Dofetilide (BioDeep_00000398943)
Main id: BioDeep_00000003119
natural product Volatile Flavor Compounds
代谢物信息卡片
Dofetilide (Tikosyn)
化学式: C19H27N3O5S2 (441.1392052)
中文名称: 多非利特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=CC(=C1)CCN(CCOC2=CC=C(C=C2)NS(C)(=O)=O)C)NS(C)(=O)=O
InChI: InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BD - Antiarrhythmics, class iii
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
4 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:4681
- KEGG: C07751
- KEGGdrug: D00647
- PubChem: 71329
- DrugBank: DB00204
- ChEMBL: CHEMBL473
- CAS: 115256-11-6
- MoNA: FiehnHILIC002672
- MoNA: FiehnHILIC001895
- MoNA: FiehnHILIC001161
- MoNA: FiehnHILIC000317
- MoNA: CCMSLIB00000078228
- PubChem: 9953
- NIKKAJI: J291.759I
- KNApSAcK: 4681
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daniel A N Mascarenhas, Praveen C Mudumbi, Bharat K Kantharia. Outpatient initiation of dofetilide: insights from the complexities of atrial fibrillation management during the COVID-19 lockdown.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing.
2022 Jan; 63(1):21-28. doi:
10.1007/s10840-021-00942-y. [PMID: 33484394] - James Crosby, Huzefa Bhopalwala, Amrin Kharawala, Nakeya Dewaswala, Subramanya Shyam Ganti, Adnan Bhopalwala. Refractory Torsades de Pointes Due to Dofetilide Overdose.
Journal of investigative medicine high impact case reports.
2021 Jan; 9(?):23247096211056492. doi:
10.1177/23247096211056492. [PMID: 34894807] - Elena You Jung Ko, Charles M Carpenter, David J Gagnon, Anne M Andrle. Pharmacist-Managed Inpatient Dofetilide Initiation Program: Description and Adherence Rate Post-Root Cause Analysis.
Journal of pharmacy practice.
2020 Dec; 33(6):784-789. doi:
10.1177/0897190019834130. [PMID: 30935279] - Muge Qile, Yuan Ji, Tyona D Golden, Marien J C Houtman, Fee Romunde, Doreth Fransen, Willem B van Ham, Ad P IJzerman, Craig T January, Laura H Heitman, Anna Stary-Weinzinger, Brian P Delisle, Marcel A G van der Heyden. LUF7244 plus Dofetilide Rescues Aberrant Kv11.1 Trafficking and Produces Functional IKv11.1.
Molecular pharmacology.
2020 06; 97(6):355-364. doi:
10.1124/mol.119.118190. [PMID: 32241959] - Murali K Matta, Suresh Narayanasamy, Jose Vicente, Robbert Zusterzeel, Vikram Patel, David G Strauss. Novel High-Throughput Quantitation of Potent hERG Blocker Dofetilide in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry: Application in a Phase 1 ECG Biomarker Validation Study.
Journal of analytical toxicology.
2020 Mar; 44(2):180-187. doi:
10.1093/jat/bkz047. [PMID: 31355881] - Hans Friedrich Stabenau, Changyu Shen, Larisa G Tereshchenko, Jonathan W Waks. Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil.
Heart rhythm.
2020 03; 17(3):460-467. doi:
10.1016/j.hrthm.2019.09.017. [PMID: 31539628] - Ksenia Blinova, Derek Schocken, Dakshesh Patel, Chathuri Daluwatte, Jose Vicente, Joseph C Wu, David G Strauss. Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs.
Clinical and translational science.
2019 11; 12(6):687-697. doi:
10.1111/cts.12674. [PMID: 31328865] - Muge Qile, Henriette D M Beekman, David J Sprenkeler, Marien J C Houtman, Willem B van Ham, Anna Stary-Weinzinger, Stanislav Beyl, Steffen Hering, Dirk-Jan van den Berg, Elizabeth C M de Lange, Laura H Heitman, Ad P IJzerman, Marc A Vos, Marcel A G van der Heyden. LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
British journal of pharmacology.
