Orlistat (BioDeep_00000398770)

   

natural product Chemicals and Drugs


代谢物信息卡片


N-formyl-L-leucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

化学式: C29H53NO5 (495.3924)
中文名称: 奥利司他
谱图信息: 最多检出来源 Escherichia coli(natural_products) 100%

分子结构信息

SMILES: C1([C@H]([C@@H](O1)C[C@H](CCCCCCCCCCC)OC(=O)[C@H](CC(C)C)NC(=O)[H])CCCCCC)=O
InChI: InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1

描述信息

A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.
A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products > A08AB - Peripherally acting antiobesity products
C471 - Enzyme Inhibitor > C29715 - Gastrointestinal Lipase Inhibitor
D057847 - Lipid Regulating Agents
D019440 - Anti-Obesity Agents
D004791 - Enzyme Inhibitors
CONFIDENCE standard compound; INTERNAL_ID 2362
CONFIDENCE standard compound; INTERNAL_ID 8541
Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity[1].?Anti-atherosclerotic?effect[2].

同义名列表

5 个代谢物同义名

Orlistat; N-formyl-L-leucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; "Orlistat (Alli, Xenical)"; Tetrahydrolipstatin; Ro-18-0647



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Felix Paulus, René Holm, Jef Stappaerts, Annette Bauer-Brandl. Absorption of cinnarizine from type II lipid-based formulations: Impact of lipid chain length, supersaturation, digestion, and precipitation inhibition. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jun; 197(?):106765. doi: 10.1016/j.ejps.2024.106765. [PMID: 38608735]
  • Arefeh Zahmatkesh, Mohammad Hassan Sohouli, Shima Shojaie, Pejman Rohani. The effect of orlistat in the treatment of non-alcoholic fatty liver in adolescents with overweight and obese. European journal of pediatrics. 2024 Mar; 183(3):1173-1182. doi: 10.1007/s00431-023-05369-3. [PMID: 38081992]
  • Grzegorz Dąbrowski, Sylwester Czaplicki, Marcin Szustak, Eliza Korkus, Edyta Gendaszewska-Darmach, Iwona Konopka. The impact of selected xanthophylls on oil hydrolysis by pancreatic lipase: in silico and in vitro studies. Scientific reports. 2024 02; 14(1):2731. doi: 10.1038/s41598-024-53312-9. [PMID: 38302772]
  • Yassmin Raafat Hassan, Riham A El-Shiekh, Hala M El Hefnawy, Osama G Mohamed, Karema Abu-Elfotuh, Ahmed M Hamdan, Alshaymaa Darwish, Ayah M H Gowifel, Ashootosh Tripathi, Camilia George Michael. A mechanistic exploration of the metabolome of African mango seeds and its potential to alleviate cognitive impairment induced by high-fat/high-carbohydrate diets: Involvement of PI3K/AKT/GSK-3β/CREB, PERK/CHOP/Bcl-2, and AMPK/SIRT-1/mTOR Axes. Journal of ethnopharmacology. 2024 Jan; 324(?):117747. doi: 10.1016/j.jep.2024.117747. [PMID: 38218500]
  • Felix Paulus, Annette Bauer-Brandl, Jef Stappaerts, René Holm. Digestion is a critical element for absorption of cinnarizine from supersaturated lipid-based type I formulations. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jan; 192(?):106634. doi: 10.1016/j.ejps.2023.106634. [PMID: 37951315]
  • Nisha Yadav, Atish T Paul. Pancreatic lipase and its related proteins: where are we now?. Drug discovery today. 2024 Jan; 29(1):103855. doi: 10.1016/j.drudis.2023.103855. [PMID: 38081381]
  • Weiwei Tang, Guangshun Sun, Gu-Wei Ji, Tingting Feng, Qian Zhang, Hengsong Cao, Wenhao Wu, Xiaoyi Zhang, Chuan Liu, Hanyuan Liu, Tian Huang, Li Liu, Yongxiang Xia, Xuehao Wang. Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinoma. Journal for immunotherapy of cancer. 2023 11; 11(11):. doi: 10.1136/jitc-2023-007030. [PMID: 38007237]
  • Haihong Cheng, Yuxin Sun, Xiaopeng Yu, Di Zhou, Jun Ding, Shouhua Wang, Fei Ma. FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling. Drug discoveries & therapeutics. 2023 Nov; 17(5):328-339. doi: 10.5582/ddt.2023.01036. [PMID: 37743521]
