Varenicline Tartrate (BioDeep_00000398898)

   

natural product


代谢物信息卡片


Varenicline Tartrate

化学式: C17H19N3O6 (361.1273794)
中文名称: 酒石酸伐伦克林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C([C@@H]([C@H](C(O)=O)O)O)(O)=O.C12C3=C(C(C1)CNC2)C=C4C(=C3)N=CC=N4
InChI: 1-,2-/m.1/s1

描述信息

D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
D000077444 - Smoking Cessation Agents
Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50 = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation[1][2][3][4][5].
Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50 = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation[1][2][3][4][5].

同义名列表

3 个代谢物同义名

Varenicline Tartrate; CP 526555-18; Varenicline (Tartrate)



数据库引用编号

9 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Hao-Xiang Lin, Zhao Liu, Peter Hajek, Wan-Tong Zhang, Yuan Wu, Bao-Chen Zhu, Hai-Hua Liu, Qiu Xiang, Yan Zhang, Shu-Bin Li, Francesca Pesola, Ying-Ying Wang. Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial. JAMA internal medicine. 2024 Mar; 184(3):291-299. doi: 10.1001/jamainternmed.2023.7846. [PMID: 38285562]
  • Wojciech Świątkowski, Barbara Budzyńska, Monika Maciąg, Agnieszka Świątkowska, Przemko Tylżanowski, Mansur Rahnama-Hezavah, Piotr Stachurski, Renata Chałas. Nicotine and Cytisine Embryotoxicity in the Experimental Zebrafish Model. International journal of molecular sciences. 2023 Jul; 24(15):. doi: 10.3390/ijms241512094. [PMID: 37569468]
  • Xuefeng Wei, Kangle Guo, Xue Shang, Shizhong Wang, Chaoqun Yang, Jieyun Li, Yanfei Li, Kehu Yang, Xiuxia Li, Xiaohui Zhang. Effects of different interventions on smoking cessation in chronic obstructive pulmonary disease patients: A systematic review and network meta-analysis. International journal of nursing studies. 2022 Dec; 136(?):104362. doi: 10.1016/j.ijnurstu.2022.104362. [PMID: 36206617]
  • Kevin G Lynch, Jennifer Plebani, Kelly Spratt, Mark Morales, Mila Tamminga, Philip Feibush, Kyle M Kampman. Varenicline for the Treatment of Cocaine Dependence. Journal of addiction medicine. 2022 Mar; 16(2):157-163. doi: 10.1097/adm.0000000000000842. [PMID: 33840773]
  • Nicolle M Gatto, Ulka B Campbell, Emily Rubinstein, Ashley Jaksa, Pattra Mattox, Jingping Mo, Robert F Reynolds. The Structured Process to Identify Fit-For-Purpose Data: A Data Feasibility Assessment Framework. Clinical pharmacology and therapeutics. 2022 01; 111(1):122-134. doi: 10.1002/cpt.2466. [PMID: 34716990]
  • Aimee L McRae-Clark, Kevin M Gray, Nathaniel L Baker, Brian J Sherman, Lindsay Squeglia, Gregory L Sahlem, Amanda Wagner, Rachel Tomko. Varenicline as a treatment for cannabis use disorder: A placebo-controlled pilot trial. Drug and alcohol dependence. 2021 12; 229(Pt B):109111. doi: 10.1016/j.drugalcdep.2021.109111. [PMID: 34655945]
  • Mi-Jeong Park, Young-Gyun Seo, Hye-Mi Noh, Yeol Kim, Jong Lull Yoon, Yu-Jin Paek. Effectiveness of National Residential Smoking Cessation Program. International journal of environmental research and public health. 2021 09; 18(18):. doi: 10.3390/ijerph18189901. [PMID: 34574823]
  • Amanda Jiménez-Pompa, Sara Sanz-Lázaro, Arik J Hone, Lola Rueda-Ruzafa, José Medina-Polo, Carmen González-Enguita, Jesús Blázquez, Cristóbal de Los Ríos, J Michael McIntosh, Almudena Albillos. Therapeutic concentrations of varenicline increases exocytotic release of catecholamines from human and rat adrenal chromaffin cells in the presence of nicotine. Neuropharmacology. 2021 09; 195(?):108632. doi: 10.1016/j.neuropharm.2021.108632. [PMID: 34097947]
