Nefiracetam (BioDeep_00000399008)

   

natural product


代谢物信息卡片


Nefiracetam (Translon)

化学式: C14H18N2O2 (246.1368208)
中文名称: 奈非西坦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(N1C(CCC1)=O)C(NC2=C(C=CC=C2C)C)=O
InChI: InChI=1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)

描述信息

D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
C26170 - Protective Agent > C1509 - Neuroprotective Agent
D020011 - Protective Agents
Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions. Target: GABA Receptor Nefiracetam induces a short-term depression of ACh-evoked currents at submicromolar concentrations (0.01-0.1 μM) and a long-term enhancement of the currents at micromolar concentrations (1-10 μM). Nefiracetam interacts with PKA and PKC pathways, which may explain a cellular mechanism for the action of cognition-enhancing agents. Lower (submicromolar) concentrations of the nootropic Nefiracetam reduces ACh-evoked currents to 30\% (0.01 μM) and 38\% (0.1 μM) of control after a 10-minute treatment [1]. Nefiracetam administered orally inhibits Ro 5-4864-induced convulsions in EL mice. Nefiracetam also efficiently inhibits Ro 5-4864-induced convulsions in DDY mice at doses higher than 10 mg/kg [2]. Nefiracetam administered daily 1 hour before each training session facilitates the acquisition process of the avoidance response [3].

