2,3-Dideoxyadenosine (BioDeep_00000398626)

   


代谢物信息卡片


2,3-Dideoxyadenosine

化学式: C10H13N5O2 (235.10691980000004)
中文名称: 2,3-二脱氧腺苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(OC1CO)N2C=NC3=C(N=CN=C32)N
InChI: InChI=1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h4-7,16H,1-3H2,(H2,11,12,13)

描述信息

C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.384
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.377
2',3'-Dideoxyadenosine is an inhibitor of HIV replication[1]. Antiretroviral activity[1]. Antiviral efficacy[1].

同义名列表

2 个代谢物同义名

2,3-Dideoxyadenosine; 2',3'-Dideoxyadenosine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Serdar Sahinturk. Elabela relaxes rat pulmonary artery and trachea via BKCa, KV, and KATP channels. Prostaglandins & other lipid mediators. 2023 Apr; 167(?):106735. doi: 10.1016/j.prostaglandins.2023.106735. [PMID: 37059294]
  • S Fernández, S Morado, P Cetica, M Córdoba. Hyaluronic acid capacitation induces intracellular signals modulated by membrane-associated adenylate cyclase and tyrosine kinase involved in bovine in vitro fertilization. Theriogenology. 2020 May; 148(?):174-179. doi: 10.1016/j.theriogenology.2020.02.033. [PMID: 32182525]
  • Hong Zhang, Xueguang Shao, François Dehez, Wensheng Cai, Christophe Chipot. Modulation of membrane permeability by carbon dioxide. Journal of computational chemistry. 2020 02; 41(5):421-426. doi: 10.1002/jcc.26063. [PMID: 31479166]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Chi Hang Tse, Jeffrey Comer, Yi Wang, Christophe Chipot. Link between Membrane Composition and Permeability to Drugs. Journal of chemical theory and computation. 2018 Jun; 14(6):2895-2909. doi: 10.1021/acs.jctc.8b00272. [PMID: 29771515]
  • Jinae N Roa, Martin Tresguerres. Soluble adenylyl cyclase is an acid-base sensor in epithelial base-secreting cells. American journal of physiology. Cell physiology. 2016 08; 311(2):C340-9. doi: 10.1152/ajpcell.00089.2016. [PMID: 27335168]
  • Mark Kwaaitaal, Rik Huisman, Jens Maintz, Anja Reinstädler, Ralph Panstruga. Ionotropic glutamate receptor (iGluR)-like channels mediate MAMP-induced calcium influx in Arabidopsis thaliana. The Biochemical journal. 2011 Dec; 440(3):355-65. doi: 10.1042/bj20111112. [PMID: 21848515]
  • Josep Bassaganya-Riera, Amir J Guri, Raquel Hontecillas. Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists. Journal of obesity. 2011; 2011(?):897894. doi: 10.1155/2011/897894. [PMID: 21253508]
  • Natarajan V Bhanu, Y Terry Lee, Patricia A Oneal, Nicole M Gantt, Wulin Aerbajinai, Pierre Noel, Craig J Thomas, Jeffery L Miller. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. Biochimica et biophysica acta. 2008 Sep; 1782(9):504-10. doi: 10.1016/j.bbadis.2008.05.004. [PMID: 18586086]
  • Kazi Mirajul Hoque, Linxi Chen, George P H Leung, Chung-Ming Tse. A purine-selective nucleobase/nucleoside transporter in PK15NTD cells. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Jun; 294(6):R1988-95. doi: 10.1152/ajpregu.00016.2008. [PMID: 18417653]
  • Gavrielle M Price, Kenneth M Chrobak, Joe Tien. Effect of cyclic AMP on barrier function of human lymphatic microvascular tubes. Microvascular research. 2008 May; 76(1):46-51. doi: 10.1016/j.mvr.2008.02.003. [PMID: 18440562]
  • Zhixiong Chen, Zach Suntres, Jeffrey Palmer, Jorge Guzman, Asad Javed, Jianjing Xue, Jun-Ge Yu, Helen Cooke, Hamdy Awad, Hamdy H Hassanain, Arturo J Cardounel, Fievos L Christofi. Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation. International journal for parasitology. 2007 Jun; 37(7):743-61. doi: 10.1016/j.ijpara.2006.12.018. [PMID: 17307183]