  • Jeffrey Nau, David J Wyatt, Hans Rollema, Christopher S Crean. A Phase I, Open-label, Randomized, 2-Way Crossover Study to Evaluate the Relative Bioavailability of Intranasal and Oral Varenicline. Clinical therapeutics. 2021 09; 43(9):1595-1607. doi: 10.1016/j.clinthera.2021.07.020. [PMID: 34456060]
  • Roger L Albin, Martijn L T M Müller, Nicolaas I Bohnen, Cathie Spino, Martin Sarter, Robert A Koeppe, Ashley Szpara, Kamin Kim, Cindy Lustig, William T Dauer. α4β2* Nicotinic Cholinergic Receptor Target Engagement in Parkinson Disease Gait-Balance Disorders. Annals of neurology. 2021 07; 90(1):130-142. doi: 10.1002/ana.26102. [PMID: 33977560]
  • Eunwoo Kim, Jun Gi Hwang, Su Jun Park, Ji Young Han, Young-Sim Choi, Se-Rin Park, Kyung-Sang Yu, Min Kyu Park, SeungHwan Lee. Pharmacokinetic comparison between tablet of varenicline tartrate and orally disintegrating film of varenicline salicylate in healthy subjects. International journal of clinical pharmacology and therapeutics. 2021 Jun; 59(6):478-484. doi: 10.5414/cp203953. [PMID: 33704052]
  • Gema Lizbeth Ramírez-Salinas, Marlet Martínez-Archundia, José Correa-Basurto, Jazmín García-Machorro. Repositioning of Ligands That Target the Spike Glycoprotein as Potential Drugs for SARS-CoV-2 in an In Silico Study. Molecules (Basel, Switzerland). 2020 Nov; 25(23):. doi: 10.3390/molecules25235615. [PMID: 33260370]
  • Kevin M Gray, Mark L Rubinstein, Judith J Prochaska, Sarah J DuBrava, Ann R Holstein, Larry Samuels, Thomas D McRae. High-dose and low-dose varenicline for smoking cessation in adolescents: a randomised, placebo-controlled trial. The Lancet. Child & adolescent health. 2020 11; 4(11):837-845. doi: 10.1016/s2352-4642(20)30243-1. [PMID: 32979939]
  • Martin C Mahoney, Rebecca Ashare, Nicolas Schlienz, CeCe Duerr, Larry W Hawk. Making lemonade from SARS coronavirus-2 lemons: Transitioning a smoking cessation trial to a virtual platform. Journal of substance abuse treatment. 2020 10; 117(?):108100. doi: 10.1016/j.jsat.2020.108100. [PMID: 32811627]
  • Jin-Woo Park, Kyoung-Ah Kim, Hankil Son, Jina Jung, Ji-Young Park. Pharmacokinetic comparisons of two different varenicline formulations in humans: Varenicline tartrate versus varenicline oxalate
. International journal of clinical pharmacology and therapeutics. 2020 Feb; 58(2):121-127. doi: 10.5414/cp203574. [PMID: 31699211]
  • Annie R Peng, Walter Swardfager, Neal L Benowitz, Jasjit S Ahluwalia, Caryn Lerman, Nicole L Nollen, Rachel F Tyndale. Impact of early nausea on varenicline adherence and smoking cessation. Addiction (Abingdon, England). 2020 01; 115(1):134-144. doi: 10.1111/add.14810. [PMID: 31502736]
  • Başak Gökçe, Nurhan Sarıoğlu, Nahit Gençer, Oktay Arslan. Association of human serum paraoxonase-1 with some respiratory drugs. Journal of biochemical and molecular toxicology. 2019 Dec; 33(12):e22407. doi: 10.1002/jbt.22407. [PMID: 31581362]
  • Brian Chan, Michele Freeman, Karli Kondo, Chelsea Ayers, Jessica Montgomery, Robin Paynter, Devan Kansagara. Pharmacotherapy for methamphetamine/amphetamine use disorder-a systematic review and meta-analysis. Addiction (Abingdon, England). 2019 12; 114(12):2122-2136. doi: 10.1111/add.14755. [PMID: 31328345]
  • Kevin M Gray, Nathaniel L Baker, Erin A McClure, Rachel L Tomko, Lindsay M Squeglia, Michael E Saladin, Matthew J Carpenter. Efficacy and Safety of Varenicline for Adolescent Smoking Cessation: A Randomized Clinical Trial. JAMA pediatrics. 2019 12; 173(12):1146-1153. doi: 10.1001/jamapediatrics.2019.3553. [PMID: 31609433]
