Biperiden hydrochloride (BioDeep_00000398864)

   

natural product


代谢物信息卡片


Biperidene hydrochloride

化学式: C21H30ClNO (347.20158000000004)
中文名称: 盐酸比哌立登
谱图信息: 最多检出来源 Escherichia coli(natural_products) 93.33%

分子结构信息

SMILES: C1(=CC(=CC=C1)C(CCN2CCCCC2)(C3CC4C=CC(C4)3)O).Cl
InChI: 1H

描述信息

D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent

同义名列表

2 个代谢物同义名

Biperidene hydrochloride; Biperiden hydrochloride



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yumi Hoshino, Masashi Yamazaki, Yusuke Mochizuki, Hideo Makishita, Kunihiro Yoshida. [A case suspected of dystonia with marked cerebellar atrophy with torsion dystonia of the neck and cerebellar ataxia that developed during pharmacologic schizophrenia treatment]. Rinsho shinkeigaku = Clinical neurology. 2020 Aug; 60(8):520-526. doi: 10.5692/clinicalneurol.60.cn-001395. [PMID: 32641633]
  • Duygu Kınay, Ahmet Zihni Soyata. Biperiden-Induced Delirium In A Five-Years Old Child. Current drug safety. 2019; 14(1):48-50. doi: 10.2174/1574886313666181029101830. [PMID: 30370855]
  • Hisahiro Yoshida, Minori Takahashi, Misuzu Honda, Hideaki Amayasu, Masazumi Ando. Co-administration of Magnesium Oxide Reduces the Serum Concentration of Hydrophobic Basic Drugs in Patients Treated with Antipsychotic Drugs. Biological & pharmaceutical bulletin. 2019; 42(6):1025-1029. doi: 10.1248/bpb.b18-00733. [PMID: 31155577]
  • Takafumi Ota, Itaru Miura, Keiko Kanno-Nozaki, Hiroshi Hoshino, Sho Horikoshi, Haruo Fujimori, Tomoyuki Kanno, Hirobumi Mashiko, Hirooki Yabe. Effects of Shakuyaku-Kanzo-to on Extrapyramidal Symptoms During Antipsychotic Treatment: A Randomized, Open-Label Study. Journal of clinical psychopharmacology. 2015 Jun; 35(3):304-7. doi: 10.1097/jcp.0000000000000312. [PMID: 25839338]
  • Victoria Samanidou, Christos Stathatos, Samuel Njau, Leda Kovatsi. Disposable pipette extraction for the simultaneous determination of biperiden and three antipsychotic drugs in human urine by GC-nitrogen phosphorus detection. Bioanalysis. 2013 Jan; 5(1):21-9. doi: 10.4155/bio.12.292. [PMID: 23256469]
  • F A Brightman, D E Leahy, G E Searle, S Thomas. Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma. Drug metabolism and disposition: the biological fate of chemicals. 2006 Jan; 34(1):94-101. doi: 10.1124/dmd.105.004838. [PMID: 16221756]
  • Kamal A Hadidi. Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden. Legal medicine (Tokyo, Japan). 2004 Oct; 6(4):233-41. doi: 10.1016/j.legalmed.2004.06.001. [PMID: 15363448]
  • Hüseyin Caksen, Dursun Odabaş, Omer Anlar. Use of biperiden hydrochloride in a child with severe dyskinesia induced by phenytoin. Journal of child neurology. 2003 Jul; 18(7):494-6. doi: 10.1177/08830738030180070101. [PMID: 12940655]
  • B R Capacio, C E Byers, S T Caro, J H McDonough. Pharmacokinetics of intramuscularly administered biperiden in guinea pigs challenged with soman. Drug and chemical toxicology. 2003 Feb; 26(1):1-13. doi: 10.1081/dct-120017553. [PMID: 12643036]
  • Jin Shimakura, Naoko Tani, Yoshiko Mizuno, Setsuko Komuro, Hiroshi Kanamaru. In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes. European journal of drug metabolism and pharmacokinetics. 2003 Jan; 28(1):67-72. doi: 10.1007/bf03190869. [PMID: 14503667]
