Silodosin (BioDeep_00000398931)
natural product
代谢物信息卡片
(R)-1-(3-hydroxypropyl)-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carboxamide
化学式: C25H32F3N3O4 (495.23447880000003)
中文名称: 西洛多辛
谱图信息:
最多检出来源 Escherichia coli(natural_products) 95.83%
分子结构信息
SMILES: C1=CC=C(C(=C1)OCCN[C@H](C)CC2=CC3=C(C(=C2)C(N)=O)N(CC3)CCCO)OCC(F)(F)F
InChI: InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)
描述信息
G - Genito urinary system and sex hormones > G04 - Urologicals > G04C - Drugs used in benign prostatic hypertrophy > G04CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D000089162 - Genitourinary Agents > D064804 - Urological Agents
Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH[1][3].
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:135929
- KEGGdrug: D01965
- PubChem: 5312125
- PubChem: 9891967
- DrugBank: DB06207
- ChEMBL: CHEMBL24778
- ChEMBL: CHEMBL3187195
- CAS: 160970-54-7
- CAS: 160970-64-9
- MoNA: CCMSLIB00000078204
- MoNA: CCMSLIB00000078203
- MoNA: CCMSLIB00000078202
- medchemexpress: HY-10122
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Mostafa AbdelRazek, Ahmad Abolyosr, Omar Mhammed, Atef Fathi, Mohammed Talaat, Ahmed Hassan. Prospective comparison of tadalafil 5 mg alone, silodosin 8 mg alone, and the combination of both in treatment of lower urinary tract symptoms related to benign prostatic hyperplasia.
World journal of urology.
2022 Aug; 40(8):2063-2070. doi:
10.1007/s00345-022-04071-7. [PMID: 35773357] - Jong Keun Kim, Chang Il Choi, Seong Ho Lee, Jun Hyun Han, Young Suk Shim, Min Soo Choo. Silodosin for Prevention of Ureteral Injuries Resulting from Insertion of a Ureteral Access Sheath: A Randomized Controlled Trial.
European urology focus.
2022 Mar; 8(2):572-579. doi:
10.1016/j.euf.2021.03.009. [PMID: 33741297] - Makinna C Oestreich, Robin Wm Vernooij, Niranjan J Sathianathen, Eu Chang Hwang, Gretchen M Kuntz, Alex Koziarz, Charles D Scales, Philipp Dahm. Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults.
The Cochrane database of systematic reviews.
2020 11; 11(?):CD013393. doi:
10.1002/14651858.cd013393.pub2. [PMID: 33179245] - Yoshiki Nagao, Shogo Shimizu, Atsushi Kurabayashi, Takahiro Shimizu, Masayuki Tsuda, Youichirou Higashi, Mikiya Fujieda, Motoaki Saito. Effects of silodosin and tadalafil on bladder dysfunction in spontaneously hypertensive rats: Possible role of bladder blood flow.
International journal of urology : official journal of the Japanese Urological Association.
2020 Mar; 27(3):258-265. doi:
10.1111/iju.14171. [PMID: 31944397] - Gajanan S Bhat, Anuradha Shastry. A prospective double-blind, randomized, placebo-controlled study to evaluate the efficacy of silodosin 8 mg as an on-demand, reversible, nonhormonal oral contraceptive for males: a pilot study.
World journal of urology.
2020 Mar; 38(3):747-751. doi:
10.1007/s00345-019-02806-7. [PMID: 31076850] - Burak Köprü, Turgay Ebiloğlu, Engin Kaya, Murat Zor, Selahattin Bedir, Bahadır Topuz, Selçuk Sarikaya, Giray Ergin, Serdar Yalçin. Does preoperative use of silodosin affect the stages of F-URS procedure?.
Archivos espanoles de urologia.
2020 Jan; 73(1):47-53. doi:
NULL. [PMID: 31950923] - Yoshihisa Matsukawa, Shun Takai, Tsuyoshi Majima, Yasuhito Funahashi, Naoto Sassa, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh. Comparison in the efficacy of fesoterodine or mirabegron add-on therapy to silodosin for patients with benign prostatic hyperplasia complicated by overactive bladder: A randomized, prospective trial using urodynamic studies.
