Dapoxetine Hydrochloride (BioDeep_00000398985)

   

natural product


代谢物信息卡片


Dapoxetine hydrochloride (Priligy)

  化学式: C21H24ClNO (341.1546)
中文名称: 达泊西汀 盐酸盐
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: C1(=CC=C2C(=C1OCC[C@@H](C3=CC=CC=C3)N(C)C)C=CC=C2).Cl
InChI: InChI=1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21


描述信息

C78272 - Agent Affecting Nervous System > C94725 - Selective Serotonin Reuptake Inhibitor
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent

同义名列表

38 个代谢物同义名

Dapoxetine Hydrochloride; Dapoxetine hydrochloride (Priligy); UNII-U4OHT63MRI; (+)-(S)-N,N-DIMETHYL-.ALPHA.-(2-(1-NAPHTHYLOXY)ETHYL)BENZYLAMINE HYDROCHLORIDE; (+)-(S)-N,N-Dimethyl-alpha-(2-(1-naphthyloxy)ethyl)benzylamine hydrochloride; (+)-Dapoxetine hydrochloride; (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine;hydrochloride; (a-S)-N,N-Dimethyl-a-[2-(1-naphthalenyloxy)ethyl]benzenemethanamine hydrochloride;LY-210448; (S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propylamine Hydrochloride; (S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenylpropylamine Hydrochloride; (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride; (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-aminehydrochloride; (S)-N,N-Dimethyl-alpha-[2-(1-naphthaleny loxy)ethyl]benzenemethanamine hydrochloride; (S)-N,N-Dimethyl-alpha-[2-(1-naphthyloxy)ethyl]benzylamine Hydrochloride; BENZENEMETHANAMINE, N,N-DIMETHYL-.ALPHA.-(2-(1-NAPHTHALENYLOXY)ETHYL)-, HYDROCHLORIDE, (S)-; Benzenemethanamine, N,N-dimethyl-a-[2-(1-naphthalenyloxy)ethyl]-,hydrochloride, (S)-; Benzenemethanamine, N,N-dimethyl-alpha-(2-(1-naphthalenyloxy)ethyl)-, hydrochloride, (alphaS)-; Benzenemethanamine, N,N-dimethyl-alpha-(2-(1-naphthalenyloxy)ethyl)-, hydrochloride, (S)-; C21H23NO.HCl; D-dapoxetine HCL; dapoxetine; Dapoxetine (as hydrochloride); Dapoxetine (hydrochloride); Dapoxetine (hydrochloride) (Standard); Dapoxetine (hydrochloride)?; Dapoxetine HCl; Dapoxetine hydrochloride - Bio-X trade mark; Dapoxetine hydrochloride (USAN); DAPOXETINE HYDROCHLORIDE [MART.]; DAPOXETINE HYDROCHLORIDE [MI]; Dapoxetine hydrochloride [USAN]; DAPOXETINE HYDROCHLORIDE [WHO-DD]; Dapoxetine hydrochloride, >=98% (HPLC); Dapoxetine, HCl; N,N-Dimethyl-3-[(naphthalen-1-yl)oxy]-1-phenylpropan-1-amine--hydrogen chloride (1/1); N,N-dimethyl-alpha-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine; Priligy; U4OHT63MRI



