imiquimod (BioDeep_00000398839)
natural product Chemicals and Drugs Antibiotics
代谢物信息卡片
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
化学式: C14H16N4 (240.13748959999998)
中文名称: 羟丙基甲基纤维素邻苯二甲酸酯, 咪喹莫特
谱图信息:
最多检出来源 Homo sapiens(natural_products) 6.25%
分子结构信息
SMILES: CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
InChI: InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
描述信息
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
D007155 - Immunologic Factors > D007369 - Interferon Inducers
D000970 - Antineoplastic Agents
C274 - Antineoplastic Agent
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:36704
- KEGGdrug: D02500
- PubChem: 57469
- Metlin: METLIN85419
- DrugBank: DB00724
- ChEMBL: CHEMBL1282
- MeSH: Imiquimod
- CAS: 99011-02-6
- CAS: 9050-31-1
- CAS: 99011-02-6, 99011-78-6 (HCl), 896106-16-4 (Maleic acid)
- MoNA: CCMSLIB00000078049
- RefMet: Imiquimod
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tingting Li, Si Gao, Yundong Wei, Gang Wu, Yiping Feng, Yanyan Wang, Xudong Jiang, Haixue Kuang, Wei Han. Combined untargeted metabolomics and network pharmacology approaches to reveal the therapeutic role of withanolide B in psoriasis.
Journal of pharmaceutical and biomedical analysis.
2024 Aug; 245(?):116163. doi:
10.1016/j.jpba.2024.116163. [PMID: 38657365] - Guomi Wang, Tingting Xue, Qi Zheng, Xun Song, Ying Zhang, Fang Shen, Xuemin Wang, Wencheng Jiang, Le Kuai, Shaoqiong Xie, Xin Ma, Xi Chen, Bin Li. Qinzhuliangxue mixture ameliorates psoriasis by restraining apoptosis in psoriasis via downregulating the MDA-5 pathway.
Journal of ethnopharmacology.
2024 Jun; 328(?):118059. doi:
10.1016/j.jep.2024.118059. [PMID: 38508430] - Jianan Wei, Junhong Zhang, Fengju Hu, Wenjuan Zhang, Yunshan Wu, Bo Liu, Yue Lu, Li Li, Ling Han, Chuanjian Lu. Anti-psoriasis effect of 18β-glycyrrhetinic acid by breaking CCL20/CCR6 axis through its vital active group targeting GUSB/ATF2 signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155524. doi:
10.1016/j.phymed.2024.155524. [PMID: 38552435] - Lijuan Liu, Huiling Zhang, Xinran Tang, Mengge Zhang, Yayun Wu, Ya Zhao, Chuanjian Lu, Ruizhi Zhao. Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4/MyD88/NF-κB p65 signaling pathway and MMP9.
International immunopharmacology.
2024 May; 133(?):112082. doi:
10.1016/j.intimp.2024.112082. [PMID: 38652958] - Zi-Ying Zhan, Zhi-Hong Zhang, Rong-Hui Sun, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. A therapeutic strategy of parthenolide in improving imiquimod-induced psoriasis-like skin inflammation targeting IL-36/NETs through skin transdermal therapeutic system.
International immunopharmacology.
2024 Apr; 131(?):111824. doi:
10.1016/j.intimp.2024.111824. [PMID: 38461633] - Xinxin Wu, Qi Zheng, Fang Shen, Jiankun Song, Yue Luo, Xiaoya Fei, Wencheng Jiang, Shaoqiong Xie, Xin Ma, Le Kuai, Ruiping Wang, Xiaojie Ding, Miao Li, Ying Luo, Bin Li. The therapeutic efficacy and mechanism action of Si Cao formula in the treatment of psoriasis: A pilot clinical investigation and animal validation.
Journal of ethnopharmacology.
2024 Apr; 323(?):117662. doi:
10.1016/j.jep.2023.117662. [PMID: 38160866] - Yazhuo Wang, Ning Zhao, Yujiao Meng, Jia Chen, Cong Qi, Xueqing Hu, Haoyue Zhu, Danyang Yang, Xiawei Zhang, Huike Ma, Jingxia Zhao, Tingting Di, Ping Li, Yan Wang. Bcat2-Mediated Branched-Chain Amino Acid Catabolism Is Linked to the Aggravated Inflammation in Obese with Psoriasis Mice.
Molecular nutrition & food research.
2024 Apr; 68(8):e2300720. doi:
10.1002/mnfr.202300720. [PMID: 38581348] - Yongjian Li, Zhengping Tan, Wencan Li, Zongxuan Li, Guiying Zhang. Rutaecarpine ameliorates imiquimod-induced psoriasis-like dermatitis in mice associated with alterations in the gut microbiota.
Acta biochimica et biophysica Sinica.
2024 03; 56(3):345-355. doi:
10.3724/abbs.2024018. [PMID: 38419497] - Lanyue Zhang, Zeting Huang, Jie Xuan, Lu Yang, Tiantian Zhao, Weihua Peng. Anti-Psoriatic Activity of Black, Green and White Tea Extracts from Southeastern China.
Molecules (Basel, Switzerland).
2024 Mar; 29(6):. doi:
10.3390/molecules29061279. [PMID: 38542915] - Prativa Biswasroy, Deepak Pradhan, Dilip Kumar Pradhan, Goutam Ghosh, Goutam Rath. Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis.
AAPS PharmSciTech.