  • Akira Ikari, Satomi Matsumoto, Hitoshi Harada, Kuniaki Takagi, Hisayoshi Hayashi, Yuichi Suzuki, Masakuni Degawa, Masao Miwa. Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions. Journal of cell science. 2006 May; 119(Pt 9):1781-9. doi: 10.1242/jcs.02901. [PMID: 16608877]
  • Svetlana Sharoyan, Alvard Antonyan, Sona Mardanyan, Giulio Lupidi, Gloria Cristalli. Influence of dipeptidyl peptidase IV on enzymatic properties of adenosine deaminase. Acta biochimica Polonica. 2006; 53(3):539-46. doi: . [PMID: 16929383]
  • Grewo Lim, Shuxing Wang, Jianren Mao. cAMP and protein kinase A contribute to the downregulation of spinal glutamate transporters after chronic morphine. Neuroscience letters. 2005 Mar; 376(1):9-13. doi: 10.1016/j.neulet.2004.11.016. [PMID: 15694265]
  • Young-Guk Park, Sung-Koo Kang, Sang-Ho Noh, Kwan-Kyu Park, Young-Chae Chang, Young-Choon Lee, Cheorl-Ho Kim. PGE2 induces IL-1beta gene expression in mouse osteoblasts through a cAMP-PKA signaling pathway. International immunopharmacology. 2004 Jun; 4(6):779-89. doi: 10.1016/j.intimp.2004.03.003. [PMID: 15135319]
  • Song Ye, Martha M Rezende, Wei-Ping Deng, Brian Herbert, John W Daly, Roger A Johnson, Kenneth L Kirk. Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. Journal of medicinal chemistry. 2004 Feb; 47(5):1207-13. doi: 10.1021/jm0303599. [PMID: 14971900]
  • Ulla C Kopp, Michael Z Cicha, Lori A Smith. PGE(2) increases release of substance P from renal sensory nerves by activating the cAMP-PKA transduction cascade. American journal of physiology. Regulatory, integrative and comparative physiology. 2002 Jun; 282(6):R1618-27. doi: 10.1152/ajpregu.00701.2001. [PMID: 12010743]
  • Harutaka Yamada, Tetsuo Adachi, Atsushi Fukatsu, Sachiko Misao, Yasukazu Yamada, Takanari Aoki, Naoto Miura, Masato Sakuma, Kazuhiro Nishikawa, Arao Futenma, Shinichi Kakumu. Extracellular superoxide dismutase and glomerular mesangial cells: its production and regulation. FEBS letters. 2002 May; 519(1-3):77-81. doi: 10.1016/s0014-5793(02)02714-x. [PMID: 12023021]
  • H Y Aboul-Enein, S Abu-Zaid. High performance liquid chromatography analysis of 9-(2',3'-dideoxy-2'beta-fluoro-D-threo-penta furanosyl) adenine and its metabolite in human plasma using solid-phase extraction on a polyfluorinated reversed stationary phase. Biomedical chromatography : BMC. 2001 Jun; 15(4):267-70. doi: 10.1002/bmc.70. [PMID: 11438969]
  • H Zhang, H Ford, J S Roth, J A Kelley. Evaluation of a fluorogenic derivatization method for the reversed-phase HPLC analysis of 2'-beta-fluoro-2',3'-dideoxyadenosine, a new anti-AIDS drug. Journal of pharmaceutical and biomedical analysis. 2001 May; 25(2):285-97. doi: 10.1016/s0731-7085(00)00496-9. [PMID: 11275436]
  • L Placidi, A Faraj, A G Loi, C Pierra, D Egron, E Cretton-Scott, G Gosseli, C Périgaud, L T Martin, R F Schinazi, J L Imbach, M H el Kouni, M L Bryant, J P Sommadossi. Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication. Antiviral chemistry & chemotherapy. 2001 Mar; 12(2):99-108. doi: 10.1177/095632020101200203. [PMID: 11527047]
  • P G Hoggard, S D Sales, S Kewn, D Sunderland, S H Khoo, C A Hart, D J Back. Correlation between intracellular pharmacological activation of nucleoside analogues and HIV suppression in vitro. Antiviral chemistry & chemotherapy. 2000 Nov; 11(6):353-8. doi: 10.1177/095632020001100601. [PMID: 11227992]
