Sildenafil citrate (BioDeep_00000398894)
natural product
代谢物信息卡片
Sildenafil citrate
化学式: C28H38N6O11S (666.2319158)
中文名称: 枸橼酸西地那非
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=C(C(=C1)C2=NC3=C(C(N2)=O)N(N=C3CCC)C)OCC)S(N4CCN(CC4)C)(=O)=O.C(C(O)=O)C(CC(O)=O)(O)C(O)=O
InChI: 13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
描述信息
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058986 - Phosphodiesterase 5 Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor > C2127 - cGMP Phosphodiesterase Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D000089162 - Genitourinary Agents > D064804 - Urological Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:58987
- KEGGdrug: D02229
- PubChem: 135413523
- ChEMBL: CHEMBL1737
- MeSH: Sildenafil Citrate
- CAS: 171599-83-0
- CAS: 171599-83-0, 139755-83-2 (FREE BASE)
- MoNA: CCMSLIB00000078144
- MoNA: CCMSLIB00000078143
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Olorunfemi Oyewole Babalola, Opeyemi Iwaloye, Paul Olamide Ottu, Precious Olayinka Aturamu, Femi Olawale. Biological activities of African medicinal plants in the treatment of erectile dysfunction: a mechanistic perspective.
Hormone molecular biology and clinical investigation.
2023 Dec; 44(4):357-370. doi:
10.1515/hmbci-2022-0090. [PMID: 38221710] - Anupam Yadav, Raghav Kumar Mishra. Withania somnifera ameliorates sexual arousal and impotence in stressed sexually sluggish male rats by modulating neurotransmitters and NO/cGMP/PDE5α pathway.
Journal of ethnopharmacology.
2023 Jul; 318(Pt B):116971. doi:
10.1016/j.jep.2023.116971. [PMID: 37532077] - Mohammad Amin Behmanesh, Amin Rasekhian, Forutan Kiani, Mostafa Dehghandoost, Davood Alinezhad Dezfuli, Behnam Ghorbanzadeh. The nitric oxide-cyclic GMP-KATP channels pathway contributes to the effects of montelukast against gastric damage induced by ethanol.
Alcohol (Fayetteville, N.Y.).
2023 Jun; ?(?):. doi:
10.1016/j.alcohol.2023.05.008. [PMID: 37295565] - Ediléia Souza Paula Caetano, Sarah Viana Mattioli, Maria Luiza Santos da Silva, Laisla Zanetoni Martins, Alaor Aparecido Almeida, Ananda Lini Vieira da Rocha, Priscila Rezeck Nunes, Núbia Alves Grandini, Camila Renata Correa, Gabriela Palma Zochio, Carlos Alan Dias-Junior. Sildenafil attenuates oxidative stress and endothelial dysfunction in lead-induced hypertension.
Basic & clinical pharmacology & toxicology.
2023 May; ?(?):. doi:
10.1111/bcpt.13904. [PMID: 37221657] - Adeniyi Adebayo, Ayokunle Ademosun, Bukola Adedayo, Ganiyu Oboh. Antioxidant-rich Terminalia catappa fruit exerts antihypertensive effect via modulation of angiotensin-1-converting enzyme activity and H2S/NO/cGMP signaling pathway in Wistar rats.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2023 Apr; ?(?):1-18. doi:
10.1080/1354750x.2023.2198680. [PMID: 37002876] - Rakesh C Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai, Lei Xi. Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-a possible prevention strategy for COVID-19?.
Molecular and cellular biochemistry.
2023 Mar; 478(3):679-696. doi:
10.1007/s11010-022-04520-2. [PMID: 36036333] - Juntao Li, Youan He, Xinyu Zheng, Senjie Li, Yue Wu, Wanyin Shi, Kaijin Pan, Jijia Sun, Zhe Wang, Jian Xu, Xiangwei Zheng. Flavonoids and prenylhydroquinones from the prepared folium of Epimedium sagittatum maxim. And their inhibition against phosphodiesterase5A.
Fitoterapia.
2023 Feb; ?(?):105465. doi:
10.1016/j.fitote.2023.105465. [PMID: 36863569] - Serkan Cerrah, Elif Cadirci, Nihat Okcu, Özcan Deveci. The determination of the protective role of sildenafil administration in rats with sepsis-induced liver injury.
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.
2023 Feb; 29(2):133-139. doi:
10.14744/tjtes.2022.45605. [PMID: 36748765] - Stephen Adeniyi Adefegha, Ganiyu Oboh, Abraham Olanrewaju Adedipe. Aqueous extract of Massularia acuminata exerts erectogenic effect by modulating critical enzymes and hormones in streptozotocin-induced erectile dysfunction in rats.
Andrologia.
2022 Dec; 54(11):e14629. doi:
10.1111/and.14629. [PMID: 36349558] - Raul Edison Luna Lazo, Mariana Mengarda, Susana Leão Almeida, Aline Caldonazo, Joel Toribio Espinoza, Fábio Seigi Murakami. Advanced formulations and nanotechnology-based approaches for pulmonary delivery of sildenafil: A scoping review.
Journal of controlled release : official journal of the Controlled Release Society.
2022 10; 350(?):308-323. doi:
10.1016/j.jconrel.2022.08.021. [PMID: 35995298] - Mona F El-Azab, Ahmed A Al-Karmalawy, Samar A Antar, Pierre A Hanna, Karim M Tawfik, Reem M Hazem. A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways.
Life sciences.