2024 Mar; 25(3):57. doi:
10.1208/s12249-024-02774-1. [PMID: 38472545] - Shuai Man, Wenke Ma, Hao Jiang, Ali Haider, Shasha Shi, Xiao Li, Zhuzhu Wu, Yongmei Song. Evaluating the efficacy and mechanisms of Hua-Zhuo-Ning-Fu-Decoction on psoriasis using integrated bioinformatics analysis and metabolomics.
Journal of ethnopharmacology.
2024 Feb; ?(?):117856. doi:
10.1016/j.jep.2024.117856. [PMID: 38316220] - Lei Fu, Meijiao Li, Peng Wang, Lang Chen, Jianqiu Huang, Hui Zhang. Tanshinone IIA, a component of the self-made Xiao-Yin decoction, ameliorates psoriasis by inhibiting IL-17/IL-23 and PTGS2/NF-κB/AP-1 pathways.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).
2024 Feb; 30(2):e13577. doi:
10.1111/srt.13577. [PMID: 38284293] - Menghang Zu, Ya Ma, Jun Zhang, Jianfeng Sun, Mohammad-Ali Shahbazi, Guoqing Pan, Rui L Reis, Subhas C Kundu, Jinyao Liu, Bo Xiao. An Oral Nanomedicine Elicits In Situ Vaccination Effect against Colorectal Cancer.
ACS nano.
2024 Jan; 18(4):3651-3668. doi:
10.1021/acsnano.3c11436. [PMID: 38241481] - Chia-Lin Lee, Chien-Ming Wang, Ying-Chyi Song, Chuan-Teng Liu, Mei-Yun Chu, Hung-Rong Yen. An alkaloid-rich phytopharmaceutical prepared from Qing Dai against IL-17A-induced psoriasis.
Journal of ethnopharmacology.
2024 Jan; 318(Pt A):116924. doi:
10.1016/j.jep.2023.116924. [PMID: 37454748] - XiaoYu Guo, Jianglu Zhou, Hong Yu, Han Cao, Xia Li, Qing Hu, YunQiu Yu. Serum lipidomic study of long-chain fatty acids in psoriasis patients prior to and after anti-IL-17A monoclonal antibody treatment by quantitative GC‒MS analysis with in situ extraction.
Lipids in health and disease.
2024 Jan; 23(1):6. doi:
10.1186/s12944-023-01999-6. [PMID: 38185620] - Eliška Petrová, Stanislav Chvíla, Martin Balouch, František Štěpánek, Jarmila Zbytovská. Nanoformulations for dermal delivery of imiquimod: The race of 'soft' against 'hard'.
International journal of pharmaceutics.
2023 Dec; 648(?):123577. doi:
10.1016/j.ijpharm.2023.123577. [PMID: 37931726] - Mingxia Wang, Xiaoxuan Ma, Chunjie Gao, Yue Luo, Xiaoya Fei, Qi Zheng, Xin Ma, Le Kuai, Bin Li, Ruiping Wang, Jiankun Song. Rutin attenuates inflammation by downregulating AGE-RAGE signaling pathway in psoriasis: Network pharmacology analysis and experimental evidence.
International immunopharmacology.
2023 Dec; 125(Pt A):111033. doi:
10.1016/j.intimp.2023.111033. [PMID: 38149569] - Pouria Rahmanian-Devin, Vahid Reza Askari, Zahra Sanei-Far, Vafa Baradaran Rahimi, Hossein Kamali, Mahmoud Reza Jaafari, Shiva Golmohammadzadeh. Preparation and characterization of solid lipid nanoparticles encapsulated noscapine and evaluation of its protective effects against imiquimod-induced psoriasis-like skin lesions.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115823. doi:
10.1016/j.biopha.2023.115823. [PMID: 37924792] - Teng Chen, Sheng-Jie Zhu, Shuai Xu, Yu-Quan Wang, Abudula Aji, Chen Zhang, He Wang, Fu-Lun Li, Yu-Xia Chu. Resting-state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis-like skin lesions.
Experimental dermatology.
2023 11; 32(11):1900-1914. doi:
10.1111/exd.14914. [PMID: 37622736] - Ya Zhong, Bo-Wen Zhang, Jin-Tao Li, Xin Zeng, Jun-Xia Pei, Ya-Mei Zhang, Yi-Xi Yang, Fu-Lun Li, Yu Deng, Qi Zhao. Ethanol extract of Herpetospermum caudigerum Wall ameliorates psoriasis-like skin inflammation and promotes degradation of keratinocyte-derived ICAM-1 and CXCL9.
Journal of integrative medicine.
2023 Nov; 21(6):584-592. doi:
10.1016/j.joim.2023.11.004. [PMID: 37989697] - Mark Zamansky, Doron Yariv, Valeria Feinshtein, Shimon Ben-Shabat, Amnon C Sintov. Cannabidiol-Loaded Lipid-Stabilized Nanoparticles Alleviate Psoriasis Severity in Mice: A New Approach for Improved Topical Drug Delivery.
Molecules (Basel, Switzerland).
2023 Oct; 28(19):. doi:
10.3390/molecules28196907. [PMID: 37836750] - Sahim Aziz Hazari, Afsana Sheikh, Mohammed A S Abourehab, Alaa S Tulbah, Prashant Kesharwani. Self-assembled Gallic acid loaded lecithin-chitosan hybrid nanostructured gel as a potential tool against imiquimod-induced psoriasis.
