Gestodene (BioDeep_00000398881)
natural product
代谢物信息卡片
Gestodene
化学式: C21H26O2 (310.1932696)
中文名称: 孕二烯酮
谱图信息:
最多检出来源 Homo sapiens(natural_products) 92.86%
分子结构信息
SMILES: C1C(C=C2[C@](C1)([C@]3([C@@](CC2)([C@]4([C@](CC3)([C@@](C=C4)(O)C#C)CC)[H])[H])[H])[H])=O
InChI: InChI=1S/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:135323
- KEGGdrug: D04316
- PubChem: 3033968
- Metlin: METLIN3062
- DrugBank: DB06730
- ChEMBL: CHEMBL1213583
- CAS: 60282-87-3
- CAS: 60282-87-3, 110541-55-4
- MoNA: CCMSLIB00000078120
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Albe Carina Swanepoel, Hildegarde Cecilia Roberts, Prashilla Soma, Barend Gerhardus Lindeque, Janette Bester. Hemorheological mechanisms for increased thrombosis in subjects using gestodene.
Microscopy research and technique.
2018 Dec; 81(12):1489-1500. doi:
10.1002/jemt.23149. [PMID: 30365192] - Matheo Augusto Morandi Stumpf, Ana Claudia Garabeli Cavalli Kluthcovsky, Jefferson Matsuiti Okamoto, Gianna Carla Alberti Schrut, Patricia de Oliveira Cajoeiro, Ana Paula Marte Chacra, Ricardo Bizeli. Acute pancreatitis secondary to oral contraceptive-induced hypertriglyceridemia: a case report.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2018 Nov; 34(11):930-932. doi:
10.1080/09513590.2018.1473365. [PMID: 29782195] - Joe-Elie Salem, Pauline Dureau, Anne Bachelot, Marine Germain, Pascal Voiriot, Bruno Lebourgeois, David-Alexandre Trégouët, Jean-Sébastien Hulot, Christian Funck-Brentano. Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women.
JAMA cardiology.
2018 09; 3(9):877-882. doi:
10.1001/jamacardio.2018.2251. [PMID: 30073300] - Chao Zhang, Haiyan Li, Xin Xiong, Suodi Zhai, Yudong Wei, Shuang Zhang, Yuanyuan Zhang, Lin Xu, Li Liu. An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch.
Drug design, development and therapy.
2017; 11(?):725-731. doi:
10.2147/dddt.s131123. [PMID: 28331292] - Chunxiao Li, Meiying Ning, Xiaodong Yao, Yankun Wang, Ying Liu. Preparation and in vitro/in vivo evaluation of gestodene (GEST) intravaginal ring.
Pakistan journal of pharmaceutical sciences.
2016 Sep; 29(5):1545-1553. doi:
NULL. [PMID: 27731811] - Julia Winkler, Mark Goldammer, Matthias Ludwig, Beate Rohde, Christian Zurth. Pharmacokinetic drug-drug interaction between ethinyl estradiol and gestodene, administered as a transdermal fertility control patch, and two CYP3A4 inhibitors and a CYP3A4 substrate.
European journal of drug metabolism and pharmacokinetics.
2015 Dec; 40(4):389-99. doi:
10.1007/s13318-014-0215-8. [PMID: 24997757] - Sahar M El-Haggar, Tarek M Mostafa. Cardiovascular risk in Egyptian healthy consumers of different types of combined oral contraceptives pills: A comparative study.
Endocrine.
2015 Aug; 49(3):820-7. doi:
10.1007/s12020-014-0507-4. [PMID: 25539793] - Birte Hofmann, Isabel Reinecke, Barbara Schuett, Martin Merz, Christian Zurth. Pharmacokinetic overview of ethinyl estradiol dose and bioavailability using two transdermal contraceptive systems and a standard combined oral contraceptive.
International journal of clinical pharmacology and therapeutics.