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Andrea Sansone, Jianlin Yuan, Guangdong Hou, Lei Zhang, Ming Gao, Zhe Zhang, Hui Jiang, Fu Wang, Jun Guo, Qiang Geng, Ming Wang, Xiansheng Zhang, Xi Yu, Yan Zhang, Jin-Chuan Liu, Yong-Gang Duan, Dinesh Nagrale, Zhiguo Chen, Emmanuele A Jannini, Elena Colonnello, Giacomo Ciocca, Erika Limoncin, Daniele Mollaioli, Xinlong Dun, Jiarui Yuan, Haocheng Lin, Hui Zhang. From Waterloo to the Great Wall: A retrospective, multicenter study on the clinical practice and cultural attitudes in the management of premature ejaculation, in China. Andrology. 2024 Feb; 12(2):247-258. doi: 10.1111/andr.13403. [PMID: 36748824]
  • Sarah Sameh Abdel-Hameed, Mahmoud El-Daly, Al-Shaimaa F Ahmed, Amany A Bekhit, Gehan H Heeba. Dapoxetine prevents neuronal damage and improves functional outcomes in a model of ischemic stroke through the modulation of inflammation and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. 2024 01; 397(1):253-266. doi: 10.1007/s00210-023-02601-7. [PMID: 37417988]
  • Bing Xu, Yong-Zhan Gong, Kai-Feng Liu, Sheng-Min Zhang, Shao Zhang, Pan-Yan Zhu, Zi-Hao Wang, Peng-Jie Lu, Zi-Song Xie. [Clinical observation of dapoxetine combined with percutaneous neuromuscular electrical stimulation in the treatment of primary premature ejaculation]. Zhonghua nan ke xue = National journal of andrology. 2023 Sep; 29(9):815-820. doi: ". [PMID: 38639594]
  • Chongfu Zhong, Chunlei Li, Qiang Geng, Qiang Han, Qinghe Gao, Jiwei Zhang, Fu Wang, Jun Guo. Reasons and treatment strategy for discontinuation of dapoxetine treatment in premature ejaculation patients in China: A retrospective observational study. Andrologia. 2022 Aug; 54(7):1598-1604. doi: 10.1111/and.14425. [PMID: 35324028]
  • Xin Zhang, Zhanwang Gao, Fei Qin, Kehan Chen, Jiansong Wang, Lingli Wang. Determination of Dapoxetine Hydrochloride in Human Plasma by HPLC-MS/MS and Its Application in a Bioequivalence Study. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092707. [PMID: 35566058]
  • Jingyan Liu, Zhihui Li, Keyu Yan, Gehang Ju, Wen Qiu. Pharmacokinetics and Safety of Dapoxetine Hydrochloride in Healthy Chinese Men: Impact of Dose and High-Fat Meal. Clinical pharmacology in drug development. 2021 10; 10(10):1216-1224. doi: 10.1002/cpdd.919. [PMID: 33528113]
  • Yuanyuan Huang, Jingjing Gao, Pan Gao, Dangwei Peng, Yutian Dai, Hui Jiang, Xiansheng Zhang. A comprehensive assessment of genetic variation in serotonin transporter gene (5-HTTLPR+rs25531) and the response to dapoxetine in Chinese patients with premature ejaculation. Andrologia. 2021 Sep; 53(8):e14141. doi: 10.1111/and.14141. [PMID: 34118072]
  • Ibrahim A El-Said, Ahmed A Aboelwafa, Omaima N ElGazayerly. Optimization of taste-masked dapoxetine oral thin films using factorial design: in vitro and in vivo evaluation. Pharmaceutical development and technology. 2021 Jun; 26(5):522-538. doi: 10.1080/10837450.2021.1894445. [PMID: 33663316]
  • Keyu Yan, Gehang Ju, Qiong Tan, Lijiao Zeng, Wen Qiu. Bioequivalence Analysis of 2 Dapoxetine Hydrochloride Formulations in Healthy Chinese Male Volunteers Under Fed and Fasting Conditions: A Randomized, Open-Label, 2-Sequence, 2-Period, 2-Way Crossover Study. Clinical pharmacology in drug development. 2021 04; 10(4):384-392. doi: 10.1002/cpdd.866. [PMID: 33385318]