Environmental research.
2023 10; 234(?):116562. doi:
10.1016/j.envres.2023.116562. [PMID: 37419194] - Shuo Zhang, Hong-Jin Li, Chun-Mei Yang, Liu Liu, Xiao-Ying Sun, Jiao Wang, Si-Ting Chen, Yi Lu, Man-Qi Hu, Ge Yan, Ya-Qiong Zhou, Xiao Miao, Xin Li, Bin Li. Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes.
Chinese journal of integrative medicine.
2023 Aug; ?(?):. doi:
10.1007/s11655-023-3599-y. [PMID: 37597119] - Xiaoying Zhou, Chunming Lyu, Xingmi Chen, Yuhan Ye, Yuanyuan Lei, Ying Liu, Tong Zhang, Yang Yang. Fufang Shengdi mixture alleviates psoriasis-like skin inflammation via promoting Annexin-A proteins expression.
Journal of ethnopharmacology.
2023 Aug; 312(?):116329. doi:
10.1016/j.jep.2023.116329. [PMID: 36940737] - Dóra Antal, Ágnes Pór, Ilona Kovács, Katalin Dull, Szilárd Póliska, Gyula Ujlaki, Máté Ágoston Demény, Attila Gábor Szöllősi, Borbála Kiss, Andrea Szegedi, Péter Bai, Magdolna Szántó. PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes.
Journal of molecular medicine (Berlin, Germany).
2023 08; 101(8):987-999. doi:
10.1007/s00109-023-02338-z. [PMID: 37351597] - Zhenguo Cai, Wuqing Wang, Yao Zhang, Yibin Zeng. Curcumin alleviates imiquimod-induced psoriasis-like inflammation and regulates gut microbiota of mice.
Immunity, inflammation and disease.
2023 08; 11(8):e967. doi:
10.1002/iid3.967. [PMID: 37647442] - Debanjan Sarkar, Partha Gorai, Anik Pramanik, Arghadip Mondal, Naba Kumar Mondal, Biplob Kr Modak, Sankar Bhattacharyya. Characterization and active component identification of Premna herbacea roxb. root extract reveals anti-inflammatory effect and amelioration of imiquimod induced psoriasis via modulation of macrophage inflammatory response.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jul; 119(?):155007. doi:
10.1016/j.phymed.2023.155007. [PMID: 37549537] - Rania M Kamal, Manal M Sabry, Ali M El-Halawany, Mostafa A Rabie, Nesrine S El Sayed, Mohamed S Hifnawy, Inas Y Younis. GC-MS analysis and the effect of topical application of essential oils of Pinus canariensis C.Sm., Cupressus lusitanica Mill. and Cupressus arizonica Greene aerial parts in Imiquimod-Induced Psoriasis in Mice.
Journal of ethnopharmacology.
2023 Jul; 318(Pt B):116947. doi:
10.1016/j.jep.2023.116947. [PMID: 37482262] - Xinran Xie, Lei Zhang, Yan Lin, Xin Liu, Xuyang Han, Ping Li. Liangxue Jiedu formula improves imiquimod-induced psoriasiform dermatitis with circadian desynchrony by regulating Th17 cell differentiation based on network pharmacological analysis.
Journal of ethnopharmacology.
2023 Jun; ?(?):116807. doi:
10.1016/j.jep.2023.116807. [PMID: 37331449] - Wen-Cheng Chen, Chang-Hui Wen, Meng Wang, Zi-Dan Xiao, Zhong-Zhao Zhang, Chun-Lan Wu, Ran Wu. IL-23/IL-17 immune axis mediates the imiquimod-induced psoriatic inflammation by activating ACT1/TRAF6/TAK1/NF-κB pathway in macrophages and keratinocytes.
The Kaohsiung journal of medical sciences.
2023 Apr; ?(?):. doi:
10.1002/kjm2.12683. [PMID: 37098777] - Po-Jen Chen, Hsin-Hui Tseng, Yi-Hsuan Wang, Shu-Yen Fang, Shun-Hua Chen, Chun-Hong Chen, Sheng-Chieh Tsai, Yu-Chia Chang, Yung-Fong Tsai, Tsong-Long Hwang. Palbociclib blocks neutrophilic PI3K activity to alleviate psoriasiform dermatitis.
British journal of pharmacology.
2023 Mar; ?(?):. doi:
10.1111/bph.16080. [PMID: 36967633] - Se-Bin Lee, Ju-Hui Kang, Eun-Jung Sim, Ye-Rin Jung, Jeong-Hyeon Kim, Prima F Hillman, Sang-Jip Nam, Tae-Bong Kang. Cornus officinalis Seed Extract Inhibits AIM2-Inflammasome Activation and Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065653. [PMID: 36982727] - Liu Liu, Yaqiong Zhou, Dan Luo, Xiaoying Sun, Hongjin Li, Yi Lu, Jiao Wang, Miao Zhang, Naixuan Lin, Chengqian Yin, Xin Li. Aberrant promoter methylation of Wnt inhibitory factor-1 gene is a potential target for treating psoriasis.
Clinical immunology (Orlando, Fla.).
2023 Mar; 250(?):109294. doi:
10.1016/j.clim.2023.109294. [PMID: 36925027] - Zi-Ying Zhan, Zhi-Hong Zhang, Hong-Xu Yang, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Potential skin health promoting benefits of costunolide: a therapeutic strategy to improve skin inflammation in imiquimod-induced psoriasis.
