Enalaprilat Dihydrate (BioDeep_00000398942)
natural product
代谢物信息卡片
Enalaprilat Dihydrate
化学式: C18H28N2O7 (384.1896)
中文名称: 依那普利拉 二水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=CC(=C1)CC[C@@H](C(O)=O)N[C@H](C(N2[C@@H](CCC2)C(=O)O)=O)C).O.O
InChI: /m0../s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:59877
- PubChem: 6917719
- ChEMBL: CHEMBL3989406
- MeSH: Enalaprilat
- CAS: 84680-54-6
- MoNA: CCMSLIB00000078227
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Enalapril Action Pathway:
Angiotensin I ⟶ Angiotensin II - Enalapril Metabolism Pathway:
Enalapril ⟶ Enalaprilat
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ekaterina Popova, Victoria Tikhomirova, Olga Beznos, Natalia Chesnokova, Yuri Grigoriev, Michael Taliansky, Olga Kost. A Direct Comparison of Peptide Drug Delivery Systems Based on the Use of Hybrid Calcium Phosphate/Chitosan Nanoparticles versus Unmixed Calcium Phosphate or Chitosan Nanoparticles In Vitro and In Vivo.
International journal of molecular sciences.
2023 Oct; 24(21):. doi:
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PloS one.
2022 ; 17(1):e0261000. doi:
10.1371/journal.pone.0261000. [PMID: 35085251] - Lucy H Her, Xinwen Wang, Jian Shi, Hee Jae Choi, Sun Min Jung, Logan S Smith, Audrey H Wu, Barry E Bleske, Hao-Jie Zhu. Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.
British journal of clinical pharmacology.
2021 12; 87(12):4691-4700. doi:
10.1111/bcp.14888. [PMID: 33963573] - Cindy Gueguen, Kristy L Jackson, Francine Z Marques, Nina Eikelis, Sarah Phillips, Emily R Stevenson, Fadi J Charchar, Gavin W Lambert, Pamela J Davern, Geoffrey A Head. Renal nerves contribute to hypertension in Schlager BPH/2J mice.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 03; 42(3):306-318. doi:
10.1038/s41440-018-0147-9. [PMID: 30531841] - David Dahlgren, Carl Roos, Pernilla Johansson, Anders Lundqvist, Christer Tannergren, Bertil Abrahamsson, Erik Sjögren, Hans Lennernäs. Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms.
Molecular pharmaceutics.
2016 09; 13(9):3022-33. doi:
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British journal of clinical pharmacology.
2015 Nov; 80(5):1131-8. doi:
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Journal of hypertension.
2015 Sep; 33(9):1931-8; discussion 1938. doi:
10.1097/hjh.0000000000000635. [PMID: 26147389] - Bjoern B Burckhardt, Jutta Tins, Stephanie Laeer. Simultaneous quantitative and qualitative analysis of aliskiren, enalapril and its active metabolite enalaprilat in undiluted human urine utilizing LC-ESI-MS/MS.
Biomedical chromatography : BMC.
2014 Dec; 28(12):1679-91. doi:
10.1002/bmc.3201. [PMID: 24788577] - Manuel Gómez-Díez, Ana Muñoz, Juan Manuel Serrano Caballero, Cristina Riber, Francisco Castejón, Juan Manuel Serrano-Rodríguez. Pharmacokinetics and pharmacodynamics of enalapril and its active metabolite, enalaprilat, at four different doses in healthy horses.
Research in veterinary science.
2014 Aug; 97(1):105-10. doi:
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Toxicology and applied pharmacology.
2014 Feb; 274(3):436-44. doi:
10.1016/j.taap.2013.12.001. [PMID: 24342267] - Martin Wolley, Richard D Gordon, Michael Stowasser. Reninoma: the importance of renal vein renin ratios for lateralisation and diagnosis.
American journal of nephrology.