2022 Aug; 303(?):120691. doi:
10.1016/j.lfs.2022.120691. [PMID: 35671809] - Olalekan Bukunmi Ogunro, Musa Toyin Yakubu. Fadogia agrestis (Schweinf. Ex Hiern) Stem Extract Restores Selected Biomolecules of Erectile Dysfunction in the Testicular and Penile Tissues of Paroxetine-Treated Wistar Rats.
Reproductive sciences (Thousand Oaks, Calif.).
2022 Aug; ?(?):. doi:
10.1007/s43032-022-01050-6. [PMID: 35969364] - Peter Manu. Drug Therapy for Unexplained Dyspnea in Post-COVID-19 Fatigue Syndrome: Empagliflozin and Sildenafil.
American journal of therapeutics.
2022 07; 29(4):e447-e448. doi:
10.1097/mjt.0000000000001483. [PMID: 35412483] - Charles McFadyen, Ben Garfield, Jennifer Mancio, Carole A Ridge, Tom Semple, Archie Keeling, Stephane Ledot, Brijesh Patel, Chinthaka B Samaranayake, Colm McCabe, S John Wort, Susanna Price, Laura C Price. Use of sildenafil in patients with severe COVID-19 pneumonitis.
British journal of anaesthesia.
2022 07; 129(1):e18-e21. doi:
10.1016/j.bja.2022.04.004. [PMID: 35568507] - Minze Xu, Falk-Bach Lichtenberger, Cem Erdoǧan, Enyin Lai, Pontus B Persson, Andreas Patzak, Pratik H Khedkar. Nitric Oxide Signalling in Descending Vasa Recta after Hypoxia/Re-Oxygenation.
International journal of molecular sciences.
2022 Jun; 23(13):. doi:
10.3390/ijms23137016. [PMID: 35806018] - Felicia Akuamoa, Toine F H Bovee, Ruud van Dam, Lilian Maro, Sebastiaan Wesseling, Jacques Vervoort, Ivonne M C M Rietjens, Ron L A P Hoogenboom. Identification of phosphodiesterase type-5 (PDE-5) inhibitors in herbal supplements using a tiered approach and associated consumer risk.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2022 Jun; 39(6):1021-1032. doi:
10.1080/19440049.2022.2052972. [PMID: 35323088] - Hannes Sallmon, Martin Koestenberger, Alexander Avian, Friedrich Reiterer, Bernhard Schwaberger, Katharina Meinel, Gerhard Cvirn, Stefan Kurath-Koller, Andreas Gamillscheg, Georg Hansmann. Extremely premature infants born at 23-25 weeks gestation are at substantial risk for pulmonary hypertension.
Journal of perinatology : official journal of the California Perinatal Association.
2022 06; 42(6):781-787. doi:
10.1038/s41372-022-01374-w. [PMID: 35365772] - Maya Radeva-Llieva, Stanila Stoeva, Nadezhda Hvarchanova, Iliya Zhelev, Kaloyan D Georgiev. Influence of methylxanthines isolated from Bancha green tea on the pharmacokinetics of sildenafil in rats.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2022 Jun; 30(1):75-84. doi:
10.1007/s40199-022-00433-z. [PMID: 35146639] - Yi Tang, Siyuan Tan, Minqi Li, Yijin Tang, Xiaoping Xu, Qinghai Zhang, Qinghua Fu, Mingxiang Tang, Jin He, Yi Zhang, Zhaofen Zheng, Jianqiang Peng, Tengteng Zhu, Wenlin Xie. Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension.
BMC pulmonary medicine.
2022 Apr; 22(1):142. doi:
10.1186/s12890-022-01939-7. [PMID: 35413880] - Silvia Limoncella, Clara Lazzaretti, Elia Paradiso, Sara D'Alessandro, Federica Barbagallo, Salvatore Pacifico, Remo Guerrini, Simonetta Tagliavini, Tommaso Trenti, Daniele Santi, Manuela Simoni, Marco Sola, Giulia Di Rocco, Livio Casarini. Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line.
Molecular and cellular endocrinology.
2022 02; 542(?):111527. doi:
10.1016/j.mce.2021.111527. [PMID: 34875337] - Mario G Santamarina, Ignacio Beddings, Felipe Martinez Lomakin, Dominique Boisier Riscal, Mónica Gutiérrez Claveria, Jaime Vidal Marambio, Nicole Retamal Báez, Cristian Pavez Novoa, César Reyes Allende, Paulina Ferreira Perey, Miguel Gutiérrez Torres, Camila Villalobos Mazza, Constanza Vergara Sagredo, Sebastian Ahumada Bermejo, Eduardo Labarca Mellado, Elizabeth Barthel Munchmeyer, Solange Marchant Ramos, Mariano Volpacchio, Jorge Vega. Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomized trial.
Critical care (London, England).
2022 01; 26(1):1. doi:
10.1186/s13054-021-03885-y. [PMID: 34980198] - Fanchao Meng, Xiaoxing Liao, Haimin Chen, Sheng Deng, Lu Wang, Mengjie Zhao, Haibin Li, Dong Liu, Guojing Gao, Haisong Li, Jisheng Wang. Bibliometric and visualization analysis of literature relating to diabetic erectile dysfunction.
Frontiers in endocrinology.
2022; 13(?):1091999. doi:
10.3389/fendo.2022.1091999. [PMID: 36568113] - Engy Refaat Rashed, Mohamed Khairy Abdel-Rafei, Noura Magdy Thabet. Roles of Simvastatin and Sildenafil in Modulation of Cranial Irradiation-Induced Bystander Multiple Organs Injury in Rats.
Inflammation.