Food & function.
2023 Feb; ?(?):. doi:
10.1039/d2fo02545k. [PMID: 36786020] - Mingxu Zhao, Shasha Zhu, Ding Zhang, Chang Zhou, Zhilai Yang, Chunhui Wang, Xuesheng Liu, Jiqian Zhang. Long-lasting postoperative analgesia with local anesthetic-loaded hydrogels prevent tumor recurrence via enhancing CD8+T cell infiltration.
Journal of nanobiotechnology.
2023 Feb; 21(1):50. doi:
10.1186/s12951-023-01803-8. [PMID: 36765361] - Wenzhu Yin, Bihua Deng, Zeyu Xu, Haiyan Wang, Fang Ma, Mingxu Zhou, Yu Lu, Jinqiu Zhang. Formulation and Evaluation of Lipidized Imiquimod as an Effective Adjuvant.
ACS infectious diseases.
2023 02; 9(2):378-387. doi:
10.1021/acsinfecdis.2c00583. [PMID: 36688646] - Zhenguo Cai, Yibin Zeng, Xunlong Shi, Xilin Zhang, Haiyan Zhu, Wuqing Wang. Benvitimod inhibits MCM6-meditated proliferation of keratinocytes by regulating the JAK/STAT3 pathway.
Journal of dermatological science.
2023 Feb; 109(2):71-79. doi:
10.1016/j.jdermsci.2023.01.010. [PMID: 36774328] - Feng Huang, Tong Zhang, Bin Li, Shaosong Wang, Chang Xu, Caihua Huang, Donghai Lin. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice.
Journal of ethnopharmacology.
2023 Jan; 300(?):115626. doi:
10.1016/j.jep.2022.115626. [PMID: 36049653] - Xinran Xie, Lei Zhang, Yan Lin, Xin Liu, Ning Wang, Ping Li. IL-17A exacerbates psoriasis in a STAT3 overexpressing mouse model.
PeerJ.
2023; 11(?):e15727. doi:
10.7717/peerj.15727. [PMID: 37465147] - Kaixuan Zhao, Siqi Pu, Liyun Sun, Dongmei Zhou. Gentiopicroside-Loaded Chitosan Nanoparticles Inhibit TNF-α-Induced Proliferation and Inflammatory Response in HaCaT Keratinocytes and Ameliorate Imiquimod-Induced Dermatitis Lesions in Mice.
International journal of nanomedicine.
2023; 18(?):3781-3800. doi:
10.2147/ijn.s406649. [PMID: 37457802] - Yingqin Wang, Chen Wang, Qiaolan He, Guannan Chen, Jie Yu, Jing Cang, Ming Zhong. Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux.
Frontiers in immunology.
2023; 14(?):1090202. doi:
10.3389/fimmu.2023.1090202. [PMID: 36798132] - Panpan Liu, Guixue Hou, Yehong Kuang, Lei Li, Chao Chen, Bei Yan, Wu Zhu, Jie Li, Mingliang Chen, Juan Su, Liang Lin, Xiang Chen, Cong Peng. Lipidomic profiling reveals metabolic signatures in psoriatic skin lesions.
Clinical immunology (Orlando, Fla.).
2023 01; 246(?):109212. doi:
10.1016/j.clim.2022.109212. [PMID: 36563946] - Sangseo Kim, Sadikalmahdi Abdella, Fatima Abid, Franklin Afinjuomo, Souha H Youssef, Amy Holmes, Yunmei Song, Sachin Vaidya, Sanjay Garg. Development and Optimization of Imiquimod-Loaded Nanostructured Lipid Carriers Using a Hybrid Design of Experiments Approach.
International journal of nanomedicine.
2023; 18(?):1007-1029. doi:
10.2147/ijn.s400610. [PMID: 36855538] - Yuxia Xiong, Jinshu Wang, Shilei Wang, Haixia Li, Xun Zhou. Tryptanthrin ameliorates imiquimod-induced psoriasis in mice by suppressing inflammation and oxidative stress via NF-κB/MAPK/Nrf2 pathways.
Journal of natural medicines.
2023 Jan; 77(1):188-201. doi:
10.1007/s11418-022-01664-9. [PMID: 36378401] - Ayami Saga, Masahiro Koseki, Kotaro Kanno, Jiuyang Chang, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Masumi Asaji, Katsunao Tanaka, Takashi Omatsu, Sae Nishihara, Yinghong Zhu, Kaori Ito, Hiroaki Hattori, Ikuyo Ichi, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Tohru Ohama, Shungo Hikoso, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata. A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice.
International journal of molecular sciences.
2022 Dec; 23(24):. doi:
10.3390/ijms232415855. [PMID: 36555497] - Hanqing Zhao, Xin Guo, Yunxuan Lei, Wenjie Xia, Feiyang Cai, Dehao Zhu, Yang An, Yebin Xi, Xiaoyin Niu, Zhaojun Wang, Tao Yue, Guangjie Chen. γ-Tocotrienol inhibits T helper 17 cell differentiation via the IL-6/JAK/STAT3 signaling pathway.
Molecular immunology.