2019 10; 176(19):3871-3885. doi:
10.1111/bph.14798. [PMID: 31339551] - Muhammad Erfan Uddin, Xinxin Sun, Kevin M Huang, Shuiying Hu, Cynthia A Carnes, Alex Sparreboom, Qiang Fu. Development and validation of a UPLC-MS/MS analytical method for dofetilide in mouse plasma and urine, and its application to pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2019 Aug; 172(?):183-188. doi:
10.1016/j.jpba.2019.04.041. [PMID: 31055183] - Laura Perissinotti, Jiqing Guo, Meruyert Kudaibergenova, James Lees-Miller, Marina Ol'khovich, Angelica Sharapova, German L Perlovich, Daniel A Muruve, Brenda Gerull, Sergei Yu Noskov, Henry J Duff. The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.
Molecular pharmacology.
2019 08; 96(2):259-271. doi:
10.1124/mol.118.115642. [PMID: 31182542] - Francisco Sahli Costabal, Jiang Yao, Anna Sher, Ellen Kuhl. Predicting critical drug concentrations and torsadogenic risk using a multiscale exposure-response simulator.
Progress in biophysics and molecular biology.
2019 07; 144(?):61-76. doi:
10.1016/j.pbiomolbio.2018.10.003. [PMID: 30482568] - James E Tisdale, Heather A Jaynes, Brian R Overholser, Kevin M Sowinski, Richard J Kovacs. Progesterone pretreatment reduces the incidence of drug-induced torsades de pointes in atrioventricular node-ablated isolated perfused rabbit hearts.
Journal of cardiovascular electrophysiology.
2019 06; 30(6):941-949. doi:
10.1111/jce.13942. [PMID: 31006943] - Gong Cheng, Jine Wu, Wenqi Han, Chaofeng Sun. F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels.
Microscopy research and technique.
2018 Jun; 81(6):663-668. doi:
10.1002/jemt.23021. [PMID: 29573040] - James T VanderLugt, Charles Bon, Dean Knuth, Rhonda Schreiber, Michael D Ruff. Pharmacokinetics and Bioequivalence of Branded and Generic Formulations of Dofetilide 0.5-mg Capsules After Single-Dose Administration in Healthy Subjects.
Clinical pharmacology in drug development.
2018 03; 7(3):311-318. doi:
10.1002/cpdd.371. [PMID: 28800211] - Zachi I Attia, Alan Sugrue, Samuel J Asirvatham, Michael J Ackerman, Suraj Kapa, Paul A Friedman, Peter A Noseworthy. Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study.
PloS one.
2018; 13(8):e0201059. doi:
10.1371/journal.pone.0201059. [PMID: 30133452] - Lieth H Quffa, Mark Panna, Michael R Kaufmann, Matthew McKillop, Nicole Maltese Dietrich, Andrew J Franck. Impact of a Pharmacy-Cardiology Collaborative Practice on Dofetilide Safety Monitoring.
The Annals of pharmacotherapy.
2017 Jan; 51(1):39-43. doi:
10.1177/1060028016669962. [PMID: 27630191] - Dingxin Qin, George Leef, Mian Bilal Alam, Rohit Rattan, Mohamad Bilal Munir, Divyang Patel, Furqan Khattak, Evan Adelstein, Sandeep K Jain, Samir Saba. Comparative effectiveness of antiarrhythmic drugs for rhythm control of atrial fibrillation.
Journal of cardiology.
2016 May; 67(5):471-6. doi:
10.1016/j.jjcc.2015.07.001. [PMID: 26233885] - Xiaoliang S Qiu, Samuel Chauveau, Evgeny P Anyukhovsky, Tania Rahim, Ya-Ping Jiang, Erin Harleton, Steven J Feinmark, Richard Z Lin, Ruben Coronel, Michiel J Janse, Tobias Opthof, Tove S Rosen, Ira S Cohen, Michael R Rosen. Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.
Circulation. Arrhythmia and electrophysiology.
2016 Apr; 9(4):e003655. doi:
10.1161/circep.115.003655. [PMID: 27071826] - Jose Vicente, Lars Johannesen, Jay W Mason, William J Crumb, Esther Pueyo, Norman Stockbridge, David G Strauss. Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil.