2014 Dec; 52(12):1059-70. doi:
10.5414/cp202064. [PMID: 25295716] - Carolyn L Westhoff, Isabel Reinecke, Keith Bangerter, Martin Merz. Impact of body mass index on suppression of follicular development and ovulation using a transdermal patch containing 0.55-mg ethinyl estradiol/2.1-mg gestodene: a multicenter, open-label, uncontrolled study over three treatment cycles.
Contraception.
2014 Sep; 90(3):272-9. doi:
10.1016/j.contraception.2014.04.018. [PMID: 24969733] - Ashish Saxena, Arun Gupta, Ravisekhar Kasibhatta, Manoj Bob, V Praveen Kumar, Bipin Purwar. Rapid and sensitive method for quantification of gestodene in human plasma as the oxime derivative by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and its application to bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jan; 945-946(?):240-6. doi:
10.1016/j.jchromb.2013.12.003. [PMID: 24361980] - Wolfgang Junge, Doris Heger-Mahn, Dietmar Trummer, Martin Merz. Investigation of the hemostatic effect of a transdermal patch containing 0.55 mg ethinyl estradiol and 2.1 mg gestodene compared with a monophasic oral contraceptive containing 0.03 mg ethinyl estradiol and 0.15 mg levonorgestrel: an open-label, randomized, crossover study.
Drugs in R&D.
2013 Sep; 13(3):223-33. doi:
10.1007/s40268-013-0028-2. [PMID: 24043457] - Zoltán Lőcsei, Dóra Horváth, Károly Rácz, István Szabolcs, Gábor L Kovács, Erzsébet Toldy. Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio.
Clinical biochemistry.
2012 Nov; 45(16-17):1516-8. doi:
10.1016/j.clinbiochem.2012.06.025. [PMID: 22750772] - N H Bjarnason, H L Jørgensen, C Christiansen. Acute and long-term estradiol kinetics in smoking postmenopausal women.
Climacteric : the journal of the International Menopause Society.
2012 Oct; 15(5):449-54. doi:
10.3109/13697137.2011.628764. [PMID: 22191426] - Christina Moser, Daniela Zoderer, Gerhard Luef, Markus Rauchenzauner, Ludwig Wildt, Andrea Griesmacher, Christoph Seger. Simultaneous online SPE-LC-MS/MS quantification of six widely used synthetic progestins in human plasma.
Analytical and bioanalytical chemistry.
2012 May; 403(4):961-72. doi:
10.1007/s00216-011-5612-0. [PMID: 22160205] - Kathleen E Brummel-Ziedins, Thomas Orfeo, Matthew Gissel, Kenneth G Mann, Frits R Rosendaal. Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation.
PloS one.
2012; 7(1):e29178. doi:
10.1371/journal.pone.0029178. [PMID: 22247769] - Sille Vaiksaar, Jaak Jürimäe, Jarek Mäestu, Priit Purge, Svetlana Kalytka, Larissa Shakhlina, Toivo Jürimäe. Phase of oral contraceptive cycle and endurance capacity of rowers.
Perceptual and motor skills.
2011 Dec; 113(3):764-72. doi:
10.2466/05.06.pms.113.6.764-772. [PMID: 22403922] - Vincenzo De Leo, Alessandra Di Sabatino, Maria C Musacchio, Giuseppe Morgante, Valeria Scolaro, Antonio Cianci, Felice Petraglia. Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome.
Contraception.
2010 Sep; 82(3):276-80. doi:
10.1016/j.contraception.2010.04.002. [PMID: 20705157] - Laurence Duvillard, Guillaume Dautin, Emmanuel Florentin, Jean-Michel Petit, Philippe Gambert, Bruno Vergès. Changes in apolipoprotein B100-containing lipoprotein metabolism due to an estrogen plus progestin oral contraceptive: a stable isotope kinetic study.
The Journal of clinical endocrinology and metabolism.
2010 May; 95(5):2140-6. doi:
10.1210/jc.2009-2480. [PMID: 20200333] - Zhili Xiong, Xiaohong Sun, Taoguang Huo, Ning Li, Yan Zheng, Yi Sun. Development and validation of UPLC-MS/MS method for simultaneous determination of gestodene and ethinyl estradiol in rat plasma.