  • Samer A El-Sawy, Yahia A Amin, Sabry A El-Naggar, Ahmed Abdelsadik. Artemisia annua L. (Sweet wormwood) leaf extract attenuates high-fat diet-induced testicular dysfunctions and improves spermatogenesis in obese rats. Journal of ethnopharmacology. 2023 Sep; 313(?):116528. doi: 10.1016/j.jep.2023.116528. [PMID: 37127141]
  • Saba Khaldoon Mohammed, Shihab Hattab Mutlag. Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats. Journal of medicine and life. 2023 Sep; 16(9):1338-1342. doi: 10.25122/jml-2023-0140. [PMID: 38107717]
  • Abdulrahim Aljamal, Mahmoud Al Shawabkeh, Kawther Amawi, Taha Alqadi, Alia Khwaldeh. Physiological Effects of Fig Leaf Extract and Orlistat on Obesity, Kidney and Liver of Rats. Pakistan journal of biological sciences : PJBS. 2023 Aug; 26(9):458-462. doi: 10.3923/pjbs.2023.458.462. [PMID: 38044695]
  • Zeinab Nikniaz, Leila Nikniaz, Mahdieh Abbasalizad Farhangi, Hossein Mehralizadeh, Shabnam Salekzamani. Effect of Orlistat on anthropometrics and metabolic indices in children and adolescents: a systematic review and meta-analysis. BMC endocrine disorders. 2023 Jul; 23(1):142. doi: 10.1186/s12902-023-01390-7. [PMID: 37420181]
  • Yun Jeong Shin, Jung-Min Bae, Hye-Rin Cho, Patience Mahoro, Hye Hyun Kim, Seon Hwa Kim, Tae Hoon Kim, Min-Jung Bae. Antiobesity Effects of Lactobacillus paracasei Subsp. paracasei, L. casei 431 on High-Fat Diet-Induced Obese Rats. Journal of medicinal food. 2023 Jul; 26(7):445-453. doi: 10.1089/jmf.2022.k.0144. [PMID: 37311176]
  • Agostina Valoy, Gabriela Alarcón, Julieta Roco, Catiana Zampini, María Ines Isla, Susana Jerez. A Flavonoid-rich Zuccagnia punctata Extract Prevents High Fat Diet-induced Normal Weight Obesity in a Rabbit Model. Planta medica. 2023 Mar; 89(3):245-253. doi: 10.1055/a-1891-3588. [PMID: 35789995]
  • Junqiang Yang, Yanyan Deng, Min Zhang, Shilun Feng, Sheng Peng, Shijia Yang, Peirong Liu, Gaozhe Cai, Guangbo Ge. Construction and Manipulation of Serial Gradient Dilution Array on a Microfluidic Slipchip for Screening and Characterizing Inhibitors against Human Pancreatic Lipase. Biosensors. 2023 Feb; 13(2):. doi: 10.3390/bios13020274. [PMID: 36832040]
  • Jovana V Jovankić, Danijela D Nikodijević, Milena G Milutinović, Aleksandra G Nikezić, Vesna V Kojić, Aleksandar M Cvetković, Danijela M Cvetković. Potential of Orlistat to induce apoptotic and antiangiogenic effects as well as inhibition of fatty acid synthesis in breast cancer cells. European journal of pharmacology. 2023 Jan; 939(?):175456. doi: 10.1016/j.ejphar.2022.175456. [PMID: 36528070]
  • Yan Li, Wenjuan Yang, Yuanyuan Zheng, Weiqi Dai, Jie Ji, Liwei Wu, Ziqi Cheng, Jie Zhang, Jingjing Li, Xuanfu Xu, Jianye Wu, Mingwei Yang, Jiao Feng, Chuanyong Guo. Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis. Journal of experimental & clinical cancer research : CR. 2023 Jan; 42(1):6. doi: 10.1186/s13046-022-02567-z. [PMID: 36604718]
  • Sowmya Shree Gopal, Shinde Vijay Sukhdeo, Baskaran Vallikannan, Ganesan Ponesakki. Lutein ameliorates high-fat diet-induced obesity, fatty liver, and glucose intolerance in C57BL/6J mice. Phytotherapy research : PTR. 2023 Jan; 37(1):329-341. doi: 10.1002/ptr.7615. [PMID: 36086831]
  • Yasemin Emur Gunay, Savaş Volkan Kişioğlu, Serdar Karakullukçu, Damla Tufekcı, Ahmet Suat Demır, Hülya Coskun, Irfan Nuhoglu, Mustafa Kocak, Halil Önder Ersöz. Comparison of orlistat and orlistat plus metformin therapy between diabetic and nondiabetic groups. Revista da Associacao Medica Brasileira (1992). 2023; 69(7):e20230174. doi: 10.1590/1806-9282.20230174. [PMID: 37466599]