Neurourology and urodynamics.
2019 03; 38(3):941-949. doi:
10.1002/nau.23935. [PMID: 30779375] - Hiroshi Takahashi, Shinichi Kubono, Takehiko Taneyama, Kiyotoshi Kuramoto, Hideki Mizutani, Noriko Tanaka, Masaki Yoshida. Post-Marketing Surveillance of Silodosin in Patients with Benign Prostatic Hyperplasia and Poor Response to Existing Alpha-1 Blockers: The SPLASH Study.
Drugs in R&D.
2019 Mar; 19(1):47-55. doi:
10.1007/s40268-018-0258-4. [PMID: 30607819] - Yoshihisa Matsukawa, Tsuyoshi Majima, Shun Takai, Yasuhito Funahashi, Masashi Kato, Momokazu Gotoh. What Are Factors Contributing to Improvement of Overactive Bladder Symptoms after Alpha-1 Blocker Treatment in Patients with Both Storage and Voiding Symptoms?.
Urologia internationalis.
2019; 103(4):439-443. doi:
10.1159/000502661. [PMID: 31554005] - Eu Chang Hwang, Shreyas Gandhi, Jae Hung Jung, Mari Imamura, Myung Ha Kim, Ran Pang, Philipp Dahm. Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia.
The Cochrane database of systematic reviews.
2018 10; 10(?):CD007360. doi:
10.1002/14651858.cd007360.pub3. [PMID: 30306544] - Dinesh Prasad Gond, Shivendra Singh, N K Agrawal. Norepinephrine augmented in vitro growth of uropathogenic E. coli in Type 2 diabetes mellitus and its suppression by silodosin (alpha blocker).
Diagnostic microbiology and infectious disease.
2018 Oct; 92(2):85-89. doi:
10.1016/j.diagmicrobio.2018.05.005. [PMID: 29934070] - Ferdinando Fusco, Massimiliano Creta, Nicola Longo, Francesco Persico, Marco Franco, Vincenzo Mirone. Silodosin 8 mg improves benign prostatic obstruction in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement: results from an explorative clinical study.
BMC urology.
2018 Mar; 18(1):12. doi:
10.1186/s12894-018-0326-7. [PMID: 29502524] - Priyanka A Shah, Pranav S Shrivastav. Determination of silodosin and its active glucuronide metabolite KMD-3213G in human plasma by LC-MS/MS for a bioequivalence study.
Biomedical chromatography : BMC.
2018 Feb; 32(2):. doi:
10.1002/bmc.4041. [PMID: 28670733] - Priyanka A Shah, Pranav S Shrivastav. Novel LC-MS/MS method for the quantification of silodosin and its metabolites in human plasma.
Bioanalysis.
2018 Jan; 10(1):7-10. doi:
10.4155/bio-2017-0242. [PMID: 29236515] - Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Walter Cazzaniga, Filippo Pederzoli, Donatella Moretti, Federico Dehò, Emanuele Montanari, Francesco Montorsi, Andrea Salonia. Clinically Meaningful Improvements in LUTS/BPH Severity in Men Treated with Silodosin Plus Hexanic Extract of Serenoa Repens or Silodosin Alone.
Scientific reports.
2017 11; 7(1):15179. doi:
10.1038/s41598-017-15435-0. [PMID: 29123161] - Rita Matos, Paula Serrão, Larissa Rodriguez, Lori Ann Birder, Francisco Cruz, Ana Charrua. The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Aug; 390(8):839-844. doi:
10.1007/s00210-017-1384-1. [PMID: 28569366] - Takashi Yoshida, Hidefumi Kinoshita, Seiji Shimada, Makoto Taguchi, Tadashi Matsuda. Comparison of Silodosin Monotherapy vs Silodosin With Tadalafil Add-on Therapy in Patients With Benign Prostatic Hyperplasia.
Urology.
2017 Aug; 106(?):153-159. doi:
10.1016/j.urology.2017.04.012. [PMID: 28431996] - Yoshihisa Matsukawa, Shohei Ishida, Tsuyoshi Majima, Yasuhito Funahashi, Naoto Sassa, Masashi Kato, Yasushi Yoshino, Momokazu Gotoh. Intravesical prostatic protrusion can predict therapeutic response to silodosin in male patients with lower urinary tract symptoms.