  • K Yokogawa, J Ishizaki, S Ohkuma, K Miyamoto. Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model. Methods and findings in experimental and clinical pharmacology. 2002 Mar; 24(2):81-93. doi: 10.1358/mf.2002.24.2.677131. [PMID: 12040887]
  • B R Capacio, S T Caro, J R Smith, C E Byers. The determination of biperiden in plasma using gas chromatography mass spectrometry: pharmacokinetics after intramuscular administration to guinea pigs. Biomedical chromatography : BMC. 2002 Feb; 16(1):47-55. doi: 10.1002/bmc.113. [PMID: 11816011]
  • S K Guthrie, L Manzey, D Scott, B Giordani, R Tandon. Comparison of central and peripheral pharmacologic effects of biperiden and trihexyphenidyl in human volunteers. Journal of clinical psychopharmacology. 2000 Feb; 20(1):77-83. doi: 10.1097/00004714-200002000-00013. [PMID: 10653212]
  • S Isawa, M Murasaki, S Miura, M Yoshioka, M Uchiumi, Y Kumagai, S Aoki, H Hisazumi, S Kudo. Pharmacokinetic and pharmacodynamic interactions among haloperidol, carteolol hydrochloride and biperiden hydrochloride. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. 1999 Jul; 19(3):111-8. doi: NULL. [PMID: 10495985]
  • Y Sudo, T Suhara, K Suzuki, Y Okubo, K Yoshikawa, S Uchida, T Sassa, T Okauchi, Y Sasaki, M Matsushita. Muscarinic receptor occupancy by biperiden in living human brain. Life sciences. 1999; 64(8):PL99-104. doi: 10.1016/s0024-3205(98)00613-4. [PMID: 10069534]
  • J Ishizaki, K Yokogawa, E Nakashima, S Ohkuma, F Ichimura. Influence of ammonium chloride on the tissue distribution of anticholinergic drugs in rats. The Journal of pharmacy and pharmacology. 1998 Jul; 50(7):761-6. doi: 10.1111/j.2042-7158.1998.tb07137.x. [PMID: 9720625]
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  • J Ishizaki, K Yokogawa, E Nakashima, T Takayasu, T Ohshima, F Ichimura. Effect of sequence of administration on the pharmacokinetic interaction between the anticholinergic drug biperiden and [3H]quinuclidinyl benzylate or [3H]N-methylscopolamine in rats. The Journal of pharmacy and pharmacology. 1998 Feb; 50(2):189-96. doi: 10.1111/j.2042-7158.1998.tb06175.x. [PMID: 9530987]
  • J Ishizaki, K Yokogawa, E Nakashima, S Ohkuma, F Ichimura. Characteristic subcellular distribution, in brain, heart and lung, of biperiden, trihexyphenidyl, and (-)-quinuclidinyl benzylate in rats. Biological & pharmaceutical bulletin. 1998 Jan; 21(1):67-71. doi: 10.1248/bpb.21.67. [PMID: 9477171]
  • K Otani, M Ishida, N Yasui, T Kondo, K Mihara, A Suzuki, S Kaneko, Y Inoue, M Shibata, K Ikeda. No effect of the anticholinergic drugs trihexyphenidyl and biperiden on the plasma concentrations of bromperidol and its reduced metabolite. Therapeutic drug monitoring. 1997 Apr; 19(2):165-8. doi: 10.1097/00007691-199704000-00008. [PMID: 9108644]
  • J Kassa. Importance of cholinolytic drug selection for the efficacy of HI-6 against soman in rats. Toxicology. 1997 Jan; 116(1-3):147-52. doi: 10.1016/s0300-483x(96)03537-8. [PMID: 9020515]
  • K Meszaros, E Lenzinger, K Hornik, G Schönbeck, R Hatzinger, G Langer, W Sieghart, H N Aschauer. Biperiden and haloperidol plasma levels and extrapyramidal side effects in schizophrenic patients. Neuropsychobiology. 1997; 36(2):69-72. doi: 10.1159/000119365. [PMID: 9267855]