2022 11; 151(?):126-133. doi:
10.1016/j.molimm.2022.09.007. [PMID: 36126500] - XueQing Hu, Cong Qi, Fang Feng, Yan Wang, TingTing Di, YuJiao Meng, Yazhuo Wang, Ning Zhao, XiaWei Zhang, Ping Li, Jingxia Zhao. Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Oct; 105(?):154384. doi:
10.1016/j.phymed.2022.154384. [PMID: 35963195] - Nojoud Al Fayez, Elham Rouhollahi, Chun Yat Ong, Jiamin Wu, Anne Nguyen, Roland Böttger, Pieter R Cullis, Dominik Witzigmann, Shyh-Dar Li. Hepatocyte-targeted delivery of imiquimod reduces hepatitis B virus surface antigen.
Journal of controlled release : official journal of the Controlled Release Society.
2022 10; 350(?):630-641. doi:
10.1016/j.jconrel.2022.08.058. [PMID: 36058352] - Xiao-Lan Ye, Chen-Chen Tang, Hui Liu, You Hu, Tian-Nan Xiang, Yue-Juan Zheng. [Reduning Injection protects flu-infected mice by inhibiting infiltration of inflammatory cells in lung and down-regulating cytokine storm].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(17):4698-4706. doi:
10.19540/j.cnki.cjcmm.20220427.402. [PMID: 36164877] - Humzah Jamshaid, Fakhar Ud Din, Maimoona Malik, Muhammad Mukhtiar, Han Gon Choi, Tofeeq Ur-Rehman, Gul Majid Khan. A cutback in Imiquimod cutaneous toxicity; comparative cutaneous toxicity analysis of Imiquimod nanotransethosomal gel with 5\% marketed cream on the BALB/c mice.
Scientific reports.
2022 08; 12(1):14244. doi:
10.1038/s41598-022-18671-1. [PMID: 35987944] - Yang Liu, Xingren Li, Xiuyin Wu, Xingyan Luo, Bingchao Yan, Chunfen Mo, Huijie Guo, Shuxia Yang, Yantang Wang, Yi Lai, Pematenzin Puno, Limei Li. Sis-25, a meroditerpenoid derivative with a cyclobutane scaffold, inhibits activated T cell proliferation by targeting GSK3β in vitro and in vivo.
European journal of pharmacology.
2022 Aug; 929(?):175151. doi:
10.1016/j.ejphar.2022.175151. [PMID: 35841942] - Bei Yan, Panpan Liu, Xiaoqin Yi, Jie Li, Nian Liu, Wu Zhu, Yehong Kuang, Xiang Chen, Cong Peng. Topical VX-509 attenuates psoriatic inflammation through the STAT3/FABP5 pathway in keratinocytes.
Pharmacological research.
2022 08; 182(?):106318. doi:
10.1016/j.phrs.2022.106318. [PMID: 35728766] - Jingyi Ma, Jiaoling Chen, Ke Xue, Chen Yu, Erle Dang, Hongjiang Qiao, Hui Fang, Bingyu Pang, Qingyang Li, Zhongbin Sun, Pei Qiao, Lei Wang, Gang Wang, Shuai Shao. LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2‒NLRC4 Axis.
The Journal of investigative dermatology.
2022 08; 142(8):2194-2204.e11. doi:
10.1016/j.jid.2022.01.012. [PMID: 35120997] - Aline Donato-Trancoso, Geórgia Correa Atella, Bruna Romana-Souza. Dietary olive oil intake aggravates psoriatic skin inflammation in mice via Nrf2 activation and polyunsaturated fatty acid imbalance.
International immunopharmacology.
2022 Jul; 108(?):108851. doi:
10.1016/j.intimp.2022.108851. [PMID: 35588658] - Wan-Jun Guo, Yi Wang, Yu Deng, Lin-Yan Cheng, Xin Liu, Ruo-Fan Xi, Sheng-Jie Zhu, Xin-Yi Feng, Liang Hua, Kan Ze, Jian-Yong Zhu, Dong-Jie Guo, Fu-Lun Li. Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61.
Journal of integrative medicine.
2022 07; 20(4):376-384. doi:
10.1016/j.joim.2022.04.004. [PMID: 35491357] - Osman Kukula, Seda Kırmızıkan, Emre Soner Tiryaki, Mustafa Nusret Çiçekli, Caner Günaydın. Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice.
Immunopharmacology and immunotoxicology.
2022 Jun; 44(3):367-372. doi:
10.1080/08923973.2022.2048849. [PMID: 35253588] - Yani Xu, Yaohui Shi, Jingxia Huang, Hongtao Gu, Chunlian Li, Lanyue Zhang, Guanting Liu, Wei Zhou, Zhiyun Du. The Essential Oil Derived from Perilla frutescens (L.) Britt. Attenuates Imiquimod-Induced Psoriasis-like Skin Lesions in BALB/c Mice.
Molecules (Basel, Switzerland).
2022 May; 27(9):. doi:
10.3390/molecules27092996. [PMID: 35566346] - Jingyi Mao, Xin Ma, Jiong Zhu, Huimin Zhang. Ginsenoside Rg1 ameliorates psoriasis-like skin lesions by suppressing proliferation and NLRP3 inflammasomes in keratinocytes.
Journal of food biochemistry.
2022 05; 46(5):e14053. doi:
10.1111/jfbc.14053. [PMID: 35218026] - Luyiyun Liang, Rina Takamiya, Yoshimi Miki, Kanako Heike, Yoshitaka Taketomi, Nao Sugimoto, Midori Yamaguchi, Hiroshi Shitara, Yasumasa Nishito, Tetsuyuki Kobayashi, Tetsuya Hirabayashi, Makoto Murakami. Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2022 05; 36(5):e22301. doi:
10.1096/fj.202101958r. [PMID: 35478358] - Theodora Tsironi, Georgios Gaitanis, Charalambos Pappas, Vasileios Koutlas, Evangelia Dounousi, Ioannis D Bassukas. Immunocryosurgery is a safe and feasible treatment for basal cell carcinoma and Bowen disease in renal transplant recipients.
