Ambrisentan (BioDeep_00000399042)
natural product
代谢物信息卡片
Ambrisentan
化学式: C22H22N2O4 (378.1579492)
中文名称: 安贝生坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
InChI: InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)/t19-/m1/s1
描述信息
C - Cardiovascular system > C02 - Antihypertensives > C02K - Other antihypertensives > C02KX - Antihypertensives for pulmonary arterial hypertension
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, COVID-19 Disease Map
C28313 - Endothelin Receptor Antagonist > C28334 - Endothelin Receptor Type A Antagonist
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Ambrisentan is a selective ET type A receptor (ETAR) antagonist.
同义名列表
3 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135949
- KEGGdrug: D07077
- PubChem: 6918493
- DrugBank: DB06403
- ChEMBL: CHEMBL1111
- CAS: 177036-94-1
- MoNA: CCMSLIB00000078432
- medchemexpress: HY-13209
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaozheng Wu, Wen Li, Zhenliang Luo, Yunzhi Chen. A comprehensive comparison of the safety and efficacy of drugs in the treatment of idiopathic pulmonary fibrosis: a network meta-analysis based on randomized controlled trials.
BMC pulmonary medicine.
2024 Jan; 24(1):58. doi:
10.1186/s12890-024-02861-w. [PMID: 38281037] - Lali Ronsoni Zancan, Franciele Aline Bruinsmann, Karine Paese, Patrick Türck, Alan Bahr, Alexsandra Zimmer, Cristina Campos Carraro, Paulo Cavalheiro Schenkel, Adriane Belló-Klein, Claiton I Schwertz, David Driemeier, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres. Oral delivery of ambrisentan-loaded lipid-core nanocapsules as a novel approach for the treatment of pulmonary arterial hypertension.
International journal of pharmaceutics.
2021 Dec; 610(?):121181. doi:
10.1016/j.ijpharm.2021.121181. [PMID: 34653563] - Tian Lan, Ping Fang, Xuemei Ye, Xia Lan, Ren-Ai Xu. Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS.
Pharmaceutical biology.
2021 Dec; 59(1):1133-1138. doi:
10.1080/13880209.2021.1964544. [PMID: 34410882] - Miren Bravo, Imma Raurell, Aurora Barberá, Diana Hide, Mar Gil, Federico Estrella, María Teresa Salcedo, Salvador Augustin, Joan Genescà, María Martell. Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH.
Disease models & mechanisms.
2021 05; 14(5):. doi:
10.1242/dmm.048884. [PMID: 34014280] - Karen Paola Camarillo Cárdenas, Joceline Estefanía Rangel Velázquez, Javier Jesús Osorio Escobar, Juan Chirinos, Murali Pendela. Bioequivalence and Tolerability of Ambrisentan: A Pharmacokinetic Study in Mexican Healthy Male Subjects.
European journal of drug metabolism and pharmacokinetics.
2020 Oct; 45(5):611-618. doi:
10.1007/s13318-020-00627-3. [PMID: 32472357] - Kevin D Hill, Anil R Maharaj, Jennifer S Li, Elizabeth Thompson, Piers C A Barker, Christoph P Hornik. A Randomized, Controlled Pharmacokinetic and Pharmacodynamics Trial of Ambrisentan After Fontan Surgery.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2020 09; 21(9):e795-e803. doi:
10.1097/pcc.0000000000002410. [PMID: 32639468] - Ing Ni Lu, Spoorthy Kulkarni, Marie Fisk, Michalis Kostapanos, Edward Banham-Hall, Sonakshi Kadyan, Simon Bond, Sam Norton, Andrew Cope, James Galloway, Frances Hall, David Jayne, Ian B Wilkinson, Joseph Cheriyan. muLTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Experimental drugs and mechanisms (TACTIC-E): A structured summary of a study protocol for a randomized controlled trial.
Trials.
2020 Jul; 21(1):690. doi:
10.1186/s13063-020-04618-2. [PMID: 32736592] - Mengtao Li, Zhi-Cheng Jing, Yang Li, Yong Huo, Zaixin Yu, Gangcheng Zhang, Ping Zhu, Jinming Liu, Qiushang Ji, Bingxiang Wu, Jinhua Zhong, Pingping Wang, Wenjing Zhu, Xiaofeng Zeng. Efficacy and safety of ambrisentan in Chinese patients with connective tissue disease-pulmonary arterial hypertension: a post-hoc analysis.
