Fluocinolone Acetonide (BioDeep_00000398789)

natural product

代谢物信息卡片

Fluocinolone acetonide (Flucort-N)

化学式: C24H30F2O6 (452.20103439999997)
中文名称: 醋酸氟轻松
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C=C2[C@](C=1)([C@]3([C@@](C[C@]2([H])F)([C@]4([C@](C[C@H]3O)([C@@]5([C@@](C4)(OC(O5)(C)C)[H])C(CO)=O)C)[H])[H])F)C)=O
InChI: InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

描述信息

C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AA - Corticosteroids
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AC - Corticosteroids, potent (group iii)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BA - Corticosteroids, plain
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
S - Sensory organs > S02 - Otologicals > S02B - Corticosteroids > S02BA - Corticosteroids
D000893 - Anti-Inflammatory Agents
CONFIDENCE standard compound; INTERNAL_ID 466; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8722; ORIGINAL_PRECURSOR_SCAN_NO 8717
CONFIDENCE standard compound; INTERNAL_ID 466; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8755; ORIGINAL_PRECURSOR_SCAN_NO 8753
CONFIDENCE standard compound; INTERNAL_ID 466; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8759; ORIGINAL_PRECURSOR_SCAN_NO 8757
CONFIDENCE standard compound; INTERNAL_ID 466; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8810; ORIGINAL_PRECURSOR_SCAN_NO 8805
CONFIDENCE standard compound; INTERNAL_ID 466; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8806; ORIGINAL_PRECURSOR_SCAN_NO 8804
CONFIDENCE standard compound; INTERNAL_ID 466; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8815; ORIGINAL_PRECURSOR_SCAN_NO 8813
CONFIDENCE standard compound; INTERNAL_ID 2402

同义名列表

2 个代谢物同义名

Fluocinolone Acetonide; Fluocinolone acetonide (Flucort-N)

数据库引用编号

25 个数据库交叉引用编号

ChEBI: CHEBI:31623
KEGGdrug: D01825
PubChem: 6215
Metlin: METLIN2741
DrugBank: DB00591
ChEMBL: CHEMBL989
MeSH: Fluocinolone Acetonide
CAS: 67-73-2
MoNA: LU046606
MoNA: LU046605
MoNA: LU046604
MoNA: LU046603
MoNA: LU046602
MoNA: LU046601
MoNA: AU240259
MoNA: AU240258
MoNA: AU240257
MoNA: AU240206
MoNA: AU240205
MoNA: AU240204
MoNA: AU240203
MoNA: AU240202
MoNA: AU240201
MoNA: CCMSLIB00000078479
MoNA: CCMSLIB00000077046

