric anaesthesia.
2019 10; 29(10):1002-1010. doi:
10.1111/pan.13715. [PMID: 31373752] - Nazari Pari, Yaghmaei Parichehreh, Rangin Alireza, Abbasi Naser. The role of Smyrnium cordifolium Boiss extract and curzerene on withdrawal syndrome in mice.
Cellular and molecular biology (Noisy-le-Grand, France).
2019 Sep; 65(7):77-83. doi:
10.14715/cmb/2019.65.7.14. [PMID: 31880522] - Fei Tang, Henrietta Bada, Chee M Ng, Markos Leggas. Validation of a HPLC/MS method for simultaneous quantification of clonidine, morphine and its metabolites in human plasma.
Biomedical chromatography : BMC.
2019 Jul; 33(7):e4527. doi:
10.1002/bmc.4527. [PMID: 30830964] - WingYee Wan, Bichle Nguyen, Sky Graybill, Jonathan Kim. Clonidine suppression testing for pheochromocytoma in neurofibromatosis type 1.
BMJ case reports.
2019 Jun; 12(6):. doi:
10.1136/bcr-2018-228263. [PMID: 31243023] - Paolo Calzavacca, Lindsea C Booth, Yugeesh R Lankadeva, Simon R Bailey, Louise M Burrell, Michael Bailey, Rinaldo Bellomo, Clive N May. Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia.
Shock (Augusta, Ga.).
2019 03; 51(3):348-355. doi:
10.1097/shk.0000000000001134. [PMID: 29489737] - Jennifer M Crawford, John A Loadsman, Kenny Xf Yang, Peter Ca Kam. Adding low concentrations of clonidine to ropivacaine for transversus abdominis plane blocks does not reduce plasma ropivacaine levels, suggesting a lack of vasoconstrictor effect.
Anaesthesia and intensive care.
2019 Mar; 47(2):134-140. doi:
10.1177/0310057x19838731. [PMID: 31070463] - Prafull Bandopant Ninave, Savita Dattatray Patil. Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma.
Respiratory physiology & neurobiology.
2019 02; 260(?):28-36. doi:
10.1016/j.resp.2018.12.001. [PMID: 30521862] - Guangzhong Zhou, Rongzeng Du. Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism.
Italian journal of pediatrics.
2019 Jan; 45(1):17. doi:
10.1186/s13052-019-0610-5. [PMID: 30691498] - Marieke Jepma, Stephen B R E Brown, Peter R Murphy, Stephany C Koelewijn, Boukje de Vries, Arn M van den Maagdenberg, Sander Nieuwenhuis. Noradrenergic and Cholinergic Modulation of Belief Updating.
Journal of cognitive neuroscience.
2018 12; 30(12):1803-1820. doi:
10.1162/jocn_a_01317. [PMID: 30063180] - Ardeshir Moayeri, Maryam Azimi, Elahe Karimi, Ali Aidy, Naser Abbasi. Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats.
Medical science monitor basic research.
2018 10; 24(?):151-158. doi:
10.12659/msmbr.909930. [PMID: 30297685] - Karen Roksund Hov, Bjørn Erik Neerland, Anders Mikal Andersen, Øystein Undseth, Vegard Bruun Wyller, Alasdair M J MacLullich, Eva Skovlund, Eirik Qvigstad, Torgeir Bruun Wyller. The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses.
BMC pharmacology & toxicology.
2018 06; 19(1):29. doi:
10.1186/s40360-018-0218-1. [PMID: 29884231] - Nandini Bhat, Eric Dulmovits, Andrew Lane, Catherine Messina, Thomas Wilson. Combined simultaneous arginine clonidine stimulation test: Timing of peak growth hormone (GH) concentration and correlation with clinical indices of GH status.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
2018 06; 40(?):28-31. doi:
10.1016/j.ghir.2018.04.002. [PMID: 29702359] - Xi Han, Yang Liu, Wendy R Kam, David A Sullivan. Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells.
Experimental eye research.
2018 05; 170(?):20-28. doi:
10.1016/j.exer.2018.02.009. [PMID: 29452108] - Sunayana Vikhe, Sunil Nirmal. Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma.
Journal of ethnopharmacology.
2018 Apr; 216(?):251-258. doi:
10.1016/j.jep.2017.12.007. [PMID: 29247697] - Nesreen M I M Elkomy, Islam A A E-H Ibrahim, Shimaa M Elshazly, Hassan M El-Fayoumi. Ameliorative effects of clonidine on ethanol induced kidney injury in rats: Potential role for imidazoline-1 receptor.
European journal of pharmacology.
2018 Apr; 824(?):148-156. doi:
10.1016/j.ejphar.2018.02.001. [PMID: 29452086] - Alexis L Cates, Scott M Wheatley, Kenneth D Katz. Clonidine Overdose in a Toddler Due to Accidental Ingestion of a Compounding Cream.
Pediatric emergency care.
2018 Apr; 34(4):e79-e81. doi:
10.1097/pec.0000000000000790. [PMID: 27455340] - Ken Matsui, Makoto Ozawa, Maki Kiso, Makoto Yamashita, Toshihiko Maekawa, Minoru Kubota, Sumio Sugano, Yoshihiro Kawaoka. Stimulation of alpha2-adrenergic receptors impairs influenza virus infection.
Scientific reports.
2018 03; 8(1):4631. doi:
10.1038/s41598-018-22927-0. [PMID: 29545586] - Fathalla Belal, Mahmoud A Omar, Sayed Derayea, Mohamed A Hammad, Sahar Zayed, Safaa F Saleh. Simultaneous Determination of Tizanidine, Nimesulide, Aceclofenac and Paracetamol in Tablets and Biological Fluids Using Micellar Liquid Chromatography.
