teniposide (BioDeep_00000398970)
natural product Chemicals and Drugs
代谢物信息卡片
Teniposide (Vumon)
化学式: C32H32O13S (656.1563542)
中文名称: 替尼泊苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C([H])54)(c(c(C(OC(C8O)(OC([H])(C7([H])C(O)8)COC(O7)c(c6)scc6)[H])C4(COC5=O)[H])3)cc(c2c3)OCO2)c(c1)cc(OC)c(c1OC)O
InChI: InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products > L01CB - Podophyllotoxin derivatives
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C1331 - Epipodophyllotoxin Compound
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C1907 - Drug, Natural Product
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- PubChem: 452548
- DrugBank: DB00444
- ChEMBL: CHEMBL452231
- MeSH: Teniposide
- CAS: 29767-20-2
- MoNA: WA002627
- MoNA: WA002626
- MoNA: WA002625
- MoNA: WA002624
- MoNA: WA002623
- MoNA: WA002622
- MoNA: WA002621
- MoNA: CCMSLIB00000078288
- MoNA: CCMSLIB00000078287
- RefMet: Teniposide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Susan Bal, Heather Landau. AL amyloidosis: untangling new therapies.
Hematology. American Society of Hematology. Education Program.
2021 12; 2021(1):682-688. doi:
10.1182/hematology.2021000305. [PMID: 34889374] - Hadas Rabani, Mira Ziv, Noa Lavi, Ariel Aviv, Celia Suriu, Adel Shalata, Yarin Haddid, Tamar Tadmor. Deletions and amplifications of the IGH variable and constant regions:a novel prognostic parameter in patients with multiple myeloma.
Leukemia research.
2020 12; 99(?):106476. doi:
10.1016/j.leukres.2020.106476. [PMID: 33171301] - Shahin Ahmadian, Sepideh Sheshpari, Mahdi Mahdipour, Mohammad Pazhang, Pei-Shiue Jason Tsai, Mohammad Nouri, Reza Rahbarghazi, Mahnaz Shahnazi. Toxic effects of VCD on kidneys and liver tissues: a histopathological and biochemical study.
BMC research notes.
2019 Jul; 12(1):446. doi:
10.1186/s13104-019-4490-y. [PMID: 31331386] - Lipei Liu, Peng Zeng, Xiaoxiao Yang, Yajun Duan, Wenwen Zhang, Chuanrui Ma, Xiaomeng Zhang, Shu Yang, Xiaoju Li, Jie Yang, Yu Liang, Hao Han, Yan Zhu, Jihong Han, Yuanli Chen. Inhibition of Vascular Calcification.
Arteriosclerosis, thrombosis, and vascular biology.
2018 10; 38(10):2382-2395. doi:
10.1161/atvbaha.118.311546. [PMID: 30354214] - Pedro Russo, Ana Luisa Tomé, Tiago Capela, Maria João Bettencourt. Anorectal involvement in a patient with multiple myeloma.
BMJ case reports.
2017 Apr; 2017(?):. doi:
10.1136/bcr-2017-219658. [PMID: 28420651] - Bingyang Chu, Shuai Shi, Xingyi Li, Lufeng Hu, Lu Shi, Haina Zhang, Qiaoqiao Xu, Lei Ye, Guanyang Lin, Nansheng Zhang, Xiuhua Zhang. Preparation and evaluation of teniposide-loaded polymeric micelles for breast cancer therapy.
International journal of pharmaceutics.
2016 Nov; 513(1-2):118-129. doi:
10.1016/j.ijpharm.2016.09.005. [PMID: 27596115] - Xinyi He, Nanxi Xiang, Jinjie Zhang, Jing Zhou, Yao Fu, Tao Gong, Zhirong Zhang. Encapsulation of teniposide into albumin nanoparticles with greatly lowered toxicity and enhanced antitumor activity.
International journal of pharmaceutics.
2015 Jun; 487(1-2):250-9. doi:
10.1016/j.ijpharm.2015.04.047. [PMID: 25899285] - Mengyang Liu, Yuanli Chen, Ling Zhang, Qixue Wang, Xingzhe Ma, Xiaoju Li, Rong Xiang, Yan Zhu, Shucun Qin, Yang Yu, Xian-cheng Jiang, Yajun Duan, Jihong Han. Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II.