  • J S Roth, J Wang, J A Kelley. Determination of lodenosine and its major metabolite in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry. Journal of mass spectrometry : JMS. 2000 Nov; 35(11):1313-9. doi: 10.1002/1096-9888(200011)35:11<1313::aid-jms65>3.0.co;2-v. [PMID: 11114090]
  • B Birmelé, A De Agostini, E P Girardin. Role of cyclic AMP in idiopathic nephrotic syndrome: a pathway involving a decrease in glomerular cell heparan sulfates?. Journal of cellular biochemistry. 2000 Jun; 78(3):363-70. doi: 10.1002/1097-4644(20000901)78:3<363::aid-jcb2>3.0.co;2-k. [PMID: 10861835]
  • NULL. Death halts study. Positively aware : the monthly journal of the Test Positive Aware Network. 2000 Jan; 11(1):23. doi: NULL. [PMID: 11366339]
  • D Kumari, K Usdin. Sequencing errors in reactions using labeled terminators. BioTechniques. 1999 Oct; 27(4):648-50. doi: 10.2144/99274bm02. [PMID: 10524297]
  • N R Srinivas, W C Shyu. Single dose and multiple dose pharmacokinetics of 2'-fluoro-2',3'-dideoxyadenosine and 2'-fluoro-2',3'-dideoxyinosine, anti-HIV agents, in rats. European journal of drug metabolism and pharmacokinetics. 1999 Oct; 24(4):329-34. doi: 10.1007/bf03190041. [PMID: 10892896]
  • J S Roth, C M McCully, F M Balis, D G Poplack, J A Kelley. 2'-beta-fluoro-2',3'-dideoxyadenosine, lodenosine, in rhesus monkeys: plasma and cerebrospinal fluid pharmacokinetics and urinary disposition. Drug metabolism and disposition: the biological fate of chemicals. 1999 Oct; 27(10):1128-32. doi: NULL. [PMID: 10497138]
  • S Takasuga, T Katada, M Ui, O Hazeki. Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes. The Journal of biological chemistry. 1999 Jul; 274(28):19545-50. doi: 10.1074/jbc.274.28.19545. [PMID: 10391887]
  • J G Hoenderop, J J De Pont, R J Bindels, P H Willems. Hormone-stimulated Ca2+ reabsorption in rabbit kidney cortical collecting system is cAMP-independent and involves a phorbol ester-insensitive PKC isotype. Kidney international. 1999 Jan; 55(1):225-33. doi: 10.1046/j.1523-1755.1999.00228.x. [PMID: 9893131]
  • J S Roth, H Ford, M Tanaka, H Mitsuya, J A Kelley. Determination of 2'-beta-fluoro-2',3'-dideoxyadenosine, an experimental anti-AIDS drug, in human plasma by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 1998 Aug; 712(1-2):199-210. doi: 10.1016/s0378-4347(98)00144-3. [PMID: 9698243]
  • U Holtbäck, Y Ohtomo, P Förberg, B Sahlgren, A Aperia. Neuropeptide Y shifts equilibrium between alpha- and beta-adrenergic tonus in proximal tubule cells. The American journal of physiology. 1998 07; 275(1):F1-7. doi: 10.1152/ajprenal.1998.275.1.f1. [PMID: 9688998]
  • F Izadyar, B Colenbrander, M M Bevers. Stimulatory effect of growth hormone on in vitro maturation of bovine oocytes is exerted through the cyclic adenosine 3',5'-monophosphate signaling pathway. Biology of reproduction. 1997 Dec; 57(6):1484-9. doi: 10.1095/biolreprod57.6.1484. [PMID: 9408258]
  • D Singhal, M E Morgan, B D Anderson. Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats. Pharmaceutical research. 1997 Jun; 14(6):786-92. doi: 10.1023/a:1012110724604. [PMID: 9210198]
  • T Koudriakova, K K Manouilov, K Shanmuganathan, L P Kotra, F D Boudinot, E Cretton-Scott, J P Sommadossi, R F Schinazi, C K Chu. In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI. Journal of medicinal chemistry. 1996 Nov; 39(23):4676-81. doi: 10.1021/jm960140c. [PMID: 8917656]
