Clemastine fumarate (BioDeep_00000398979)
natural product
代谢物信息卡片
Clemastine fumarate
化学式: C25H30ClNO5 (459.18124000000006)
中文名称: 富马酸氯马斯汀
谱图信息:
最多检出来源 Escherichia coli(natural_products) 96.67%
分子结构信息
SMILES: C1(=C(C=CC(=C1)Cl)[C@](OCC[C@@H]2N(CCC2)C)(C3=CC=CC=C3)C).OC(/C=C/C(O)=O)=O
InChI: /m1./s1
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D018926 - Anti-Allergic Agents
Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:3739
- PubChem: 5281069
- ChEMBL: CHEMBL1200795
- MeSH: Clemastine
- CAS: 14976-57-9
- CAS: 14976-57-9, 15686-51-8 (free base)
- MoNA: CCMSLIB00000078312
- medchemexpress: HY-B0298A
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Lijuan Tian, Yue Liu, Yuda Fei, Hong Lv, Fuxia Yan, Lihuan Li, Jia Shi. Effect of Clemastine Fumarate on Perioperative Hemodynamic Instability Mediated by Anaphylaxis During Cardiopulmonary Bypass Surgery.
Medical science monitor : international medical journal of experimental and clinical research.
2022 Jun; 28(?):e936367. doi:
10.12659/msm.936367. [PMID: 35651299] - Xiaowan Wang, Di Xie, Hui Dai, Jiawei Ye, Yuqi Liu, Aihua Fei. Clemastine protects against sepsis-induced myocardial injury in vivo and in vitro.
Bioengineered.
2022 03; 13(3):7134-7146. doi:
10.1080/21655979.2022.2047256. [PMID: 35274595] - Fabio Urbina, Ana C Puhl, Sean Ekins. Recent advances in drug repurposing using machine learning.
Current opinion in chemical biology.
2021 12; 65(?):74-84. doi:
10.1016/j.cbpa.2021.06.001. [PMID: 34274565] - Samuel K Jensen, Nathan J Michaels, Slava Ilyntskyy, Michael B Keough, Olga Kovalchuk, V Wee Yong. Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α.
Cell reports.
2018 09; 24(12):3167-3179. doi:
10.1016/j.celrep.2018.08.060. [PMID: 30232000] - K M S Kanhai, R G J A Zuiker, I Stavrakaki, W Gladdines, P J Gaillard, E S Klaassen, G J Groeneveld. Glutathione-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study.
British journal of clinical pharmacology.
2018 05; 84(5):1020-1028. doi:
10.1111/bcp.13525. [PMID: 29385232] - Ari J Green, Jeffrey M Gelfand, Bruce A Cree, Carolyn Bevan, W John Boscardin, Feng Mei, Justin Inman, Sam Arnow, Michael Devereux, Aya Abounasr, Hiroko Nobuta, Alyssa Zhu, Matt Friessen, Roy Gerona, Hans Christian von Büdingen, Roland G Henry, Stephen L Hauser, Jonah R Chan. Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial.
Lancet (London, England).
2017 Dec; 390(10111):2481-2489. doi:
10.1016/s0140-6736(17)32346-2. [PMID: 29029896] - Annica Tevell Aberg, Helena Löfgren, Ulf Bondesson, Mikael Hedeland. Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification.
Rapid communications in mass spectrometry : RCM.
2010 May; 24(10):1447-56. doi:
10.1002/rcm.4535. [PMID: 20411584] - G Ahrenstorf, O Burkhardt, T Witte, M Stoll, R E Schmidt. [Chikungunya: fever and joint pains after vacation in a tropical area].
Deutsche medizinische Wochenschrift (1946).
2008 Feb; 133(9):406-8. doi:
10.1055/s-2008-1046727. [PMID: 18288627] - Zhiyong Xie, Qiongfeng Liao, Zuojun Li, Chenchen Zhu, Yuaner Zeng, Shikun Liu. Development and full validation of a sensitive quantitative assay for the determination of clemastine in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2007 Aug; 44(4):924-30. doi:
10.1016/j.jpba.2007.03.019. [PMID: 17475437] - John M Ridley, James T Milnes, Jules C Hancox, Harry J Witchel. Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.
Journal of molecular and cellular cardiology.
2006 Jan; 40(1):107-18. doi:
10.1016/j.yjmcc.2005.09.017. [PMID: 16288909] - Viola Horváth, Antal Tolokán, Andrea Egresi, Tímea Pap, George Horvai, Katalin Balogh-Nemes, Imre Klebovich. High-performance liquid chromatographic-tandem mass spectrometric method for the determination of clemastine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Feb; 816(1-2):153-9. doi:
10.1016/j.jchromb.2004.11.025. [PMID: 15664345] - H Hansson, K Bergvall, U Bondesson, M Hedeland, K Törneke. Clinical pharmacology of clemastine in healthy dogs.