  • F Unal, S Hizli, H Ozyürek, B Sonuvar. Fever and altered consciousness are not always equal to central nervous system infection: neuroleptic malignant syndrome in a 15-year-old girl. The Turkish journal of pediatrics. 1996 Oct; 38(4):505-10. doi: NULL. [PMID: 8993181]
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  • S Ulrich, F P Meyer, B Bogerts. A capillary gas-liquid chromatographic method for the assay of the neuroleptic drug zotepine in human serum or plasma. Journal of pharmaceutical and biomedical analysis. 1996 Feb; 14(4):441-9. doi: 10.1016/0731-7085(95)01637-6. [PMID: 8729643]
  • J Fritze, M Lanczik, E Sofic, M Struck, P Riederer. Cholinergic neurotransmission seems not to be involved in depression but possibly in personality. Journal of psychiatry & neuroscience : JPN. 1995 Jan; 20(1):39-48. doi: . [PMID: 7865500]
  • B H Ahlner, E Hagelqvist, M G Lind. Influence on rabbit submandibular gland injury by stimulation or inhibition of gland function during irradiation. Histology and morphometry after 15 gray. The Annals of otology, rhinology, and laryngology. 1994 Feb; 103(2):125-34. doi: 10.1177/000348949410300208. [PMID: 8311388]
  • E Nakashima, J Ishizaki, M Takeda, R Matsushita, K Yokogawa, F Ichimura. Pharmacokinetics of anticholinergic drugs and brain muscarinic receptor alterations in streptozotocin diabetic rats. Biopharmaceutics & drug disposition. 1993 Nov; 14(8):673-84. doi: 10.1002/bdd.2510140804. [PMID: 8305628]
  • W Yisak, L Farde, C von Bahr, L B Nilsson, G Fredriksson, S Ogenstad. Interaction study between remoxipride and biperiden. Psychopharmacology. 1993; 111(1):27-32. doi: 10.1007/bf02257403. [PMID: 7870930]
  • K Otani, T Hirano, T Kondo, S Kaneko, Y Fukushima, K Noda, Y Tashiro. Biperiden and piroheptine do not affect the serum level of zotepine, a new antipsychotic drug. The British journal of psychiatry : the journal of mental science. 1990 Jul; 157(?):128-30. doi: 10.1192/bjp.157.1.128. [PMID: 1975759]
  • J M Rabey, Z Oberman, M Scharf, M Isakov, M Bar, E Graff. Bromocriptine blood levels after the concomitant administration of levodopa, amantadine and biperiden in Parkinson's disease. Acta neurologica Scandinavica. 1990 May; 81(5):411-5. doi: 10.1111/j.1600-0404.1990.tb00986.x. [PMID: 2375243]
  • K Yokogawa, E Nakashima, F Ichimura. Effect of fat tissue volume on the distribution kinetics of biperiden as a function of age in rats. Drug metabolism and disposition: the biological fate of chemicals. 1990 Mar; 18(2):258-63. doi: NULL. [PMID: 1971583]
  • W Yisak, C von Bahr, L Farde, M Grind, M Mattila, S Ogenstad. Drug interaction studies with remoxipride. Acta psychiatrica Scandinavica. Supplementum. 1990; 358(?):58-62. doi: 10.1111/j.1600-0447.1990.tb05290.x. [PMID: 1978492]
  • L Stoll, P Fleckenstein, D Riemann, W E Müller. A simple but highly sensitive radioreceptor assay for the determination of scopolamine and biperiden in human plasma. Research communications in chemical pathology and pharmacology. 1989 Apr; 64(1):59-68. doi: NULL. [PMID: 2749003]