2021 Dec; 44(6):2554-2579. doi:
10.1007/s10753-021-01524-w. [PMID: 34420155] - Yaolu Zhu, Yabin Sun, Shichang Zhang, Chuyuan Li, Yiwei Zhao, Boxin Zhao, Guofeng Li. Xinmai 'an extract enhances the efficacy of sildenafil in the treatment of pulmonary arterial hypertension via inhibiting MAPK signalling pathway.
Pharmaceutical biology.
2021 Dec; 59(1):594-605. doi:
10.1080/13880209.2021.1917629. [PMID: 34010580] - Melanie Reinero, Maurice Beghetti, Piergiorgio Tozzi, Ludwig K von Segesser, Michele Samaja, Giuseppina Milano. Nitric Oxide-cGMP Pathway Modulation in an Experimental Model of Hypoxic Pulmonary Hypertension.
Journal of cardiovascular pharmacology and therapeutics.
2021 11; 26(6):665-676. doi:
10.1177/10742484211014162. [PMID: 33969747] - Felix R De Bie, Francesca M Russo, Pieter Van Brantegem, Barbara E Coons, James K Moon, Zexuan Yang, Chengcheng Pang, Janaina C Senra, Camilla Omann, Pieter Annaert, Karel Allegaert, Marcus G Davey, Alan W Flake, Jan Deprest. Pharmacokinetics and pharmacodynamics of sildenafil in fetal lambs on extracorporeal support.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112161. doi:
10.1016/j.biopha.2021.112161. [PMID: 34537676] - Hamed Hajipour, Roshanak Sambrani, Marjan Ghorbani, Zahra Mirzamohammadi, Mohammad Nouri. Sildenafil citrate-loaded targeted nanostructured lipid carrier enhances receptivity potential of endometrial cells via LIF and VEGF upregulation.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 11; 394(11):2323-2331. doi:
10.1007/s00210-021-02153-8. [PMID: 34515834] - Antônio Rafael Coelho Jorge, Aline Diogo Marinho, João Alison de Moraes Silveira, Francisco Assis Nogueira Junior, Pedro Everson Alexandre de Aquino, Ana Paula Negreiros Nunes Alves, Roberta Jeane Bezerra Jorge, Rui Seabra Ferreira Junior, Helena Serra Azul Monteiro. Phosphodiesterase-5 inhibitor sildenafil attenuates kidney injury induced by Bothrops alternatus snake venom.
Toxicon : official journal of the International Society on Toxinology.
2021 Oct; 202(?):46-52. doi:
10.1016/j.toxicon.2021.08.024. [PMID: 34516995] - Yan-Ying Xu, Fei Qin, Yi-Xin Dai, Xue-Feng Zhong, Juan Yan, Su-Mei Xu, Ping-Sheng Xu. Method development and validation of sildenafil, N-desmethylsildenafil and N1,N4-desmethylsildenafil by LC-MS/MS and its application.
Analytical biochemistry.
2021 10; 631(?):114355. doi:
10.1016/j.ab.2021.114355. [PMID: 34461080] - Wen Ling Zhu, Chao Zheng, Wen Gang Xiong, Cai Li Chen, Jin Ling Yi, Xiu Jin Zhang, Xi Luo. UPLC-MS/MS for the Simultaneous Determination of Sildenafil and N-Desmethyl Sildenafil.
Journal of chromatographic science.
2021 Sep; 59(9):823-829. doi:
10.1093/chromsci/bmaa138. [PMID: 33517421] - Walaa Wadie, Nermeen S Abdel-Razek, Hesham A Salem. Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats.
Life sciences.
2021 Jul; 277(?):119506. doi:
10.1016/j.lfs.2021.119506. [PMID: 33865881] - Eriko Okuyama, Masahito Kawatani, Junichi Hashimoto, Keisuke Tanimoto, Manabu Hashimoto, Kazumasa Matsumoto-Miyai. The nitric oxide-cyclic guanosine monophosphate pathway inhibits the bladder ATP release in response to a physiological or pathological stimulus.
Physiological reports.
2021 07; 9(14):e14938. doi:
10.14814/phy2.14938. [PMID: 34288526] - Ramanachary Namoju, Naga Kavitha Chilaka, Durga Prasad Beda, Srinivasa Rao Avanapu. Pre-pubertal cyclophosphamide exposure-induced mutilation in spermatogenesis, steroidogenesis and testicular architecture in SD rat: Protection from an alternative herbal viagra.
Revista internacional de andrologia.
2021 Jul; 19(3):177-186. doi:
10.1016/j.androl.2020.01.009. [PMID: 32682734] - Moein Ala, Razieh Mohammad Jafari, Ahmad Reza Dehpour. Sildenafil beyond erectile dysfunction and pulmonary arterial hypertension: Thinking about new indications.
Fundamental & clinical pharmacology.
2021 Apr; 35(2):235-259. doi:
10.1111/fcp.12633. [PMID: 33226665] - Clarissa Corinaldesi, Rebecca L Ross, Giuseppina Abignano, Cristina Antinozzi, Francesco Marampon, Luigi di Luigi, Maya H Buch, Valeria Riccieri, Andrea Lenzi, Clara Crescioli, Francesco Del Galdo. Muscle Damage in Systemic Sclerosis and CXCL10: The Potential Therapeutic Role of PDE5 Inhibition.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062894. [PMID: 33809279] - Daoyuan Sun, Wenlan Yang, Zhenwei Wang, Beilan Gao. Efficacy of Beraprost Sodium Combined with Sildenafil and Its Effects on Vascular Endothelial Function and Inflammation in Patients Experiencing Left Heart Failure Complicated with Pulmonary Arterial Hypertension.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Feb; 27(?):e928413. doi:
10.12659/msm.928413. [PMID: 33531453] - Jie Huang, Hualin Cai, Wenqun Li, Xiaomei Huang, Huiyu Guan, Xi Wang, Yamin Yin, Binbin He, Jian Huang, Bikui Zhang. A UPLC-MS/MS method for simultaneous quantification of sildenafil and N-desmethyl sildenafil applied in pharmacokinetic and bioequivalence studies in a Chinese population.