International journal of urology : official journal of the Japanese Urological Association.
2017 06; 24(6):454-459. doi:
10.1111/iju.13333. [PMID: 28370376] - Basri Cakiroglu, Aydin Ismet Hazar, Orhun Sinanoglu, Ersan Arda, Sinan Ekici. Comparison of transurethral incision of the prostate and silodosin in patients having benign prostatic obstruction in terms of retrograde ejaculation.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica.
2017 Mar; 89(1):31-33. doi:
10.4081/aiua.2017.1.31. [PMID: 28403592] - Mahmoud A Omar, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed. Selective Spectrofluorimetric Method with Enhanced Sensitivity for Determination of Silodosine in Dosage Form and Human Plasma. Application to Stability Studies and Content Uniformity Testing.
Journal of fluorescence.
2017 Mar; 27(2):473-482. doi:
10.1007/s10895-016-1973-2. [PMID: 27864702] - Chiguru Vishnuvardhan, Saibaba Baikadi, Roshan M Borkar, R Srinivas, N Satheeshkumar. In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites.
Journal of mass spectrometry : JMS.
2016 Oct; 51(10):867-882. doi:
10.1002/jms.3795. [PMID: 27747994] - Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiro Ashitomi, Tomoyuki Ueda, Hideyuki Yamamoto. Effects of silodosin on bladder activity in rats with frequent urination induced by pelvic venous congestion.
International journal of urology : official journal of the Japanese Urological Association.
2016 10; 23(10):881-887. doi:
10.1111/iju.13158. [PMID: 27418315] - Eleftherios P Diamandis. Significant increase of serum prostate-specific antigen after exercise.
Clinical chemistry and laboratory medicine.
2016 Sep; 54(9):e245-6. doi:
10.1515/cclm-2016-0018. [PMID: 26910748] - Cosimo De Nunzio, Aldo Brassetti, Mariangela Bellangino, Alberto Trucchi, Stefano Petta, Fabrizio Presicce, Andrea Tubaro. Tamsulosin or Silodosin Adjuvant Treatment Is Ineffective in Improving Shockwave Lithotripsy Outcome: A Short-Term Follow-Up Randomized, Placebo-Controlled Study.
Journal of endourology.
2016 07; 30(7):817-21. doi:
10.1089/end.2016.0113. [PMID: 27080916] - Lewis Jeremy Johnson, Daniel Davenport, Ramakrishna Venkatesh. Effects of Alpha-Blockade on Ureteral Peristalsis and Intrapelvic Pressure in an In Vivo Stented Porcine Model.
Journal of endourology.
2016 Apr; 30(4):417-21. doi:
10.1089/end.2015.0251. [PMID: 26650710] - Yoshihisa Matsukawa, Shun Takai, Yasuhito Funahashi, Masashi Kato, Tokunori Yamamoto, Akihiro Hirakawa, Momokazu Gotoh. The Change of Testosterone Secretion During the Treatment of Alpha-1 Blocker in Patients with Benign Prostatic Hyperplasia.
Urology.
2016 Feb; 88(?):149-54. doi:
10.1016/j.urology.2015.11.010. [PMID: 26592467] - Kazuhisa Hagiwara, Takuya Koie, Hiromichi Iwamura, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama. Efficacy and Safety of Silodosin and Dutasteride Combination Therapy in Acute Urinary Retention due to Benign Prostatic Hyperplasia: A Single-Arm Prospective Study.
BioMed research international.
2016; 2016(?):4975851. doi:
10.1155/2016/4975851. [PMID: 27195288] - Tomonori Yamanishi, Kanya Kaga, Miki Fuse, Chiharu Shibata, Takao Kamai, Tomoyuki Uchiyama. Six-year follow up of silodosin monotherapy for the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: What are the factors for continuation or withdrawal?.
International journal of urology : official journal of the Japanese Urological Association.