Biomedical chromatography : BMC.
2010 Feb; 24(2):160-8. doi:
10.1002/bmc.1265. [PMID: 19591119] - Giovanni Fazio, Filippo Ferrara, Giuseppe Barbaro, Gullotti Alessandro, Giovanni Ferrro, Giuseppina Novo, Salvatore Novo. Protrhombotic effects of contraceptives.
Current pharmaceutical design.
2010; 16(31):3490-6. doi:
10.2174/138161210793563374. [PMID: 20858187] - Xiao-Fen Liu, Cun-Gang Ding, Qing-Hua Ge, Zhen Zhou, Xiao-Jin Zhi. [Simultaneous determination of gestodene, etonogestrel and ethinylestradiol in plasma by LC-MS/MS following derivatization].
Yao xue xue bao = Acta pharmaceutica Sinica.
2010 Jan; 45(1):87-92. doi:
NULL. [PMID: 21351455] - Mary J G Zamboni, Carlos A P Cabral, Francisco J B Sampaio, Luiz E M Cardoso. Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women.
International urogynecology journal and pelvic floor dysfunction.
2009 Nov; 20(11):1353-9. doi:
10.1007/s00192-009-0948-0. [PMID: 19578802] - Recep Yildizhan, Begum Yildizhan, Ertan Adali, Pinar Yoruk, Fatih Birol, Necdet Suer. Effects of two combined oral contraceptives containing ethinyl estradiol 30 microg combined with either gestodene or drospirenone on hemostatic parameters, lipid profiles and blood pressure.
Archives of gynecology and obstetrics.
2009 Aug; 280(2):255-61. doi:
10.1007/s00404-008-0907-x. [PMID: 19125264] - Lisa H Xie, Qigui Li, Jing Zhang, Peter J Weina. Pharmacokinetics, tissue distribution and mass balance of radiolabeled dihydroartemisinin in male rats.
Malaria journal.
2009 May; 8(?):112. doi:
10.1186/1475-2875-8-112. [PMID: 19470172] - Kostas Stylianou, George Tsirakis, Elpis Mantadakis, Irini Xylouri, Andreas Foudoulakis, Eleftheria Vardaki, Irene Katsipi, Eugene Daphnis, George Samonis. Refractory thrombotic thrombocytopenic purpura associated with oral contraceptives and factor V Leiden: a case report.
Cases journal.
2009 May; 2(?):6611. doi:
10.1186/1757-1626-2-6611. [PMID: 19829833] - Reagan L Ross, Michelle R Serock, Raouf A Khalil. Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease.
Current cardiology reviews.
2008 Nov; 4(4):309-22. doi:
10.2174/157340308786349462. [PMID: 20066139] - Yi Sun, Jiancheng Wang, Xuan Zhang, Zhijun Zhang, Yan Zheng, Dawei Chen, Qiang Zhang. Synchronic release of two hormonal contraceptives for about one month from the PLGA microspheres: in vitro and in vivo studies.
Journal of controlled release : official journal of the Controlled Release Society.
2008 Aug; 129(3):192-9. doi:
10.1016/j.jconrel.2008.04.022. [PMID: 18539353] - Marjo J Karjalainen, Pertti J Neuvonen, Janne T Backman. In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions.
Basic & clinical pharmacology & toxicology.
2008 Aug; 103(2):157-65. doi:
10.1111/j.1742-7843.2008.00252.x. [PMID: 18816299] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Shu-Feng Zhou. Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.
Current drug metabolism.
2008 May; 9(4):310-22. doi:
10.2174/138920008784220664. [PMID: 18473749] - B Jakov. [The place of miligest in the clinical practice ].
Akusherstvo i ginekologiia.
2008; 47 Suppl 2(?):10-2. doi:
". [PMID: 19504702] - G Radinski. [Modern extremely low dose oral contraception with lindynette 20].