  • Jun Guo, Fu Wang, Qing Zhou, Qiang Geng, Qinghe Gao, Rui Zhang, Chunhe Zhang, Zhihua Xuan, Jian Cai, Bin Bin, Qiang Han, Boda Guo, Bin Yan, Jiwei Zhang, Elena Colonnello, Emmanuele A Jannini. Safety and efficacy of traditional Chinese medicine, Qiaoshao formula, combined with dapoxetine in the treatment of premature ejaculation: An open-label, real-life, retrospective multicentre study in Chinese men. Andrologia. 2021 Feb; 53(1):e13915. doi: 10.1111/and.13915. [PMID: 33236403]
  • Ahmed A Abu-Hassan, Ramadan Ali, Sayed M Derayea. One-pot micellar augmented native fluorescence for facile fluorimetric assay of dapoxetine hydrochloride in biological plasma and tablets. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Oct; 239(?):118512. doi: 10.1016/j.saa.2020.118512. [PMID: 32470817]
  • Gergő Tóth, Erzsébet Fogarasi, Ágnes Bartalis-Fábián, Mohammadhassan Foroughbakhshfasaei, Imre Boldizsár, András Darcsi, Szilvia Lohner, Gerhard K E Scriba, Zoltán-István Szabó. Liquid chromatographic method for the simultaneous determination of achiral and chiral impurities of dapoxetine in approved and counterfeit products. Journal of chromatography. A. 2020 Aug; 1626(?):461388. doi: 10.1016/j.chroma.2020.461388. [PMID: 32797859]
  • Guangsen Li, Degui Chang, Di'ang Chen, Peihai Zhang, Yaodong You, Xiaopeng Huang, Jian Cai. Selective dorsal neurotomy in the treatment of premature ejaculation: A protocol for systematic review and meta-analysis. Medicine. 2020 Aug; 99(34):e21866. doi: 10.1097/md.0000000000021866. [PMID: 32846840]
  • Rana Said, Basel Arafat, Tawfiq Arafat. High performance liquid chromatography - Mass spectrometric bioanalytical method for the determination of dapoxetine in human plasma: Application for bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jul; 1149(?):122154. doi: 10.1016/j.jchromb.2020.122154. [PMID: 32485631]
  • Hong-Chang Yuan, Zhi-Jian Deng, Xin-Min Liu, Ting-Fang Dong, Xiang-Jun Qiu, Zeng Nan. Effect of Wuziyanzong pill on metabolism of dapoxetine in vivo and in vitro. Journal of pharmaceutical and biomedical analysis. 2019 Mar; 166(?):119-127. doi: 10.1016/j.jpba.2018.12.022. [PMID: 30639931]
  • Jun Guo, Bin Yan, Fu Wang, Qing-He Gao, Xiu-Ju Zhang, Guo-Jin Yu, Yin Zeng, Jun-Feng Qiu, Qiang Geng, Qiang Han. [Qiaoshao Prescription improves premature ejaculation in male rats by increasing the content of 5-hydroxytryptamine]. Zhonghua nan ke xue = National journal of andrology. 2018 08; 24(8):724-728. doi: . [PMID: 30173433]
  • Mohammed As Abourehab, Osama Aa Ahmed, Gehan F Balata, Waleed H Almalki. Self-assembled biodegradable polymeric micelles to improve dapoxetine delivery across the blood-brain barrier. International journal of nanomedicine. 2018; 13(?):3679-3687. doi: 10.2147/ijn.s168148. [PMID: 29983562]
  • Khaled S Abdlekawy, Ahmed M Donia, Fawzy Elbarbry. Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects. European journal of drug metabolism and pharmacokinetics. 2017 Jun; 42(3):397-405. doi: 10.1007/s13318-016-0352-3. [PMID: 27294349]
  • Thomas Y Hsueh, Jing-Kai Ho, Lie-Chwen Lin, Allen W Chiu, Chi-Hung Lin, Tung-Hu Tsai. Herb-drug interaction of Epimedium extract on the pharmacokinetic of dapoxetine in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Mar; 1014(?):64-9. doi: 10.1016/j.jchromb.2016.02.001. [PMID: 26874879]