Dermatologic therapy.
2022 05; 35(5):e15405. doi:
10.1111/dth.15405. [PMID: 35194902] - Chih-Hua Tseng, Chwan-Fwu Lin, Ibrahim A Aljuffali, Jhao-Rong Huang, Sien-Hung Yang, Jia-You Fang. The effectiveness of synthetic methoxylated isoflavones in delivering to the skin and alleviating psoriasiform lesions via topical absorption.
International journal of pharmaceutics.
2022 Apr; 617(?):121629. doi:
10.1016/j.ijpharm.2022.121629. [PMID: 35245633] - Rodrigo Rocco, Adrián E Cambindo Botto, Manuel J Muñoz, Hernán Reingruber, Rosa Wainstok, Adriana Cochón, Silvina Gazzaniga. Early redox homeostasis disruption contributes to the differential cytotoxicity of imiquimod on transformed and normal endothelial cells.
Experimental dermatology.
2022 04; 31(4):608-614. doi:
10.1111/exd.14499. [PMID: 34758172] - Claudia Cervantes-Durán, Miguel Avalos-Viveros, Luz Torner, Sandra-Guadalupe Sánchez-Ceja, Alain-Raimundo Rodríguez-Orozco, Héctor-Eduardo Martínez-Flores, Martha-Estrella García-Pérez. The 5-HT1A receptor agonist, 8-OH-DPAT, attenuates long-lasting pain in imiquimod-induced psoriasis in mice.
Experimental dermatology.
2022 04; 31(4):600-607. doi:
10.1111/exd.14492. [PMID: 34726306] - Tingjun Tao, Yan Chen, Bochen Lai, Jinhua Wang, Weiliang Wang, Weimian Xiao, Xushan Cha. Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis.
Bioengineered.
2022 04; 13(4):11146-11155. doi:
10.1080/21655979.2022.2062090. [PMID: 35485255] - Yang Su, Fan Zhang, Lun Wu, Haixue Kuang, Qiuhong Wang, Genhong Cheng. Total withanolides ameliorates imiquimod-induced psoriasis-like skin inflammation.
Journal of ethnopharmacology.
2022 Mar; 285(?):114895. doi:
10.1016/j.jep.2021.114895. [PMID: 34875348] - Ruo-Xi Chen, Sheng Zheng, Chun-Yan Guo, Qiang Zhang. [Effects of Astragalus polysaccharide on imiquimod-induced psoriasiform dermatitis in mice and its mechanisms].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2022 Mar; 38(2):154-159. doi:
10.12047/j.cjap.6214.2022.022. [PMID: 36031574] - Jingjing Lv, Yan Wang, Jingna Xu, Tao Zhou, Zhaoxia Chen, Haoyu Yang, Tingting Di, Ping Li. Protective effect of Yangxue Jiedu Soup against psoriasis-like lesions by regulating TLR4/NF-κB signaling pathway mediated by secretion of exosome HSP70.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Mar; 147(?):112604. doi:
10.1016/j.biopha.2021.112604. [PMID: 34998030] - Liu Liu, Xi Chen, Yi Lu, Xiao-Ying Sun, Kan Ze, Ya-Qiong Zhou, Wei Li, Xin Li, Hong-Jin Li, Bin Li. Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Mar; 147(?):112644. doi:
10.1016/j.biopha.2022.112644. [PMID: 35051865] - Qingqing Xu, Zhaoyang Liu, Zhiqiang Cao, Yongjian Shi, Ning Yang, Guangshang Cao, Chunmin Zhang, Rong Sun, Chunhong Zhang. Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis.
Journal of cellular and molecular medicine.
2022 02; 26(4):1281-1292. doi:
10.1111/jcmm.17184. [PMID: 35023281] - Hong Li, Caiguo Zhang, Li Bian, Hui Deng, Melanie Blevins, Gangwen Han, Bin Fan, Chunxia Yang, Rui Zhao, Whitney High, David Norris, Mayumi Fujita, Xiao-Jing Wang, Mingxia Huang. Inhibition of CtBP-Regulated Proinflammatory Gene Transcription Attenuates Psoriatic Skin Inflammation.
The Journal of investigative dermatology.
2022 02; 142(2):390-401. doi:
10.1016/j.jid.2021.06.029. [PMID: 34293351] - Jiankun Song, Jingsi Jiang, Le Kuai, Yue Luo, Meng Xing, Ying Luo, Yi Ru, Xiaoying Sun, Huiping Zhang, Taiyi Liu, Xin Li, Bin Li. TMT-based proteomics analysis reveals the protective effect of Jueyin granules on imiquimod-induced psoriasis mouse model by causing autophagy.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Feb; 96(?):153846. doi:
10.1016/j.phymed.2021.153846. [PMID: 34785109] - Yu-Jiao Meng, Yu Liu, Zheng-Rong Liu, Zhao-Xia Chen, Ting-Ting Di, Jing-Xia Zhao, Yan Wang, Ping Li. [Effect of moxibustion on skin lesions and immune inflammatory response in psoriasis mice].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2022 Jan; 42(1):66-72. doi:
10.13703/j.0255-2930.20210218-0004. [PMID: 35025160] - Atsushi Nomura, Miho Mizuno, Daisuke Noto, Aki Aoyama, Taiga Kuga, Goh Murayama, Asako Chiba, Sachiko Miyake. Different Spatial and Temporal Roles of Monocytes and Monocyte-Derived Cells in the Pathogenesis of an Imiquimod Induced Lupus Model.