2015 Dec; 22(12):1143-8. doi:
10.1111/iju.12915. [PMID: 26310102] - Blayne Welk, Eric McArthur, Lisa-Ann Fraser, Jade Hayward, Stephanie Dixon, Y Joseph Hwang, Michael Ordon. The risk of fall and fracture with the initiation of a prostate-selective α antagonist: a population based cohort study.
BMJ (Clinical research ed.).
2015 Oct; 351(?):h5398. doi:
10.1136/bmj.h5398. [PMID: 26502947] - Yoshiaki Goi, Yoshitaka Tomiyama, Ayaka Yokoyama, Satoshi Tatemichi, Kazuyasu Maruyama, Mamoru Kobayashi, Osamu Yamaguchi. Effect of silodosin, a selective α(1A)-adrenoceptor antagonist, on voiding behavior and bladder blood flow in a rat model of bladder outlet obstruction.
European journal of pharmacology.
2015 Oct; 764(?):489-496. doi:
10.1016/j.ejphar.2015.07.037. [PMID: 26189024] - Satoshi Tatemichi, Kumi Tsuchioka, Saori Yonekubo, Kazuyasu Maruyama, Mamoru Kobayashi. Effects of Silodosin, an α1A-Adrenoceptor Antagonist, and Distigmine, an Acetylcholinesterase Inhibitor, and Their Combined Effects on Impaired Voiding Function in Zucker Diabetic Fatty Rats.
Pharmacology.
2015; 95(5-6):285-92. doi:
10.1159/000398811. [PMID: 26023044] - Kyung Hyun Moon, Choal-Hee Park, Hee-Chang Jung, Tae-Hee Oh, Jae-Soo Kim, Duk-Yoon Kim. A 12-Week, Open Label, Multi-Center Study to Evaluate the Clinical Efficacy and Safety of Silodosin on Voiding Dysfunction in Patients with Neurogenic Bladder.
Lower urinary tract symptoms.
2015 Jan; 7(1):27-31. doi:
10.1111/luts.12044. [PMID: 26663648] - Satabdi Pande, Avijit Hazra, Anup Kumar Kundu. Evaluation of silodosin in comparison to tamsulosin in benign prostatic hyperplasia: a randomized controlled trial.
Indian journal of pharmacology.
2014 Nov; 46(6):601-7. doi:
10.4103/0253-7613.144912. [PMID: 25538330] - Yoshiaki Goi, Yoshitaka Tomiyama, Masanori Nomiya, Koji Sagawa, Ken Aikawa, Osamu Yamaguchi. Effects of silodosin, a selective α1A-adrenoceptor antagonist, on bladder blood flow and bladder function in a rat model of atherosclerosis induced chronic bladder ischemia without bladder outlet obstruction.
The Journal of urology.
2013 Sep; 190(3):1116-22. doi:
10.1016/j.juro.2013.03.110. [PMID: 23545103] - Toshiro Shirakawa, Takahiro Haraguchi, Katsumi Shigemura, Shinichi Morishita, Kohji Minayoshi, Jiro Miyazaki, Yuji Yamada, Hideaki Miyake, Kazushi Tanaka, Masato Fujisawa. Silodosin versus naftopidil in Japanese patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized multicenter study.
International journal of urology : official journal of the Japanese Urological Association.
2013 Sep; 20(9):903-10. doi:
10.1111/iju.12055. [PMID: 23252453] - Santosh Kumar, Devi Prasad Tiwari, Raguram Ganesamoni, Shrawan K Singh. Prospective randomized placebo-controlled study to assess the safety and efficacy of silodosin in the management of acute urinary retention.
Urology.
2013 07; 82(1):171-5. doi:
10.1016/j.urology.2013.02.020. [PMID: 23561712] - L Villa, R Buono, N Fossati, P Rigatti, F Montorsi, F Benigni, P Hedlund. Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters.
British journal of pharmacology.
2013 May; 169(1):230-8. doi:
10.1111/bph.12123. [PMID: 23373675] - Motoaki Saito, Shogo Shimizu, Fumiya Ohmasa, Ryo Oikawa, Panagiota Tsounapi, Fotios Dimitriadis, Yukako Kinoshita, Keisuke Satoh. Characterization of silodosin and naftopidil in the treatment of bladder dysfunction in the spontaneously hypertensive rat.