  • D Singhal, M E Morgan, B D Anderson. Role of altered metabolism in dideoxynucleoside pharmacokinetics. Studies of 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats. Drug metabolism and disposition: the biological fate of chemicals. 1996 Oct; 24(10):1155-61. doi: . [PMID: 8894519]
  • D A Campbell, V R Shah, N R Srinivas, W C Shyu. High-performance liquid chromatographic analysis of 2'-fluoro-2',3'-dideoxyadenosine and 2'-fluoro-2',3'-dideoxyinosine in dog plasma and urine. Journal of pharmaceutical sciences. 1996 Aug; 85(8):890-2. doi: 10.1021/js960025p. [PMID: 8863284]
  • K Ogawa, M Tashima, Y Takeda, H Sawai, T Toi, H Sawada, Y Maruyama, M Okuma. Erythroid differentiation and growth inhibition of K562 cells by 2',5'-dideoxyadenosine: synergism with interferon-alpha. Leukemia research. 1995 Oct; 19(10):749-55. doi: 10.1016/0145-2126(95)00053-q. [PMID: 7500653]
  • B A Donzanti, J A Kelley, J E Tomaszewski, J S Roth, P Tosca, M Placke, A Singer, J T Yarrington, J S Driscoll. Acute cardiotoxicity of the Anti-HIV dideoxynucleoside, F-ddA, in the rat. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1995 Sep; 27(2):167-76. doi: 10.1006/faat.1995.1121. [PMID: 8529811]
  • J Rodriguez-Commes, J N Forrest, R Lopez, J Gasalla-Herraiz, C M Isales. Parathyroid hormone stimulates electrogenic sodium transport in A6 cells. Biochemical and biophysical research communications. 1995 Aug; 213(2):688-98. doi: 10.1006/bbrc.1995.2186. [PMID: 7646525]
  • M J Boyle, M Connors, M E Flanigan, S P Geiger, H Ford, M Baseler, J Adelsberger, R T Davey, H C Lane. The human HIV/peripheral blood lymphocyte (PBL)-SCID mouse. A modified human PBL-SCID model for the study of HIV pathogenesis and therapy. Journal of immunology (Baltimore, Md. : 1950). 1995 Jun; 154(12):6612-23. doi: NULL. [PMID: 7759895]
  • M E Hawkins, H Mitsuya, C M McCully, K S Godwin, K Murakami, D G Poplack, F M Balis. Pharmacokinetics of dideoxypurine nucleoside analogs in plasma and cerebrospinal fluid of rhesus monkeys. Antimicrobial agents and chemotherapy. 1995 Jun; 39(6):1259-64. doi: 10.1128/aac.39.6.1259. [PMID: 7574512]
  • M Shahedi, K Laborde, S Azimi, S Hamdani, C Sachs. Mechanisms of dopamine effects on Na-K-ATPase activity in Madin-Darby canine kidney (MDCK) epithelial cells. Pflugers Archiv : European journal of physiology. 1995 Apr; 429(6):832-40. doi: 10.1007/bf00374808. [PMID: 7541525]
  • G S Ahluwalia, D A Cooney, T Shirasaka, H Mitsuya, J S Driscoll, D G Johns. Enhancement by 2'-deoxycoformycin of the 5'-phosphorylation and anti-human immunodeficiency virus activity of 2',3'-dideoxyadenosine and 2'-beta-fluoro-2',3'-dideoxyadenosine. Molecular pharmacology. 1994 Nov; 46(5):1002-8. doi: . [PMID: 7969062]
  • J P Sommadossi. [What is known about the cellular and molecular pharmacodynamics of nucleosides?]. Pathologie-biologie. 1993 Oct; 41(8 Pt 2):781-7. doi: NULL. [PMID: 8309721]
  • R A Heijtink, G A De Wilde, J Kruining, L Berk, J Balzarini, E De Clercq, A Holy, S W Schalm. Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection. Antiviral research. 1993 Jun; 21(2):141-53. doi: 10.1016/0166-3542(93)90050-s. [PMID: 8338351]
  • C L Burns, M H St Clair, L W Frick, T Spector, D R Averett, M L English, T J Holmes, T A Krenitsky, G W Koszalka. Novel 6-alkoxypurine 2',3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus. Journal of medicinal chemistry. 1993 Feb; 36(3):378-84. doi: 10.1021/jm00055a009. [PMID: 8426365]
