Mosapride citrate (BioDeep_00000398886)
natural product
代谢物信息卡片
Mosapride citrate
化学式: C27H33ClFN3O10 (613.18384)
中文名称: 枸橼酸莫沙必利
谱图信息:
最多检出来源 Escherichia coli(natural_products) 33.33%
分子结构信息
SMILES: C1(=C(C=C(C(=C1)C(NCC2OCCN(C2)CC3=CC=C(C=C3)F)=O)OCC)N)Cl.OC(CC(CC(O)=O)(C(=O)O)O)=O
InChI: 13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D005765 - Gastrointestinal Agents
Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases[1][2][3][4][5][6][7].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 119583
- ChEMBL: CHEMBL1733174
- CAS: 112885-42-4
- CAS: 112885-42-4, 1229354-90-8, 112885-41-3 (free base)
- MoNA: CCMSLIB00000078128
- medchemexpress: HY-B0189A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Na-Ri Choi, Daehwa Jung, Sang-Chan Kim, Jae-Woo Park, Woo-Gyun Choi, Byung-Joo Kim. Analysis of Network Pharmacological Efficacy and Therapeutic Effectiveness in Animal Models for Functional Dyspepsia of Foeniculi fructus.
Nutrients.
2023 Jun; 15(12):. doi:
10.3390/nu15122644. [PMID: 37375548] - Ya-Lin Liu, Jian-Jun Xu, Lin-Ran Han, Xiang-Fei Liu, Mu-Hai Lin, Yun Wang, Zhe Xiao, Yun-Ke Huang, Ping Ren, Xi Huang. Meranzin Hydrate Improves Depression-Like Behaviors and Hypomotility via Ghrelin and Neurocircuitry.
Chinese journal of integrative medicine.
2022 Jul; ?(?):. doi:
10.1007/s11655-022-3308-2. [PMID: 35881212] - Dongya Chen, Jingfang Xiong, Hui Feng, Yihui Liu, Jianjun Xu, Hong Xu. The influence of mosapride on gut microbiota of carbon tetrachloride-induced cirrhosis rats based on 16S rRNA gene sequencing.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2022 Jun; 31(6):623-633. doi:
10.17219/acem/146320. [PMID: 35275452] - Karen Paola Camarillo Cárdenas, Jessica García González, Federico Alberto Argüelles Tello, Jorge Arturo Ocampo Ramírez, José Belisario Moreno Hernández, Murali Mohan Pendela. Relative bioavailability and pharmacokinetic comparison of a fixed-dose combination tablet of mosapride, pancreatin, and simethicone relative to single-component mosapride tablets in healthy Mexican subjects.
Fundamental & clinical pharmacology.
2022 Apr; 36(2):427-435. doi:
10.1111/fcp.12739. [PMID: 34837418] - Zhenyun Dou, Zhou Xu, Qizheng Wang, Jiangshu Li, Chunlin Yu, Yequan Miao, Tailiang Ren, Haijun Wang. Mosapride Citrate Combined with Divine Qu Disinfectant Oral Liquid for Children Function Dyspepsia and the Influence of Serum Factors.
Journal of healthcare engineering.
2022; 2022(?):3053277. doi:
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Journal of pharmacological sciences.
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PloS one.
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Digestive diseases and sciences.
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Diabetes research and clinical practice.
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World journal of gastroenterology.
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10.3748/wjg.v21.i31.9358. [PMID: 26309361] - Longshan Zhao, Xiaohong Sun, Zhili Xiong, Shaojie Wang. Simultaneous determination of mosapride and its active des-p-fluorobenzyl and 4'-N-oxide metabolites in rat plasma using UPLC-MS/MS: an application for a pharmacokinetic study.
Talanta.
2015 May; 137(?):130-5. doi:
10.1016/j.talanta.2015.01.021. [PMID: 25770615] - Daisuke Maruoka, Makoto Arai, Takeshi Tanaka, Kenichiro Okimoto, Arata Oyamada, Shoko Minemura, Masaru Tsuboi, Tomoaki Matsumura, Tomoo Nakagawa, Tatsuo Kanda, Tatsuro Katsuno, Fumio Imazeki, Osamu Yokosuka. Mosapride citrate increases postprandial glucagon-like peptide-1, insulin, and gene expression of sweet taste receptors.
Digestive diseases and sciences.
2015 Feb; 60(2):345-53. doi:
10.1007/s10620-014-3271-7. [PMID: 25008428] - Hirofumi Okubo, Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Toshiaki Fukushima, Yasuka Matsunaga, Haruya Ohno, Masayasu Yoneda, Hideaki Kamata, Takanori Shinjo, Misaki Iwashita, Fusanori Nishimura, Tomoichiro Asano. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model.
American journal of physiology. Gastrointestinal and liver physiology.
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2012 Jul; 50(7):524-31. doi:
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Journal of burn care & research : official publication of the American Burn Association.
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Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
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Arzneimittel-Forschung.
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Diabetes research and clinical practice.
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Japanese heart journal.
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