Sumatriptan succinate (BioDeep_00000398895)
natural product
代谢物信息卡片
Sumatriptan succinate
化学式: C18H27N3O6S (413.162)
中文名称: 琥珀酸舒马坦
谱图信息:
最多检出来源 Escherichia coli(natural_products) 100%
分子结构信息
SMILES: C1(=CC=C2C(=C1)C(=CN2)CCN(C)C)CS(NC)(=O)=O.OC(CCC(O)=O)=O
InChI: 1-2H2,(H,5,6)(H,7,8)
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan succinate can be used for migraine headache research[1][2][3][4].
同义名列表
2 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:64359
- KEGGdrug: D00676
- PubChem: 59772
- ChEMBL: CHEMBL1201150
- MeSH: Sumatriptan
- CAS: 103628-47-3
- CAS: 103628-48-4
- CAS: 103628-48-4, 103628-62-2 (HCl)
- MoNA: CCMSLIB00000078145
- medchemexpress: HY-B0121
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Ramesh Boinpally, Abhijeet Jakate, Matthew Butler, Antonia Periclou. Atogepant and sumatriptan: no clinically relevant drug-drug interactions in a randomized, open-label, crossover trial.
Pain management.
2022 May; 12(4):499-508. doi:
10.2217/pmt-2021-0073. [PMID: 34898273] - Hasan Yousefi-Manesh, Samira Shirooie, Tayebeh Noori, Seyed Mohammad Tavangar, Mohammad Sheibani, Alireza Chaboki, Sina Mohammadi, Ahmad Reza Dehpour. Assessment of Sumatriptan on Sepsis-Induced Kidney injury in the Cecal Ligation and Puncture Mice Model.
Drug research.
2022 Mar; 72(3):156-162. doi:
10.1055/a-1685-0482. [PMID: 34852366] - Ibrahim Ethem Torun, Yasemin Baranoglu Kılınc, Erkan Kilinc. Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats.
Arquivos de neuro-psiquiatria.
2022 01; 80(1):48-55. doi:
10.1590/0004-282x-anp-2021-0101. [PMID: 35239805] - Rakesh Kumar Yadav, Kamal Shah, Hitesh Kumar Dewangan. Intranasal drug delivery of sumatriptan succinate-loaded polymeric solid lipid nanoparticles for brain targeting.
Drug development and industrial pharmacy.
2022 Jan; 48(1):21-28. doi:
10.1080/03639045.2022.2090575. [PMID: 35703403] - Ahmad Reza Dehpour, Hasan Yousefi-Manesh, Mohammad Sheibani, Mohammad Amin Sadeghi, Sara Hemmati, Tayebeh Noori, Samira Shirooie. Evaluation of Anti-inflammatory and Antioxidant Effects of Sumatriptan on Carbon Tetrachloride-induced Hepatotoxicity in Rats.
Drug research.
2022 Jan; 72(1):41-46. doi:
10.1055/a-1589-5395. [PMID: 34500479] - Olafur B Davidsson, Isa A Olofsson, Lisette Ja Kogelman, Michael Asger Andersen, Klaus Rostgaard, Henrik Hjalgrim, Jes Olesen, Thomas Folkmann Hansen. Twenty-five years of triptans - a nationwide population study.
Cephalalgia : an international journal of headache.
2021 07; 41(8):894-904. doi:
10.1177/0333102421991809. [PMID: 33583217] - Mona H Abo Zaid, Samah Abo El Abass, Nahed El-Enany, Fatma Aly. Spectrofluorimetric investigation for determination of sumatriptan succinate: application to tablets and spiked human plasma.
Luminescence : the journal of biological and chemical luminescence.
2021 May; 36(3):755-760. doi:
10.1002/bio.4000. [PMID: 33368986] - Bridget L Morse, John K Fallon, Anil Kolur, Andrew T Hogan, Philip C Smith, Kathleen M Hillgren. Comparison of Hepatic Transporter Tissue Expression in Rodents and Interspecies Hepatic OCT1 Activity.
The AAPS journal.
2021 04; 23(3):58. doi:
10.1208/s12248-021-00583-z. [PMID: 33903987] - Moein Masjedi, Amir Azadi, Reza Heidari, Soliman Mohammadi-Samani. Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation.
The Journal of pharmacy and pharmacology.
2020 Oct; 72(10):1341-1351. doi:
10.1111/jphp.13316. [PMID: 32579251] - Fatemeh Gharishvandi, Alireza Abdollahi, Hamed Shafaroodi, Razieh Mohammad Jafari, Parvin Pasalar, Ahmad Reza Dehpour. Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats.
European journal of pharmacology.
2020 Sep; 882(?):173265. doi:
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Headache.
2020 07; 60(7):1340-1350. doi:
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Mikrochimica acta.