  • T Satoh, M Ominato, H T Cohen, A I Katz. Role of the phospholipase C-protein kinase C pathway in proximal tubule Na-K-ATPase regulation. Transactions of the Association of American Physicians. 1993; 106(?):196-200. doi: NULL. [PMID: 8036742]
  • H Nagaoka, H Nohta, M Saito, Y Ohkura. Determination of 2',3'-dideoxyinosine and 2',3'-dideoxyadenosine in rat plasma by high-performance liquid chromatography with precolumn fluorescence derivatization. Chemical & pharmaceutical bulletin. 1992 Aug; 40(8):2202-4. doi: 10.1248/cpb.40.2202. [PMID: 1423782]
  • K B Mullah, T S Rao, J Balzarini, E De Clercq, W G Bentrude. Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities. Journal of medicinal chemistry. 1992 Jul; 35(15):2728-35. doi: 10.1021/jm00093a003. [PMID: 1495007]
  • B E Korba, J L Gerin. Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication. Antiviral research. 1992 Jul; 19(1):55-70. doi: 10.1016/0166-3542(92)90056-b. [PMID: 1444322]
  • I A Feoktistov, S Paul, A S Hollister, D Robertson, I Biaggioni. Role of cyclic AMP in adenosine inhibition of intracellular calcium rise in human platelets. Comparison of adenosine effects on thrombin- and epinephrine-induced platelet stimulation. American journal of hypertension. 1992 Jun; 5(6 Pt 2):147S-153S. doi: 10.1093/ajh/5.6.147s. [PMID: 1321639]
  • R Coulson, R A Johnson, R A Olsson, D R Cooper, S J Scheinman. Adenosine stimulates phosphate and glucose transport in opossum kidney epithelial cells. The American journal of physiology. 1991 Jun; 260(6 Pt 2):F921-8. doi: 10.1152/ajprenal.1991.260.6.f921. [PMID: 1647692]
  • M G Wientjes, M E Placke, M J Chang, J G Page, W M Kluwe, J E Tomaszewski. Pharmacokinetics of 2',3'-dideoxyadenosine in dogs. Investigational new drugs. 1991 May; 9(2):159-68. doi: 10.1007/bf00175083. [PMID: 1908444]
  • D E Chapman, G Powis. Disposition and metabolism in mice of the potential antitumor and anti-human immunodeficiency virus-1 agent, 2-chloro-2',3'-dideoxyadenosine. Cancer chemotherapy and pharmacology. 1991; 27(4):285-9. doi: 10.1007/bf00685113. [PMID: 1998984]
  • I Teitelbaum, A Strasheim. AVP stimulates adenylyl cyclase and phospholipase C in reciprocal fashion in cultured RIMCT cells. The American journal of physiology. 1990 Oct; 259(4 Pt 1):C693-6. doi: 10.1152/ajpcell.1990.259.4.c693. [PMID: 2221046]
  • N R Hartman, R Yarchoan, J M Pluda, R V Thomas, K S Marczyk, S Broder, D G Johns. Pharmacokinetics of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in patients with severe human immunodeficiency virus infection. Clinical pharmacology and therapeutics. 1990 May; 47(5):647-54. doi: 10.1038/clpt.1990.86. [PMID: 2111751]
  • K N Masihi, W Lange, B Rohde-Schulz, L Chedid. Muramyl dipeptide inhibits replication of human immunodeficiency virus in vitro. AIDS research and human retroviruses. 1990 Mar; 6(3):393-9. doi: 10.1089/aid.1990.6.393. [PMID: 2111159]
  • K N Masihi, W Lange, B Rohde-Schulz. Exacerbation of human immunodeficiency virus infection in promonocytic cells by bacterial immunomodulators. Journal of acquired immune deficiency syndromes. 1990; 3(3):200-5. doi: ". [PMID: 2106022]
  • K J Martin, C L McConkey, J C Garcia, D Montani, C R Betts. Protein kinase-A and the effects of parathyroid hormone on phosphate uptake in opossum kidney cells. Endocrinology. 1989 Jul; 125(1):295-301. doi: 10.1210/endo-125-1-295. [PMID: 2544405]
