Dyclonine hydrochloride (BioDeep_00000399028)
natural product
代谢物信息卡片
化学式: C18H28ClNO2 (325.18084580000004)
中文名称: 盐酸达克罗宁
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=C(C=CC(=C1)C(CCN2CCCCC2)=O)OCCCC).Cl
InChI: 1H
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain[1][2][3].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:4725
- KEGGdrug: D00735
- PubChem: 68304
- ChEMBL: CHEMBL1200478
- CAS: 536-43-6
- MoNA: CCMSLIB00000078406
- medchemexpress: HY-B0364A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Adnan Iqbal, Joanna Bocian, Mateusz Przyborowski, Wacław Orczyk, Anna Nadolska-Orczyk. Are TaNAC Transcription Factors Involved in Promoting Wheat Yield by cis-Regulation of TaCKX Gene Family?.
International journal of molecular sciences.
2024 Feb; 25(4):. doi:
10.3390/ijms25042027. [PMID: 38396706] - Monika Vranic, Alexandre Perochon, Harriet Benbow, Fiona M Doohan. Comprehensive analysis of pathogen-responsive wheat NAC transcription factors: new candidates for crop improvement.
G3 (Bethesda, Md.).
2022 11; 12(11):. doi:
10.1093/g3journal/jkac247. [PMID: 36130261] - Qiang Liu, Jin Wang, Xin Wei, Juan Hu, Conghui Ping, Yue Gao, Chang Xie, Peiyu Wang, Peng Cao, Zhengyu Cao, Ye Yu, Dongdong Li, Jing Yao. Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine.
eLife.
2021 04; 10(?):. doi:
10.7554/elife.68128. [PMID: 33876725] - Jian-Ming Chen, Dong-Dong Li, Yi-Shan Chen, Bo Lian, Xiao-Peng Wang, Yu-Hong Guo, Xiao-Long Xu, Po Huang, Teng-Fei Chen, Yang Liu, Qing-Quan Liu. The effectiveness of electro-acupuncture combined with dyclonine hydrochloride in relieving the side effects of gastroscopy: a controlled trial.
Annals of palliative medicine.
2021 Mar; 10(3):2958-2970. doi:
10.21037/apm-20-831. [PMID: 33691439] - Tuğçe Oruç, Sami Emre Küçük, Deniz Sezer. Lipid bilayer permeation of aliphatic amine and carboxylic acid drugs: rates of insertion, translocation and dissociation from MD simulations.
Physical chemistry chemical physics : PCCP.
2016 Sep; 18(35):24511-25. doi:
10.1039/c6cp05278a. [PMID: 27539552] - Liying Wu, Jianfang Liu, Yunhao Zhang, Yanning Hou. Development of a HPLC/MS/MS method for simultaneous determination of tinidazole, dyclonine and chlorhexidine in rat plasma and its application in the pharmacokinetic research of a film-forming solution.
Journal of pharmaceutical and biomedical analysis.
2012 Mar; 62(?):224-7. doi:
10.1016/j.jpba.2012.01.009. [PMID: 22305084] - H Groeben, J Peters. Lidocaine exerts its effect on induced bronchospasm by mitigating reflexes, rather than by attenuation of smooth muscle contraction.
Acta anaesthesiologica Scandinavica.
2007 Mar; 51(3):359-64. doi:
10.1111/j.1399-6576.2006.01205.x. [PMID: 17390422] - Harald Groeben, Markus Schlicht, Sven Stieglitz, Goran Pavlakovic, Jürgen Peters. Both local anesthetics and salbutamol pretreatment affect reflex bronchoconstriction in volunteers with asthma undergoing awake fiberoptic intubation.
Anesthesiology.
2002 Dec; 97(6):1445-50. doi:
10.1097/00000542-200212000-00016. [PMID: 12459670] - H Groeben, T Grosswendt, M T Silvanus, G Pavlakovic, J Peters. Airway anesthesia alone does not explain attenuation of histamine-induced bronchospasm by local anesthetics: a comparison of lidocaine, ropivacaine, and dyclonine.
Anesthesiology.
2001 Mar; 94(3):423-8; discussion 5A. doi:
10.1097/00000542-200103000-00010. [PMID: 11374600]