  • Francesca Blasi, Federica Ianni, Luciano Mangiapelo, Nicola Pinna, Lina Cossignani. In vitro anti-obesity activity by pancreatic lipase inhibition - Simple HPLC approach using EVOO as natural substrate. Journal of the science of food and agriculture. 2022 Dec; ?(?):. doi: 10.1002/jsfa.12417. [PMID: 36583522]
  • Maria Fernanda Taviano, Sonia Núñez, Adrián Millán-Laleona, Concetta Condurso, Antonella Verzera, Maria Merlino, Monica Ragusa, Natalizia Miceli, Víctor López. Volatile composition, antidiabetic, and anti-obesity potential of Brassica incana leaf and flowering top extracts. Pharmaceutical biology. 2022 Dec; 60(1):1994-2001. doi: 10.1080/13880209.2022.2128825. [PMID: 36219451]
  • Uriel Urbizo-Reyes, Andrea M Liceaga, Lavanya Reddivari, Shiyu Li, Kee-Hong Kim, Abigail D Cox, Joseph M Anderson. Canary Seed (Phalaris canariensis L.) Peptides Prevent Obesity and Glucose Intolerance in Mice Fed a Western Diet. International journal of molecular sciences. 2022 Nov; 23(23):. doi: 10.3390/ijms232314927. [PMID: 36499253]
  • Michael G Ross, Ken Kobayashi, Guang Han, Mina Desai. Modulation of Milk and Lipid Synthesis and Secretion in a3-Dimensional Mouse Mammary Epithelial Cell Culture Model: Effects of Palmitate and Orlistat. Nutrients. 2022 Nov; 14(23):. doi: 10.3390/nu14234948. [PMID: 36500977]
  • J Alanazi, A Unnisa, S Ahmad, R Itumalla, M Alanazi, T N Alharby, S Anwar, K M Younes, T Hussain, A Hussain, B A Elamine, O A Mohamed. Significance of Orlistat in management of dyslipidemia, systolic blood pressure and body mass index. European review for medical and pharmacological sciences. 2022 11; 26(22):8326-8332. doi: 10.26355/eurrev_202211_30365. [PMID: 36459016]
  • Guangming Zhao, Qi Zhang, Fan Wu, Shuang Yin, Yiqi Xie, Hongyan Liu. Comparison of weight loss and adverse events of obesity drugs in children and adolescents: a systematic review and meta-analysis. Expert review of clinical pharmacology. 2022 Sep; 15(9):1119-1125. doi: 10.1080/17512433.2022.2117152. [PMID: 36039827]
  • Sumit Kumar Mandal, Banoth Karan Kumar, Pankaj Kumar Sharma, Sankaranarayanan Murugesan, P R Deepa. In silico and in vitro analysis of PPAR - α / γ dual agonists: Comparative evaluation of potential phytochemicals with anti-obesity drug orlistat. Computers in biology and medicine. 2022 08; 147(?):105796. doi: 10.1016/j.compbiomed.2022.105796. [PMID: 35809408]
  • Mubtasim Murshed, Anna Pham, Kapilkumar Vithani, Malinda Salim, Ben J Boyd. Controlling drug release by introducing lipase inhibitor within a lipid formulation. International journal of pharmaceutics. 2022 Jul; 623(?):121958. doi: 10.1016/j.ijpharm.2022.121958. [PMID: 35760262]
  • Tengfei Liu, Junming Yu, Chao Ge, Fangyu Zhao, Jing Chen, Chunxiao Miao, Wenjiao Jin, Qingqing Zhou, Qin Geng, Hechun Lin, Hua Tian, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Xiuying Xiao, Jinjun Li, Hong Li. Sperm associated antigen 4 promotes SREBP1-mediated de novo lipogenesis via interaction with lamin A/C and contributes to tumor progression in hepatocellular carcinoma. Cancer letters. 2022 06; 536(?):215642. doi: 10.1016/j.canlet.2022.215642. [PMID: 35307486]
  • Marlies Braeckmans, Joachim Brouwers, Raf Mols, Cécile Servais, Jan Tack, Patrick Augustijns. Orlistat disposition in the human jejunum and the effect of lipolysis inhibition on bile salt concentrations and composition. International journal of pharmaceutics. 2022 Jun; 621(?):121807. doi: 10.1016/j.ijpharm.2022.121807. [PMID: 35533920]