Veterinary dermatology.
2004 Jun; 15(3):152-8. doi:
10.1111/j.1365-3164.2004.00367.x. [PMID: 15214951] - Annica Tevell, Ulf Bondesson, Karolina Törneke, Mikael Hedeland. Identification of some new clemastine metabolites in dog, horse, and human urine with liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2004; 18(19):2267-72. doi:
10.1002/rcm.1622. [PMID: 15384147] - K Törneke, C Ingvast-Larsson, K Pettersson, K Bergvall, M Hedeland, U Bondesson, H Broström. Pharmacokinetics and pharmacodynamics of clemastine in healthy horses.
Journal of veterinary pharmacology and therapeutics.
2003 Apr; 26(2):151-7. doi:
10.1046/j.1365-2885.2003.00460.x. [PMID: 12667185] - G Lehmann, F Asskali, H Förster. [Severe adverse event following iv administration of 10 ml 6\% Dextran60 (0.6 g) in a healthy volunteer].
Der Anaesthesist.
2002 Oct; 51(10):820-4. doi:
10.1007/s00101-002-0399-1. [PMID: 12395173] - C R Mallet, J R Mazzeo, U Neue. Evaluation of several solid phase extraction liquid chromatography/tandem mass spectrometry on-line configurations for high-throughput analysis of acidic and basic drugs in rat plasma.
Rapid communications in mass spectrometry : RCM.
2001; 15(13):1075-83. doi:
10.1002/rcm.346. [PMID: 11404844] - N N Davydova, S U Yasuda, R L Woosley, I W Wainer. Determination of clemastine in human plasma by gas chromatography with nitrogen-phosphorus detection.
Journal of chromatography. B, Biomedical sciences and applications.
2000 Jul; 744(1):177-81. doi:
10.1016/s0378-4347(00)00216-4. [PMID: 10985579] - M H Choi, B H Jung, B C Chung. Identification of urinary metabolites of clemastine after oral administration to man.
The Journal of pharmacy and pharmacology.
1999 Jan; 51(1):53-9. doi:
10.1211/0022357991772097. [PMID: 10197418] - H F Schran, L Petryk, C T Chang, R O'Connor, M B Gelbert. The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations.
Journal of clinical pharmacology.
1996 Oct; 36(10):911-22. doi:
10.1002/j.1552-4604.1996.tb04758.x. [PMID: 8930778] - W R Lamadé, W Friedl, B Schmid, P J Meeder. Bone cement implantation syndrome. A prospective randomised trial for use of antihistamine blockade.
Archives of orthopaedic and trauma surgery.
1995; 114(6):335-9. doi:
10.1007/bf00448957. [PMID: 8588965] - P W van der Linden, C E Hack, J Poortman, Y C Vivié-Kipp, A Struyvenberg, J K van der Zwan. Insect-sting challenge in 138 patients: relation between clinical severity of anaphylaxis and mast cell activation.
The Journal of allergy and clinical immunology.
1992 Jul; 90(1):110-8. doi:
10.1016/s0091-6749(06)80017-5. [PMID: 1629497] - A W Nichols. Exercise-induced anaphylaxis and urticaria.
Clinics in sports medicine.
1992 Apr; 11(2):303-12. doi:
10.1016/s0278-5919(20)30532-9. [PMID: 1591787] - L K Gavrovskaia, V M Sedov, E N Kharchevnikova, V P Morozov. [Physiological significance of gastroduodenal blood flow and possibilities of its regulation by drugs].
Vestnik Rossiiskoi akademii meditsinskikh nauk.
1992; ?(8):52-6. doi:
". [PMID: 1282420] - C F Wahlgren. Itch and atopic dermatitis: clinical and experimental studies.
Acta dermato-venereologica. Supplementum.
1991; 165(?):1-53. doi:
. [PMID: 1686130] - M Tryba, I Linde, G Voshage, M Zenz. [Histamine release and cardiovascular reactions to implantation of bone cement during total hip replacement].
Der Anaesthesist.
1991 Jan; 40(1):25-32. doi:
NULL. [PMID: 1706562] - J Porszász, F Varga, K G Porszász, J Szolscányi, L Barthó, L Petöcz, L Kápolnai. Pharmacology of the new H1-receptor antagonist setastine hydrochloride.
Arzneimittel-Forschung.
1990 Dec; 40(12):1340-5. doi:
NULL. [PMID: 1982751] - H Habazettl, P F Conzen, B Vollmar, E Yekebas, R Gutmann, J Hobbhahn, W Brendel, K Peter. Pulmonary hypertension after heparin-protamine: roles of left-sided infusion, histamine, and platelet-activating factor.