2014; 39(1):16-9. doi:
10.1159/000357410. [PMID: 24401674] - Mihaela Cheregi, Florin Albu, Ştefan Udrescu, Nicoleta Răducanu, Andrei Medvedovici. Greener bioanalytical approach for LC/MS-MS assay of enalapril and enalaprilat in human plasma with total replacement of acetonitrile throughout all analytical stages.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 May; 927(?):124-32. doi:
10.1016/j.jchromb.2012.11.023. [PMID: 23266124] - Vanessa Fontana, Pamela S Silva, Tatiane C Izidoro-Toledo, Celso Biagi, Eduardo B Oliveira, Raquel F Gerlach, Jose E Tanus-Santos. Comprehensive evaluation of the effects of enalapril on matrix metalloproteinases levels in hypertension.
Cardiovascular drugs and therapy.
2012 Dec; 26(6):511-9. doi:
10.1007/s10557-012-6420-2. [PMID: 23085896] - B-T Bi, Y-B Yang, A-D Ma, T Lin, H-B Lin, X-M Yang, J-P Xu. The effect of candesartan on the pharmacokinetics of enalaprilat in nephrotic rats.
European review for medical and pharmacological sciences.
2012 Dec; 16(15):2162-70. doi:
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Biomedical chromatography : BMC.
2012 Jun; 26(6):691-6. doi:
10.1002/bmc.1715. [PMID: 21932385] - Sergej Ramusovic, Gabriele Thielking, Stephanie Läer. Determination of enalapril and enalaprilat in small human serum quantities for pediatric trials by HPLC-tandem mass spectrometry.
Biomedical chromatography : BMC.
2012 Jun; 26(6):697-702. doi:
10.1002/bmc.1716. [PMID: 21953651] - Ingrid A-L Persson. The pharmacological mechanism of angiotensin-converting enzyme inhibition by green tea, Rooibos and enalaprilat - a study on enzyme kinetics.
Phytotherapy research : PTR.
2012 Apr; 26(4):517-21. doi:
10.1002/ptr.3588. [PMID: 22095883] - Min Yu, Yang Zheng, Hong-Xia Sun, Du-Juan Yu. Inhibitory effects of enalaprilat on rat cardiac fibroblast proliferation via ROS/P38MAPK/TGF-β1 signaling pathway.
Molecules (Basel, Switzerland).
2012 Mar; 17(3):2738-51. doi:
10.3390/molecules17032738. [PMID: 22395404] - Chinmoy Ghosh, Ina Jain, Chandrakant P Shinde, Bhaswat S Chakraborty. Rapid and sensitive liquid chromatography/tandem mass spectrometry method for simultaneous determination of enalapril and its major metabolite enalaprilat, in human plasma: application to a bioequivalence study.
Drug testing and analysis.
2012 Feb; 4(2):94-103. doi:
10.1002/dta.241. [PMID: 21341376] - Maxim N Petrov, Valery Y Shilo, Alexandr V Tarasov, David E Schwartz, Joe G N Garcia, Olga A Kost, Sergei M Danilov. Conformational changes of blood ACE in chronic uremia.
PloS one.
2012; 7(11):e49290. doi:
10.1371/journal.pone.0049290. [PMID: 23166630] - Diamantino Ribeiro Salgado, Xinrong He, Fuhong Su, Dalton Barros de Sousa, Laura Penaccini, Leonardo Kfuri Maciel, Fabio Taccone, José Rodolfo Rocco, Eliézer Silva, Daniel De Backer, Jean-Louis Vincent. Sublingual microcirculatory effects of enalaprilat in an ovine model of septic shock.
Shock (Augusta, Ga.).
2011 Jun; 35(6):542-9. doi:
10.1097/shk.0b013e3182115e6a. [PMID: 21283060] - Rocio Bautista-Pérez, Abraham Arellano, Martha Franco, Horacio Osorio, Israel Coronel. Enalaprilat-mediated activation of kinin b(1) receptors and vasodilation in the rat isolated perfused kidney.
Pharmacology.
2011; 87(3-4):195-203. doi:
10.1159/000324513. [PMID: 21430409] - Md Abdul Hye Khan, Mohammed Toriqul Islam, Alexander Castillo, Dewan Syed Abdul Majid. Attenuation of renal excretory responses to ANG II during inhibition of superoxide dismutase in anesthetized rats.