  • Chloe J Jordan, Jianjing Cao, Amy Hauck Newman, Zheng-Xiong Xi. Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine. Neuropharmacology. 2019 11; 158(?):107609. doi: 10.1016/j.neuropharm.2019.04.015. [PMID: 31009632]
  • Amol V Shivange, Philip M Borden, Anand K Muthusamy, Aaron L Nichols, Kallol Bera, Huan Bao, Ishak Bishara, Janice Jeon, Matthew J Mulcahy, Bruce Cohen, Saidhbhe L O'Riordan, Charlene Kim, Dennis A Dougherty, Edwin R Chapman, Jonathan S Marvin, Loren L Looger, Henry A Lester. Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors. The Journal of general physiology. 2019 06; 151(6):738-757. doi: 10.1085/jgp.201812201. [PMID: 30718376]
  • Paul J Fletcher, Zhaoxia Li, Leo B Silenieks, Cam MacMillan, Ines DeLannoy, Guy A Higgins. Preclinical evidence for combining the 5-HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence. Addiction biology. 2019 05; 24(3):376-387. doi: 10.1111/adb.12602. [PMID: 29498158]
  • Dennis Thomas, Michael Farrell, Hayden McRobbie, Piotr Tutka, Dennis Petrie, Robert West, Mohammad Siahpush, Coral Gartner, Natalie Walker, Colin P Mendelsohn, Wayne Hall, Christine Paul, Nicholas Zwar, Stuart G Ferguson, Veronica C Boland, Robyn Richmond, Christopher M Doran, Anthony Shakeshaft, Richard P Mattick, Ryan J Courtney. The effectiveness, safety and cost-effectiveness of cytisine versus varenicline for smoking cessation in an Australian population: a study protocol for a randomized controlled non-inferiority trial. Addiction (Abingdon, England). 2019 05; 114(5):923-933. doi: 10.1111/add.14541. [PMID: 30589984]
  • Lance R McMahon. Green tobacco sickness: mecamylamine, varenicline, and nicotine vaccine as clinical research tools and potential therapeutics. Expert review of clinical pharmacology. 2019 Mar; 12(3):189-195. doi: 10.1080/17512433.2019.1570844. [PMID: 30650314]
  • Lauren R Pacek, F Joseph McClernon, Hayden B Bosworth. Adherence to Pharmacological Smoking Cessation Interventions: A Literature Review and Synthesis of Correlates and Barriers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2018 09; 20(10):1163-1172. doi: 10.1093/ntr/ntx210. [PMID: 29059394]
  • Matthew Clyde, Andrew Pipe, Charl Els, Robert Reid, Angel Fu, Alexa Clark, Heather Tulloch. Nicotine metabolite ratio and smoking outcomes using nicotine replacement therapy and varenicline among smokers with and without psychiatric illness. Journal of psychopharmacology (Oxford, England). 2018 09; 32(9):979-985. doi: 10.1177/0269881118773532. [PMID: 29788791]
  • Yoko Kamizono, Yuhei Shiga, Yasunori Suematsu, Satoshi Imaizumi, Hitomi Tsukahara, Keita Noda, Takashi Kuwano, Kanta Fujimi, Keijiro Saku, Shin-Ichiro Miura. Impact of cigarette smoking cessation on plasma α-klotho levels. Medicine. 2018 Aug; 97(35):e11947. doi: 10.1097/md.0000000000011947. [PMID: 30170389]
  • Marisa Briones, Steven Shoptaw, Ryan Cook, Matthew Worley, Aimee-Noelle Swanson, David E Moody, Wenfang B Fang, John Tsuang, Benjamin Furst, Keith Heinzerling. Varenicline treatment for methamphetamine dependence: A randomized, double-blind phase II clinical trial. Drug and alcohol dependence. 2018 Aug; 189(?):30-36. doi: 10.1016/j.drugalcdep.2018.04.023. [PMID: 29860057]