The Journal of biological chemistry.
2015 Jun; 290(23):14418-29. doi:
10.1074/jbc.m115.643015. [PMID: 25914138] - Thi Thanh Hanh Nguyen, Seung-Jin Jung, Hee-Kyoung Kang, Young-Min Kim, Young-Hwan Moon, Misook Kim, Doman Kim. Production of rubusoside from stevioside by using a thermostable lactase from Thermus thermophilus and solubility enhancement of liquiritin and teniposide.
Enzyme and microbial technology.
2014 Oct; 64-65(?):38-43. doi:
10.1016/j.enzmictec.2014.07.001. [PMID: 25152415] - Liliane Hobeika, Sally E Self, Juan Carlos Q Velez. Renal thrombotic microangiopathy and podocytopathy associated with the use of carfilzomib in a patient with multiple myeloma.
BMC nephrology.
2014 Sep; 15(?):156. doi:
10.1186/1471-2369-15-156. [PMID: 25267524] - Ayato Tsukamoto, Yumiko Yoshiki, Sho Yamazaki, Keiki Kumano, Fumihiko Nakamura, Mineo Kurokawa. The significance of free light chain measurements in the diagnosis of myelomatous pleural effusion.
Annals of hematology.
2014 Mar; 93(3):507-8. doi:
10.1007/s00277-013-1818-x. [PMID: 23797638] - Zhiwen Zhang, Zeying Liu, Li Ma, Shijun Jiang, Yixin Wang, Haijun Yu, Qi Yin, Jingbin Cui, Yaping Li. Reversal of multidrug resistance by mitochondrial targeted self-assembled nanocarrier based on stearylamine.
Molecular pharmaceutics.
2013 Jun; 10(6):2426-34. doi:
10.1021/mp400039j. [PMID: 23679827] - Ling Zhang, Meixiu Jiang, Yongsheng Shui, Yuanli Chen, Qixue Wang, Wenquan Hu, Xingzhe Ma, Xiaoju Li, Xin Liu, Xingyue Cao, Mengyang Liu, Yajun Duan, Jihong Han. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.
Biochimica et biophysica acta.
2013 Jun; 1831(6):1134-45. doi:
10.1016/j.bbalip.2013.02.007. [PMID: 23466610] - Suna He, Zheng Cui, Dong Mei, Hua Zhang, Xueqing Wang, Wenbing Dai, Qiang Zhang. A cremophor-free self-microemulsified delivery system for intravenous injection of teniposide: evaluation in vitro and in vivo.
AAPS PharmSciTech.
2012 Sep; 13(3):846-52. doi:
10.1208/s12249-012-9809-0. [PMID: 22644709] - Jaciana S Aguiar, Rosilma O Araújo, Maria Do Desterro Rodrigues, Kêsia X F R Sena, André M Batista, Maria M P Guerra, Steno L Oliveira, Josean F Tavares, Marcelo S Silva, Silene C Nascimento, Teresinha Gonçalves Da Silva. Antimicrobial, antiproliferative and proapoptotic activities of extract, fractions and isolated compounds from the stem of Erythroxylum caatingae plowman.
International journal of molecular sciences.
2012; 13(4):4124-4140. doi:
10.3390/ijms13044124. [PMID: 22605969] - Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions.
Frontiers in pharmacology.
2012; 3(?):69. doi:
10.3389/fphar.2012.00069. [PMID: 22557968] - S A Bakheet, S M Attia, N M Al-Rasheed, M M Al-Harbi, A E Ashour, H M Korashy, A R Abd-Allah, Q Saquib, A A Al-Khedhairy, J Musarrat. Salubrious effects of dexrazoxane against teniposide-induced DNA damage and programmed cell death in murine marrow cells.
Mutagenesis.
2011 Jul; 26(4):533-43. doi:
10.1093/mutage/ger013. [PMID: 21430063] - Xiaoqiang Xu, Xiuhong Gao, Linhong Jin, Pinaki S Bhadury, Kai Yuan, Deyu Hu, Baoan Song, Song Yang. Antiproliferation and cell apoptosis inducing bioactivities of constituents from Dysosma versipellis in PC3 and Bcap-37 cell lines.