American journal of physiology. Renal physiology.
2010 Feb; 298(2):F401-7. doi:
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Hypertension (Dallas, Tex. : 1979).
2010 Feb; 55(2):298-304. doi:
10.1161/hypertensionaha.109.135426. [PMID: 20048199] - Dione M Lima, Iram M Mundim, Paulo César B V Jardim, Thiago S V Jardim, Danielle G A Diniz, Eliana M Lima. A high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using solid phase extraction for the simultaneous determination of plasma concentrations of enalapril and enalaprilate in hypertensive patients treated with different pharmaceutical formulations.
Therapeutic drug monitoring.
2009 Dec; 31(6):710-6. doi:
10.1097/ftd.0b013e3181b8f1b6. [PMID: 19701113] - A V Kutina, Iu V Natochin, E I Shakhmatova. [Influence of the angiotensin converting enzyme inhibition on the functional proteinuria in rats].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.
2009 Oct; 95(10):1151-9. doi:
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Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2009 Jun; 25(3):180-3. doi:
. [PMID: 19842552] - Shan Lu, Kun Jiang, Feng Qin, Xiumei Lu, Famei Li. Simultaneous quantification of enalapril and enalaprilat in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2009 Jan; 49(1):163-7. doi:
10.1016/j.jpba.2008.10.012. [PMID: 19046843] - Rong Xiao, Yue-sheng Huang, Ze-yuan Lei, Jing Ruan. [Effects of single or combined administration of cedilanid and enalaprilat on visceral damages in early stage of severe scald in rats].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2008 Dec; 24(6):428-31. doi:
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La Clinica terapeutica.
2008 May; 159(3):151-4. doi:
NULL. [PMID: 18594743] - Fredrik Palm, Stephanie G Connors, Margarida Mendonca, William J Welch, Christopher S Wilcox. Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2008 Feb; 51(2):345-51. doi:
10.1161/hypertensionaha.107.097832. [PMID: 18158356] - Beata Marie Redublo Quinto, Maria Claudina Camargo de Andrade, Fernanda Aparecida Ronchi, Edson Lucas Santos, Silvana Aparecida Alves Correa, Suma Imura Shimuta, João Bosco Pesquero, Renato Arruda Mortara, Dulce Elena Casarini. Expression of angiotensin I-converting enzymes and bradykinin B2 receptors in mouse inner medullary-collecting duct cells.
International immunopharmacology.
2008 Feb; 8(2):254-60. doi:
10.1016/j.intimp.2007.09.013. [PMID: 18182236] - Serdar Turkyilmaz, Etem Alhan, Cengiz Ercin, Birgul Kural Vanizor. Effects of enalaprilat on acute necrotizing pancreatitis in rats.
Inflammation.
2007 Dec; 30(6):205-12. doi:
10.1007/s10753-007-9038-y. [PMID: 17653597] - B V Karanam, A Jayraj, M Rabe, Z Wang, C Keohane, J Strauss, S Vincent. Effect of enalapril on the in vitro and in vivo peptidyl cleavage of a potent VLA-4 antagonist.
Xenobiotica; the fate of foreign compounds in biological systems.
2007 May; 37(5):487-502. doi:
10.1080/00498250701316663. [PMID: 17523052] - Cristina E Okuyama, Gustavo Duarte Mendes, Renato Faro, Vinicius M Rezende, Rodolfo Monaco Lagos, Rafael E B Astigarraga, Edson Antunes, Gilberto De Nucci. Pharmacokinetics and pharmacodynamics of a nitric oxide-releasing derivative of enalapril in male beagles.
Clinical and experimental pharmacology & physiology.
2007 Apr; 34(4):290-5. doi:
10.1111/j.1440-1681.2007.04559.x. [PMID: 17324140] - U Schaefer, T Kurz, H Bonnemeier, A Dendorfer, F Hartmann, H Schunkert, G Richardt. Intracoronary enalaprilat during angioplasty for acute myocardial infarction: alleviation of postischaemic neurohumoral and inflammatory stress?.