Neurourology and urodynamics.
2013 Apr; 32(4):393-8. doi:
10.1002/nau.22297. [PMID: 22907830] - Zining Wang, Qian Xiang, Yimin Cui, Xia Zhao, Ying Zhou. The influence of UGT2B7, UGT1A8, MDR1, ALDH, ADH, CYP3A4 and CYP3A5 genetic polymorphisms on the pharmacokinetics of silodosin in healthy Chinese volunteers.
Drug metabolism and pharmacokinetics.
2013; 28(3):239-43. doi:
10.2133/dmpk.dmpk-12-rg-106. [PMID: 23257391] - Hui Ding, Wan Du, Zi-Zhen Hou, Han-Zhang Wang, Zhi-Ping Wang. Silodosin is effective for treatment of LUTS in men with BPH: a systematic review.
Asian journal of andrology.
2013 Jan; 15(1):121-8. doi:
10.1038/aja.2012.102. [PMID: 23223034] - Yoshihisa Matsukawa, Momokazu Gotoh, Tomonori Komatsu, Yasuhito Funahashi, Naoto Sassa, Ryohei Hattori. Efficacy of silodosin for relieving benign prostatic obstruction: prospective pressure flow study.
The Journal of urology.
2013 Jan; 189(1 Suppl):S117-21. doi:
10.1016/j.juro.2012.11.031. [PMID: 23234615] - Ch R Chapple, F Montorsi, T L J Tammela, M Wirth, E Koldewijn, E Fernandez Fernandez. [Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe].
Urologiia (Moscow, Russia : 1999).
2012 Sep; ?(5):38-42, 44. doi:
NULL. [PMID: 23342615] - Martin Hennenberg, Frank Strittmatter, Christer Beckmann, Beata Rutz, Claudius Füllhase, Raphaela Waidelich, Francesco Montorsi, Petter Hedlund, Karl-Erik Andersson, Christian G Stief, Christian Gratzke. Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle.
PloS one.
2012; 7(11):e50904. doi:
10.1371/journal.pone.0050904. [PMID: 23226423] - Hideyasu Tsumura, Takefumi Satoh, Hiromichi Ishiyama, Ken-ichi Tabata, Shouko Kotani, Satoru Minamida, Masaki Kimura, Tetsuo Fujita, Kazumasa Matsumoto, Masashi Kitano, Kazushige Hayakawa, Shiro Baba. Comparison of prophylactic naftopidil, tamsulosin, and silodosin for 125I brachytherapy-induced lower urinary tract symptoms in patients with prostate cancer: randomized controlled trial.
International journal of radiation oncology, biology, physics.
2011 Nov; 81(4):e385-92. doi:
10.1016/j.ijrobp.2011.04.026. [PMID: 21664068] - Yang Wang, Zhishun Liu, Jinna Yu, Yulong Ding, Xuan Liu. Efficacy of electroacupuncture at Zhongliao point (BL33) for mild and moderate benign prostatic hyperplasia: study protocol for a randomized controlled trial.
Trials.
2011 Sep; 12(?):211. doi:
10.1186/1745-6215-12-211. [PMID: 21943105] - Teruhiko Yokoyama, Ryoei Hara, Kazuhiko Fukumoto, Tomohiro Fujii, Yoshimasa Jo, Yoshiyuki Miyaji, Atsushi Nagai, Atsushi Sone. Effects of three types of alpha-1 adrenoceptor blocker on lower urinary tract symptoms and sexual function in males with benign prostatic hyperplasia.
International journal of urology : official journal of the Japanese Urological Association.
2011 Mar; 18(3):225-30. doi:
10.1111/j.1442-2042.2010.02708.x. [PMID: 21272091] - Christopher R Chapple, Francesco Montorsi, Teuvo L J Tammela, Manfred Wirth, Evert Koldewijn, Eldiberto Fernández Fernández. Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe.
European urology.