Cell division.
2011 Jun; 6(1):14. doi:
10.1186/1747-1028-6-14. [PMID: 21676247] - Weiqiang Lu, Chengxin Fu, Yunpeng Zhao. [Review on biosynthesis of podophyllotoxin].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 May; 36(9):1109-14. doi:
10.4268/cjcmm20110901. [PMID: 21842631] - Astha Varma, Harish Padh, Neeta Shrivastava. Andrographolide: a new plant-derived antineoplastic entity on horizon.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):815390. doi:
10.1093/ecam/nep135. [PMID: 19752167] - Sachin Patil, R C M Kaza, A K Kakkar, Ronald S Chamberlain. Small cell carcinoma of the renal pelvis: a case report and review of the literature.
ISRN urology.
2011; 2011(?):786505. doi:
10.5402/2011/786505. [PMID: 22084805] - Kefei Hu, Saideh Berenjian, Rolf Larsson, Joachim Gullbo, Peter Nygren, Tanja Lövgren, Bror Morein. Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index.
International journal of nanomedicine.
2010 Feb; 5(?):51-62. doi:
. [PMID: 20161987] - Supriya Baikar, Nutan Malpathak. Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.
Pharmacognosy reviews.
2010 Jan; 4(7):12-26. doi:
10.4103/0973-7847.65320. [PMID: 22228937] - Walid Fayad, Mårten Fryknäs, Slavica Brnjic, Maria Hägg Olofsson, Rolf Larsson, Stig Linder. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.
PloS one.
2009 Oct; 4(10):e7238. doi:
10.1371/journal.pone.0007238. [PMID: 19798419] - Jing Wang, Yu Zhang, Tingting Guan, Xia Lin, Xing Tang, Hui Xu. Determination of teniposide in rat plasma by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry after intravenous administration.
Biomedical chromatography : BMC.
2009 Sep; 23(9):999-1006. doi:
10.1002/bmc.1214. [PMID: 19382244] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Menka Khoobchandani, B K Ojeswi, Bhavna Sharma, Man Mohan Srivastava. Chenopodium album prevents progression of cell growth and enhances cell toxicity in human breast cancer cell lines.
Oxidative medicine and cellular longevity.
2009 Jul; 2(3):160-5. doi:
10.4161/oxim.2.3.8837. [PMID: 20592771] - Jing Wang, Yue Cui, Xing Tang. Chemical stability of teniposide in aqueous and parenteral lipid emulsions.
Drug development and industrial pharmacy.
2009 Apr; 35(4):508-13. doi:
10.1080/03639040802468016. [PMID: 18991092] - Ketan V Hirpara, Pawan Aggarwal, Amrita J Mukherjee, Narendra Joshi, Anand C Burman. Quercetin and its derivatives: synthesis, pharmacological uses with special emphasis on anti-tumor properties and prodrug with enhanced bio-availability.
Anti-cancer agents in medicinal chemistry.
2009 Feb; 9(2):138-61. doi:
10.2174/187152009787313855. [PMID: 19199862] - Hemant Lata, Cassia S Mizuno, Rita M Moraes. The role of biotechnology in the production of the anticancer compound podophyllotoxin.
Methods in molecular biology (Clifton, N.J.).
2009; 547(?):387-402. doi:
10.1007/978-1-60327-287-2_31. [PMID: 19521861] - Jonathan C Cheng, Timothy E Schultheiss, Jeffrey Y C Wong. Impact of drug therapy, radiation dose, and dose rate on renal toxicity following bone marrow transplantation.
International journal of radiation oncology, biology, physics.
2008 Aug; 71(5):1436-43. doi:
10.1016/j.ijrobp.2007.12.009. [PMID: 18355974] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Ron H N van Schaik. CYP450 pharmacogenetics for personalizing cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
2008 Jun; 11(3):77-98. doi:
10.1016/j.drup.2008.03.002. [PMID: 18486526] - Frédéric Lamblin, Christophe Hano, Ophélie Fliniaux, François Mesnard, Marc-André Fliniaux, Eric Lainé. [Interest of lignans in prevention and treatment of cancers].