同义名列表

4 个代谢物同义名

Nefiracetam; Nefiracetam (Translon); DM9384; DZL-221



数据库引用编号

7 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Chuan-Yi Fu, Xu-Ying He, Xi-Feng Li, Xin Zhang, Zhi-Wei Huang, Jun Li, Min Chen, Chuan-Zhi Duan. Nefiracetam Attenuates Pro-Inflammatory Cytokines and GABA Transporter in Specific Brain Regions of Rats with Post-Ischemic Seizures. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2015; 37(5):2023-31. doi: 10.1159/000438562. [PMID: 26584300]
  • Yasuhito Shirai, Takeshi Kouzuki, Kenichi Kakefuda, Shigeki Moriguchi, Atsushi Oyagi, Kyoji Horie, Shin-ya Morita, Masamitsu Shimazawa, Kohji Fukunaga, Junji Takeda, Naoaki Saito, Hideaki Hara. Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function. PloS one. 2010 Jul; 5(7):e11602. doi: 10.1371/journal.pone.0011602. [PMID: 20657643]
  • Yoshimi Tsuchiya, Yuri Tominaga, Kyuichi Matsubayashi, Toshimasa Jindo, Kazuhisa Furuhama, Kazuo T Suzuki. Investigation on urinary proteins and renal mRNA expression in canine renal papillary necrosis induced by nefiracetam. Archives of toxicology. 2005 Sep; 79(9):500-7. doi: 10.1007/s00204-005-0666-4. [PMID: 16007418]
  • Yoshimi Tsuchiya, Koichi Yabe, Sanae Takada, Yoshikazu Ishii, Toshimasa Jindo, Kazuhisa Furuhama, Kazuo T Suzuki. Early pathophysiological features in canine renal papillary necrosis induced by nefiracetam. Toxicologic pathology. 2005; 33(5):561-9. doi: 10.1080/01926230500222593. [PMID: 16105799]
  • Kazuhiro Shimomura, Makoto Shimada, Miyoko Hagiwara, Shigeo Harada, Michiyuki Kato, Kazuhisa Furuhama. Testicular toxicity induced in dogs by nefiracetam, a neutrotransmission enhancer. Reproductive toxicology (Elmsford, N.Y.). 2004 May; 18(3):423-30. doi: 10.1016/j.reprotox.2004.01.008. [PMID: 15082078]
  • Mutsumi Ueda, Ryousuke Fujita, Takehiko Koji, Hiroshi Ueda. The cognition-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. 2004 Apr; 309(1):200-7. doi: 10.1124/jpet.103.061127. [PMID: 14718588]
  • Makoto Shimada, Yukari Shikanai, Kazuhiro Shimomura, Shigeo Harada, Gen Watanabe, Kazuyoshi Taya, Michiyuki Kato, Kazuhisa Furuhama. Investigation of testicular toxicity of nefiracetam, a neurotransmission enhancer, in rats. Toxicology letters. 2003 Aug; 143(3):307-15. doi: 10.1016/s0378-4274(03)00197-8. [PMID: 12849691]
  • Yoshimi Tsuchiya, Yuji Takahashi, Toshimasa Jindo, Kazuhisa Furuhama, Kazuo T Suzuki. Comprehensive evaluation of canine renal papillary necrosis induced by nefiracetam, a neurotransmission enhancer. European journal of pharmacology. 2003 Aug; 475(1-3):119-28. doi: 10.1016/s0014-2999(03)02123-x. [PMID: 12954368]
  • Ryousuke Fujita, Naoko Takayama, Hiroshi Ueda. The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition. Neurochemistry international. 2002 Feb; 40(2):139-43. doi: 10.1016/s0197-0186(01)00080-8. [PMID: 11738480]
  • X Zhao, A Kuryatov, J M Lindstrom, J Z Yeh, T Narahashi. Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. Molecular pharmacology. 2001 Apr; 59(4):674-83. doi: 10.1124/mol.59.4.674. [PMID: 11259610]
  • Y Kashida, M Yoshida, Y Ishii, M Nomura, M Kato. Examination of lesions in the urinary bladder and kidney of dogs induced by nefiracetam, a new nootropic agent. Toxicologic pathology. 1996 Sep; 24(5):549-57. doi: 10.1177/019262339602400503. [PMID: 8923675]
  • W N Hooks, K A Colman, C Gopinath, F Inage, M Kato, S Takayama. Fifty-two-week oral toxicity study of the new cognition-enhancing agent nefiracetam in rats. Arzneimittel-Forschung. 1994 Feb; 44(2A):220-8. doi: NULL. [PMID: 8018094]
  • T Jindo, Y Shimizu, M Kato, S Takayama. Thirteen-week oral toxicity study of the new cognition-enhancing agent nefiracetam in rats. Arzneimittel-Forschung. 1994 Feb; 44(2A):214-6. doi: NULL. [PMID: 8018092]
  • W N Hooks, P Burford, S Begg, C Gopinath, F Inage, M Kato, S Takayama. Fifty-two-week oral toxicity study of the new cognition-enhancing agent nefiracetam in dogs. Arzneimittel-Forschung. 1994 Feb; 44(2A):228-38. doi: NULL. [PMID: 8018095]
  • T Sugawara, M Kato, N Suzuki, K Akahane, S Takayama. Thirteen-week oral toxicity study of the new cognition-enhancing agent nefiracetam in dogs. Arzneimittel-Forschung. 1994 Feb; 44(2A):217-9. doi: NULL. [PMID: 8018093]
  • Y Fujimaki, K Sudo, H Hakusui. Pharmacokinetics of nefiracetam and three metabolites in humans and stereoselective hydroxylation of its pyrrolidine ring. Xenobiotica; the fate of foreign compounds in biological systems. 1993 Jan; 23(1):61-70. doi: 10.3109/00498259309059362. [PMID: 8484264]
  • Y Fujimaki, K Sudo, H Hakusui, H Tachizawa, M Murasaki. Single- and multiple-dose pharmacokinetics of nefiracetam, a new nootropic agent, in healthy volunteers. The Journal of pharmacy and pharmacology. 1992 Sep; 44(9):750-4. doi: 10.1111/j.2042-7158.1992.tb05513.x. [PMID: 1360528]
  • Y Fujimaki, K Sudo, H Hakusui. Simultaneous determination of nefiracetam and its metabolites by high-performance liquid chromatography. Journal of chromatography. 1992 Mar; 575(2):261-8. doi: 10.1016/0378-4347(92)80154-i. [PMID: 1629302]
  • Y Fujimaki, K Hashimoto, K Sudo, H Tachizawa. Biotransformation of a new pyrrolidinone cognition-enhancing agent: isolation and identification of metabolites in human urine. Xenobiotica; the fate of foreign compounds in biological systems. 1990 Oct; 20(10):1081-94. doi: 10.3109/00498259009046828. [PMID: 2082597]
  • Y Fujimaki, K Sudo, H Tachizawa. High-performance liquid chromatographic determination of a new nootropic, N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide, in human serum and urine. Journal of chromatography. 1988 Dec; 433(?):235-42. doi: 10.1016/s0378-4347(00)80602-7. [PMID: 3235551]