Journal of internal medicine.
2007 Feb; 261(2):188-200. doi:
10.1111/j.1365-2796.2006.01757.x. [PMID: 17241184] - I Gammelgaard, S Wamberg, P Bie. Systemic effects of angiotensin III in conscious dogs during acute double blockade of the renin-angiotensin-aldosterone-system.
Acta physiologica (Oxford, England).
2006 Oct; 188(2):129-38. doi:
10.1111/j.1748-1716.2006.01595.x. [PMID: 16948800] - Hein A van Onzenoort, Michiel Bussink, Paul P Menheere, Walther N van Mook, Paul-Hugo M van der Kuy. The effect of sublingual captopril versus intravenous enalaprilat on angiotensin II plasma levels.
Pharmacy world & science : PWS.
2006 Jun; 28(3):131-4. doi:
10.1007/s11096-006-9024-8. [PMID: 17004021] - J Schumacher, M R Puchakayala, K Binkowski, W Eichler, A Dendorfer, K-F Klotz. Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats.
British journal of anaesthesia.
2006 Apr; 96(4):437-43. doi:
10.1093/bja/ael030. [PMID: 16490762] - Rene M Oliveira, Antonio A Oliveira Neto, Luiz C Miranda. Interference of enalaprilat on glomerular permeability to macromolecules (IgG) in acute unilateral ureteral obstruction in rats.
International braz j urol : official journal of the Brazilian Society of Urology.
2006 Mar; 32(2):216-21. doi:
10.1590/s1677-55382006000200016. [PMID: 16650303] - Marcelo Rodrigues Borba, Roberto Iglesias Lopes, Murilo Carmona, Boulangier Mioto Neto, Sérgio Carlos Nahas, Paulo Roberto Bueno Pereira. Effects of enalaprilat on the renin-angiotensin-aldosterone system and on renal function during CO2 pneumoperitoneum.
Journal of endourology.
2005 Oct; 19(8):1026-31. doi:
10.1089/end.2005.19.1026. [PMID: 16253075] - Farid Nakhoul, Rawi Ramadan, Eliyahu Khankin, Afif Yaccob, Zoya Kositch, Moshe Lewin, Suheir Assady, Zaid Abassi. Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies.
American journal of physiology. Renal physiology.
2005 Oct; 289(4):F880-90. doi:
10.1152/ajprenal.00451.2004. [PMID: 15942045] - T Arafat, R Awad, M Hamad, R Azzam, A Al-Nasan, A Jehanli, K Matalka. Pharmacokinetics and pharmacodynamics profiles of enalapril maleate in healthy volunteers following determination of enalapril and enalaprilat by two specific enzyme immunoassays.
Journal of clinical pharmacy and therapeutics.
2005 Aug; 30(4):319-28. doi:
10.1111/j.1365-2710.2005.00646.x. [PMID: 15985045] - Thomas Elung-Jensen, Jens Heisterberg, Jesper Sonne, Svend Strandgaard, Anne-Lise Kamper. Enalapril dosage in progressive chronic nephropathy: a randomised, controlled trial.
European journal of clinical pharmacology.
2005 Apr; 61(2):87-96. doi:
10.1007/s00228-005-0893-x. [PMID: 15761754] - Phensri Thongnopnua, Chotima Poeaknapo. High-performance liquid chromatographic determination of enalapril in human plasma by enzyme kinetic analytical method.
Journal of pharmaceutical and biomedical analysis.
2005 Apr; 37(4):763-9. doi:
10.1016/j.jpba.2004.10.053. [PMID: 15797799] - Jill M Wecht, Miroslav Radulovic, Joseph P Weir, Joanah Lessey, Ann M Spungen, William A Bauman. Partial angiotensin-converting enzyme inhibition during acute orthostatic stress in persons with tetraplegia.
The journal of spinal cord medicine.
