Malotilate (BioDeep_00000398825)
natural product
代谢物信息卡片
Malotilate
化学式: C12H16O4S2 (288.0489976)
中文名称: 马洛替酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(=O)OC(C)C)=C1SC=CS1)(=O)OC(C)C
InChI: InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3
描述信息
C26170 - Protective Agent > C2081 - Hepatoprotective Agent
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:31798
- KEGGdrug: D01770
- PubChem: 4006
- ChEMBL: CHEMBL1697754
- CAS: 59937-28-9
- MoNA: CCMSLIB00000078022
- MoNA: CCMSLIB00000078021
- medchemexpress: HY-A0060
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Jianjun Zhang, Yuan Gao, Shuai Qian, Xin Liu, Hui Zu. Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion.
International journal of pharmaceutics.
2011 Jul; 414(1-2):186-92. doi:
10.1016/j.ijpharm.2011.05.032. [PMID: 21619915] - Camilla Nøjgaard, Julia S Johansen, Erik Christensen, Lene Theil Skovgaard, Paul A Price, Ulrik Becker. Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease.
Journal of hepatology.
2003 Aug; 39(2):179-86. doi:
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2002 Jan; 25(1):31-3. doi:
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British journal of cancer.
1998 May; 77(9):1371-7. doi:
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Ugeskrift for laeger.
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Biochemical pharmacology.
1996 Oct; 52(8):1219-25. doi:
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Hepatology (Baltimore, Md.).
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Journal of hepatology.
1996 Feb; 24(2):238-45. doi:
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Journal of hepatology.
1993 Feb; 17(2):227-35. doi:
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European journal of cell biology.
1993 Feb; 60(1):48-56. doi:
NULL. [PMID: 8462600] - S Takase, Y Matsuda, M Yasuhara, A Takada. Effects of malotilate treatment on alcoholic liver disease.
Alcohol (Fayetteville, N.Y.).
1989 May; 6(3):219-22. doi:
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Nihon juigaku zasshi. The Japanese journal of veterinary science.
1989 Feb; 51(1):119-27. doi:
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Gastroenterologia Japonica.
1988 Dec; 23(6):639-45. doi:
10.1007/bf02782949. [PMID: 2851477] - P R Ryle, J Chakraborty, A D Thomson. The effect of di-isopropyl 1,3 dithiol-2-ylidenemalonate (malotilate) on the hepatic changes induced by ethanol administration in the rat.
Biochemical pharmacology.
1988 Nov; 37(22):4341-51. doi:
10.1016/0006-2952(88)90616-8. [PMID: 3143367] - K Kai, S Kobayashi, E Uchida, H Sakai, E Tanaka, N Kurata, H Yasuhara. The effects of malotilate on hepatic drug metabolizing systems in different strains of rats.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.
1988; 90(1):13-9. doi:
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Archives internationales de pharmacodynamie et de therapie.
1987 Oct; 289(2):296-310. doi:
NULL. [PMID: 3426350] - K Akahane, K Furuhama, F Inage, T Onodera. Effects of malotilate on rat erythrocytes.
Japanese journal of pharmacology.
1987 Sep; 45(1):15-25. doi:
10.1254/jjp.45.15. [PMID: 3682419] - L Ala-Kokko, F Stenbäck, L Ryhänen. Preventive effect of malotilate on carbon tetrachloride-induced liver damage and collagen accumulation in the rat.
The Biochemical journal.
1987 Sep; 246(2):503-9. doi:
10.1042/bj2460503. [PMID: 2825640] - S Igarashi, T Hatahara, Y Nagai, H Hori, K Sakakibara, M Katoh, A Sakai, T Sugimoto. Anti-fibrotic effect of malotilate on liver fibrosis induced by carbon tetrachloride in rats.
The Japanese journal of experimental medicine.
1986 Oct; 56(5):235-45. doi:
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The Journal of toxicological sciences.
1986 Aug; 11(3):225-36. doi:
10.2131/jts.11.225. [PMID: 3795300] - C P Siegers, V Pauli, G Korb, M Younes. Hepatoprotection by malotilate against carbon tetrachloride-alcohol-induced liver fibrosis.
Agents and actions.
1986 Aug; 18(5-6):600-3. doi:
10.1007/bf01964970. [PMID: 3766314] - M Bührer, J Y Le Cotonnec, M Wermeille, J Bircher. Treatment of liver disease with malotilate. A pharmacokinetic and pharmacodynamic phase II study in cirrhosis.
European journal of clinical pharmacology.
1986; 30(4):407-16. doi:
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Journal of hepatology.
1986; 3(2):260-8. doi:
10.1016/s0168-8278(86)80036-8. [PMID: 3794306] - M Nokata, M Katoh, T Sugimoto. Protective effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on carbon tetrachloride-induced liver injury in mice and rats.
The Journal of toxicological sciences.
1985 Nov; 10(4):279-88. doi:
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Journal of chromatography.
1985 Aug; 342(2):349-58. doi:
10.1016/s0378-4347(00)84526-0. [PMID: 4055956] - J Wakasugi, K Tawara, K Katami, T Ikeda, M Tomikawa. Action of malotilate on reduced serum cholesterol level in rats with carbon tetrachloride-induced liver damage.
Japanese journal of pharmacology.
1985 Aug; 38(4):391-401. doi:
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The Journal of toxicological sciences.
1982 Feb; 7(1):13-8. doi:
10.2131/jts.7.13. [PMID: 7097806] - M Katoh, M Kitada, T Satoh, H Kitagawa, T Sugimoto, T Kasai. Further studies on the in vivo effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on the liver microsomal drug oxidation system in rats.
Biochemical pharmacology.
1981 Oct; 30(20):2759-65. doi:
10.1016/0006-2952(81)90412-3. [PMID: 6119083] - S Nakayama. [Effects of diispropyl 1, 3-dithiol-2-ylidene malonate (NKK-105) on the drug-metabolizing enzymes and fine structure of rat liver (author's transl)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1979 Sep; 75(6):571-84. doi:
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