  • Nagashree Shamarao, Mukunda Chethankumar. Antiobesity drug-likeness properties and pancreatic lipase inhibition of a novel low molecular weight lutein oxidized product, LOP6. Food & function. 2022 Jun; 13(11):6036-6055. doi: 10.1039/d1fo04064b. [PMID: 35615990]
  • Zhangming Chen, Zhaowei Cai. Effects of oral contraceptives plus orlistat in patients with polycystic ovary syndrome and overweight/obesity: A meta-analysis. The journal of obstetrics and gynaecology research. 2022 Jun; 48(6):1399-1408. doi: 10.1111/jog.15211. [PMID: 35302695]
  • Tao Xu, Liping Sheng, Xianwen Guo, Zhen Ding. Free Fatty Acid Increases the Expression of NLRP3-Caspase1 in Adipose Tissue Macrophages in Obese Severe Acute Pancreatitis. Digestive diseases and sciences. 2022 Jun; 67(6):2220-2231. doi: 10.1007/s10620-021-07027-w. [PMID: 34114155]
  • Happy Kurnia Permatasari, Novi Khila Firani, Bambang Prijadi, Dicky Faizal Irnandi, Wibi Riawan, Muhammad Yusuf, Nasim Amar, Liani Amelia Chandra, Vincentius Mario Yusuf, Anita Dominique Subali, Fahrul Nurkolis. Kombucha drink enriched with sea grapes (Caulerpa racemosa) as potential functional beverage to contrast obesity: An in vivo and in vitro approach. Clinical nutrition ESPEN. 2022 06; 49(?):232-240. doi: 10.1016/j.clnesp.2022.04.015. [PMID: 35623818]
  • Xinyuan Cui, Xiaojun Chen, Yifu Li, Xiao Fu, Pan'ai Song, Li Xiao, Lin Sun, Hong Liu, Xuejing Zhu, Shuguang Yuan. Oxalate crystal-related acute renal injury caused by orlistat: A case report. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2022 May; 47(5):583-587. doi: 10.11817/j.issn.1672-7347.2022.210393. [PMID: 35753728]
  • Vian Ahmed Wasta Esmail, Marwan S M Al-Nimer, Mohammed Omer Mohammed. Effects of Orlistat or Telmisartan on the Serum Free Fatty Acids in Non-alcoholic Fatty Liver Disease Patients: An Open-Labeled Randomized Controlled Study. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2022 05; 33(5):421-426. doi: 10.5152/tjg.2020.19365. [PMID: 35678800]
  • Chunliang Shang, Yuan Li, Tianhui He, Yuandong Liao, Qiqiao Du, Pan Wang, Jie Qiao, Hongyan Guo. The prognostic miR-532-5p-correlated ceRNA-mediated lipid droplet accumulation drives nodal metastasis of cervical cancer. Journal of advanced research. 2022 03; 37(?):169-184. doi: 10.1016/j.jare.2021.09.009. [PMID: 35499057]
  • Willian Peter Boelcke, Isadora Ferrari Teixeira, Iara Gonçalves Aquino, Amanda Ramos Mazzaro, Florence Juana Maria Cuadra-Zelaya, Ana Paula de Souza, Tuula Salo, Ricardo Della Coletta, Edgard Graner, Débora Campanella Bastos. Pharmacological fatty acid synthase inhibitors differently affect the malignant phenotype of oral cancer cells. Archives of oral biology. 2022 Mar; 135(?):105343. doi: 10.1016/j.archoralbio.2021.105343. [PMID: 35026648]
  • Maddalena Ardissino, Matthew Vincent, Oliver Hines, Ravi Amin, Christian Eichhorn, Alice R Tang, Peter Collins, Osama Moussa, Sanjay Purkayastha. Long-term cardiovascular outcomes after orlistat therapy in patients with obesity: a nationwide, propensity-score matched cohort study. European heart journal. Cardiovascular pharmacotherapy. 2022 02; 8(2):179-186. doi: 10.1093/ehjcvp/pvaa133. [PMID: 33991094]
  • Laila Moustafa El-Shal, Alyaa A Abd El-Star, Abeer M Azmy, Heba M Elnegris. The possible protective role of N-acetyl cysteine on duodenal mucosa of high fat diet and orlistat treated adult male albino rats and the active role of tumor necrosis factor α (TNFα) and Interleukin 6 (IL6) (histological and biochemical study). Ultrastructural pathology. 2022 Jan; 46(1):18-36. doi: 10.1080/01913123.2021.2007194. [PMID: 34979873]