2011 Mar; 59(3):342-52. doi:
10.1016/j.eururo.2010.10.046. [PMID: 21109344] - Ying Zhou, Pei-Hong Sun, Yu-Wang Liu, Xia Zhao, Lei Meng, Yi-Min Cui. Safety and pharmacokinetic studies of silodosin, a new α1A-adrenoceptor selective antagonist, in healthy Chinese male subjects.
Biological & pharmaceutical bulletin.
2011; 34(8):1240-5. doi:
10.1248/bpb.34.1240. [PMID: 21804212] - J Morganroth, H Lepor, L A Hill, W Volinn, G Hoel. Effects of the selective alpha 1a-adrenoceptor antagonist silodosin on ECGs of healthy men in a randomized, double-blind, placebo- and moxifloxacin-controlled study.
Clinical pharmacology and therapeutics.
2010 May; 87(5):609-13. doi:
10.1038/clpt.2009.265. [PMID: 20220748] - Ryoji Furuya, Naoya Masumori, Seiji Furuya, Hiroshi Ogura, Masatoshi Mutoh, Ko Kobayashi, Shin-ichi Hisasue, Taiji Tsukamoto. [Investigation of adverse events and the continuance rate of silodosin in all patients who received silodosin for lower urinary tract symptoms suggestive of benign prostatic hyperplasia].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2010 Jan; 101(1):13-7. doi:
10.5980/jpnjurol.101.13. [PMID: 20158073] - Naoya Masumori, Taiji Tsukamoto, Masahiro Yanase, Hiroki Horita, Masaharu Aoki. The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction.
Advances in urology.
2010; ?(?):205251. doi:
10.1155/2010/205251. [PMID: 20981257] - Yoshihisa Matsukawa, Momokazu Gotoh, Tomonori Komatsu, Yasuhito Funahashi, Naoto Sassa, Ryohei Hattori. Efficacy of silodosin for relieving benign prostatic obstruction: prospective pressure flow study.
The Journal of urology.
2009 Dec; 182(6):2831-5. doi:
10.1016/j.juro.2009.08.030. [PMID: 19837428] - Xia Zhao, Yuwang Liu, Junyu Xu, Dan Zhang, Ying Zhou, Jingkai Gu, Yimin Cui. Determination of silodosin in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Nov; 877(29):3724-8. doi:
10.1016/j.jchromb.2009.08.025. [PMID: 19782650] - Haruko Yanase, Xiaojun Wang, Yoshiharu Momota, Toshie Nimura, Masahito Kawatani. The involvement of urothelial alpha1A adrenergic receptor in controlling the micturition reflex.
Biomedical research (Tokyo, Japan).
2008 Oct; 29(5):239-44. doi:
10.2220/biomedres.29.239. [PMID: 18997438] - Ko Kobayashi, Naoya Masumori, Shin-ichi Hisasue, Ryuichi Kato, Kohei Hashimoto, Naoki Itoh, Taiji Tsukamoto. Inhibition of Seminal emission is the main cause of anejaculation induced by a new highly selective alpha1A-blocker in normal volunteers.
The journal of sexual medicine.
2008 Sep; 5(9):2185-90. doi:
10.1111/j.1743-6109.2008.00779.x. [PMID: 18399947] - Zakia Sultana Sathi, Abu Syed Md Anisuzzaman, Shigeru Morishima, Fumiko Suzuki, Takashi Tanaka, Hatsumi Yoshiki, Ikunobu Muramatsu. Different affinities of native alpha1B-adrenoceptors for ketanserin between intact tissue segments and membrane preparations.
European journal of pharmacology.
2008 Apr; 584(2-3):222-8. doi:
10.1016/j.ejphar.2008.02.003. [PMID: 18336813] - Shizuo Yamada, Yasuhiro Kato, Takashi Okura, Yoshiyuki Kagawa, Kazuki Kawabe. Prediction of alpha1-adrenoceptor occupancy in the human prostate from plasma concentrations of silodosin, tamsulosin and terazosin to treat urinary obstruction in benign prostatic hyperplasia.
Biological & pharmaceutical bulletin.
2007 Jul; 30(7):1237-41. doi:
10.1248/bpb.30.1237. [PMID: 17603160] - Kazuki Kawabe, Masaki Yoshida, Yukio Homma. Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men.