Frontiers in immunology.
2022; 13(?):764557. doi:
10.3389/fimmu.2022.764557. [PMID: 35371102] - Wei Li, Wei Yang, Can Yang. Knockdown of Bcl-3 alleviates psoriasis and dyslipidemia comorbidity by regulating Akt pathway.
Allergologia et immunopathologia.
2022; 50(6):115-121. doi:
10.15586/aei.v50i6.683. [PMID: 36335454] - Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang. A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jan; 145(?):112482. doi:
10.1016/j.biopha.2021.112482. [PMID: 34915669] - Yi Kong, Jian Jiang, Yuqiong Huang, Xin Liu, Zilin Jin, Li Li, Fen Wei, Xinxin Liu, Jie Yin, Yonghui Zhang, Qingyi Tong, Hongxiang Chen. Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.
Frontiers in immunology.
2022; 13(?):1094375. doi:
10.3389/fimmu.2022.1094375. [PMID: 36700214] - Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen. Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4+Foxp3+ Regulatory T Cells and Alleviates Imiquimod-Induced Psoriasis in Mice.
Frontiers in immunology.
2022; 13(?):800283. doi:
10.3389/fimmu.2022.800283. [PMID: 35464441] - Ching-Fen Shen, Chia-Liang Yen, Yi-Chen Fu, Chao-Min Cheng, Tzu-Chi Shen, Pei-De Chang, Kuang-Hsiung Cheng, Ching-Chuan Liu, Yu-Tzu Chang, Po-Lin Chen, Wen-Chien Ko, Chi-Chang Shieh. Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 Vaccination.
Frontiers in immunology.
2022; 13(?):807454. doi:
10.3389/fimmu.2022.807454. [PMID: 35145520] - Jianning Guo, Cong Qi, Yu Liu, Xiaoyao Guo, Yujiao Meng, Jingxia Zhao, Jing Fu, Tingting Di, Lu Zhang, Xinwei Guo, Qingwu Liu, Yazhuo Wang, Ping Li, Yan Wang. Terrestrosin D ameliorates skin lesions in an imiquimod-induced psoriasis-like murine model by inhibiting the interaction between Substance P and Dendritic cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jan; 95(?):153864. doi:
10.1016/j.phymed.2021.153864. [PMID: 34923236] - Chenglin Song, Chenxi Yang, Siwei Meng, Manru Li, Xiao Wang, Yaoxuan Zhu, Lingdong Kong, Wen Lv, Hongzhi Qiao, Yang Sun. Deciphering the mechanism of Fang-Ji-Di-Huang-Decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23/Th17 cell axis.
Journal of ethnopharmacology.
2021 Dec; 281(?):114571. doi:
10.1016/j.jep.2021.114571. [PMID: 34464701] - C Ogawa, R Inoue, Y Yonejima, K Hisa, Y Yamamoto, T Suzuki. Supplemental Leuconostoc mesenteroides strain NTM048 attenuates imiquimod-induced psoriasis in mice.
Journal of applied microbiology.
2021 Dec; 131(6):3043-3055. doi:
10.1111/jam.15161. [PMID: 34028144] - Ying Zhang, Jian-Kun Song, Jing-Si Jiang, Shuang-Yi Yin, Yue Luo, Ying Luo, Xiao-Jie Ding, Yi Ru, Liu Liu, Wei Li, Le Kuai, Bin Li. Modular pharmacology-based approach to identify hub genes and kernel pathways of taodan granules treated psoriasis.
Journal of ethnopharmacology.
2021 Nov; 280(?):114485. doi:
10.1016/j.jep.2021.114485. [PMID: 34348195] - Katarzyna Bocheńska, Marta Moskot, Magdalena Gabig-Cimińska. Use of Cytokine Mix-, Imiquimod-, and Serum-Induced Monoculture and Lipopolysaccharide- and Interferon Gamma-Treated Co-Culture to Establish In Vitro Psoriasis-like Inflammation Models.
Cells.
2021 11; 10(11):. doi:
10.3390/cells10112985. [PMID: 34831208] - Silvia Fontenete, Catharina M Lerche, Uwe Paasch, Mirna Perez-Moreno, Uffe H Olesen, Merete Haedersdal. Tumor Clearance and Immune Cell Recruitment in UV-Induced Murine Squamous Cell Carcinoma Exposed to Ablative Fractional Laser and Imiquimod Treatment.
Lasers in surgery and medicine.
2021 11; 53(9):1227-1237. doi:
10.1002/lsm.23406. [PMID: 33811359] - Qian Jing, Hang Ruan, Jiaqi Li, Zhi Wang, Lixia Pei, Hongmei Hu, Zehui He, Tong Wu, Shuyao Ruan, Teng Guo, Youjie Wang, Nianping Feng, Yongtai Zhang. Keratinocyte membrane-mediated nanodelivery system with dissolving microneedles for targeted therapy of skin diseases.
Biomaterials.