International journal of clinical pharmacology and therapeutics.
2021 Feb; 59(2):164-174. doi:
10.5414/cp203838. [PMID: 33210997] - Saurabh K Chhonker, Divya Rawat, Raj Kumar Koiri. Protective and therapeutic effects of sildenafil and tadalafil on aflatoxin B1-induced hepatocellular carcinoma.
Molecular and cellular biochemistry.
2021 Feb; 476(2):1195-1209. doi:
10.1007/s11010-020-03982-6. [PMID: 33216253] - Soyoung Lee, Andrew HyoungJin Kim, Sumin Yoon, Jieon Lee, Yujin Lee, Sang Chun Ji, Seo Hyun Yoon, SeungHwan Lee, Kyung-Sang Yu, In-Jin Jang, Joo-Youn Cho. The utility of CYP3A activity endogenous markers for evaluating drug-drug interaction between sildenafil and CYP3A inhibitors in healthy subjects.
Drug metabolism and pharmacokinetics.
2021 Feb; 36(?):100368. doi:
10.1016/j.dmpk.2020.11.003. [PMID: 33348240] - Meriç Emre Bostancı, Ceylan Hepokur, Erol Kisli. The effects of sildenafil and N-acetylcysteine the zone of stasis in burns.
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.
2021 01; 27(1):9-16. doi:
10.14744/tjtes.2020.25679. [PMID: 33394467] - Sara N Salerno, Andrea Edginton, Jacqueline G Gerhart, Matthew M Laughon, Namasivayam Ambalavanan, Gregory M Sokol, Chi D Hornik, Dan Stewart, Mary Mills, Karen Martz, Daniel Gonzalez. Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants.
Clinical pharmacology and therapeutics.
2021 01; 109(1):253-262. doi:
10.1002/cpt.1990. [PMID: 32691891] - Jung Suk Kim, Fakhar Ud Din, Sang Min Lee, Dong Shik Kim, Mi Ran Woo, Seunghyun Cheon, Sang Hun Ji, Jong Oh Kim, Yu Seok Youn, Kyung Taek Oh, Soo-Jeong Lim, Sung Giu Jin, Han-Gon Choi. Comparison of Three Different Aqueous Microenvironments for Enhancing Oral Bioavailability of Sildenafil: Solid Self-Nanoemulsifying Drug Delivery System, Amorphous Microspheres and Crystalline Microspheres.
International journal of nanomedicine.
2021; 16(?):5797-5810. doi:
10.2147/ijn.s324206. [PMID: 34465992] - Laura E J Peeters, Suzan C M Cochius-den Otter, Bregje C M Witjes, Saskia J Gischler, Robert B Flint. An Accidental Repetitive 10-Fold Overdose of Sildenafil in a Young Infant with Pulmonary Hypertension.
Neonatology.
2021; 118(3):354-358. doi:
10.1159/000514380. [PMID: 33780926] - Yukino Oya, Daisuke Watahiki, Mitsuki Matsunaga, Keiichi Hirono, Fukiko Ichida, Masaya Aoki, Naoki Yoshimura, Masato Taguchi. The Pharmacokinetics of Sildenafil May Be Affected by Intestinal Absorption Rate in Children Admitted to the Intensive Care Unit.
Biological & pharmaceutical bulletin.
2020 Dec; 43(12):1917-1923. doi:
10.1248/bpb.b20-00614. [PMID: 33012742] - Wei-Tian Chen, Wen-Bin Zhou, Yu-Neng Gu, Zhi-Ming Hong, Quan Wang, Yang-Ling Zeng, Zhong-Wang Huang. [Coridius Decoction increases penile erection hardness, IIEF-5 scores and testosterone level in patients with erectile dysfunction].
Zhonghua nan ke xue = National journal of andrology.
2020 Dec; 26(12):1124-1128. doi:
". [PMID: 34898089] - Nikolaos Tzoumas, Tariq E Farrah, Neeraj Dhaun, David J Webb. Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease.
British journal of pharmacology.
2020 12; 177(24):5467-5488. doi:
10.1111/bph.14920. [PMID: 31721165] - Anthony P Carnicelli, Jie-Lena Sun, Brooke Alhanti, Magnus Bjursell, Shira Perl, Barbara Lytle, Matthew T Roe, Robert J Mentz. Elevated Uric Acid Prevalence and Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction: Insights from RELAX.
The American journal of medicine.
2020 12; 133(12):e716-e721. doi:
10.1016/j.amjmed.2020.03.054. [PMID: 32416181] - Lamiaa R Abdelalim, Yosra S R Elnaggar, Ossama Y Abdallah. Oleosomes Encapsulating Sildenafil Citrate as Potential Topical Nanotherapy for Palmar Plantar Erythrodysesthesia with High Ex vivo Permeation and Deposition.
AAPS PharmSciTech.