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Andréa Carolina Pinheiro de Freitas, Roberta Balansin Rigon, Ediléia Bagatin, Gislaine Ricci Leonardi. Perspectives of topical formulations for melasma. International journal of dermatology. 2023 Feb; 62(2):260-268. doi: 10.1111/ijd.16421. [PMID: 36083295]
Yongsu Choi, Masaki Takasugi, Kazuaki Takemura, Yuya Yoshida, Tomonori Kamiya, Jun Adachi, Daisuke Tsuruta, Naoko Ohtani. Characterization of Transcriptomic and Proteomic Changes in the Skin after Chronic Fluocinolone Acetonide Treatment. Biomolecules. 2022 12; 12(12):. doi: 10.3390/biom12121822. [PMID: 36551249]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Uriel Villela-Segura, Alessandra Irais Miranda-Aguirre, Lorena Estrada-Aguilar. Crateriform plaques in a patient with end-stage renal disease. The case of an acquired reactive perforating collagenosis. Nefrologia. 2020 May; 40(3):358-360. doi: 10.1016/j.nefro.2019.04.005. [PMID: 31351699]
Joaquín Felipe Ramírez-Oliveros, Luciana de Abreu, Carla Tamler, Paula Vilhena, Mayara Hamilko de Barros. Microneedling with Drug Delivery (Hydroquinone 4\% Serum) as an Adjuvant Therapy for Recalcitrant Melasma. Skinmed. 2020; 18(1):38-40. doi: . [PMID: 32167455]
Jatin Singla, Tanya Bajaj, Amit K Goyal, Goutam Rath. Development of Nanofibrous Ocular Insert for Retinal Delivery of Fluocinolone Acetonide. Current eye research. 2019 05; 44(5):541-550. doi: 10.1080/02713683.2018.1563196. [PMID: 30577701]
Frane Banovic, Carmen Jerry, Elizabeth Howerth. Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti-inflammatory therapy (doxycycline/niacinamide and topical fluocinolone) in a dog. Veterinary dermatology. 2018 Feb; 29(1):85-e35. doi: 10.1111/vde.12502. [PMID: 28990239]
Luong T H Nguyen, Aristo Muktabar, Jinkai Tang, Yee Shan Wong, Colby S Thaxton, Subbu S Venkatraman, Kee Woei Ng. The Potential of Fluocinolone Acetonide to Mitigate Inflammation and Lipid Accumulation in 2D and 3D Foam Cell Cultures. BioMed research international. 2018; 2018(?):3739251. doi: 10.1155/2018/3739251. [PMID: 30596089]
Madhulika Pradhan, Deependra Singh, S Narasimha Murthy, Manju Rawat Singh. Design, characterization and skin permeating potential of Fluocinolone acetonide loaded nanostructured lipid carriers for topical treatment of psoriasis. Steroids. 2015 Sep; 101(?):56-63. doi: 10.1016/j.steroids.2015.05.012. [PMID: 26049018]
Frances E Kane, Kenneth E Green. Ocular pharmacokinetics of fluocinolone acetonide following Iluvien implantation in the vitreous humor of rabbits. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2015 Feb; 31(1):11-6. doi: 10.1089/jop.2014.0100. [PMID: 25562126]
Madhulika Pradhan, Deependra Singh, Manju Rawat Singh. Development characterization and skin permeating potential of lipid based novel delivery system for topical treatment of psoriasis. Chemistry and physics of lipids. 2015 Feb; 186(?):9-16. doi: 10.1016/j.chemphyslip.2014.11.004. [PMID: 25447290]
T Veloukas, P Kalogeropoulou, A N Markoglou, G S Karaoglanidis. Fitness and competitive ability of Botrytis cinerea field isolates with dual resistance to SDHI and QoI fungicides, associated with several sdhB and the cytb G143A mutations. Phytopathology. 2014 Apr; 104(4):347-56. doi: 10.1094/phyto-07-13-0208-r. [PMID: 24168041]
Vinita Batra, Zanobia Syed, Jennifer N Gill, Malari A Coburn, Patrick Adegboyega, John DiGiovanni, J Michael Mathis, Runhua Shi, John L Clifford, Heather E Kleiner-Hancock. Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice. Journal of experimental & clinical cancer research : CR. 2012 Jun; 31(?):57. doi: 10.1186/1756-9966-31-57. [PMID: 22704648]
Neerja Puri. A study of pathogenesis of acanthosis nigricans and its clinical implications. Indian journal of dermatology. 2011 Nov; 56(6):678-83. doi: 10.4103/0019-5154.91828. [PMID: 22345770]
G Miolo, S Caffieri, D Dalzoppo, F Gallocchio, E Fasani, G M J Beyersbergen van Henegouwen. Photoactivation of corticosteroids in UVB-exposed skin. Journal of photochemistry and photobiology. B, Biology. 2011 Apr; 103(1):35-41. doi: 10.1016/j.jphotobiol.2011.01.009. [PMID: 21324709]
Jeffrey L Edelman. Differentiating intraocular glucocorticoids. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 2010; 224 Suppl 1(?):25-30. doi: 10.1159/000315158. [PMID: 20714178]