  • Sarah E Maggio, Meredith A Saunders, Thomas A Baxter, Kimberly Nixon, Mark A Prendergast, Guangrong Zheng, Peter Crooks, Linda P Dwoskin, Rachel D Slack, Amy H Newman, Richard L Bell, Michael T Bardo. Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. Psychopharmacology. 2018 05; 235(5):1439-1453. doi: 10.1007/s00213-018-4853-4. [PMID: 29455292]
  • Walter Roberts, Sherry A McKee. Effects of varenicline on cognitive performance in heavy drinkers: Dose-response effects and associations with drinking outcomes. Experimental and clinical psychopharmacology. 2018 02; 26(1):49-57. doi: 10.1037/pha0000161. [PMID: 29389170]
  • Seong Shin Kwak, Eun Seok Lee, Ho Yub Yoon, Chang Hyun Kim, Yoon Tae Goo, Myung Joo Kang, Sangkil Lee, Bong Sang Lee, Hong Ryeol Jeon, Chang Hyun Oh, Young Wook Choi. Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers. Drug design, development and therapy. 2018; 12(?):3377-3392. doi: 10.2147/dddt.s178456. [PMID: 30349192]
  • Edna B Foa, Anu Asnaani, David Rosenfield, Laurie J Zandberg, Peter Gariti, Patricia Imms. Concurrent varenicline and prolonged exposure for patients with nicotine dependence and PTSD: A randomized controlled trial. Journal of consulting and clinical psychology. 2017 Sep; 85(9):862-872. doi: 10.1037/ccp0000213. [PMID: 28569519]
  • Ignatios Ikonomidis, Margarita Marinou, Dimitrios Vlastos, Kallirhoe Kourea, Ioanna Andreadou, Nikolaos Liarakos, Helen Triantafyllidi, George Pavlidis, Elias Tsougos, John Parissis, John Lekakis. Effects of varenicline and nicotine replacement therapy on arterial elasticity, endothelial glycocalyx and oxidative stress during a 3-month smoking cessation program. Atherosclerosis. 2017 07; 262(?):123-130. doi: 10.1016/j.atherosclerosis.2017.05.012. [PMID: 28549278]
  • Walter Roberts, Terril L Verplaetse, Kelly Moore, Lindsay Oberleitner, Marina R Picciotto, Sherry A McKee. Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms. Journal of psychopharmacology (Oxford, England). 2017 07; 31(7):906-914. doi: 10.1177/0269881117699618. [PMID: 28351203]
  • Juraj Piešťanský, Katarína Maráková, Jaroslav Galba, Andrej Kováč, Peter Mikuš. Comparison of hydrodynamically closed two-dimensional capillary electrophoresis coupled with ultraviolet detection and hydrodynamically open capillary electrophoresis hyphenated with mass spectrometry in the bioanalysis of varenicline. Journal of separation science. 2017 May; 40(10):2292-2303. doi: 10.1002/jssc.201700098. [PMID: 28322496]
  • Mojdeh Mostafavi, Paul Hardy, L Eugene Arnold. Varenicline in Autism: Theory and Case Report of Clinical and Biochemical Changes. Journal of child and adolescent psychopharmacology. 2016 11; 26(9):792-797. doi: 10.1089/cap.2015.0230. [PMID: 27123827]
  • Terril L Verplaetse, Brian P Pittman, Julia M Shi, Jeanette M Tetrault, Sabrina Coppola, Sherry A McKee. Effect of Lowering the Dose of Varenicline on Alcohol Self-administration in Drinkers With Alcohol Use Disorders. Journal of addiction medicine. 2016 May; 10(3):166-73. doi: 10.1097/adm.0000000000000208. [PMID: 27159341]
  • Bin Jiang, Yao He, Fang Zuo, Lei Wu, Qing-Hui Liu, Li Zhang, Chang-Xi Zhou, K K Cheng, Sophia S C Chan, Tai Hing Lam. Effectiveness of varenicline and counselling for smoking cessation in an observational cohort study in China. BMJ open. 2016 Jan; 6(1):e009381. doi: 10.1136/bmjopen-2015-009381. [PMID: 26739730]
  • Melissa A Little, Jon O Ebbert. The safety of treatments for tobacco use disorder. Expert opinion on drug safety. 2016; 15(3):333-41. doi: 10.1517/14740338.2016.1131817. [PMID: 26715118]