2020 Nov; 21(8):310. doi:
10.1208/s12249-020-01862-2. [PMID: 33164131] - Yasunori Nio, Mitsugi Ookawara, Midori Yamasaki, Guido Hanauer, Kimio Tohyama, Sachio Shibata, Tomoya Sano, Fumi Shimizu, Hisashi Anayama, Masatoshi Hazama, Takanori Matsuo. Ameliorative effect of phosphodiesterase 4 and 5 inhibitors in deoxycorticosterone acetate-salt hypertensive uni-nephrectomized KKAy mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 11; 34(11):14997-15014. doi:
10.1096/fj.202001084r. [PMID: 32939821] - Shereen B Gad, Mona H Hafez, Yasser S El-Sayed. Platelet-rich plasma and/or sildenafil topical applications accelerate and better repair wound healing in rats through regulation of proinflammatory cytokines and collagen/TGF-β1 pathway.
Environmental science and pollution research international.
2020 Nov; 27(32):40757-40768. doi:
10.1007/s11356-020-10042-5. [PMID: 32671702] - Nde Zacharie, Massoma Lembè Dieudonné, Wankeu Nya Modeste, Ngaha Marie Ide, Koloko Brice Landry, Bend Emma, Etaga Noël, Mbock Armel, Toham Yebga, Mboumwa Paul Valerie G, Nyonseu Nzeubang Doriane Camille. Potential activity of Aframomum daniellii (Zingiberaceae) dry seeds: A case study of its action mechanism on the Wistar rat strain with testicular deficiency.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Nov; 131(?):110759. doi:
10.1016/j.biopha.2020.110759. [PMID: 33152923] - G G Krivoborodov, K A Zakharov, V B Vasilyuk, G G Rodionov, M V Vetrova. [Pharmacokinetic features of sildenafil spray in healthy men depending on food intake].
Urologiia (Moscow, Russia : 1999).
2020 11; ?(5):41-47. doi:
10.18565/urology.2020.5.41-47. [PMID: 33185345] - Richard I Horowitz, Phyllis R Freeman. Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials.
Medical hypotheses.
2020 Oct; 143(?):109851. doi:
10.1016/j.mehy.2020.109851. [PMID: 32534175] - Lin-Ling Li, Xiu-Jin Zhang, Chao Zheng, Ming-Xia Fan, Hao-Yun Xu, Jin-Ling Yi, Yan Feng, Xi Luo, Wei-Hua Li, Ze-Neng Cheng. Simultaneous determination and determination of sildenafil and its active metabolite in human plasma using LC-MS/MS method.
Biomedical chromatography : BMC.
2020 Oct; 34(10):e4927. doi:
10.1002/bmc.4927. [PMID: 32562289] - Fabrizio Dal Moro, Igor Vendramin, Ugolino Livi. The war against the SARS-CoV2 infection: Is it better to fight or mitigate it?.
Medical hypotheses.
2020 Oct; 143(?):110129. doi:
10.1016/j.mehy.2020.110129. [PMID: 32721814] - Wioletta Szczurek, Mariusz Gąsior, Michał Skrzypek, Jacek Kaczmarski, Bożena Szyguła-Jurkiewicz. Modified Model for End-Stage Liver Disease Is an Indicator of the Ineffectiveness of Sildenafil Treatment in Patients With Advanced Heart Failure and Increased Pulmonary Vascular Resistance.
Transplantation proceedings.
2020 Oct; 52(8):2440-2446. doi:
10.1016/j.transproceed.2020.01.103. [PMID: 32299711] - Hatice Tuba Atalay, Ahmet Yucel Ucgul, Ummuhani Ozel Turkcu, Mehmet Cuneyt Ozmen, Samet Yilmaz, Ayse Bilgihan. The Effect of Sildenafil on Selenite-Induced Cataract in Rats.
Current eye research.
2020 09; 45(9):1082-1088. doi:
10.1080/02713683.2020.1726405. [PMID: 32023416] - Andrei Mihai Iordache, Ana Maria Buga, Dana Albulescu, Ramona Constantina Vasile, Radu Mitrut, George Georgiadis, Ioannis-Erineos Zisis, Charalampos Mamoulakis, Aristidis Tsatsakis, Anca Oana Docea, Daniela Calina. Phosphodiesterase-5 inhibitors ameliorate structural kidney damage in a rat model of contrast-induced nephropathy.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Sep; 143(?):111535. doi:
10.1016/j.fct.2020.111535. [PMID: 32622850] - Marek Brzezinski, Gabriela R Dincheva, Kelsey Alloo, Celeste Wong, Chun-Miao Feng, Wynnis L Tom, Ali Salahieh, Arthur W Wallace. Combined Intravenous Sildenafil and L-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow.
Drugs in R&D.
2020 Sep; 20(3):279-290. doi:
10.1007/s40268-020-00318-z. [PMID: 32720006] - Yuan Lv, Bin-Yu Luo, Robert R LaBadie, Hua Zhu, Yan Feng, Cynthia Ernst, Penelope H Crownover, Yali Liang, Qinying Zhao. Bioequivalence and Bioavailability of an Orodispersible Tablet of Sildenafil Citrate in Healthy Chinese Male Subjects.
Clinical pharmacology in drug development.
2020 07; 9(5):573-581. doi:
10.1002/cpdd.806. [PMID: 32463593] - Hannah R Turbeville, Ashley C Johnson, Michael R Garrett, Jennifer M Sasser. Sildenafil Citrate Does Not Reprogram Risk of Hypertension and Chronic Kidney Disease in Offspring of Preeclamptic Pregnancies in the Dahl SS/Jr Rat.
Kidney360.
2020 06; 1(6):510-520. doi:
10.34067/kid.0001062020. [PMID: 35368603] - Yufan Gu, Qing Hu, Jian Sun, Hong Yu, Huiqin Pan, Xiaotong Zhao, Shen Ji. Isolation and identification of a new sildenafil analogue, hydroxycarbodenafil, found as an adulterant in a health supplement.