Medecine sciences : M/S.
2008 May; 24(5):511-9. doi:
10.1051/medsci/2008245511. [PMID: 18466729] - K K Dholwani, A K Saluja, A R Gupta, D R Shah. A review on plant-derived natural products and their analogs with anti-tumor activity.
Indian journal of pharmacology.
2008 Mar; 40(2):49-58. doi:
10.4103/0253-7613.41038. [PMID: 21279166] - Sanjay K Srivastava, Amrita Jha, Shiv K Agarwal, Rama Mukherjee, Anand C Burman. Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.
Anti-cancer agents in medicinal chemistry.
2007 Nov; 7(6):685-709. doi:
10.2174/187152007784111313. [PMID: 18045063] - Ritu Aneja, Surya N Vangapandu, Manu Lopus, Ramesh Chandra, Dulal Panda, Harish C Joshi. Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.
Molecular pharmacology.
2006 Jun; 69(6):1801-9. doi:
10.1124/mol.105.021899. [PMID: 16517755] - Vandana Srivastava, Arvind Singh Negi, J K Kumar, M M Gupta, Suman P S Khanuja. Plant-based anticancer molecules: a chemical and biological profile of some important leads.
Bioorganic & medicinal chemistry.
2005 Nov; 13(21):5892-908. doi:
10.1016/j.bmc.2005.05.066. [PMID: 16129603] - Sunita Farkya, V S Bisaria, A K Srivastava. Biotechnological aspects of the production of the anticancer drug podophyllotoxin.
Applied microbiology and biotechnology.
2004 Oct; 65(5):504-19. doi:
10.1007/s00253-004-1680-9. [PMID: 15378293] - D Le Garrec, S Gori, L Luo, D Lessard, D C Smith, M-A Yessine, M Ranger, J-C Leroux. Poly(N-vinylpyrrolidone)-block-poly(D,L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation.
Journal of controlled release : official journal of the Controlled Release Society.
2004 Sep; 99(1):83-101. doi:
10.1016/j.jconrel.2004.06.018. [PMID: 15342183] - Natalia Y Ragozina, Michael Pütz, Stefan Heissler, Werner Faubel, Ute Pyell. Quantification of etoposide and etoposide phosphate in human plasma by micellar electrokinetic chromatography and near-field thermal lens detection.
Analytical chemistry.
2004 Jul; 76(13):3804-9. doi:
10.1021/ac0304222. [PMID: 15228358] - Q Y Liu, J X Lei, J LeBlanc, C Sodja, D Ly, C Charlebois, P R Walker, T Yamada, S Hirohashi, M Sikorska. Regulation of DNaseY activity by actinin-alpha4 during apoptosis.
Cell death and differentiation.
2004 Jun; 11(6):645-54. doi:
10.1038/sj.cdd.4401401. [PMID: 15002038] - S G O'Brien, P Meinhardt, E Bond, J Beck, B Peng, C Dutreix, G Mehring, S Milosavljev, C Huber, R Capdeville, T Fischer. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.
British journal of cancer.
2003 Nov; 89(10):1855-9. doi:
10.1038/sj.bjc.6601152. [PMID: 14612892] - Wan-tao Chen, Xiao-jian Zhou, Qin Xu, Wei Guo, Han-guang Zhu, Wei-min Ye. [Chemosensitivity testing of oral squamous cell carcinomas with teniposide].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology.
2003 Nov; 38(6):441-3. doi:
NULL. [PMID: 14703479] - E Erba, M Serafini, G Gaipa, G Tognon, S Marchini, N Celli, D Rotilio, M Broggini, J Jimeno, G T Faircloth, A Biondi, M D'Incalci. Effect of Aplidin in acute lymphoblastic leukaemia cells.
British journal of cancer.
2003 Aug; 89(4):763-73. doi:
10.1038/sj.bjc.6601130. [PMID: 12915891] - Saurabh Chattopadhyay, Virendra S Bisaria, Ashok K Srivastava. Enhanced production of podophyllotoxin by Podophyllum hexandrum using in situ cell retention bioreactor.
Biotechnology progress.