Journal of the American Heart Association.
2015 Apr; 4(4):. doi:
10.1161/jaha.114.001615. [PMID: 25870186] - Helen E Ritchie, Cecilie Haaland Svensson, Mats F Nilsson, William S Webster. A comparison of drug-induced cardiotoxicity in rat embryos cultured in human serum or protein free media.
Journal of pharmacological and toxicological methods.
2014 Nov; 70(3):276-82. doi:
10.1016/j.vascn.2014.07.008. [PMID: 25091319] - Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):581-94. doi:
10.1093/toxsci/kft205. [PMID: 24052561] - R Varkevisser, M J C Houtman, T Linder, K C G de Git, H D M Beekman, R R Tidwell, A P Ijzerman, A Stary-Weinzinger, M A Vos, M A G van der Heyden. Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.
British journal of pharmacology.
2013 Jul; 169(6):1322-34. doi:
10.1111/bph.12208. [PMID: 23586323] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Louise Marks, Samantha Borland, Karen Philp, Lorna Ewart, Pierre Lainée, Matthew Skinner, Sarah Kirk, Jean-Pierre Valentin. The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds.
Toxicology and applied pharmacology.
2012 Sep; 263(2):171-83. doi:
10.1016/j.taap.2012.06.007. [PMID: 22714037] - Ishrat Jabeen, Karin Pleban, Uwe Rinner, Peter Chiba, Gerhard F Ecker. Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Journal of medicinal chemistry.
2012 Apr; 55(7):3261-73. doi:
10.1021/jm201705f. [PMID: 22452412] - C Y DU, A El Harchi, Y H Zhang, C H Orchard, J C Hancox. Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis.
Journal of cardiovascular electrophysiology.
2011 Oct; 22(10):1163-70. doi:
10.1111/j.1540-8167.2011.02060.x. [PMID: 21489024] - Vera H M Deneer, Norbert M van Hemel. Is antiarrhythmic treatment in the elderly different? a review of the specific changes.
Drugs & aging.
2011 Aug; 28(8):617-33. doi:
10.2165/11591680-000000000-00000. [PMID: 21812498] - Tina H Denetclaw, Nancy Oshima, Thomas C Dowling. Dofetilide dose calculation errors in elderly associated with use of the modification of diet in renal disease equation.
The Annals of pharmacotherapy.
2011 Jul; 45(7-8):e44. doi:
10.1345/aph.1q159. [PMID: 21712508] - Ingemar Jacobson, Leif Carlsson, Göran Duker. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
Journal of pharmacological and toxicological methods.
2011 Jan; 63(1):40-6. doi:
10.1016/j.vascn.2010.04.010. [PMID: 20451633] - James C Coons, Kara M Plauger, Amy L Seybert, George G Sokos. Worsening heart failure in the setting of dronedarone initiation.
The Annals of pharmacotherapy.
2010 Sep; 44(9):1496-500. doi:
10.1345/aph.1p075. [PMID: 20628043] - Anne Friemel, Bernd J Zünkler. Interactions at human ether-à-go-go-related gene channels.
Toxicological sciences : an official journal of the Society of Toxicology.
2010 Apr; 114(2):346-55. doi:
10.1093/toxsci/kfq011. [PMID: 20071423] - Qiang-Ni Liu, Li Zhang, Pei-Li Gong, Xiao-Yan Yang, Fan-Dian Zeng. Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current.
The American journal of Chinese medicine.
2010; 38(1):37-49. doi:
10.1142/s0192415x1000766x. [PMID: 20128043] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - A John Camm. Safety considerations in the pharmacological management of atrial fibrillation.
International journal of cardiology.
2008 Jul; 127(3):299-306. doi:
10.1016/j.ijcard.2007.11.006. [PMID: 18191470] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Anna Ollerstam, Sandra A G Visser, Göran Duker, Tomas Forsberg, Anna H Persson, Lars B Nilsson, Jan-Arne Björkman, Johan Gabrielsson, Ahmad Al-Saffar. Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs.
Journal of pharmacological and toxicological methods.