BMC cardiovascular disorders.
2020 07; 20(1):339. doi:
10.1186/s12872-020-01591-1. [PMID: 32680480] - Daan van de Velde, Soma Bahmany, Emilie Hitzerd, Bart van Domburg, Jorie Versmissen, A H Jan Danser, Birgit C P Koch. Simultaneous quantification of ambrisentan, macitentan and sitaxentan in human plasma using UPLC-MS/MS.
Biomedical chromatography : BMC.
2020 Mar; 34(3):e4787. doi:
10.1002/bmc.4787. [PMID: 31875652] - José Ramón Santos, Ana Merino, Walter E Haefeli, Cristina Miranda, Marisol Prats, Ioana Bancu, Lucía Bailón, José Moltó. Ambrisentan use in a HIV-1 infected patient with end-stage renal disease and pulmonary hypertension: minimal removal by hemodialysis - a case report.
BMC nephrology.
2020 01; 21(1):24. doi:
10.1186/s12882-019-1659-5. [PMID: 31992232] - H Kazimoglu, E Uysal, M Dokur, A O Gurer, K Batcioglu, B A Uyumlu, E Petekkaya, M Karadag. Comparison of the protective effects of selective endothelin-a receptor antagonist, ambrisentan, and dual endothelin-A/B receptor antagonist, bosentan, in experimental renal ischemia reperfusion injury.
Bratislavske lekarske listy.
2020; 121(8):547-553. doi:
10.4149/bll_2020_091. [PMID: 32726116] - Malgorzata Kasztan, David M Pollock. Impact of ET-1 and sex in glomerular hyperfiltration in humanized sickle cell mice.
Clinical science (London, England : 1979).
2019 07; 133(13):1475-1486. doi:
10.1042/cs20190215. [PMID: 31273050] - Crystal Taylor, Malgorzata Kasztan, Binli Tao, Jennifer S Pollock, David M Pollock. Combined hydroxyurea and ETA receptor blockade reduces renal injury in the humanized sickle cell mouse.
Acta physiologica (Oxford, England).
2019 02; 225(2):e13178. doi:
10.1111/apha.13178. [PMID: 30144292] - P Johnsi Rani, Chiguru Vishnuvardhan, Rakesh D Nimbalkar, Prabha Garg, N Satheeshkumar. Metabolite characterization of ambrisentan, in in vitro and in vivo matrices by UHPLC/QTOF/MS/MS: Detection of glutathione conjugate of epoxide metabolite evidenced by in vitro GSH trapping assay.
Journal of pharmaceutical and biomedical analysis.
2018 Jun; 155(?):320-328. doi:
10.1016/j.jpba.2018.04.013. [PMID: 29684813] - Jiro Kino, Shoji Tsuji, Tetsuya Kitao, Yuko Akagawa, Sohsaku Yamanouchi, Takahisa Kimata, Kazunari Kaneko. Antiproteinuric effect of an endothelin-1 receptor antagonist in puromycin aminonucleoside-induced nephrosis in rat.
Pediatric research.
2018 05; 83(5):1041-1048. doi:
10.1038/pr.2018.11. [PMID: 29360807] - Soledad Garcia-Martínez, Estitxu Rico, Enriqueta Casal, Alba Grisaleña, Eider Alcaraz, Nicholas King, Nerea Leal, Iker Navarro, Miguel Ángel Campanero. Bionalytical validation study for the determination of unbound ambrisentan in human plasma using rapid equilibrium dialysis followed by ultra performance liquid chromatography coupled to mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2018 Feb; 150(?):427-435. doi:
10.1016/j.jpba.2017.12.030. [PMID: 29289894] - Malgorzata Kasztan, Brandon M Fox, Joshua S Speed, Carmen De Miguel, Eman Y Gohar, Tim M Townes, Abdullah Kutlar, Jennifer S Pollock, David M Pollock. Long-Term Endothelin-A Receptor Antagonism Provides Robust Renal Protection in Humanized Sickle Cell Disease Mice.
Journal of the American Society of Nephrology : JASN.
2017 Aug; 28(8):2443-2458. doi:
10.1681/asn.2016070711. [PMID: 28348063] - James A Angus, Paul F Soeding, Richard J A Hughes, Christine E Wright. Functional estimation of endothelin-1 receptor antagonism by bosentan, macitentan and ambrisentan in human pulmonary and radial arteries in vitro.