  • Michael J Marks, Heidi C O'Neill, Kelly M Wynalda-Camozzi, Nick C Ortiz, Emily E Simmons, Caitlin A Short, Christopher M Butt, J Michael McIntosh, Sharon R Grady. Chronic treatment with varenicline changes expression of four nAChR binding sites in mice. Neuropharmacology. 2015 Dec; 99(?):142-55. doi: 10.1016/j.neuropharm.2015.07.019. [PMID: 26192545]
  • Raka Jain, Sonali Jhanjee, Veena Jain, Tina Gupta, Swati Mittal, Prashant Chauhan, Rahul Raghav, Patricia Goelz, Robert A Schnoll. Biochemical Validation of Self-Reported Smokeless Tobacco Abstinence among Smokeless Tobacco Users: Results from a Clinical Trial of Varenicline in India. Journal of psychoactive drugs. 2015 Sep; 47(4):331-5. doi: 10.1080/02791072.2015.1073412. [PMID: 26317285]
  • Lei Wu, Samio Sun, Yao He, Jing Zeng. Effect of Smoking Reduction Therapy on Smoking Cessation for Smokers without an Intention to Quit: An Updated Systematic Review and Meta-Analysis of Randomized Controlled. International journal of environmental research and public health. 2015 Aug; 12(9):10235-53. doi: 10.3390/ijerph120910235. [PMID: 26308034]
  • Akif Koç, Haydar Ali Erken, Fatma Emel Koçak, Arzu Yay, Aydin Güçlü, Erhan Sari, Hasan Şimşek, Gözde Özge Önder, Osman Genç. Nephrotoxic effects of varenicline as the most effective drug used for smoking cessation: a preliminary experimental study. International urology and nephrology. 2015 May; 47(5):823-9. doi: 10.1007/s11255-015-0949-5. [PMID: 25812822]
  • Michael E Saladin, Erin A McClure, Nathaniel L Baker, Matthew J Carpenter, Viswanathan Ramakrishnan, Karen J Hartwell, Kevin M Gray. Increasing progesterone levels are associated with smoking abstinence among free-cycling women smokers who receive brief pharmacotherapy. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2015 Apr; 17(4):398-406. doi: 10.1093/ntr/ntu262. [PMID: 25762749]
  • Oren Rom, Abraham Z Reznick, Zohar Keidar, Khaled Karkabi, Dror Aizenbud. Smoking cessation-related weight gain--beneficial effects on muscle mass, strength and bone health. Addiction (Abingdon, England). 2015 Feb; 110(2):326-35. doi: 10.1111/add.12761. [PMID: 25312589]
  • Engin Burak Selçuk, Meltem Sungu, Hakan Parlakpinar, Necip Ermiş, Elif Taslıdere, Nigar Vardı, Murat Yalçınsoy, Mustafa Sagır, Alaaddin Polat, Mehmet Karatas, Burcu Kayhan-Tetik. Evaluation of the cardiovascular effects of varenicline in rats. Drug design, development and therapy. 2015; 9(?):5705-17. doi: 10.2147/dddt.s92268. [PMID: 26543352]
  • Bin Jiang, Yao He, Fang Zuo, Lei Wu, Qinghui Liu, Li Zhang, Changxi Zhou, Kk Cheng, Sc Chan, Th Lam. [Effectiveness of Varenicline with counseling programs on smoking cessation in a targeted clinical setting in China]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 2014 Dec; 35(12):1349-53. doi: ". [PMID: 25623452]
  • R Booth, H Kim. Permeability analysis of neuroactive drugs through a dynamic microfluidic in vitro blood-brain barrier model. Annals of biomedical engineering. 2014 Dec; 42(12):2379-91. doi: 10.1007/s10439-014-1086-5. [PMID: 25118670]
  • Masahiko Iwaoka, Hiromasa Shimamura, Takeshi Tsuji, Kiyotaka Kugiyama. Twelve weeks of smoking cessation therapy with varenicline increases the serum levels of apolipoprotein A-I only in the success group. Journal of cardiology. 2014 Oct; 64(4):318-23. doi: 10.1016/j.jjcc.2014.02.009. [PMID: 24674749]