Pornpan Youngnak-Piboonratanakit, Kittipong Dhanuthai, Kobkan Thongprasom, Pimporn Luckprom, Wilairat Sarideechaigul, Lakana Luangjarmekorn, Miyuki Azuma. Expression of IFN-gamma before and after treatment of oral lichen planus with 0.1\% fluocinolone acetonide in orabase. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2009 Oct; 38(9):689-94. doi: 10.1111/j.1600-0714.2009.00805.x. [PMID: 19614863]
Alissar Nehmé, Edward K Lobenhofer, W Daniel Stamer, Jeffrey L Edelman. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC medical genomics. 2009 Sep; 2(?):58. doi: 10.1186/1755-8794-2-58. [PMID: 19744340]
Magdalene A Dohil, Elizabeth Alvarez-Connelly, Lawrence F Eichenfield. Fluocinolone acetonide 0.01\% in peanut oil: safety and efficacy data in the treatment of childhood atopic dermatitis in infants as young as 3 months of age. Pediatric dermatology. 2009 May; 26(3):262-8. doi: 10.1111/j.1525-1470.2008.00856.x. [PMID: 19706085]
Surya P Ayalasomayajula, Paul Ashton, Uday B Kompella. Fluocinolone inhibits VEGF expression via glucocorticoid receptor in human retinal pigment epithelial (ARPE-19) cells and TNF-alpha-induced angiogenesis in chick chorioallantoic membrane (CAM). Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2009 Apr; 25(2):97-103. doi: 10.1089/jop.2008.0090. [PMID: 19284324]
Bing Shao, Xiaoliang Cui, Yi Yang, Jing Zhang, Yongnin Wu. Validation of a solid-phase extraction and ultra-performance liquid chromatographic tandem mass spectrometric method for the detection of 16 glucocorticoids in pig tissues. Journal of AOAC International. 2009 Mar; 92(2):604-11. doi: . [PMID: 19485221]
Ahmad Kantar, Salman Mroueh, Alessandro Fiocchi. A reappraisal of the clinical efficacy of nebulized flunisolide in pediatric asthma: the Italian experience. Allergy and asthma proceedings. 2007 Nov; 28(6):671-87. doi: 10.2500/aap.2007.28.2979. [PMID: 17883883]
M Vaughn Emerson, Andreas K Lauer. Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2007; 21(4):245-57. doi: 10.2165/00063030-200721040-00005. [PMID: 17628122]
Carol R Reinero, Lisa Brownlee, Kendra C Decile, Bernard Seguin, Roy D Berghaus, Richard W Nelson, Laurel J Gershwin. Inhaled flunisolide suppresses the hypothalamic-pituitary-adrenocortical axis, but has minimal systemic immune effects in healthy cats. Journal of veterinary internal medicine. 2006 Jan; 20(1):57-64. doi: 10.1892/0891-6640(2006)20[57:ifstha]2.0.co;2. [PMID: 16496924]
Carol R Reinero, Kendra C Decile, Jenni R Byerly, Roy D Berghaus, William E Walby, Londa J Berghaus, Dallas M Hyde, Edward S Schelegle, Laurel J Gershwin. Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma. American journal of veterinary research. 2005 Jul; 66(7):1121-7. doi: 10.2460/ajvr.2005.66.1121. [PMID: 16111148]
Giorgia Miolo, Sergio Caffieri, Daniele Dalzoppo, Andrea Ricci, Elisa Fasani, Angelo Albini. Photochemistry and phototoxicity of fluocinolone 16,17-acetonide. Photochemistry and photobiology. 2005 Mar; 81(2):291-8. doi: 10.1562/2004-05-25-ra-178. [PMID: 15535735]
E Pujos, M M Flament-Waton, O Paisse, M F Grenier-Loustalot. Comparison of the analysis of corticosteroids using different techniques. Analytical and bioanalytical chemistry. 2005 Jan; 381(1):244-54. doi: 10.1007/s00216-004-2890-9. [PMID: 15700162]
Jean-Yves Driot, Gary D Novack, Kay D Rittenhouse, Chris Milazzo, P Andrew Pearson. Ocular pharmacokinetics of fluocinolone acetonide after Retisert intravitreal implantation in rabbits over a 1-year period. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2004 Jun; 20(3):269-75. doi: 10.1089/1080768041223611. [PMID: 15279731]
Amy S Paller, Sai Nimmagadda, Lawrence Schachner, Susan B Mallory, Teri Kahn, Isaac Willis, Lawrence F Eichenfield. Fluocinolone acetonide 0.01\% in peanut oil: therapy for childhood atopic dermatitis, even in patients who are peanut sensitive. Journal of the American Academy of Dermatology. 2003 Apr; 48(4):569-77. doi: 10.1067/mjd.2003.174. [PMID: 12664021]
Kobkan Thongprasom, Pornpan Youngnak, Vilaiwan Aneksuk. Hematologic abnormalities in recurrent oral ulceration. The Southeast Asian journal of tropical medicine and public health. 2002 Dec; 33(4):872-7. doi: NULL. [PMID: 12757242]
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