2003 May; 19(3):1026-8. doi:
10.1021/bp025765k. [PMID: 12790673] - John D Allen, Sonja C Van Dort, Marije Buitelaar, Olaf van Tellingen, Alfred H Schinkel. Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein.
Cancer research.
2003 Mar; 63(6):1339-44. doi:
. [PMID: 12649196] - Jin-Ming Kong, Ngoh-Khang Goh, Lian-Sai Chia, Tet-Fatt Chia. Recent advances in traditional plant drugs and orchids.
Acta pharmacologica Sinica.
2003 Jan; 24(1):7-21. doi:
". [PMID: 12511224] - Annick Rousseau, Pierre Marquet. Application of pharmacokinetic modelling to the routine therapeutic drug monitoring of anticancer drugs.
Fundamental & clinical pharmacology.
2002 Aug; 16(4):253-62. doi:
10.1046/j.1472-8206.2002.00086.x. [PMID: 12570013] - Rita M Moraes, Ebru Bedir, Holly Barrett, Charles Burandt, Camilo Canel, Ikhlas A Khan. Evaluation of Podophyllum peltatum accessions for podophyllotoxin production.
Planta medica.
2002 Apr; 68(4):341-4. doi:
10.1055/s-2002-26740. [PMID: 11988859] - M Baumhäkel, D Kasel, R A Rao-Schymanski, R Böcker, K T Beckurts, M Zaigler, D Barthold, U Fuhr. Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes.
International journal of clinical pharmacology and therapeutics.
2001 Dec; 39(12):517-28. doi:
10.5414/cpp39517. [PMID: 11770832] - E J Estlin, S M Yule, S P Lowis. Consolidation therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of cytosine arabinoside, epipodophyllotoxins and cyclophosphamide.
Cancer treatment reviews.
2001 Dec; 27(6):339-50. doi:
10.1053/ctrv.2002.0244. [PMID: 11908927] - U Naumann, S Weit, J Wischhusen, M Weller. Diva/Boo is a negative regulator of cell death in human glioma cells.
FEBS letters.
2001 Sep; 505(1):23-6. doi:
10.1016/s0014-5793(01)02768-5. [PMID: 11557035] - S Pang, N Zheng, C A Felix, J Scavuzzo, R Boston, I A Blair. Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry.
Journal of mass spectrometry : JMS.
2001 Jul; 36(7):771-81. doi:
10.1002/jms.173. [PMID: 11473400] - E Solary, L Mannone, D Moreau, D Caillot, R O Casasnovas, H Guy, M Grandjean, J E Wolf, F André, P Fenaux, P Canal, B Chauffert, A Wotawa, M Bayssas, P Genne. Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lymphoproliferative syndromes.
Leukemia.
2000 Dec; 14(12):2085-94. doi:
10.1038/sj.leu.2401945. [PMID: 11187897] - S Pandey, B Smith, P R Walker, M Sikorska. Caspase-dependent and independent cell death in rat hepatoma 5123tc cells.
Apoptosis : an international journal on programmed cell death.
2000 Jun; 5(3):265-75. doi:
10.1023/a:1009608630145. [PMID: 11225848] - J Zhou, Q Zhu, H Yao. [Chemotherapy of non-small-cell lung cancer (NSCLC) and changes in serum sAPO-1/Fas and nitric oxide (NO) levels].
Zhonghua zhong liu za zhi [Chinese journal of oncology].
2000 May; 22(3):225-7. doi:
NULL. [PMID: 11778237] - G Toffoli, P Aita, R Sorio, G Corona, A Bertola, A M Colussi, I Robieux, M Boiocchi. Effect of cyclosporin A on protein binding of teniposide in cancer patients.
Anti-cancer drugs.
1999 Jul; 10(6):511-8. doi:
10.1097/00001813-199907000-00001. [PMID: 10885897] - M Kool, M van der Linden, M de Haas, G L Scheffer, J M de Vree, A J Smith, G Jansen, G J Peters, N Ponne, R J Scheper, R P Elferink, F Baas, P Borst. MRP3, an organic anion transporter able to transport anti-cancer drugs.
Proceedings of the National Academy of Sciences of the United States of America.