European journal of pharmacology.
2017 Jun; 804(?):111-116. doi:
10.1016/j.ejphar.2017.03.014. [PMID: 28300593] - Magali Vercauteren, Frederic Trensz, Anne Pasquali, Christophe Cattaneo, Daniel S Strasser, Patrick Hess, Marc Iglarz, Martine Clozel. Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention.
The Journal of pharmacology and experimental therapeutics.
2017 05; 361(2):322-333. doi:
10.1124/jpet.116.234930. [PMID: 28223322] - Ekkehard Grünig, Johanna Ohnesorge, Nicola Benjamin, Jürgen Burhenne, Yeliz Enderle, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Andrea Huppertz, Hans Klose, Walter E Haefeli. Plasma Drug Concentrations in Patients with Pulmonary Arterial Hypertension on Combination Treatment.
Respiration; international review of thoracic diseases.
2017; 94(1):26-37. doi:
10.1159/000470916. [PMID: 28494463] - Y Huo, Z C Jing, X F Zeng, J M Liu, Z X Yu, G C Zhang, Y Li, Y Wang, Q S Ji, P Zhu, B X Wu, Y Zheng, P P Wang, J Li. Evaluation of efficacy, safety and tolerability of Ambrisentan in Chinese adults with pulmonary arterial hypertension: a prospective open label cohort study.
BMC cardiovascular disorders.
2016 10; 16(1):201. doi:
10.1186/s12872-016-0361-9. [PMID: 27770771] - Mengchun Chen, Wenjie Song, Shuanghu Wang, Qiulei Chen, Peipei Pan, Tao Xu, Guoxin Hu, Zhiqiang Zheng. Simultaneous Determination of Bosentan, Glimepiride, HYBOS and M1 in Rat Plasma by UPLC-MS-MS and its Application to Pharmacokinetic Study.
Journal of chromatographic science.
2016 Aug; 54(7):1159-65. doi:
10.1093/chromsci/bmw003. [PMID: 27240565] - A Hakamata, K Odagiri, S Miyakawa, H Irisawa, K Takeuchi, N Inui, S Tanaka, S Uchida, H Watanabe. Pharmacokinetic and Pharmacodynamic Comparison of Sildenafil-Bosentan and Sildenafil-Ambrisentan Combination Therapies for Pulmonary Hypertension.
Clinical and translational science.
2016 Feb; 9(1):29-35. doi:
10.1111/cts.12382. [PMID: 26756977] - Yeliz Enderle, Andreas D Meid, Jörg Friedrich, Ekkehard Grünig, Heinrike Wilkens, Walter E Haefeli, Jürgen Burhenne. Dried Blood Spot Technique for the Monitoring of Ambrisentan, Bosentan, Sildenafil, and Tadalafil in Patients with Pulmonary Arterial Hypertension.
Analytical chemistry.
2015 Dec; 87(24):12112-20. doi:
10.1021/acs.analchem.5b03077. [PMID: 26583764] - Christoph Markert, Ida Maria Kastner, Regina Hellwig, Peter Kalafut, Yvonne Schweizer, Michael Marcus Hoffmann, Jürgen Burhenne, Johanna Weiss, Gerd Mikus, Walter Emil Haefeli. The effect of induction of CYP3A4 by St John's wort on ambrisentan plasma pharmacokinetics in volunteers of known CYP2C19 genotype.
Basic & clinical pharmacology & toxicology.
2015 May; 116(5):423-8. doi:
10.1111/bcpt.12332. [PMID: 25286744] - J Gerry Kenna, Simone H Stahl, Julie A Eakins, Alison J Foster, Linda C Andersson, Jonas Bergare, Martin Billger, Marie Elebring, Charles S Elmore, Richard A Thompson. Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists.
The Journal of pharmacology and experimental therapeutics.
2015 Feb; 352(2):281-90. doi:
10.1124/jpet.114.220491. [PMID: 25467130] - Christoph Markert, Theresia Wirsching, Regina Hellwig, Jürgen Burhenne, Johanna Weiss, Klaus-Dieter Riedel, Gerd Mikus, Walter E Haefeli. Lack of a clinically significant interaction of grapefruit juice with ambrisentan and bosentan in healthy adults.