2005; 28(2):103-8. doi:
10.1080/10790268.2005.11753806. [PMID: 15889697] - Qi Gu, Xiaoyan Chen, Dafang Zhong, Yingwu Wang. Simultaneous determination of enalapril and enalaprilat in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Dec; 813(1-2):337-42. doi:
10.1016/j.jchromb.2004.09.031. [PMID: 15556550] - Handan Türker, Asli Dönmez, Pinar Zeyneloğlu, Atilla Sezgin, Melek Uluçam. Effects of enalaprilat infusion on hemodynamics and renal function in patients undergoing cardiac surgery.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.
2004 Dec; 4(4):296-300. doi:
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American journal of physiology. Renal physiology.
2004 Nov; 287(5):F907-13. doi:
10.1152/ajprenal.00060.2004. [PMID: 15475543] - Joseph Francis, Shun-Guang Wei, Robert M Weiss, Robert B Felder. Brain angiotensin-converting enzyme activity and autonomic regulation in heart failure.
American journal of physiology. Heart and circulatory physiology.
2004 Nov; 287(5):H2138-46. doi:
10.1152/ajpheart.00112.2004. [PMID: 15475532] - Kate M Denton, Amany Shweta, Rebecca L Flower, Warwick P Anderson. Predominant postglomerular vascular resistance response to reflex renal sympathetic nerve activation during ANG II clamp in rabbits.
American journal of physiology. Regulatory, integrative and comparative physiology.
2004 Oct; 287(4):R780-6. doi:
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Critical care (London, England).
2004 Aug; 8(4):R163-71. doi:
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Journal of cardiovascular pharmacology.
2004 May; 43(5):737-44. doi:
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Journal of veterinary internal medicine.
2004 Mar; 18(2):231-7. doi:
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Journal of the American Society of Nephrology : JASN.
2004 Jan; 15(1):52-60. doi:
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Vascular pharmacology.
2003 Dec; 40(5):253-9. doi:
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2003 Oct; 86(10):947-52. doi:
NULL. [PMID: 14650707] - Masayo Naito, Akira Kawashima, Takashi Akiba, Minoko Takanashi, Hiroshi Nihei. Effects of an angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitors on burst forming units-erythroid in chronic hemodialysis patients.
American journal of nephrology.
2003 Sep; 23(5):287-93. doi:
10.1159/000072705. [PMID: 12897465] - Kijun Kim, Sung Hoon Kim, Chul Woo Yang, Can Li, Yong An Chung, Sung Yong Lee, Hyung Sun Sohn, Soo Kyo Chung. Differentiation between acute cyclosporine nephrotoxicity and acute tubular necrosis using enalaprilat renal scintigraphy in rats.
Investigative radiology.
2003 Aug; 38(8):473-81. doi:
10.1097/01.rli.0000065696.41011.ce. [PMID: 12874513] - Kathryn Rouine-Rapp, Dennis M Mello, Frank L Hanley, V Mohan Reddy, Scott Soifer. Effect of enalaprilat on postoperative hypertension after surgical repair of coarctation of the aorta.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2003 Jul; 4(3):327-32. doi:
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European journal of clinical investigation.
2003 May; 33(5):363-9. doi:
10.1046/j.1365-2362.2003.01160.x. [PMID: 12713448] - Frank Wagner, Ruhi Yeter, Susanne Bisson, Henryk Siniawski, Roland Hetzer. Beneficial hemodynamic and renal effects of intravenous enalaprilat following coronary artery bypass surgery complicated by left ventricular dysfunction.
Critical care medicine.
2003 May; 31(5):1421-8. doi:
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International journal of clinical pharmacology and therapeutics.
2003 May; 41(5):226-30. doi:
10.5414/cpp41226. [PMID: 12776814] - Marie E Le Fevre, Sarah-Jane Guild, Rohit Ramchandra, Carolyn J Barrett, Simon C Malpas. Role of angiotensin II in the neural control of renal function.
Hypertension (Dallas, Tex. : 1979).
2003 Mar; 41(3):583-91. doi:
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