  • Toru Kato, Akira Umeda, Kazuya Miyagawa, Hiroshi Takeda, Taichi Adachi, Shigeru Toyoda, Isao Taguchi, Teruo Inoue, Koichi Node. Varenicline-assisted smoking cessation decreases oxidative stress and restores endothelial function. Hypertension research : official journal of the Japanese Society of Hypertension. 2014 Jul; 37(7):655-8. doi: 10.1038/hr.2014.52. [PMID: 24646641]
  • Catriona Jennings, Kornelia Kotseva, Dirk De Bacquer, Arno Hoes, Jose de Velasco, Silvio Brusaferro, Alison Mead, Jennifer Jones, Serena Tonstad, David Wood. Effectiveness of a preventive cardiology programme for high CVD risk persistent smokers: the EUROACTION PLUS varenicline trial. European heart journal. 2014 Jun; 35(21):1411-20. doi: 10.1093/eurheartj/ehu051. [PMID: 24616337]
  • Juraj Piešťanský, Katarína Maráková, Lucia Veizerová, Jaroslav Galba, Peter Mikuš. On-line column coupled isotachophoresis-capillary zone electrophoresis hyphenated with tandem mass spectrometry in drug analysis: varenicline and its metabolite in human urine. Analytica chimica acta. 2014 May; 826(?):84-93. doi: 10.1016/j.aca.2014.04.003. [PMID: 24793857]
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  • Joanna Leaviss, William Sullivan, Shijie Ren, Emma Everson-Hock, Matt Stevenson, John W Stevens, Mark Strong, Anna Cantrell. What is the clinical effectiveness and cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation. Health technology assessment (Winchester, England). 2014 May; 18(33):1-120. doi: 10.3310/hta18330. [PMID: 24831822]
  • Kohei Takata, Satoshi Imaizumi, Emi Kawachi, Yasunori Suematsu, Tomohiko Shimizu, Satomi Abe, Yoshino Matsuo, Hitomi Tsukahara, Keita Noda, Eiji Yahiro, Bo Zhang, Yoshinari Uehara, Shin-Ichiro Miura, Keijiro Saku. Impact of cigarette smoking cessation on high-density lipoprotein functionality. Circulation journal : official journal of the Japanese Circulation Society. 2014; 78(12):2955-62. doi: 10.1253/circj.cj-14-0638. [PMID: 25319317]
  • Wilson Kwong, Christine A White. Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. BMC nephrology. 2013 Nov; 14(?):248. doi: 10.1186/1471-2369-14-248. [PMID: 24215355]
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  • Can Peng, Clare Stokes, Yann S Mineur, Marina R Picciotto, Chengju Tian, Christoph Eibl, Isabelle Tomassoli, Daniela Guendisch, Roger L Papke. Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule. The Journal of pharmacology and experimental therapeutics. 2013 Nov; 347(2):424-37. doi: 10.1124/jpet.113.206904. [PMID: 23959137]
  • Dean F Wong, Hiroto Kuwabara, Jongho Kim, James R Brasic, Wichana Chamroonrat, Yongjun Gao, Heather Valentine, William Willis, Anil Mathur, Mary E McCaul, Gary Wand, Emily G Gean, Robert F Dannals, Andrew G Horti. PET imaging of high-affinity α4β2 nicotinic acetylcholine receptors in humans with 18F-AZAN, a radioligand with optimal brain kinetics. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 Aug; 54(8):1308-14. doi: 10.2967/jnumed.112.108001. [PMID: 23801676]
  • Ayoub Al-Haj, Mahmoud Alawi, Tawfiq Arafat, Mohammad Khair Hourani. Method development, validation and bioequivalence of varenicline in human plasma by liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Jul; 931(?):134-9. doi: 10.1016/j.jchromb.2013.05.019. [PMID: 23774248]
  • Björn Pasternak, Henrik Svanström, Anders Hviid. Use of varenicline versus bupropion and risk of psychiatric adverse events. Addiction (Abingdon, England). 2013 Jul; 108(7):1336-43. doi: 10.1111/add.12165. [PMID: 23445269]
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