BJU international.
2006 Nov; 98(5):1019-24. doi:
10.1111/j.1464-410x.2006.06448.x. [PMID: 16945121] - Tomoji Shimizu, Itaru Miyashita, Yasuhito Matsubara, Mitsugu Ikeda, Masayuki Yamaguchi. [Pharmacokinetic profile of silodosin in clinical practice].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2006 Mar; 126 Spec no.(?):257-63. doi:
10.1248/yakushi.126.257. [PMID: 16518091] - Yasuhito Matsubara, Toru Kanazawa, Yasunari Kojima, Yoshikazu Abe, Kaoru Kobayashi, Hiroki Kanbe, Hiroshi Harada, Yasunori Momose, Sakae Terakado, Yasuhisa Adachi, Ian Midgley. [Pharmacokinetics and disposition of silodosin (KMD-3213)].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2006 Mar; 126 Spec no.(?):237-45. doi:
10.1248/yakushi.126.237. [PMID: 16518089] - Mamoru Kobayashi, Satoshi Tatemichi, Kumi Kobayashi, Takahiro Imamura, Itaru Maruyama, Yoshinobu Yamazaki, Nobuo Shibata. [Duration of action of silodosin (KMD-3213) against phenylephrine-induced increase in intraurethral pressure in rats].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2006 Mar; 126 Spec no.(?):231-6. doi:
10.1248/yakushi.126.231. [PMID: 16518088] - Satoshi Tatemichi, Sumiyoshi Kiguchi, Mamoru Kobayashi, Yoshinobu Yamazaki, Nobuo Shibata, Tsutomu Uruno. Cardiovascular effects of the selective alphalA-adrenoceptor antagonist silodosin (KMD-3213), a drug for the treatment of voiding dysfunction.
Arzneimittel-Forschung.
2006; 56(10):682-7. doi:
10.1055/s-0031-1296773. [PMID: 17225563] - Taka-Aki Koshimizu, Gozoh Tsujimoto, Akira Hirasawa, Yoko Kitagawa, Akito Tanoue. Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors.
Cardiovascular research.
2004 Sep; 63(4):662-72. doi:
10.1016/j.cardiores.2004.05.014. [PMID: 15306222] - T Okura, S Yamada, Y Abe, R Kimura. Selective and sustained occupancy of prostatic alpha1-adrenoceptors by oral administration of KMD-3213 and its plasma concentration in rats.
The Journal of pharmacy and pharmacology.
2002 Jul; 54(7):975-82. doi:
10.1211/002235702760089108. [PMID: 12162717] - Li Zhang, Takanobu Taniguchi, Takashi Tanaka, Kazumasa Shinozuka, Masaru Kunitomo, Masahiko Nishiyama, Koji Kamata, Ikunobu Muramatsu. Alpha-1 adrenoceptor up-regulation induced by prazosin but not KMD-3213 or reserpine in rats.
British journal of pharmacology.
2002 Apr; 135(7):1757-64. doi:
10.1038/sj.bjp.0704639. [PMID: 11934817] - Katsuyoshi Akiyama, Satoshi Tatemichi, Susumu Katayama, Mariko Nakajima, Tomomi Oki, Takashi Okura, Shizuo Yamada, Ryohei Kimura. Relationship between prostatic alpha(1)-adrenoceptor binding and reduction in intraurethral pressure following continuous infusion of KMD-3213 in rats.
Pharmacology.
2002; 64(3):140-7. doi:
10.1159/000056163. [PMID: 11834890] - S Yamada, T Okura, R Kimura. In vivo demonstration of alpha(1A)-adrenoceptor subtype selectivity of KMD-3213 in rat tissues.
The Journal of pharmacology and experimental therapeutics.
2001 Jan; 296(1):160-7. doi:
NULL. [PMID: 11123376] - S Murata, T Taniguchi, I Muramatsu. Pharmacological analysis of the novel, selective alpha1-adrenoceptor antagonist, KMD-3213, and its suitability as a tritiated radioligand.
British journal of pharmacology.
1999 May; 127(1):19-26. doi:
10.1038/sj.bjp.0702489. [PMID: 10369451]