Akusherstvo i ginekologiia.
2008; 47 Suppl 2(?):40-2. doi:
". [PMID: 19504706] - Subroto Acharjee, Francine K Welty. Atorvastatin and cardiovascular risk in the elderly--patient considerations.
Clinical interventions in aging.
2008; 3(2):299-314. doi:
10.2147/cia.s2442. [PMID: 18686752] - Shu-Feng Zhou, Charlie Changli Xue, Xue-Qing Yu, Chunguang Li, Guangji Wang. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring.
Therapeutic drug monitoring.
2007 Dec; 29(6):687-710. doi:
10.1097/ftd.0b013e31815c16f5. [PMID: 18043468] - Svetlana N Tchaikovski, Huib A A M van Vliet, M C L G D Thomassen, Rogier M Bertina, Frits R Rosendaal, Per-Morten Sandset, Frans M Helmerhorst, Guido Tans, Jan Rosing. Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography.
Thrombosis and haemostasis.
2007 Dec; 98(6):1350-6. doi:
. [PMID: 18064335] - L Keski-Nisula, J Pekkanen, B Xu, T Putus, P Koskela. Does the pill make a difference? Previous maternal use of contraceptive pills and allergic diseases among offspring.
Allergy.
2006 Dec; 61(12):1467-72. doi:
10.1111/j.1398-9995.2006.01201.x. [PMID: 17073879] - Svetlana Tchaikovski, Guido Tans, Jan Rosing. Venous thrombosis and oral contraceptives: current status.
Women's health (London, England).
2006 Sep; 2(5):761-72. doi:
10.2217/17455057.2.5.761. [PMID: 19803829] - Marco Gambacciani, Barbara Cappagli, Veronica Lazzarini, Massimo Ciaponi, Franca Fruzzetti, Andrea Riccardo Genazzani. Longitudinal evaluation of perimenopausal bone loss: effects of different low dose oral contraceptive preparations on bone mineral density.
Maturitas.
2006 May; 54(2):176-80. doi:
10.1016/j.maturitas.2005.10.007. [PMID: 16332417] - M O Verhoeven, M Hemelaar, M J van der Mooren, P Kenemans, T Teerlink. Oral, more than transdermal, oestrogen therapy lowers asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study.
Journal of internal medicine.
2006 Feb; 259(2):199-208. doi:
10.1111/j.1365-2796.2005.01602.x. [PMID: 16420549] - Marika T Granfors, Janne T Backman, Jouko Laitila, Pertti J Neuvonen. Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and effects of tizanidine by inhibiting cytochrome P450 1A2.
Clinical pharmacology and therapeutics.
2005 Oct; 78(4):400-11. doi:
10.1016/j.clpt.2005.06.009. [PMID: 16198659] - Majoie Hemelaar, Marius J van der Mooren, W Marchien van Baal, Casper G Schalkwijk, Peter Kenemans, Coen D A Stehouwer. Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women.
Menopause (New York, N.Y.).
2005 Sep; 12(5):526-35. doi:
10.1097/01.gme.0000153888.94399.af. [PMID: 16145306] - Christina Aparecida Falbo Guazzelli, Prescilla Chow Lindsey, Fabio Fernando de Araújo, Márcia Barbieri, Carlos Alberto Petta, Jose Mendes Aldrighi. Evaluation of lipid profile in adolescents during long-term use of combined oral hormonal contraceptives.
Contraception.
2005 Feb; 71(2):118-21. doi:
10.1016/j.contraception.2004.08.002. [PMID: 15707561] - Carmine Nappi, Attilio Di Spiezio Sardo, Elena Greco, Giovanni A Tommaselli, Elena Giordano, Maurizio Guida. Effects of an oral contraceptive containing drospirenone on bone turnover and bone mineral density.
Obstetrics and gynecology.