Anesthesia and analgesia.
1990 Dec; 71(6):637-44. doi:
10.1213/00000539-199012000-00011. [PMID: 2240637] - B Göber, M A al Mardini, P Franke. [Clemastine metabolites in the feces and urine of the rat].
Die Pharmazie.
1989 Dec; 44(12):847-51. doi:
NULL. [PMID: 2635321] - B Göber, M A Al Mardini, P Franke. [Isolation and identification of clemastine metabolites in rat feces].
Die Pharmazie.
1988 Aug; 43(8):558-9. doi:
NULL. [PMID: 3237752] - L M Williamson, K Sheppard, J M Davies, J Fletcher. Neutrophils are involved in the increased vascular permeability produced by activated complement in man.
British journal of haematology.
1986 Oct; 64(2):375-84. doi:
10.1111/j.1365-2141.1986.tb04131.x. [PMID: 3778830] - D J Morgan, I Moodley, D R Cundell, B D Sheinman, W Smart, R J Davies. Circulating histamine and neutrophil chemotactic activity during allergen-induced asthma: the effect of inhaled antihistamines and anti-allergic compounds.
Clinical science (London, England : 1979).
1985 Jul; 69(1):63-9. doi:
10.1042/cs0690063. [PMID: 2866059] - H I Beck, M Cramers, T Herlin, I Søndergaard, H Zachariae. Comparison of oxatomide and clemastine in the treatment of chronic urticaria. A double blind study.
Dermatologica.
1985; 171(1):49-51. doi:
10.1159/000249387. [PMID: 2863185] - R Betti, F F Casanueva, S G Cella, E E Müller. Activation of the cholinergic system and growth hormone release in the dog: functional interactions with other neurotransmitters.
Acta endocrinologica.
1985 Jan; 108(1):36-43. doi:
10.1530/acta.0.1080036. [PMID: 2982238] - S G Cella, G B Picotti, M Morgese, P Mantegazza, E E Müller. Presynaptic alpha 2 -adrenergic stimulation leads to growth hormone release in the dog.
Life sciences.
1984 Jan; 34(5):447-54. doi:
10.1016/0024-3205(84)90499-5. [PMID: 6141513] - J L Menardo, J Bousquet, A Bataille, G Restagny, F B Michel. Effects of diluents on skin tests.
Annals of allergy.
1983 Nov; 51(5):535-8. doi:
NULL. [PMID: 6638615] - B Allolio, U Deuss, D Kaulen, W Winkelmann. Effect of meclastine, a selective H1 receptor antagonist, upon ACTH release.
Clinical endocrinology.
1983 Aug; 19(2):239-45. doi:
10.1111/j.1365-2265.1983.tb02986.x. [PMID: 6309434] - J H Olafsson, G Granerus, G Roupe. Effect of antihistamins (H1 and H2), cortisone and beta-adrenergic stimulator on murine contact sensitivity and histamine metabolism.
International archives of allergy and applied immunology.
1983; 70(2):174-7. doi:
10.1159/000233318. [PMID: 6130044] - B Allolio, W Winkelmann, F X Hipp. Effect of meclastine, an H1-antihistamine, on plasma ACTH in adrenal insufficiency.
Acta endocrinologica.
1981 May; 97(1):98-102. doi:
10.1530/acta.0.0970098. [PMID: 6261510] - F Casanueva, R Betti, D Cocchi, T Chieli, P Mantegazza, E E Müller. Proof for histaminergic but not for adrenergic involvement in the growth hormone-releasing effect of an enkephalin analog in the dog.
Endocrinology.
1981 Jan; 108(1):157-63. doi:
10.1210/endo-108-1-157. [PMID: 7460816] - K Aas. Effects of ketotifen and clemastine on passive transfer of reaginic reaction.
Allergy.
1979 Apr; 34(2):121-4. doi:
10.1111/j.1398-9995.1979.tb01372.x. [PMID: 38677] - R P Brettle, L Curtis, A J Pinching, C J Spry. Tartrazine sensitivity in renal failure.
Lancet (London, England).
1979 Jan; 1(8108):167. doi:
10.1016/s0140-6736(79)90570-1. [PMID: 84198] - R Tham, B Norlander, O Hägermark, L Fransson. Gaschromatography of clemastine. A study of plasma kinetics and biological effect.
Arzneimittel-Forschung.
1978; 28(6):1017-20. doi:
NULL. [PMID: 35180] - I Roots, K Saalfrank, A G Hildebrandt. Comparison of methods to study enzyme induction in man.
Advances in experimental medicine and biology.
1975; 58(00):485-502. doi:
10.1007/978-1-4615-9026-2_33. [PMID: 239546]