1999 Jun; 96(12):6914-9. doi:
10.1073/pnas.96.12.6914. [PMID: 10359813] - A Cheng, Z Peng, Z Hong. [A pharmacokinetic study of teniposide in intraperitoneal chemotherapy of ovarian cancer].
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao.
1999 Mar; 30(1):95-8. doi:
NULL. [PMID: 12205938] - R S de Jong, N H Mulder, D R Uges, D T Sleijfer, F J Höppener, H J Groen, P H Willemse, W T van der Graaf, E G de Vries. Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin.
British journal of cancer.
1999 Feb; 79(5-6):882-7. doi:
10.1038/sj.bjc.6690141. [PMID: 10070885] - A Hueber, S Durka, M Weller. CD95-mediated apoptosis: no variation in cellular sensitivity during cell cycle progression.
FEBS letters.
1998 Aug; 432(3):155-7. doi:
10.1016/s0014-5793(98)00855-2. [PMID: 9720915] - P Solal-Céligny, E Lepage, N Brousse, C L Tendler, P Brice, C Haïoun, J Gabarre, B Pignon, G Tertian, R Bouabdallah, J F Rossi, C Doyen, B Coiffier. Doxorubicin-containing regimen with or without interferon alfa-2b for advanced follicular lymphomas: final analysis of survival and toxicity in the Groupe d'Etude des Lymphomes Folliculaires 86 Trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1998 Jul; 16(7):2332-8. doi:
10.1200/jco.1998.16.7.2332. [PMID: 9667247] - N Nagai, T Shikii, K Mihara, H Ogata, Y Sasaki. Improved high-performance liquid chromatographic analysis of teniposide in human plasma.
Journal of chromatography. B, Biomedical sciences and applications.
1998 May; 709(2):315-9. doi:
10.1016/s0378-4347(98)00059-0. [PMID: 9657231] - V T Solov'yan, I O Andreev, T Y Kolotova, P V Pogribniy, D T Tarnavsky, V A Kunakh. The cleavage of nuclear DNA into high molecular weight DNA fragments occurs not only during apoptosis but also accompanies changes in functional activity of the nonapoptotic cells.
Experimental cell research.
1997 Aug; 235(1):130-7. doi:
10.1006/excr.1997.3651. [PMID: 9281361] - L C Bowman, R P Castleberry, A Cantor, V Joshi, S L Cohn, E I Smith, A Yu, G M Brodeur, F A Hayes, A T Look. Genetic staging of unresectable or metastatic neuroblastoma in infants: a Pediatric Oncology Group study.
Journal of the National Cancer Institute.
1997 Mar; 89(5):373-80. doi:
10.1093/jnci/89.5.373. [PMID: 9060959] - L Testolin, C Carson, Y Wang, P R Walker, U Armato, M Sikorska. Jun and JNK kinase are activated in thymocytes in response to VM26 and radiation but not glucocorticoids.
Experimental cell research.
1997 Feb; 230(2):220-32. doi:
10.1006/excr.1996.3419. [PMID: 9024781] - P R Andreassen, F B Lacroix, R L Margolis. Chromosomes with two intact axial cores are induced by G2 checkpoint override: evidence that DNA decatenation is not required to template the chromosome structure.
The Journal of cell biology.
1997 Jan; 136(1):29-43. doi:
10.1083/jcb.136.1.29. [PMID: 9008701] - G Toffoli, R Sorio, M Gigante, G Corona, E Galligioni, M Boiocchi. Cyclosporin A as a multidrug-resistant modulator in patients with renal cell carcinoma treated with teniposide.
British journal of cancer.
1997; 75(5):715-21. doi:
10.1038/bjc.1997.127. [PMID: 9043030] - O van Tellingen, W Boogerd, W J Nooijen, J H Beijnen. The vascular compartment hampers accurate determination of teniposide penetration into brain tumor tissue.
Cancer chemotherapy and pharmacology.
1997; 40(4):330-4. doi:
10.1007/s002800050665. [PMID: 9225951] - K Son, H Alkan-Onyuksel. Stabilization of teniposide in aqueous mixtures of detergent-phospholipid.
PDA journal of pharmaceutical science and technology.