2007 Sep; 56(2):131-44. doi:
10.1016/j.vascn.2007.05.002. [PMID: 17689270] - Icilio Cavero. Using pharmacokinetic/pharmacodynamic modelling in safety pharmacology to better define safety margins: a regional workshop of the Safety Pharmacology Society.
Expert opinion on drug safety.
2007 Jul; 6(4):465-71. doi:
10.1517/14740338.6.4.465. [PMID: 17688390] - J Lowe, S Drozda, W Qian, M-C Peakman, J Liu, J Gibbs, J Harms, C Schmidt, K Fisher, C Strick, A Schmidt, M Vanase, L Lebel. A novel, non-substrate-based series of glycine type 1 transporter inhibitors derived from high-throughput screening.
Bioorganic & medicinal chemistry letters.
2007 Mar; 17(6):1675-8. doi:
10.1016/j.bmcl.2006.12.109. [PMID: 17257843] - Anna Ollerstam, Anna H Persson, Sandra A G Visser, J Magnus Fredriksson, Tomas Forsberg, Lars B Nilsson, Göran Eklund, Stig Johan Wiklund, Johan Gabrielsson, Göran Duker, Ahmad Al-Saffar. A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.
Journal of pharmacological and toxicological methods.
2007 Jan; 55(1):35-48. doi:
10.1016/j.vascn.2006.02.009. [PMID: 16581270] - M B Thomsen, J D M Beekman, N J M Attevelt, A Takahara, A Sugiyama, K Chiba, M A Vos. No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block.
British journal of pharmacology.
2006 Dec; 149(8):1039-48. doi:
10.1038/sj.bjp.0706900. [PMID: 17088870] - James T Limberis, Zhi Su, Bryan F Cox, Gary A Gintant, Ruth L Martin. Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels.
Clinical and experimental pharmacology & physiology.
2006 Nov; 33(11):1059-65. doi:
10.1111/j.1440-1681.2006.04487.x. [PMID: 17042915] - Xian Chen, Jason S Cordes, Jenifer A Bradley, Zhuoqian Sun, Jun Zhou. Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs.
Journal of pharmacological and toxicological methods.
2006 Nov; 54(3):261-72. doi:
10.1016/j.vascn.2006.02.005. [PMID: 16564186] - Anna Ollerstam, Sandra A G Visser, Anna H Persson, Göran Eklund, Lars B Nilsson, Tomas Forsberg, Stig Johan Wiklund, Johan Gabrielsson, Göran Duker, Ahmad Al-Saffar. Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs.
Journal of pharmacological and toxicological methods.
2006 Mar; 53(2):174-83. doi:
10.1016/j.vascn.2005.07.002. [PMID: 16140023] - Khuram W Chaudhary, Janet M O'Neal, Zun-Li Mo, Bernard Fermini, Robert H Gallavan, Anthony Bahinski. Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.
Assay and drug development technologies.
2006 Feb; 4(1):73-82. doi:
10.1089/adt.2006.4.73. [PMID: 16506891] - Boni Elewski, Amir Tavakkol. Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality.
Therapeutics and clinical risk management.
2005 Dec; 1(4):299-306. doi:
. [PMID: 18360572] - Xian Chen, Jessica D Cass, Jenifer A Bradley, Corinn M Dahm, Zhuoqian Sun, Edmund Kadyszewski, Michael J Engwall, Jun Zhou. QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome.
British journal of pharmacology.
2005 Nov; 146(6):792-9. doi:
10.1038/sj.bjp.0706389. [PMID: 16158069] - Jun Zhou, Corinne E Augelli-Szafran, Jenifer A Bradley, Xian Chen, Bryan J Koci, Walter A Volberg, Zhuoqian Sun, Jason S Cordes. Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity.
Molecular pharmacology.
2005 Sep; 68(3):876-84. doi:
10.1124/mol.105.014035. [PMID: 15976038] - H van der Linde, A Van de Water, W Loots, B Van Deuren, H R Lu, K Van Ammel, M Peeters, D J Gallacher. A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs.
Journal of pharmacological and toxicological methods.