  • Yu-Jin Kwon, Go Eun Kwon, Hye Sun Lee, Man Ho Choi, Ji-Won Lee. The Effect of Orlistat on Sterol Metabolism in Obese Patients. Frontiers in endocrinology. 2022; 13(?):824269. doi: 10.3389/fendo.2022.824269. [PMID: 35282441]
  • Djamila Zouheira, Sylvie Lea Wansi Ngnokam, Sylviane Laure Poualeu Kamani, Billy Toussie Tchegnitegni, Jean Bosco Jouda, Jean Romuald Mba, Moïse Legentil Nchouwet, Njini Gael Nfor, Alain K Nyirimigabo, Théodora Kopa Kowa, Gabriel A Agbor. In Vitro Antilipidic and Antithrombotic Activities of Plectranthus glandulosus (Lamiaceae) Leaves Extracts and Fractions. BioMed research international. 2022; 2022(?):4145659. doi: 10.1155/2022/4145659. [PMID: 35178447]
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  • Wenjing Zhou, Jing Zhang, Mingkun Yan, Jin Wu, Shuo Lian, Kang Sun, Baiqing Li, Jia Ma, Jun Xia, Chaoqun Lian. Orlistat induces ferroptosis-like cell death of lung cancer cells. Frontiers of medicine. 2021 Dec; 15(6):922-932. doi: 10.1007/s11684-020-0804-7. [PMID: 34085184]
  • Soheila Noori, Atieh Mirzababaei, Mohammad Reza Amini, Cain C T Clark, Khadijeh Mirzaei. Effect of orlistat on serum uric acid level in adults: A systematic review and meta-analysis of randomised controlled trials. International journal of clinical practice. 2021 Nov; 75(11):e14674. doi: 10.1111/ijcp.14674. [PMID: 34324762]
  • Junjun Chu, Changsheng Xing, Yang Du, Tianhao Duan, Siyao Liu, Pengfei Zhang, Chumeng Cheng, Jill Henley, Xin Liu, Chen Qian, Bingnan Yin, Helen Yicheng Wang, Rong-Fu Wang. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nature metabolism. 2021 11; 3(11):1466-1475. doi: 10.1038/s42255-021-00479-4. [PMID: 34580494]
  • Michael E Hall, Jordana B Cohen, Jamy D Ard, Brent M Egan, John E Hall, Carl J Lavie, Jun Ma, Chiadi E Ndumele, Philip R Schauer, Daichi Shimbo. Weight-Loss Strategies for Prevention and Treatment of Hypertension: A Scientific Statement From the American Heart Association. Hypertension (Dallas, Tex. : 1979). 2021 11; 78(5):e38-e50. doi: 10.1161/hyp.0000000000000202. [PMID: 34538096]
  • Yoshiyuki Sakai, Tatsuki Fukami, Mai Nagaoka, Keiya Hirosawa, Hiroyuki Ichida, Rei Sato, Kohei Suzuki, Masataka Nakano, Miki Nakajima. Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans. Life sciences. 2021 Nov; 284(?):119896. doi: 10.1016/j.lfs.2021.119896. [PMID: 34450168]
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  • Zaidatul Akmal Othman, Zaida Zakaria, Joseph Bagi Suleiman, Victor Udo Nna, Aminah Che Romli, Wan Syaheedah Wan Ghazali, Mahaneem Mohamed. Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22084225. [PMID: 33921777]
  • Ravindra Patil, Samadhan Patil, Vijay Maheshwari, Mohini Patil. Inhibitory kinetics and mechanism of pentacyclic triterpenoid from endophytic Colletotrichum gigasporum against pancreatic lipase. International journal of biological macromolecules. 2021 Apr; 175(?):270-280. doi: 10.1016/j.ijbiomac.2021.02.036. [PMID: 33561462]
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  • Vian Ahmed Wasta Esmail, Mohammed Omer Mohammed, Marwan S M Al-Nimer. Short-term orlistat therapy improves fatty infiltration indices and liver fibrosis scores in patients with non-alcoholic fatty liver disease and metabolic syndrome. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 2021 Mar; 22(1):1-5. doi: 10.1016/j.ajg.2020.12.005. [PMID: 33664007]
  • Adam Kawiński, Magdalena Miklaszewska, Szymon Stelter, Bartosz Głąb, Antoni Banaś. Lipases of germinating jojoba seeds efficiently hydrolyze triacylglycerols and wax esters and display wax ester-synthesizing activity. BMC plant biology. 2021 Jan; 21(1):50. doi: 10.1186/s12870-020-02823-4. [PMID: 33468064]
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