1996 Nov; 50(6):366-71. doi:
NULL. [PMID: 9038082] - E Liliemark, L Herngren, B Pettersson, C Peterson, J Liliemark. Ultrafiltration and subsequent high performance liquid chromatography for in vivo determinations of the protein binding of etoposide.
Cancer letters.
1996 Aug; 106(1):91-6. doi:
10.1016/0304-3835(96)04307-8. [PMID: 8827051] - K Son, H Alkan-Onyuksel. Physical stability of teniposide in bile salt-egg phosphatidylcholine mixed micelles and liposomes.
PDA journal of pharmaceutical science and technology.
1996 Mar; 50(2):89-93. doi:
". [PMID: 8935776] - J H Lin, F J Castora. Response of purified mitochondrial DNA topoisomerase I from bovine liver to camptothecin and m-AMSA.
Archives of biochemistry and biophysics.
1995 Dec; 324(2):293-9. doi:
10.1006/abbi.1995.0042. [PMID: 8554321] - E Liliemark, J Liliemark, N Kållberg, M Björkholm, B Sjöström, C Peterson. Studies of the organ distribution in mice of teniposide liposomes designed for treatment of diseases in the mononuclear phagocytic system.
Pediatric research.
1995 Jul; 38(1):7-10. doi:
10.1203/00006450-199507000-00002. [PMID: 7478800] - M Gigante, R Sorio, A M Colussi, A Sandrin, L De Appollonia, E Galligioni, A Freschi, R Talamini, G Toffoli, M Boiocchi. Effect of cyclosporine on teniposide pharmacokinetics and pharmacodynamics in patients with renal cell cancer.
Anti-cancer drugs.
1995 Jun; 6(3):479-82. doi:
10.1097/00001813-199506000-00019. [PMID: 7670149] - E Liliemark, B Sjöström, J Liliemark, C Peterson, N Kållberg, B S Larsson. Targeting of teniposide to the mononuclear phagocytic system (MPS) by incorporation in liposomes and submicron lipid particles; an autoradiographic study in mice.
Leukemia & lymphoma.
1995 Jun; 18(1-2):113-8. doi:
10.3109/10428199509064930. [PMID: 8580812] - P Kubisz, F Seghier, M Dobrotorá, J Stasko, S Cronberg. Influence of teniposide on platelet functions in vitro.
Thrombosis research.
1995 Jan; 77(2):145-8. doi:
10.1016/0049-3848(95)91620-z. [PMID: 7740506] - V T Solovyan, I O Andreyev. Structural domains of plant nuclear DNA as a constitutive component of the topoisomerase II/DNA complex.
Acta biochimica Polonica.
1995; 42(2):201-4. doi:
10.18388/abp.1995_4609. [PMID: 8588464] - P A Permana, R M Snapka, L L Shen, D T Chu, J J Clement, J J Plattner. Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors.
Biochemistry.
1994 Sep; 33(37):11333-9. doi:
10.1021/bi00203a031. [PMID: 7727384] - S P Joel, M L Slevin. Schedule-dependent topoisomerase II-inhibiting drugs.
Cancer chemotherapy and pharmacology.
1994; 34 Suppl(?):S84-8. doi:
10.1007/bf00684869. [PMID: 8070033] - M V Relling, R K Mulhern, D Fairclough, D Baker, C H Pui. Chlorpromazine with and without lorazepam as antiemetic therapy in children receiving uniform chemotherapy.
The Journal of pediatrics.
1993 Nov; 123(5):811-6. doi:
10.1016/s0022-3476(05)80866-2. [PMID: 8229497] - D Z D'Argenio, J H Rodman. Targeting the systemic exposure of teniposide in the population and the individual using a stochastic therapeutic objective.
Journal of pharmacokinetics and biopharmaceutics.
1993 Apr; 21(2):223-51. doi:
10.1007/bf01059772. [PMID: 8229682] - M L Espinás, M Carballo. Pulsed-field gel electrophoresis analysis of higher-order chromatin structures of Zea mays. Highly methylated DNA in the 50 kb chromatin structure.
Plant molecular biology.