Journal of pharmaceutical and biomedical analysis.
2020 Jun; 185(?):113222. doi:
10.1016/j.jpba.2020.113222. [PMID: 32145539] - Reham M El-Deen, Gehan H Heeba, Rania G Abdel-Latif, Mohamed M A Khalifa. Comparative effectiveness of phosphodiesterase 3, 4, and 5 inhibitors in amelioration of high-fat diet-induced nonalcoholic fatty liver in rats.
Fundamental & clinical pharmacology.
2020 Jun; 34(3):353-364. doi:
10.1111/fcp.12530. [PMID: 31885103] - Tracy Kumar, Hardeep Aujla, Marcin Woźniak, Will Dott, Nikol Sullo, Lathishia Joel-David, Paolo Pais, Dawn Smallwood, Douglas Miller, Bryony Eagle-Hemming, Ana Suazo Di Paola, Shaun Barber, Cassandra Brookes, Nigel J Brunskill, Gavin J Murphy. Intravenous sildenafil citrate and post-cardiac surgery acute kidney injury: a double-blind, randomised, placebo-controlled trial.
British journal of anaesthesia.
2020 06; 124(6):693-701. doi:
10.1016/j.bja.2020.01.030. [PMID: 32245569] - Shi Shi, Yuanyang Wu, Minghao Zhou, Qiaoyuan Cheng. Simultaneous analysis of 31 anti-impotence compounds potentially illegally added to herbal-based dietary supplements by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 May; 1144(?):122077. doi:
10.1016/j.jchromb.2020.122077. [PMID: 32251992] - Valeria M Pinto, Giorgio E Derchi, Lorenzo Bacigalupo, Emanuele Pontali, Gian Luca Forni. COVID-19 in a Patient with β-Thalassemia Major and Severe Pulmonary Arterial Hypertension.
Hemoglobin.
2020 May; 44(3):218-220. doi:
10.1080/03630269.2020.1779082. [PMID: 32552139] - Ryota Akabane, Touko Sato, Atsushi Sakatani, Mizuki Ogawa, Masayoshi Nagakawa, Hirosumi Miyakawa, Yuichi Miyagawa, Hiroyuki Tazaki, Naoyuki Takemura. Pharmacokinetics of single dose sildenafil orally administered in canine models of chronic embolic pulmonary hypertension.
The Journal of veterinary medical science.
2020 Apr; 82(4):446-451. doi:
10.1292/jvms.19-0595. [PMID: 32101822] - Ravi B Patel, Rupal Mehta, Margaret M Redfield, Barry A Borlaug, Adrian F Hernandez, Sanjiv J Shah, Ruth F Dubin. Renal Dysfunction in Heart Failure With Preserved Ejection Fraction: Insights From the RELAX Trial.
Journal of cardiac failure.
2020 Mar; 26(3):233-242. doi:
10.1016/j.cardfail.2020.01.003. [PMID: 31931098] - David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Armando Valenzuela Peraza, Gerardo Barragán Mejía, Hugo Juárez Olguín, Francisca Trujillo Jiménez. Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats.
Acta pharmaceutica (Zagreb, Croatia).
2020 Mar; 70(1):121-127. doi:
10.2478/acph-2020-0016. [PMID: 31677373] - Brice Landry Koloko, Ijaz Bushra, Modeste Wankeu-Nya, Marie Ide Ngaha Njila, Hubert Kenmogne, Doriane Camille Nyonseu Nzeubang, Calvin Bogning Nzangueu, Théophile Dimo, Alain Bertrand Dongmo, Dieudonné Massoma Lembe. In vivo effects of Rauvolfia vomitoria (Apocynaceae) ethanolic extract on sexual performance and reproductive activity in male rats.
Andrologia.
2020 Feb; 52(1):e13414. doi:
10.1111/and.13414. [PMID: 31692024] - Suzan C M Cochius-den Otter, Florian Kipfmueller, Brenda C M de Winter, Karel Allegaert, Dick Tibboel, Andreas Mueller, Birgit C P Koch. Pharmacokinetic modeling of intravenous sildenafil in newborns with congenital diaphragmatic hernia.
European journal of clinical pharmacology.
2020 Feb; 76(2):219-227. doi:
10.1007/s00228-019-02767-1. [PMID: 31740991] - Ahsas Goyal, Debapriya Garabadu. Sildenafil promotes the anti-amnesic activity of estrogen receptor alpha agonist in animals with estrogen insufficiency.
Neurochemistry international.
2020 01; 132(?):104609. doi:
10.1016/j.neuint.2019.104609. [PMID: 31778728] - Amira M Ghoneim, Suzan M Mansour. The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling.
Drug design, development and therapy.
2020; 14(?):1469-1479. doi:
10.2147/dddt.s246229. [PMID: 32341640] - Marcos A S Leal, Rafaela Aires, Thamirys Pandolfi, Vinicius Bermond Marques, Bianca Prandi Campagnaro, Thiago M C Pereira, Silvana S Meyrelles, Manuel Campos-Toimil, Elisardo C Vasquez. Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.
Vascular pharmacology.