  • E Martignoni, F Facchinetti, G Sances, F Petraglia, G Nappi, A R Genazzani. Acetyl-L-carnitine acutely administered raises beta-endorphin and cortisol plasma levels in humans. Clinical neuropharmacology. 1988 Oct; 11(5):472-7. doi: 10.1097/00002826-198810000-00009. [PMID: 2975529]
  • W Hewer, S Biedert. [Delirium syndrome in biperiden poisoning]. Fortschritte der Neurologie-Psychiatrie. 1988 Apr; 56(4):133-6. doi: 10.1055/s-2007-1001778. [PMID: 3384382]
  • M Hollmann, H Müller-Peltzer, G Greger, E Brode, E Perucca, R Grimaldi, A Crema. Pharmacokinetic-dynamic study on different oral biperiden formulations in volunteers. Pharmacopsychiatry. 1987 Mar; 20(2):72-7. doi: 10.1055/s-2007-1017079. [PMID: 3588663]
  • E Nakashima, K Yokogawa, F Ichimura, T Hashimoto, T Yamana, A Tsuji. Effects of fasting on biperiden pharmacokinetics in the rat. Journal of pharmaceutical sciences. 1987 Jan; 76(1):10-3. doi: 10.1002/jps.2600760104. [PMID: 3585715]
  • K Yokogawa, E Nakashima, F Ichimura, T Yamana. Fundamental pharmacokinetic properties of biperiden: tissue distribution and elimination in rabbits. Journal of pharmacobio-dynamics. 1986 Apr; 9(4):409-16. doi: 10.1248/bpb1978.9.409. [PMID: 3735062]
  • R Grimaldi, E Perucca, G Ruberto, C Gelmi, F Trimarchi, M Hollmann, A Crema. Pharmacokinetic and pharmacodynamic studies following the intravenous and oral administration of the antiparkinsonian drug biperiden to normal subjects. European journal of clinical pharmacology. 1986; 29(6):735-7. doi: 10.1007/bf00615970. [PMID: 3709619]
  • K Yokogawa, E Nakashima, F Ichimura, T Yamana. Simultaneous microdetermination of biperiden, haloperidol, and trihexyphenidyl in plasma and its application to pharmacokinetic analysis after concomitant intravenous administration of the drugs to rabbits. Chemical & pharmaceutical bulletin. 1985 Oct; 33(10):4581-6. doi: 10.1248/cpb.33.4581. [PMID: 4092273]
  • T Le Bris, E Brode. Capillary gas chromatographic determination of biperiden in human plasma. Arzneimittel-Forschung. 1985; 35(1):149-51. doi: NULL. [PMID: 4039144]
  • M Kuniyoshi, K Inanaga. Haloperidol and biperiden plasma levels in a pregnant atypical psychotic woman and a neonate--a case report. The Kurume medical journal. 1985; 32(3):199-202. doi: 10.2739/kurumemedj.32.199. [PMID: 3835398]
  • Y Fujii, M Tateyama, M Kamisada, A Tanoue, M Takamiya, S Nakajima, H Itoh. Clinical efficacy, extrapyramidal symptoms and serum levels: influence of administration schedules and concomitant drugs on serum bromperidol concentrations. Folia psychiatrica et neurologica japonica. 1984; 38(2):121-36. doi: 10.1111/j.1440-1819.1984.tb00360.x. [PMID: 6152433]
  • M Hollmann, E Brode, G Greger, H Müller-Peltzer, N Wetzelsberger. Biperiden effects and plasma levels in volunteers. European journal of clinical pharmacology. 1984; 27(5):619-21. doi: 10.1007/bf00556903. [PMID: 6519170]
  • P Ottoila, J Taskinen. Determination of biperiden in human serum by glass capillary gas chromatography with isothermal splitless injection and nitrogen-sensitive detection. Journal of chromatography. 1981 Dec; 226(2):488-91. doi: 10.1016/s0378-4347(00)86086-7. [PMID: 7320179]
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