2005 Jan; 105(1):53-60. doi:
10.1097/01.aog.0000148344.26475.fc. [PMID: 15625142] - K Guzelmeric, N Seker, O Unal, C Turan. High serum prostate-specific antigen concentrations in hirsute women do not decrease with treatment by the combination of spironolactone and the contraceptive pill.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2004 Oct; 19(4):190-5. doi:
10.1080/09513590400012069. [PMID: 15724801] - G Benagiano, F M Primiero, M Farris. Clinical profile of contraceptive progestins.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2004 Sep; 9(3):182-93. doi:
10.1080/13625180400007736. [PMID: 15697108] - D Heger-Mahn, C Warlimont, T Faustmann, C Gerlinger, C Klipping. Combined ethinylestradiol/gestodene contraceptive patch: two-center, open-label study of ovulation inhibition, acceptability and safety over two cycles in female volunteers.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.
2004 Sep; 9(3):173-81. doi:
10.1080/13625180400008940. [PMID: 15697107] - Tomasz Rechberger, Jacek Tomaszewski, Anna Pieprzowska-Białek, Beata Kulik-Rechberger, Paweł Skorupski. Serum resistin levels in women taking combined oral contraceptives containing desogestrel or gestodene.
Contraception.
2004 Jun; 69(6):477-80. doi:
10.1016/j.contraception.2004.01.003. [PMID: 15157792] - J Endrikat, J Wessel, P Rosenbaum, B Düsterberg. Plasma concentrations of endogenous hormones during one regular treatment cycle with a low-dose oral contraceptive and during two cycles with deliberate omission of two tablets.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2004 Jun; 18(6):318-26. doi:
10.1080/0951359042000199869. [PMID: 15497494] - Margit Fröhlich, Jürgen Burhenne, Meret Martin-Facklam, Johanna Weiss, Michael von Wolff, Thomas Strowitzki, Ingeborg Walter-Sack, Walter E Haefeli. Oral contraception does not alter single dose saquinavir pharmacokinetics in women.
British journal of clinical pharmacology.
2004 Mar; 57(3):244-52. doi:
10.1111/j.1365-2125.2003.01983.x. [PMID: 14998420] - Angela Döring, Margit Fröhlich, Hannelore Löwel, Wolfgang Koenig. Third generation oral contraceptive use and cardiovascular risk factors.
Atherosclerosis.
2004 Feb; 172(2):281-6. doi:
10.1016/j.atherosclerosis.2003.10.005. [PMID: 15019538] - Anne Bloch Thomsen, Sandra Silvestri, Jens Haarbo, Claus Christiansen, Nina H Bjarnason. Associated response in bone and lipids during hormone replacement therapy.
Maturitas.
2004 Jan; 47(1):39-45. doi:
10.1016/s0378-5122(03)00225-1. [PMID: 14706764] - F Orio, S Palomba, T Cascella, L Tauchmanovà, S Di Biase, D Labella, T Russo, M Pellicano, S Savastano, F Zullo, G Lombardi, A Colao. Adrenal adenoma and normal androgen levels in a young woman with polycystic ovaries: a case of idiopathic hirsutism?.
Journal of endocrinological investigation.
2004 Jan; 27(1):61-6. doi:
10.1007/bf03350913. [PMID: 15053246] - Majoie Hemelaar, Marius J van der Mooren, Velja Mijatovic, Anneke A Bouman, Charles P T Schijf, Maurice V A M Kroeks, Henk R Franke, Peter Kenemans. Oral, more than transdermal, estrogen therapy improves lipids and lipoprotein(a) in postmenopausal women: a randomized, placebo-controlled study.
Menopause (New York, N.Y.).
2003 Nov; 10(6):550-8. doi:
10.1097/01.gme.0000064866.58809.e5. [PMID: 14627865] - M Bayés, X Rabasseda, J R Prous. Gateways to clinical trials.
Methods and findings in experimental and clinical pharmacology.
2003 Jul; 25(6):483-506. doi:
. [PMID: 12949633] - Marinka S Post, M Christella, L G D Thomassen, Marius J van der Mooren, W Marchien van Baal, Jan Rosing, Peter Kenemans, Coen D A Stehouwer. Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women.