  • Wei-min Zhang, Wu Qiang, Wang Ying-Fei, Sun Ming, Rong Wang. Development and validation of a sensitive UPLC-MS/MS method for the simultaneous determination of dapoxetine and its two metabolites in human plasma. Journal of pharmaceutical and biomedical analysis. 2016 Feb; 119(?):45-9. doi: 10.1016/j.jpba.2015.11.018. [PMID: 26641706]
  • Rui-fang Li, Jun-min Fu, Xing-zhi Lv, Dong-tao Zhang, Yong-yang Pan, Da-pang Rao, Kai-yuan Yu. Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine in Rats. Pharmacology. 2016; 97(1-2):43-7. doi: 10.1159/000441568. [PMID: 26588583]
  • Hegazy Maha, Kessiba Amira, Abdelkawy Mohamed, El Gindy Ahmed Emad. A novel liquid chromatographic method with fluorescence detection for quantitation of tadalafil and dapoxetine hydrochloride in pharmaceutical dosage form and human plasma. Se pu = Chinese journal of chromatography. 2015 Jul; 33(7):765-70. doi: 10.3724/sp.j.1123.2015.02063. [PMID: 26672207]
  • Yo Han Kim, Hee Youn Choi, Shi Hyang Lee, Hae Sun Jeon, Hyeong-Seok Lim, Mi Young Bahng, Kyun-Seop Bae. Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers. Drug design, development and therapy. 2015; 9(?):1209-16. doi: 10.2147/dddt.s78713. [PMID: 25759565]
  • Tae Kon Kim, In Sook Kim, Seok Hyun Hong, Yun Kyoung Choi, Hohyun Kim, Hye Hyun Yoo. Determination of dapoxetine in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 May; 926(?):42-6. doi: 10.1016/j.jchromb.2013.03.002. [PMID: 23542722]
  • An Thyssen, Om Sharma, Si Tianmei, Joseph W Aquilina, An Vandebosch, Shean-Sheng Wang, Ramagopal Mudumbi, Hsiu-Ling Hsiao. Pharmacokinetics of dapoxetine hydrochloride in healthy Chinese, Japanese, and Caucasian men. Journal of clinical pharmacology. 2010 Dec; 50(12):1450-60. doi: 10.1177/0091270009359183. [PMID: 20097934]
  • N B Modi, S Kell, J Aquilina, D Rivas. Effect of dapoxetine on the pharmacokinetics and hemodynamic effects of tamsulosin in men on a stable dose of tamsulosin. Journal of clinical pharmacology. 2008 Dec; 48(12):1438-50. doi: 10.1177/0091270008324695. [PMID: 18832488]
  • Mark J Dresser, Dongwoo Kang, Peter Staehr, Shalini Gidwani, Cindy Guo, John P Mulhall, Nishit B Modi. Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal. Journal of clinical pharmacology. 2006 Sep; 46(9):1023-9. doi: 10.1177/0091270006291033. [PMID: 16920897]
  • Marcel D Waldinger. Emerging drugs for premature ejaculation. Expert opinion on emerging drugs. 2006 Mar; 11(1):99-109. doi: 10.1517/14728214.11.1.99. [PMID: 16503829]
  • Nishit B Modi, Mark J Dresser, Mary Simon, Denise Lin, Dhaval Desai, Suneel Gupta. Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation. Journal of clinical pharmacology. 2006 Mar; 46(3):301-9. doi: 10.1177/0091270005284850. [PMID: 16490806]
  • Karl-Erik Andersson, John P Mulhall, Michael G Wyllie. Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for 'on-demand' treatment of premature ejaculation. BJU international. 2006 Feb; 97(2):311-5. doi: 10.1111/j.1464-410x.2006.05911.x. [PMID: 16430636]
  • M J Dresser, D Desai, S Gidwani, A D Seftel, N B Modi. Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors. International journal of impotence research. 2006 Jan; 18(1):104-10. doi: 10.1038/sj.ijir.3901420. [PMID: 16307008]
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