2020 01; 124(?):106601. doi:
10.1016/j.vph.2019.106601. [PMID: 31689530] - Andrei Mihai Iordache, Anca Oana Docea, Ana Maria Buga, Ovidiu Zlatian, Marius Eugen Ciurea, Otilia Constantina Rogoveanu, Florin Burada, Simona Sosoi, Radu Mitrut, Charalampos Mamoulakis, Dana Albulescu, Ramona Constantina Vasile, Aristides Tsatsakis, Daniela Calina. Sildenafil and tadalafil reduce the risk of contrast-induced nephropathy by modulating the oxidant/antioxidant balance in a murine model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Jan; 135(?):111038. doi:
10.1016/j.fct.2019.111038. [PMID: 31825855] - Daniel Gonzalez, Matthew M Laughon, P Brian Smith, Shufan Ge, Namasivayam Ambalavanan, Andrew Atz, Gregory M Sokol, Chi D Hornik, Dan Stewart, Gratias Mundakel, Brenda B Poindexter, Roger Gaedigk, Mary Mills, Michael Cohen-Wolkowiez, Karen Martz, Christoph P Hornik. Population pharmacokinetics of sildenafil in extremely premature infants.
British journal of clinical pharmacology.
2019 12; 85(12):2824-2837. doi:
10.1111/bcp.14111. [PMID: 31475367] - Karen Lavie-Nevo, Kevin C Harris, Joseph Y Ting. Use of sildenafil in an infant with persistent pulmonary hypertension secondary to lung and renal hypoplasia - a case report.
BMC pediatrics.
2019 11; 19(1):416. doi:
10.1186/s12887-019-1801-3. [PMID: 31690278] - Philipp Schick, Maximilian Sager, Franziska Wegner, Markus Wiedmann, Elisabeth Schapperer, Werner Weitschies, Mirko Koziolek. Application of the GastroDuo as an in Vitro Dissolution Tool To Simulate the Gastric Emptying of the Postprandial Stomach.
Molecular pharmaceutics.
2019 11; 16(11):4651-4660. doi:
10.1021/acs.molpharmaceut.9b00799. [PMID: 31593480] - A Zucchi, E Costantini, F I Scroppo, M Silvani, Z Kopa, E Illiano, M G Petrillo, L Cari, G Nocentini. The first-generation phosphodiesterase 5 inhibitors and their pharmacokinetic issue.
Andrology.
2019 11; 7(6):804-817. doi:
10.1111/andr.12683. [PMID: 31350821] - Noémie Simon-Tillaux, Edouard Lecarpentier, Vassilis Tsatsaris, Alexandre Hertig. Sildenafil for the treatment of preeclampsia, an update: should we still be enthusiastic?.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2019 11; 34(11):1819-1826. doi:
10.1093/ndt/gfy328. [PMID: 30403811] - Ayokunle O Ademosun, Adeniyi A Adebayo, Ganiyu Oboh. Orange peels modulate antioxidant markers and key enzymes relevant to erection in the penile tissue of paroxetine-treated rats.
Andrologia.
2019 Oct; 51(9):e13371. doi:
10.1111/and.13371. [PMID: 31347717] - Dao Thi Cam Minh, Le Anh Thi, Nguyen Thi Thanh Huyen, Le Van Vu, Nguyen Thi Kieu Anh, Pham Thi Thanh Ha. Detection of sildenafil adulterated in herbal products using thin layer chromatography combined with surface enhanced Raman spectroscopy: 'Double coffee-ring effect' based enhancement.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):340-347. doi:
10.1016/j.jpba.2019.05.043. [PMID: 31202876] - Jos Bloemers, Jeroen Gerritsen, Kim van Rooij, Leo de Leede, Ronald van der Geest, Henderik W Frijlink, Hans P F Koppeschaar, Berend Olivier, Adriaan Tuiten. The Effect of Food on the Pharmacokinetics of Sildenafil after Single Administration of a Sublingual Testosterone and Oral Sildenafil Combination Tablet in Healthy Female Subjects.
The journal of sexual medicine.
2019 09; 16(9):1433-1443. doi:
10.1016/j.jsxm.2019.06.015. [PMID: 31488289] - Mary Anna Venneri, Federica Barbagallo, Daniela Fiore, Rita De Gaetano, Elisa Giannetta, Emilia Sbardella, Carlotta Pozza, Federica Campolo, Fabio Naro, Andrea Lenzi, Andrea M Isidori. PDE5 Inhibition Stimulates Tie2-Expressing Monocytes and Angiopoietin-1 Restoring Angiogenic Homeostasis in Diabetes.
The Journal of clinical endocrinology and metabolism.
2019 07; 104(7):2623-2636. doi:
10.1210/jc.2018-02525. [PMID: 31102457] - Leah A Sabato, Daniel C Johnson, Nicholas Haglund, Mary Keebler, Zachary L Cox. Pharmacokinetics of Sildenafil in Patients with a Left Ventricular Assist Device: A Word of Caution.
ASAIO journal (American Society for Artificial Internal Organs : 1992).
2019 07; 65(5):530-532. doi:
10.1097/mat.0000000000000886. [PMID: 30299299] - Janneke M Brussee, Elke H J Krekels, Elisa A M Calvier, Semra Palić, Amin Rostami-Hodjegan, Meindert Danhof, Jeffrey S Barrett, Saskia N de Wildt, Catherijne A J Knibbe. A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.
The AAPS journal.
2019 06; 21(5):81. doi:
10.1208/s12248-019-0351-9. [PMID: 31250333] - Vijaya Laxmi, Rachna Gupta, Swapan K Bhattacharya, Arunabha Ray, Kavita Gulati. Inhibitory effects of sildenafil and tadalafil on inflammation, oxidative stress and nitrosative stress in animal model of bronchial asthma.
Pharmacological reports : PR.