International journal of clinical pharmacology and therapeutics.
2014 Nov; 52(11):957-64. doi:
10.5414/cp202164. [PMID: 25207548] - Ojit Kumar Lukram, Ramkishor Sharma. High-performance liquid chromatography tandem mass spectrometry method for quantification of endothelin receptor antagonist drug, ambrisentan, in human plasma and its application in a pharmacokinetic study.
Biomedical chromatography : BMC.
2014 Aug; 28(8):1147-55. doi:
10.1002/bmc.3136. [PMID: 24616031] - Yoshinari Yokoyama, Miho Tomatsuri, Hideki Hayashi, Keita Hirai, Yasuo Ono, Yuto Yamada, Kenichiro Todoroki, Toshimasa Toyo'oka, Hiroshi Yamada, Kunihiko Itoh. Simultaneous microdetermination of bosentan, ambrisentan, sildenafil, and tadalafil in plasma using liquid chromatography/tandem mass spectrometry for pediatric patients with pulmonary arterial hypertension.
Journal of pharmaceutical and biomedical analysis.
2014 Feb; 89(?):227-32. doi:
10.1016/j.jpba.2013.11.007. [PMID: 24309556] - Yoshinari Yokoyama, Ayaka Osano, Hideki Hayashi, Kunihiko Itoh, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito, Shizuo Yamada. Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020.
Biological & pharmaceutical bulletin.
2014; 37(3):461-5. doi:
10.1248/bpb.b13-00881. [PMID: 24583865] - L Zhang, Y Zou, S-H Song, Z-X Wang, G-S Ding, J Ma, Z-J Ni, H Fu, X-M Shi, X-G Gao, Q-C Han, W-Y Guo, Z-R Fu. Ambrisentan improves the outcome of rats with liver transplantation partially through reducing nephrotoxicity.
European review for medical and pharmacological sciences.
2014; 18(17):2575-83. doi:
NULL. [PMID: 25268107] - Christoph Markert, Regina Hellwig, Jürgen Burhenne, Michael Marcus Hoffmann, Johanna Weiss, Gerd Mikus, Walter E Haefeli. Interaction of ambrisentan with clarithromycin and its modulation by polymorphic SLCO1B1.
European journal of clinical pharmacology.
2013 Oct; 69(10):1785-93. doi:
10.1007/s00228-013-1529-1. [PMID: 23748747] - Bradley A Maron, Aaron B Waxman, Alexander R Opotowsky, Hunter Gillies, Christiana Blair, Reza Aghamohammadzadeh, Joseph Loscalzo, Jane A Leopold. Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials).
The American journal of cardiology.
2013 Sep; 112(5):720-5. doi:
10.1016/j.amjcard.2013.04.051. [PMID: 23751938] - Deborah Stuart, Mark Chapman, Sara Rees, Stephanie Woodward, Donald E Kohan. Myocardial, smooth muscle, nephron, and collecting duct gene targeting reveals the organ sites of endothelin A receptor antagonist fluid retention.
The Journal of pharmacology and experimental therapeutics.
2013 Aug; 346(2):182-9. doi:
10.1124/jpet.113.205286. [PMID: 23709116] - Shinichi Takatsuki, Erika B Rosenzweig, Warren Zuckerman, Daniela Brady, Michelle Calderbank, D Dunbar Ivy. Clinical safety, pharmacokinetics, and efficacy of ambrisentan therapy in children with pulmonary arterial hypertension.
Pediatric pulmonology.
2013 Jan; 48(1):27-34. doi:
10.1002/ppul.22555. [PMID: 22511577] - Jürgen Venitz, Julia Zack, Hunter Gillies, Martine Allard, Jean Regnault, Christopher Dufton. Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension.
Journal of clinical pharmacology.
2012 Dec; 52(12):1784-805. doi:
10.1177/0091270011423662. [PMID: 22205719] - Janet J Maguire, Rhoda E Kuc, Anthony P Davenport. Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues.
Life sciences.
2012 Oct; 91(13-14):681-6. doi:
10.1016/j.lfs.2012.05.008. [PMID: 22634326] - Ramakrishna Nirogi, Vishwottam Kandikere, Prashanth Komarneni, Raghupathi Aleti, Nagasuryaprakash Padala, Ilayaraja Kalaikadhiban. LC-ESI-MS/MS method for quantification of ambrisentan in plasma and application to rat pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Oct; 26(10):1150-6. doi:
10.1002/bmc.2670. [PMID: 22222607] - Shunji Yoshida, Kunio Shirato, Ryutaro Shimamura, Takayuki Iwase, Narumi Aoyagi, Hiromu Nakajima. Long-term safety and efficacy of ambrisentan in Japanese adults with pulmonary arterial hypertension.