1993 Mar; 21(5):847-57. doi:
10.1007/bf00027116. [PMID: 8385508] - J H Rodman, W L Furman, M Sunderland, G Rivera, W E Evans. Escalating teniposide systemic exposure to increase dose intensity for pediatric cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1993 Feb; 11(2):287-93. doi:
10.1200/jco.1993.11.2.287. [PMID: 8426206] - D J Stewart, D Grewaal, M D Redmond, N Z Mikhael, V A Montpetit, R Goel, R M Green. Human autopsy tissue distribution of the epipodophyllotoxins etoposide and teniposide.
Cancer chemotherapy and pharmacology.
1993; 32(5):368-72. doi:
10.1007/bf00735921. [PMID: 8339387] - H Alkan-Onyuksel, K Son. Mixed micelles as proliposomes for the solubilization of teniposide.
Pharmaceutical research.
1992 Dec; 9(12):1556-62. doi:
10.1023/a:1015804206414. [PMID: 1488398] - E Friche, M K Danks, W T Beck. Characterization of tumor cell resistance to 4'-deoxy-4'-iododoxorubicin developed in Ehrlich ascites cells in vivo.
Cancer research.
1992 Oct; 52(20):5701-6. doi:
. [PMID: 1356619] - G Rappa, A Lorico, A C Sartorelli. Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26).
International journal of cancer.
1992 Jul; 51(5):780-7. doi:
10.1002/ijc.2910510519. [PMID: 1377186] - M Boiocchi, L Tumiotto, F Giannini, A Viel, G Biscontin, F Sartor, G Toffoli. P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines.
Tumori.
1992 Jun; 78(3):159-66. doi:
10.1177/030089169207800303. [PMID: 1359686] - P I Clark. Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives.
Seminars in oncology.
1992 Apr; 19(2 Suppl 6):20-7. doi:
NULL. [PMID: 1411635] - T A Splinter, J J Holthuis, T C Kok, M H Post. Absolute bioavailability and pharmacokinetics of oral teniposide.
Seminars in oncology.
1992 Apr; 19(2 Suppl 6):28-34. doi:
NULL. [PMID: 1411636] - P R Andreassen, R L Margolis. 2-Aminopurine overrides multiple cell cycle checkpoints in BHK cells.
Proceedings of the National Academy of Sciences of the United States of America.
1992 Mar; 89(6):2272-6. doi:
10.1073/pnas.89.6.2272. [PMID: 1549593] - D K Baker, M V Relling, C H Pui, M L Christensen, W E Evans, J H Rodman. Increased teniposide clearance with concomitant anticonvulsant therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1992 Feb; 10(2):311-5. doi:
10.1200/jco.1992.10.2.311. [PMID: 1732431] - W P Petros, J H Rodman, M V Relling, M Christensen, C H Pui, G K Rivera, W E Evans. Variability in teniposide plasma protein binding is correlated with serum albumin concentrations.
Pharmacotherapy.
1992; 12(4):273-7. doi:
. [PMID: 1518726] - W E Evans, J H Rodman, M V Relling, W P Petros, C F Stewart, C H Pui, G K Rivera. Differences in teniposide disposition and pharmacodynamics in patients with newly diagnosed and relapsed acute lymphocytic leukemia.
The Journal of pharmacology and experimental therapeutics.
1992 Jan; 260(1):71-7. doi:
NULL. [PMID: 1731053] - W K Nishioka, R M Welsh. Inhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II.
The Journal of experimental medicine.
1992 Jan; 175(1):23-7. doi:
10.1084/jem.175.1.23. [PMID: 1309853] - F Manso, J L Bello, J Feliu, J García de Bustos, G Losada, E Quevedo. [Plasma cell leukemia: our experience in 4 cases].
Revista clinica espanola.
1991 Nov; 189(7):328-30. doi:
NULL. [PMID: 1767090] - F A van der Horst, M A van Opstal, J Teeuwsen, M H Post, J J Holthuis, U A Brinkman. Comparative study on the determination of the anti-neoplastic drug teniposide in plasma using micellar liquid chromatography and surfactant-mediated plasma clean-up.
Journal of chromatography.
1991 Jun; 567(1):161-74. doi:
10.1016/0378-4347(91)80320-c. [PMID: 1918243]