2005 Jul; 52(1):168-77. doi:
10.1016/j.vascn.2005.03.005. [PMID: 15935709] - Gilbert J Diaz, Katina Daniell, Sandra T Leitza, Ruth L Martin, Zhi Su, Jeffrey S McDermott, Bryan F Cox, Gary A Gintant. The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.
Journal of pharmacological and toxicological methods.
2004 Nov; 50(3):187-99. doi:
10.1016/j.vascn.2004.04.001. [PMID: 15519905] - Jiesheng Kang, Xiao-Liang Chen, Hongge Wang, Junzhi Ji, William Reynolds, Sungtaek Lim, James Hendrix, David Rampe. Cardiac ion channel effects of tolterodine.
The Journal of pharmacology and experimental therapeutics.
2004 Mar; 308(3):935-40. doi:
10.1124/jpet.103.062182. [PMID: 14711935] - Sabina Kupershmidt, Iris C-H Yang, Kenshi Hayashi, Jian Wei, Siprachanh Chanthaphaychith, Christina I Petersen, Daivid C Johns, Alfred L George, Dan M Roden, Jeffrey R Balser. The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 Dec; 17(15):2263-5. doi:
10.1096/fj.02-1057fje. [PMID: 14525949] - S G O'Brien, P Meinhardt, E Bond, J Beck, B Peng, C Dutreix, G Mehring, S Milosavljev, C Huber, R Capdeville, T Fischer. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.
British journal of cancer.
2003 Nov; 89(10):1855-9. doi:
10.1038/sj.bjc.6601152. [PMID: 14612892] - Morten B Thomsen, Paul G A Volders, Milan Stengl, Roel L H M G Spätjens, Jet D M Beekman, Ulrike Bischoff, Morten A Kall, Kristen Frederiksen, Jørgen Matz, Marc A Vos. Electrophysiological safety of sertindole in dogs with normal and remodeled hearts.
The Journal of pharmacology and experimental therapeutics.
2003 Nov; 307(2):776-84. doi:
10.1124/jpet.103.052753. [PMID: 12966159] - Nancy M Allen LaPointe, Anita Chen, Bradley Hammill, Elizabeth DeLong, Judith M Kramer, Robert M Califf. Evaluation of the dofetilide risk-management program.
American heart journal.
2003 Nov; 146(5):894-901. doi:
10.1016/s0002-8703(03)00409-5. [PMID: 14597941] - Atsushi Sugiyama, Yoshioki Satoh, Akira Takahara, Yuji Nakamura, Masao Shimizu-Sasamata, Shuichi Sato, Keiji Miyata, Keitaro Hashimoto. Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems.
European journal of pharmacology.
2003 Apr; 466(1-2):137-46. doi:
10.1016/s0014-2999(03)01559-0. [PMID: 12679150] - Weeranuj Yamreudeewong, Michael DeBisschop, Linda G Martin, Dennis L Lower. Potentially significant drug interactions of class III antiarrhythmic drugs.
Drug safety.
2003; 26(6):421-38. doi:
10.2165/00002018-200326060-00004. [PMID: 12688833] - Thai V Pham, Eugene A Sosunov, Evgeny P Anyukhovsky, Peter Danilo, Michael R Rosen. Testosterone diminishes the proarrhythmic effects of dofetilide in normal female rabbits.
Circulation.
2002 Oct; 106(16):2132-6. doi:
10.1161/01.cir.0000033596.21845.d8. [PMID: 12379585] - Zhang Wei, Dierk Thomas, Christoph A Karle, Sven Kathöfer, Johannes Schenkel, Volker A W Kreye, Eckhard Ficker, Barbara A Wible, Johann Kiehn. Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line.
Chinese medical journal.
2002 May; 115(5):668-76. doi:
NULL. [PMID: 12133532] - Howard N E Stevens, Clive G Wilson, Peter G Welling, Massoud Bakhshaee, Julie S Binns, Alan C Perkins, Malcolm Frier, Elaine P Blackshaw, Margaret W Frame, Don J Nichols, Michael J Humphrey, Steve R Wicks. Evaluation of Pulsincap to provide regional delivery of dofetilide to the human GI tract.