Current medical research and opinion.
2012 Jun; 28(6):1069-76. doi:
10.1185/03007995.2012.685930. [PMID: 22506623] - Feng Li, John R Hagaman, Hyung-Suk Kim, Nobuyo Maeda, J Charles Jennette, James E Faber, S Ananth Karumanchi, Oliver Smithies, Nobuyuki Takahashi. eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype.
Journal of the American Society of Nephrology : JASN.
2012 Apr; 23(4):652-60. doi:
10.1681/asn.2011040369. [PMID: 22282588] - Shirin Bruderer, Päivi Aänismaa, Marie-Claude Homery, Stephanie Häusler, Kyle Landskroner, Patricia N Sidharta, Alexander Treiber, Jasper Dingemanse. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist.
The AAPS journal.
2012 Mar; 14(1):68-78. doi:
10.1208/s12248-011-9316-3. [PMID: 22189899] - M A Judson, K B Highland, S Kwon, J F Donohue, R Aris, N Craft, S Burt, H J Ford. Ambrisentan for sarcoidosis associated pulmonary hypertension.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG.
2011 Oct; 28(2):139-45. doi:
. [PMID: 22117505] - Patricia N Sidharta, Paul L M van Giersbergen, Atef Halabi, Jasper Dingemanse. Macitentan: entry-into-humans study with a new endothelin receptor antagonist.
European journal of clinical pharmacology.
2011 Oct; 67(10):977-84. doi:
10.1007/s00228-011-1043-2. [PMID: 21541781] - Shunji Yoshida, Kunio Shirato, Ryutaro Shimamura, Norie Nakahara, Takayuki Iwase, Hiromu Nakajima. Efficacy, safety, and pharmacokinetics of ambrisentan in Japanese adults with pulmonary arterial hypertension.
Current medical research and opinion.
2011 Sep; 27(9):1827-34. doi:
10.1185/03007995.2011.605440. [PMID: 21812736] - Rebecca Spence, Arun Mandagere, Gennyne Walker, Christopher Dufton, Ramesh Boinpally. Effect of steady-state ambrisentan on the pharmacokinetics of a single dose of the oral contraceptive norethindrone (norethisterone) 1 mg/ethinylestradiol 35 microg in healthy subjects: an open-label, single-sequence, single-centre study.
Clinical drug investigation.
2010; 30(5):313-24. doi:
10.2165/11534940-000000000-00000. [PMID: 20384387] - Brooke Harrison, Mindy H Magee, Arun Mandagere, Gennyne Walker, Christopher Dufton, Linda S Henderson, Ramesh Boinpally. Effects of rifampicin (rifampin) on the pharmacokinetics and safety of ambrisentan in healthy subjects: a single-sequence, open-label study.
Clinical drug investigation.
2010; 30(12):875-885. doi:
10.2165/11539110-000000000-00000. [PMID: 20923245] - Rebecca Spence, Arun Mandagere, Brooke Harrison, Christopher Dufton, Ramesh Boinpally. No clinically relevant pharmacokinetic and safety interactions of ambrisentan in combination with tadalafil in healthy volunteers.
Journal of pharmaceutical sciences.
2009 Dec; 98(12):4962-74. doi:
10.1002/jps.21789. [PMID: 19455620] - Caterina P Minniti, Roberto F Machado, Wynona A Coles, Vandana Sachdev, Mark T Gladwin, Gregory J Kato. Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease.
British journal of haematology.
2009 Dec; 147(5):737-43. doi:
10.1111/j.1365-2141.2009.07906.x. [PMID: 19775299] - Gennyne Walker, Arun Mandagere, Christopher Dufton, Jürgen Venitz. The pharmacokinetics and pharmacodynamics of warfarin in combination with ambrisentan in healthy volunteers.
British journal of clinical pharmacology.
2009 May; 67(5):527-34. doi:
10.1111/j.1365-2125.2009.03384.x. [PMID: 19552747] - Rebecca Spence, Arun Mandagere, Christopher Dufton, Jürgen Venitz. Pharmacokinetics and safety of ambrisentan in combination with sildenafil in healthy volunteers.