2019 Jun; 71(3):517-521. doi:
10.1016/j.pharep.2019.02.008. [PMID: 31009843] - Fatma Zohra Chioukh, Kamel Monastiri. Primary Pulmonary Hypertension Associated with Asymptomatic Methylmalonic Aciduria in a Child.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Jun; 29(6):S43-S44. doi:
10.29271/jcpsp.2019.06.s43. [PMID: 31142418] - S Giannattasio, C Corinaldesi, M Colletti, L Di Luigi, C Antinozzi, T Filardi, S Scolletta, S Basili, A Lenzi, S Morano, C Crescioli. The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence.
Journal of endocrinological investigation.
2019 Jun; 42(6):715-725. doi:
10.1007/s40618-018-0977-y. [PMID: 30415310] - Thiago N Menezes, Gustavo B Naumann, Allan B Mendonça, Marcos A Leal, Marcella L Porto, André Teixeira-Ferreira, Jonas Perales, Silvana S Meyrelles, Suely G Figueiredo, Elisardo C Vasquez. Antioxidant effect of sildenafil: Potential hepatoprotection via differential expression of mitochondrial proteins in apolipoprotein E knockout mice.
Pharmacological reports : PR.
2019 Jun; 71(3):422-429. doi:
10.1016/j.pharep.2019.01.005. [PMID: 31003152] - Zhen Wang, Xiangrui Jiang, Xianglei Zhang, Guanghui Tian, Rulei Yang, Jianzhong Wu, Xiaoli Zou, Zheng Liu, Xiaojun Yang, Chunhui Wu, Jing Shi, Jianfeng Li, Jin Suo, Yu Wang, Rongxia Zhang, Zhijian Xu, Xudong Gong, Yang He, Weiliang Zhu, Haji Akber Aisa, Hualiang Jiang, Yechun Xu, Jingshan Shen. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.
Journal of medicinal chemistry.
2019 05; 62(10):4979-4990. doi:
10.1021/acs.jmedchem.9b00123. [PMID: 31021628] - Hosam Eldin Dahshan, Mohamed A Helal, Samia M Mostafa, Mohamed Saleh Elgawish. Development and validation of an HPLC-UV method for simultaneous determination of sildenafil and tramadol in biological fluids: Application to drug-drug interaction study.
Journal of pharmaceutical and biomedical analysis.
2019 May; 168(?):201-208. doi:
10.1016/j.jpba.2019.02.025. [PMID: 30825803] - Yu Ueda, Lynelle R Johnson, Eric S Ontiveros, Lance C Visser, Catherine T Gunther-Harrington, Joshua A Stern. Effect of a phosphodiesterase-5A (PDE5A) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension.
Scientific reports.
2019 05; 9(1):6899. doi:
10.1038/s41598-019-43318-z. [PMID: 31053768] - Fernanda Carolina Ribeiro Dias, Ana Luiza Pereira Martins, Fabiana Cristina Silveira Alves de Melo, Marli do Carmo Cupertino, Marcos de Lucca Moreira Gomes, Jerusa Maria de Oliveira, Eduardo Medeiros Damasceno, Janaina Silva, Wagner Campos Otoni, Sérgio Luis Pinto da Matta. Hydroalcoholic extract of Pfaffia glomerata alters the organization of the seminiferous tubules by modulating the oxidative state and the microstructural reorganization of the mice testes.
Journal of ethnopharmacology.
2019 Apr; 233(?):179-189. doi:
10.1016/j.jep.2018.12.047. [PMID: 30605740] - Luis García Aguirre, Isabel Ruiz Olmedo, Araceli Medina Nolasco, Yamanqui Ibáñez Romo, Liz Medina Reyes, Dolores Adriana Aguilera Hernández, Ana Laura Rojas Vargas. Comparative Bioavailability of Sildenafil 50-mg Film-Coated Tablets and 50-mg Orally Disintegrating Films in Healthy Mexican Subjects: Results From a Randomized, Open-Label, Crossover Study.
Clinical pharmacology in drug development.
2019 04; 8(3):404-410. doi:
10.1002/cpdd.599. [PMID: 29947474] - Ayokunle O Ademosun, Adeniyi A Adebayo, Ganiyu Oboh. Anogeissus leiocarpus attenuates paroxetine-induced erectile dysfunction in male rats via enhanced sexual behavior, nitric oxide level and antioxidant status.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Mar; 111(?):1029-1035. doi:
10.1016/j.biopha.2019.01.022. [PMID: 30841416] - Taymour Mostafa, Laila A Rashed, Dina A Sabry, Ihab Osman, Nashaat Nabil, Firas Kareem, Ingi A Mostafa. Serum L-carnitine and vitamin D levels may be low among oral sildenafil citrate non-responders.
International journal of impotence research.
2019 Mar; 31(2):85-91. doi:
10.1038/s41443-018-0036-4. [PMID: 30287894] - Mariana M Clavé, Nair Y Maeda, Ana M Thomaz, Sergio P Bydlowski, Antonio A Lopes. Phosphodiesterase type 5 inhibitors improve microvascular dysfunction markers in pulmonary arterial hypertension associated with congenital heart disease.
Congenital heart disease.
2019 Mar; 14(2):246-255. doi:
10.1111/chd.12688. [PMID: 30343508] - Ruipeng Zhang, Yang Wang, Longfei Pan, Hongyan Tian. N-Acetylcysteine potentiates the haemodynamic-improving effect of sildenafil in a rabbit model of acute pulmonary thromboembolism via the p38 MAPK pathway.
Clinical and experimental pharmacology & physiology.
2019 02; 46(2):163-172. doi:
10.1111/1440-1681.13039. [PMID: 30289994]