2021 11; 278(?):121142. doi:
10.1016/j.biomaterials.2021.121142. [PMID: 34571433] - Yung-Fong Tsai, Chun-Yu Chen, I-Wen Lin, Yann-Lii Leu, Shun-Chin Yang, Yu-Ting Syu, Po-Jen Chen, Tsong-Long Hwang. Imperatorin Alleviates Psoriasiform Dermatitis by Blocking Neutrophil Respiratory Burst, Adhesion, and Chemotaxis Through Selective Phosphodiesterase 4 Inhibition.
Antioxidants & redox signaling.
2021 10; 35(11):885-903. doi:
10.1089/ars.2019.7835. [PMID: 33107318] - Isabella Luiz Suzuki, Margarete Moreno de Araujo, Vanderlei Salvador Bagnato, Maria Vitoria Lopes Badra Bentley. TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.
Journal of controlled release : official journal of the Controlled Release Society.
2021 10; 338(?):316-329. doi:
10.1016/j.jconrel.2021.08.039. [PMID: 34437914] - Namkyung Kim, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Yong Hyun Jang, Gil-Saeng Jeong, Sang-Hyun Kim. Cudraxanthone D Ameliorates Psoriasis-like Skin Inflammation in an Imiquimod-Induced Mouse Model via Inhibiting the Inflammatory Signaling Pathways.
Molecules (Basel, Switzerland).
2021 Oct; 26(19):. doi:
10.3390/molecules26196086. [PMID: 34641629] - Jill M Krapf, Kathryn Cavallo, Monica Saleeb, Andrew T Goldstein. Plasma Cell Vulvitis: A Systematic Review.
Journal of lower genital tract disease.
2021 Oct; 25(4):312-317. doi:
10.1097/lgt.0000000000000617. [PMID: 34224535] - Tingting Di, Chunyan Zhai, Jingxia Zhao, Yan Wang, Zhaoxia Chen, Ping Li. Taxifolin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like mouse model via regulating cytoplasmic phospholipase A2 and PPAR-γ pathway.
International immunopharmacology.
2021 Oct; 99(?):107900. doi:
10.1016/j.intimp.2021.107900. [PMID: 34233233] - Ahmed Alalaiwe, Chi-Yuan Chen, Zi-Yu Chang, Jui-Tai Sung, Shih-Yi Chuang, Jia-You Fang. Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910410. [PMID: 34638757] - Sudeep Sudesh Pukale, Anupama Mittal, Deepak Chitkara. Topical Application of Vitamin D3-Loaded Hybrid Nanosystem to Offset Imiquimod-Induced Psoriasis.
AAPS PharmSciTech.
2021 Sep; 22(7):238. doi:
10.1208/s12249-021-02116-5. [PMID: 34561775] - Tingting Di, Jingxia Zhao, Yan Wang, Lin Han, Xiaoyao Guo, Xuyang Han, Zhaoxia Chen, Ping Li, Chuanjian Lu. Tuhuaiyin alleviates imiquimod-induced psoriasis via inhibiting the properties of IL-17-producing cells and remodels the gut microbiota.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111884. doi:
10.1016/j.biopha.2021.111884. [PMID: 34243099] - Matteo Mombelli, Katja Hoschler, Matthias Cavassini, Manuel Pascual, Oriol Manuel. Seasonal trivalent inactivated influenza vaccine with topical imiquimod in immunocompromised patients: A randomized controlled trial.
The Journal of infection.
2021 09; 83(3):354-360. doi:
10.1016/j.jinf.2021.07.010. [PMID: 34298035] - Vivek Choudhary, Ismail Kaddour-Djebbar, Victoria E Custer, Rawipan Uaratanawong, Xunsheng Chen, Elyssa Cohen, Rong Yang, Etsubdenk Ajebo, Sarah Hossack, Wendy B Bollag. Glycerol Improves Skin Lesion Development in the Imiquimod Mouse Model of Psoriasis: Experimental Confirmation of Anecdotal Reports from Patients with Psoriasis.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168749. [PMID: 34445455] - Michal Korinek, Pei-Shan Hsieh, Yu-Li Chen, Pei-Wen Hsieh, Shih-Hsin Chang, Yi-Hsiu Wu, Tsong-Long Hwang. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo.
Biochemical pharmacology.
2021 08; 190(?):114596. doi:
10.1016/j.bcp.2021.114596. [PMID: 33964283] - Miaomiao Zhang, Ning Li, Ruhang Cai, Jiangyong Gu, Fuda Xie, Hong Wei, Chuanjian Lu, Dinghong Wu. Rosmarinic acid protects mice from imiquimod induced psoriasis-like skin lesions by inhibiting the IL-23/Th17 axis via regulating Jak2/Stat3 signaling pathway.
Phytotherapy research : PTR.
2021 Aug; 35(8):4526-4537. doi:
10.1002/ptr.7155. [PMID: 34008239] - Jesse D Sheldon, Kaila Buckley, Catherine Ulman, Catherine G Chung. Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature.
Journal of cutaneous pathology.
2021 Aug; 48(8):1075-1079. doi:
10.1111/cup.14029. [PMID: 33893742] - Rajendra Sangaraju, Sateesh Alavala, Nasiruddin Nalban, Mahesh Kumar Jerald, Ramakrishna Sistla. Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways.
International immunopharmacology.
2021 Jul; 96(?):107754. doi:
10.1016/j.intimp.2021.107754. [PMID: 34162135]