Dronedarone hydrochloride (BioDeep_00000399049)
natural product
代谢物信息卡片
化学式: C31H45ClN2O5S (592.2738)
中文名称: 决奈达隆盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=C2C(=C1)C(=C(O2)CCCC)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC)NS(=O)(C)=O.Cl
InChI: InChI=1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3
描述信息
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D03914
- PubChem: 219025
- ChEMBL: CHEMBL1201729
- CAS: 141625-93-6
- MoNA: CCMSLIB00000078444
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Laura Barrie Smith, Nihar R Desai, Bryan Dowd, Alexander Everhart, Jeph Herrin, Lucas Higuera, Molly Moore Jeffery, Anupam B Jena, Joseph S Ross, Nilay D Shah, Pinar Karaca-Mandic. Patient and provider-level factors associated with changes in utilization of treatments in response to evidence on ineffectiveness or harm.
International journal of health economics and management.
2020 Sep; 20(3):299-317. doi:
10.1007/s10754-020-09282-2. [PMID: 32350680] - Yiyan Yu, Dan Luo, Zhiyi Li, Juan Zhang, Fang Li, Jie Qiao, Fengxu Yu, Miaoling Li. Inhibitory Effects of Dronedarone on Small Conductance Calcium Activated Potassium Channels in Patients with Chronic Atrial Fibrillation: Comparison to Amiodarone.
Medical science monitor : international medical journal of experimental and clinical research.
2020 May; 26(?):e924215. doi:
10.12659/msm.924215. [PMID: 32470968] - Vaishali M Gambhire, Makarand S Gambhire, Nisharani S Ranpise. Solid Lipid Nanoparticles of Dronedarone Hydrochloride for Oral Delivery: Optimization, In Vivo Pharmacokinetics and Uptake Studies.
Pharmaceutical nanotechnology.
2019; 7(5):375-388. doi:
10.2174/2211738507666190802140607. [PMID: 31376827] - Li-Qin Jiang, Shan-Jiang Chen, Jian-Jiang Xu, Zhang Ran, Wang Ying, Sheng-Gang Zhao. Dronedarone and Amiodarone Induce Dyslipidemia and Thyroid Dysfunction in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 38(6):2311-22. doi:
10.1159/000445585. [PMID: 27197836] - Elena Piccoli, Matteo Nadai, Carla Mucignat Caretta, Valeria Bergonzini, Claudia Del Vecchio, Huy Riem Ha, Laurent Bigler, Daniele Dal Zoppo, Elisabetta Faggin, Andrea Pettenazzo, Rocco Orlando, Cristiano Salata, Arianna Calistri, Giorgio Palù, Aldo Baritussio. Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype.
Biochemical pharmacology.
2011 Nov; 82(9):1234-49. doi:
10.1016/j.bcp.2011.07.090. [PMID: 21878321]