International journal of pharmaceutics.
2002 Apr; 236(1-2):27-34. doi:
10.1016/s0378-5173(02)00012-1. [PMID: 11891067] - Michael J Allen, Stuart D Oliver, Margaret W Newgreen, Donald J Nichols. Pharmacodynamic effect of continuous vs intermittent dosing of dofetilide on QT interval.
British journal of clinical pharmacology.
2002 Jan; 53(1):59-65. doi:
10.1046/j.0306-5251.2001.01511.x. [PMID: 11849196] - S M Cobbe, R W Campbell, A J Camm, A W Nathan, E Rowland, P E Bloch-Thomsen, M Møller, L Jordaens. Effects of intravenous dofetilide on induction of atrioventricular re-entrant tachycardia.
Heart (British Cardiac Society).
2001 Nov; 86(5):522-6. doi:
10.1136/heart.86.5.522. [PMID: 11602544] - B F Johnson, S L Cheng, J Venitz. Transient kinetic and dynamic interactions between verapamil and dofetilide, a class III antiarrhythmic.
Journal of clinical pharmacology.
2001 Nov; 41(11):1248-56. doi:
10.1177/00912700122012805. [PMID: 11697758] - K Finlayson, L Turnbull, C T January, J Sharkey, J S Kelly. [3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
European journal of pharmacology.
2001 Oct; 430(1):147-8. doi:
10.1016/s0014-2999(01)01362-0. [PMID: 11698075] - T V Pham, E A Sosunov, R Z Gainullin, P Danilo, M R Rosen. Impact of sex and gonadal steroids on prolongation of ventricular repolarization and arrhythmias induced by I(K)-blocking drugs.
Circulation.
2001 May; 103(17):2207-12. doi:
10.1161/01.cir.103.17.2207. [PMID: 11331264] - J A Reiffel, G Appel. Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy.
Journal of cardiovascular pharmacology and therapeutics.
2001 Apr; 6(2):111-9. doi:
10.1177/107424840100600202. [PMID: 11509917] - W I Saliba. Dofetilide (Tikosyn): a new drug to control atrial fibrillation.
Cleveland Clinic journal of medicine.
2001 Apr; 68(4):353-63. doi:
10.3949/ccjm.68.4.353. [PMID: 11326815] - X Xu, S J Rials, Y Wu, J J Salata, T Liu, D B Bharucha, R A Marinchak, P R Kowey. Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits.
Circulation.
2001 Mar; 103(11):1585-90. doi:
10.1161/01.cir.103.11.1585. [PMID: 11257089] - T L Lenz, D E Hilleman. Dofetilide: A new antiarrhythmic agent approved for conversion and/or maintenance of atrial fibrillation/atrial flutter.
Drugs of today (Barcelona, Spain : 1998).
2000 Nov; 36(11):759-71. doi:
10.1358/dot.2000.36.11.601530. [PMID: 12845335] - M J Allen, D J Nichols, S D Oliver. The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing.
British journal of clinical pharmacology.
2000 Sep; 50(3):247-53. doi:
10.1046/j.1365-2125.2000.00243.x. [PMID: 10971309] - T L Lenz, D E Hilleman. Dofetilide, a new class III antiarrhythmic agent.
Pharmacotherapy.
2000 Jul; 20(7):776-86. doi:
10.1592/phco.20.9.776.35208. [PMID: 10907968] - S Abel, D J Nichols, C J Brearley, M D Eve. Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide.
British journal of clinical pharmacology.
2000 Jan; 49(1):64-71. doi:
10.1046/j.1365-2125.2000.00114.x. [PMID: 10606839] - A M Choy, D Darbar, S Dell'Orto, D M Roden. Exaggerated QT prolongation after cardioversion of atrial fibrillation.
Journal of the American College of Cardiology.
1999 Aug; 34(2):396-401. doi:
10.1016/s0735-1097(99)00226-0. [PMID: 10440151] - D R Davis, G N Beatch, D R Dickenson, A S Tang. Dofetilide enhances shock-induced extension of refractoriness and lowers defibrillation threshold.