Journal of clinical pharmacology.
2008 Dec; 48(12):1451-9. doi:
10.1177/0091270008324180. [PMID: 18832294] - Nazzareno Galiè, Horst Olschewski, Ronald J Oudiz, Fernando Torres, Adaani Frost, Hossein A Ghofrani, David B Badesch, Michael D McGoon, Vallerie V McLaughlin, Ellen B Roecker, Michael J Gerber, Christopher Dufton, Brian L Wiens, Lewis J Rubin. Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.
Circulation.
2008 Jun; 117(23):3010-9. doi:
10.1161/circulationaha.107.742510. [PMID: 18506008] - Giorgio Tamborrini, Meike Distler, Oliver Distler. [Systemic sclerosis].
Medizinische Monatsschrift fur Pharmazeuten.
2008 May; 31(5):162-70; quiz 171. doi:
. [PMID: 18552072] - N S Kirkby, P W F Hadoke, A J Bagnall, D J Webb. The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?.
British journal of pharmacology.
2008 Mar; 153(6):1105-19. doi:
10.1038/sj.bjp.0707516. [PMID: 17965745] - Dirk Uhlmann, Heike Lauer, Frederik Serr, Stefan Ludwig, Andrea Tannapfel, Martin Fiedler, Johann Hauss, Helmut Witzigmann. Pathophysiological role of platelets in acute experimental pancreatitis: influence of endothelin A receptor blockade.
Cell and tissue research.
2007 Mar; 327(3):485-92. doi:
10.1007/s00441-006-0319-9. [PMID: 17093924] - Sidney G Shaw, Jane P Boden, Erwin Biecker, Juerg Reichen, Barbara Rothen. Endothelin antagonism prevents diabetic retinopathy in NOD mice: a potential role of the angiogenic factor adrenomedullin.
Experimental biology and medicine (Maywood, N.J.).
2006 Jun; 231(6):1101-5. doi:
NULL. [PMID: 16741057] - Dirk Uhlmann, Gabor Gaebel, Barbara Armann, Stefan Ludwig, Jochen Hess, Uta-Carolin Pietsch, Martin Fiedler, Andrea Tannapfel, Johann Hauss, Helmut Witzigmann. Attenuation of proinflammatory gene expression and microcirculatory disturbances by endothelin A receptor blockade after orthotopic liver transplantation in pigs.
Surgery.
2006 Jan; 139(1):61-72. doi:
10.1016/j.surg.2005.07.006. [PMID: 16364719] - Nazzareno Galié, David Badesch, Ronald Oudiz, Gérald Simonneau, Michael D McGoon, Anne M Keogh, Adaani E Frost, Diane Zwicke, Robert Naeije, Shelley Shapiro, Horst Olschewski, Lewis J Rubin. Ambrisentan therapy for pulmonary arterial hypertension.
Journal of the American College of Cardiology.
2005 Aug; 46(3):529-35. doi:
10.1016/j.jacc.2005.04.050. [PMID: 16053970] - Dirk Uhlmann, Sebastian Glasser, Gabor Gaebel, Barbara Armann, Stefan Ludwig, Andrea Tannapfel, Johann Hauss, Helmut Witzigmann. Improvement of postischemic hepatic microcirculation after endothelinA receptor blockade--endothelin antagonism influences platelet-endothelium interactions.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
2005 Feb; 9(2):187-97. doi:
10.1016/j.gassur.2004.06.006. [PMID: 15694814] - George E Billman. Ambrisentan (Myogen).
Current opinion in investigational drugs (London, England : 2000).
2002 Oct; 3(10):1483-6. doi:
NULL. [PMID: 12431023] - Bruno Balsiger, Andreas Rickenbacher, Penelope Jane Boden, Erwin Biecker, Janice Tsui, Michael Dashwood, Jürg Reichen, Sidney George Shaw. Endothelin A-receptor blockade in experimental diabetes improves glucose balance and gastrointestinal function.
Clinical science (London, England : 1979).
2002 Aug; 103 Suppl 48(?):430S-433S. doi:
10.1042/cs103s430s. [PMID: 12193138] - . .
.
. doi:
. [PMID: 20811346] - . .
.
. doi:
. [PMID: 19920913]