Arteriosclerosis, thrombosis, and vascular biology.
2003 Jun; 23(6):1116-21. doi:
10.1161/01.atv.0000074146.36646.c8. [PMID: 12730085] - C Nappi, A Di Spiezio Sardo, G Acunzo, G Bifulco, G A Tommaselli, M Guida, C Di Carlo. Effects of a low-dose and ultra-low-dose combined oral contraceptive use on bone turnover and bone mineral density in young fertile women: a prospective controlled randomized study.
Contraception.
2003 May; 67(5):355-9. doi:
10.1016/s0010-7824(03)00025-8. [PMID: 12742557] - H Seeger, D Wallwiener, A O Mueck. The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2003 Feb; 35(2):76-80. doi:
10.1055/s-2003-39061. [PMID: 12734785] - Guido Tans, Bonno N Bouma, Harry R Büller, Jan Rosing. Changes of hemostatic variables during oral contraceptive use.
Seminars in vascular medicine.
2003 Feb; 3(1):61-8. doi:
10.1055/s-2003-38333. [PMID: 15199493] - R G V Smolders, M J van der Mooren, T Teerlink, J M W M Merkus, M V A M Kroeks, H R Franke, C D A Stehouwer, P Kenemans. A randomized placebo-controlled study of the effect of transdermal vs. oral estradiol with or without gestodene on homocysteine levels.
Fertility and sterility.
2003 Feb; 79(2):261-7. doi:
10.1016/s0015-0282(02)04661-7. [PMID: 12568832] - Bea C Tanis, Frits R Rosendaal. Venous and arterial thrombosis during oral contraceptive use: risks and risk factors.
Seminars in vascular medicine.
2003 Feb; 3(1):69-84. doi:
10.1055/s-2003-38334. [PMID: 15199494] - Salvatore Caruso, Luigi Maiolino, Salvatore Rugolo, Giorgia Intelisano, Marco Farina, Salvatore Cocuzza, Agostino Serra. Auditory brainstem response in premenopausal women taking oral contraceptives.
Human reproduction (Oxford, England).
2003 Jan; 18(1):85-9. doi:
10.1093/humrep/deg003. [PMID: 12525445] - Stefan Störk, Clemens von Schacky, Peter Angerer. The effect of 17beta-estradiol on endothelial and inflammatory markers in postmenopausal women: a randomized, controlled trial.
Atherosclerosis.
2002 Dec; 165(2):301-7. doi:
10.1016/s0021-9150(02)00242-3. [PMID: 12417281] - M S Post, M J van der Mooren, C D A Stehouwer, W M van Baal, V Mijatovic, C G Schalkwijk, P Kenemans. Effects of transdermal and oral oestrogen replacement therapy on C-reactive protein levels in postmenopausal women: a randomised, placebo-controlled trial.
Thrombosis and haemostasis.
2002 Oct; 88(4):605-10. doi:
10.1055/s-0037-1613263. [PMID: 12362231] - Gabriele S Merki-Feld, Bruno Imthurn, Paul J Keller. Effects of two oral contraceptives on plasma levels of nitric oxide, homocysteine, and lipid metabolism.
Metabolism: clinical and experimental.
2002 Sep; 51(9):1216-21. doi:
10.1053/meta.2002.34038. [PMID: 12200770] - C Kluft, J A Gevers Leuven, F M Helmerhorst, H M J Krans. Pro-inflammatory effects of oestrogens during use of oral contraceptives and hormone replacement treatment.
Vascular pharmacology.
2002 Aug; 39(3):149-54. doi:
10.1016/s1537-1891(02)00304-x. [PMID: 12616983] - Kitty W M Bloemenkamp, Moniek P M de Maat, Marianne C Dersjant-Roorda, Frans M Helmerhorst, Cornelis Kluft. Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction.
Vascular pharmacology.
2002 Aug; 39(3):131-6. doi:
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