Journal of chromatographic science.
2018 Mar; 56(3):233-241. doi:
10.1093/chromsci/bmx105. [PMID: 29236980] - William J Kowalczyk, Landhing M Moran, Jeremiah W Bertz, Karran A Phillips, Udi E Ghitza, Massoud Vahabzadeh, Jia-Ling Lin, David H Epstein, Kenzie L Preston. Using ecological momentary assessment to examine the relationship between craving and affect with opioid use in a clinical trial of clonidine as an adjunct medication to buprenorphine treatment.
The American journal of drug and alcohol abuse.
2018; 44(5):502-511. doi:
10.1080/00952990.2018.1454933. [PMID: 29634425] - Gustav Folmer Genét, Peter Bentzer, Morten Bagge Hansen, Sisse Rye Ostrowski, Pär Ingemar Johansson. Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat.
The journal of trauma and acute care surgery.
2018 01; 84(1):89-96. doi:
10.1097/ta.0000000000001708. [PMID: 28930945] - Mahroo Baharfar, Yadollah Yamini, Shahram Seidi, Monireh Karami. Quantitative analysis of clonidine and ephedrine by a microfluidic system: On-chip electromembrane extraction followed by high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Nov; 1068-1069(?):313-321. doi:
10.1016/j.jchromb.2017.10.062. [PMID: 29127057] - Natalia Malikowska, Łukasz Fijałkowski, Alicja Nowaczyk, Piotr Popik, Kinga Sałat. Antidepressant-like activity of venlafaxine and clonidine in mice exposed to single prolonged stress - A model of post-traumatic stress disorder. Pharmacodynamic and molecular docking studies.
Brain research.
2017 Oct; 1673(?):1-10. doi:
10.1016/j.brainres.2017.08.001. [PMID: 28797691] - Kaïs Rtibi, Imen Hammami, Slimen Selmi, Dhekra Grami, Hichem Sebai, Mohamed Amri, Lamjed Marzouki. Phytochemical properties and pharmacological effects of Quercus ilex L. aqueous extract on gastrointestinal physiological parameters in vitro and in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Oct; 94(?):787-793. doi:
10.1016/j.biopha.2017.08.008. [PMID: 28802231] - Mascha Thurm, Britt-Inger Kröger Dahlin, Ola Winsö, Börje Ljungberg. Spinal analgesia improves surgical outcome after open nephrectomy for renal cell carcinoma: a randomized controlled study.
Scandinavian journal of urology.
2017 Aug; 51(4):277-281. doi:
10.1080/21681805.2017.1318300. [PMID: 28532200] - Bérangère Vasseur, Alain Dufour, Laetitia Houdas, Helen Goodwin, Kathryn Harries, Neslihan Yesiltas Emul, Simon Hutchings. Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial.
Advances in therapy.
2017 08; 34(8):2022-2032. doi:
10.1007/s12325-017-0585-9. [PMID: 28726169] - Fergus D Law, Alison M Diaper, Jan K Melichar, Simon Coulton, David J Nutt, Judy S Myles. Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals.
Journal of psychopharmacology (Oxford, England).
2017 08; 31(8):1046-1055. doi:
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Post reproductive health.
2017 Jun; 23(2):71-75. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 May; 1052(?):150-157. doi:
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Journal of clinical anesthesia.
2017 May; 38(?):140-153. doi:
10.1016/j.jclinane.2017.02.003. [PMID: 28372656] - Matthew Emile Li Kam Wa, Patricia Taraborrelli, Sajad Hayat, Phang Boon Lim. Respiration driven excessive sinus tachycardia treated with clonidine.
BMJ case reports.
2017 Apr; 2017(?):. doi:
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Pest management science.
2017 Apr; 73(4):752-760. doi:
10.1002/ps.4358. [PMID: 27414472] - Dan Fan, Ting-Jun Fan. Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 03; 156(1):252-260. doi:
10.1093/toxsci/kfw249. [PMID: 28115640] - Ines G Alamo, Kolenkode B Kannan, Harry Ramos, Tyler J Loftus, Philip A Efron, Alicia M Mohr. Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress.
Surgery.
2017 03; 161(3):795-802. doi:
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Bulletin of experimental biology and medicine.
2017 Jan; 162(3):357-361. doi:
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Pharmacotherapy.
2016 12; 36(12):1290-1299. doi:
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European journal of drug metabolism and pharmacokinetics.
2016 Dec; 41(6):819-824. doi:
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European journal of clinical pharmacology.
2016 Sep; 72(9):1051-8. doi:
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Brain research bulletin.
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Journal of psychiatric research.
2016 May; 76(?):38-43. doi:
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2016 05; 23(4):320-9. doi:
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Journal of veterinary pharmacology and therapeutics.
2016 Apr; 39(2):122-30. doi:
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Human & experimental toxicology.
2016 Apr; 35(4):371-6. doi:
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European journal of endocrinology.
2016 Mar; 174(3):R71-7. doi:
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2016 Mar; 12(1):134-8. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Feb; 1011(?):1-5. doi:
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Die Pharmazie.
2016 Feb; 71(2):76-83. doi:
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Liver international : official journal of the International Association for the Study of the Liver.
2016 Feb; 36(2):205-11. doi:
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Rinsho shinkeigaku = Clinical neurology.
2016; 56(2):108-11. doi:
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European neurology.
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PloS one.
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Xenotransplantation.
2015 Nov; 22(6):413-26. doi:
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BMC pediatrics.
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Vascular pharmacology.
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The American journal of psychiatry.
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Biomedical chromatography : BMC.
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Critical care medicine.
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BMC anesthesiology.
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JAMA.
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Clinical autonomic research : official journal of the Clinical Autonomic Research Society.
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Fundamental & clinical pharmacology.
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