The Canadian journal of cardiology.
1999 Feb; 15(2):193-200. doi:
. [PMID: 10079779] - S G Priori, C Napolitano, V Paganini, F Cantù, P J Schwartz. Molecular biology of the long QT syndrome: impact on management.
Pacing and clinical electrophysiology : PACE.
1997 Aug; 20(8 Pt 2):2052-7. doi:
10.1111/j.1540-8159.1997.tb03626.x. [PMID: 9272507] - D K Walker, K C Beaumont, D A Stopher, D A Smith. Pharmacokinetics of a series of bis(methanesulphonamido-arylalkyl)amines in the beagle dog.
Xenobiotica; the fate of foreign compounds in biological systems.
1996 Oct; 26(10):1101-11. doi:
10.3109/00498259609167425. [PMID: 8905922] - D J Snyders, A Chaudhary. High affinity open channel block by dofetilide of HERG expressed in a human cell line.
Molecular pharmacology.
1996 Jun; 49(6):949-55. doi:
. [PMID: 8649354] - D K Walker, C T Alabaster, G S Congrave, M B Hargreaves, R Hyland, B C Jones, L J Reed, D A Smith. Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Apr; 24(4):447-55. doi:
. [PMID: 8801060] - W S Webster, P D Brown-Woodman, M D Snow, B R Danielsson. Teratogenic potential of almokalant, dofetilide, and d-sotalol: drugs with potassium channel blocking activity.
Teratology.
1996 Mar; 53(3):168-75. doi:
10.1002/(sici)1096-9926(199603)53:3<168::aid-tera4>3.0.co;2-0. [PMID: 8761884] - Y Bashir, P E Thomsen, J H Kingma, M Møller, C Wong, S M Cobbe, L Jordaens, R W Campbell, H S Rasmussen, A J Camm. Electrophysiologic profile and efficacy of intravenous dofetilide (UK-68,798), a new class III antiarrhythmic drug, in patients with sustained monomorphic ventricular tachycardia. Dofetilide Arrhythmia Study Group.
The American journal of cardiology.
1995 Nov; 76(14):1040-4. doi:
10.1016/s0002-9149(99)80293-8. [PMID: 7484858] - F Le Coz, C Funck-Brentano, T Morell, M M Ghadanfar, P Jaillon. Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization.
Clinical pharmacology and therapeutics.
1995 May; 57(5):533-42. doi:
10.1016/0009-9236(95)90038-1. [PMID: 7768076] - D A Smith, H S Rasmussen, D A Stopher, D K Walker. Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man.
Xenobiotica; the fate of foreign compounds in biological systems.
1992 Jun; 22(6):709-19. doi:
10.3109/00498259209053133. [PMID: 1441594] - H S Rasmussen, M J Allen, K J Blackburn, G S Butrous, H W Dalrymple. Dofetilide, a novel class III antiarrhythmic agent.
Journal of cardiovascular pharmacology.
1992; 20 Suppl 2(?):S96-105. doi:
. [PMID: 1279316] - D K Walker, D A Smith, D A Stopher. Liquid-liquid extraction and high-performance liquid chromatography for the determination of a novel antidysrhythmic agent (UK-68,798) in human urine.
Journal of chromatography.
1991 Aug; 568(2):475-80. doi:
10.1016/0378-4347(91)80186-g. [PMID: 1783653] - M Sedgwick, H S Rasmussen, D Walker, S M Cobbe. Pharmacokinetic and pharmacodynamic effects of UK-68,798, a new potential class III antiarrhythmic drug.
British journal of clinical pharmacology.
1991 May; 31(5):515-9. doi:
10.1111/j.1365-2125.1991.tb05572.x. [PMID: 1888617] - D K Walker, G W Aherne, J E Arrowsmith, P E Cross, B Kaye, D A Smith, D A Stopher, W Wild. Measurement of the class III antidysrhythmic drug, UK-68,798, in plasma by radioimmunoassay.
Journal of pharmaceutical and biomedical analysis.
1991; 9(2):141-9. doi:
10.1016/0731-7085(91)80137-x. [PMID: 1873305]