2020 06; 187(7):402. doi:
10.1007/s00604-020-04366-9. [PMID: 32572633] - Parnia Mobasheran, Nazanin Rajai, Parichehr Kohansal, Ahmad Reza Dehpour, Hamed Shafaroodi. The effects of acute sumatriptan treatment on renal ischemia/reperfusion injury in rat and the possible involvement of nitric oxide.
Canadian journal of physiology and pharmacology.
2020 Apr; 98(4):252-258. doi:
10.1139/cjpp-2019-0301. [PMID: 31604019] - Li Guo, Muxin Gong, Sha Wu, Feng Qiu, Li Ma. Identification and quantification of the quality markers and anti-migraine active components in Chuanxiong Rhizoma and Cyperi Rhizoma herbal pair based on chemometric analysis between chemical constituents and pharmacological effects.
Journal of ethnopharmacology.
2020 Jan; 246(?):112228. doi:
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Chemistry and physics of lipids.
2019 12; 225(?):104792. doi:
10.1016/j.chemphyslip.2019.104792. [PMID: 31361986] - Mohammad Sheibani, Hedyeh Faghir-Ghanesefat, Saman Dehpour, Hedieh Keshavarz-Bahaghighat, Mohammad Reza Sepand, Mohammad Hossein Ghahremani, Yaser Azizi, Nastaran Rahimi, Ahmad Reza Dehpour. Sumatriptan protects against myocardial ischaemia-reperfusion injury by inhibition of inflammation in rat model.
Inflammopharmacology.
2019 Oct; 27(5):1071-1080. doi:
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Cephalalgia : an international journal of headache.
2019 01; 39(1):100-110. doi:
10.1177/0333102418776017. [PMID: 29783863] - Xiujuan Mi, Li Ran, Lixue Chen, Guangcheng Qin. Recurrent Headache Increases Blood-Brain Barrier Permeability and VEGF Expression in Rats.
Pain physician.
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Journal of mass spectrometry : JMS.
2018 Oct; 53(10):963-975. doi:
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European biophysics journal : EBJ.
2018 Jul; 47(5):561-571. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Mar; 114(?):84-92. doi:
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International journal of nanomedicine.
2018; 13(?):3093-3103. doi:
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Journal of clinical pharmacology.
2017 Nov; 57(11):1472-1478. doi:
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2016 Dec; 30(6):583-593. doi:
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Headache.
2016 Oct; 56(9):1455-1465. doi:
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Headache.
2016 Sep; 56(8):1300-9. doi:
10.1111/head.12895. [PMID: 27474357] - Priti Girotra, Shailendra Kumar Singh. A Comparative Study of Orally Delivered PBCA and ApoE Coupled BSA Nanoparticles for Brain Targeting of Sumatriptan Succinate in Therapeutic Management of Migraine.
Pharmaceutical research.
2016 07; 33(7):1682-95. doi:
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Analytical and bioanalytical chemistry.
2016 Jun; 408(15):3981-92. doi:
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Clinical pharmacology and therapeutics.
2016 06; 99(6):633-41. doi:
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The journal of headache and pain.
2016; 17(?):23. doi:
10.1186/s10194-016-0614-0. [PMID: 26969187] - Girotra Priti Hansraj, Shailendra Kumar Singh, Pawan Kumar. Sumatriptan succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential.
International journal of biological macromolecules.
2015 Nov; 81(?):467-76. doi:
10.1016/j.ijbiomac.2015.08.035. [PMID: 26299709] - Erik Sjögren, David Dahlgren, Carl Roos, Hans Lennernäs. Human in vivo regional intestinal permeability: quantitation using site-specific drug absorption data.
Molecular pharmaceutics.
2015 Jun; 12(6):2026-39. doi:
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Canadian family physician Medecin de famille canadien.
2015 May; 61(5):435-7. doi:
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Journal of analytical toxicology.
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Biological & pharmaceutical bulletin.
2015; 38(3):365-73. doi:
10.1248/bpb.b14-00502. [PMID: 25757917] - Kentaro Tokuoka, Risa Takayanagi, Yuji Suzuki, Masayuki Watanabe, Yasuhisa Kitagawa, Yasuhiko Yamada. Theory-based analysis of clinical efficacy of triptans using receptor occupancy.
The journal of headache and pain.
2014 Dec; 15(?):85. doi:
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Journal of molecular modeling.
2014 Oct; 20(10):2463. doi:
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Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2014 Aug; 35(8):1167-71. doi:
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Pain management.
2014 Mar; 4(2):123-8. doi:
10.2217/pmt.13.71. [PMID: 24641436] - Mehdi Maghbooli, Farhad Golipour, Alireza Moghimi Esfandabadi, Mehran Yousefi. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine.
Phytotherapy research : PTR.
2014 Mar; 28(3):412-5. doi:
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Drug delivery.
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Cephalalgia : an international journal of headache.
2013 Dec; 33(16):1292-301. doi:
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European biophysics journal : EBJ.
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Colloids and surfaces. B, Biointerfaces.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
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The journal of headache and pain.
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Drug development and industrial pharmacy.
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
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Journal of liposome research.
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