  • S M el Dareer, K F Tillery, J R Kalin, D L Hill. Disposition of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine in mice. Investigational new drugs. 1989 Jul; 7(2-3):139-46. doi: 10.1007/bf00170850. [PMID: 2507472]
  • P G Plagemann, C Woffendin. Permeation and salvage of dideoxyadenosine in mammalian cells. Molecular pharmacology. 1989 Jul; 36(1):185-92. doi: . [PMID: 2787472]
  • J W Russell, L J Klunk. Comparative pharmacokinetics of new anti-HIV agents: 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine. Biochemical pharmacology. 1989 May; 38(9):1385-8. doi: 10.1016/0006-2952(89)90176-7. [PMID: 2497744]
  • C C Felder, P A Jose, J Axelrod. The dopamine-1 agonist, SKF 82526, stimulates phospholipase-C activity independent of adenylate cyclase. The Journal of pharmacology and experimental therapeutics. 1989 Jan; 248(1):171-5. doi: . [PMID: 2563286]
  • J R Kalin, D L Hill. Determination of 2',3'-dideoxyadenosine, 2',3'-dideoxyinosine and 2',3'-dideoxycytidine in biological samples. Journal of chromatography. 1988 Sep; 431(1):184-91. doi: 10.1016/s0378-4347(00)83083-2. [PMID: 2853167]
  • J A Cole, L R Forte, S Eber, P K Thorne, R E Poelling. Regulation of sodium-dependent phosphate transport by parathyroid hormone in opossum kidney cells: adenosine 3',5'-monophosphate-dependent and -independent mechanisms. Endocrinology. 1988 Jun; 122(6):2981-9. doi: 10.1210/endo-122-6-2981. [PMID: 2836179]
  • J A Shayman, J J Morrissey, A R Morrison. Islet activating protein inhibits kinin-stimulated inositol phosphate production, calcium mobilization, and prostaglandin E2 synthesis in renal papillary collecting tubule cells independent of cyclic AMP. The Journal of biological chemistry. 1987 Dec; 262(35):17083-7. doi: 10.1016/s0021-9258(18)45494-4. [PMID: 2824514]
  • D D Richman, R S Kornbluth, D A Carson. Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. The Journal of experimental medicine. 1987 Oct; 166(4):1144-9. doi: 10.1084/jem.166.4.1144. [PMID: 2821152]
  • P A Blau, J W Hines, R D Voyksner. Application of high-performance liquid chromatography and thermospray high-performance liquid chromatography-mass spectrometry to the analysis and identification of 2',3'-dideoxyadenosine and its metabolite in biological media. Journal of chromatography. 1987 Sep; 420(1):1-12. doi: 10.1016/0378-4347(87)80149-4. [PMID: 3499445]
  • J M Onoda, T Braun, S M Wrenn. Characterization of the purine-reactive site of the rat testis cytosolic adenylate cyclase. Biochemical pharmacology. 1987 Jun; 36(12):1907-12. doi: 10.1016/0006-2952(87)90487-4. [PMID: 3496100]
  • Y Hakeda, T Yoshino, Y Natakani, N Kurihara, N Maeda, M Kumegawa. Prostaglandin E2 stimulates DNA synthesis by a cyclic AMP-independent pathway in osteoblastic clone MC3T3-E1 cells. Journal of cellular physiology. 1986 Aug; 128(2):155-61. doi: 10.1002/jcp.1041280204. [PMID: 2426284]
  • R Gärtner, W Greil, R Demharter, K Horn. Involvement of cyclic AMP, iodide and metabolites of arachidonic acid in the regulation of cell proliferation of isolated porcine thyroid follicles. Molecular and cellular endocrinology. 1985 Sep; 42(2):145-55. doi: 10.1016/0303-7207(85)90102-9. [PMID: 2998905]
  • M A Dillingham, R J Anderson. Purinergic regulation of basal and arginine vasopressin-stimulated hydraulic conductivity in rabbit cortical collecting tubule. The Journal of membrane biology. 1985; 88(3):277-81. doi: 10.1007/bf01871091. [PMID: 3007763]
  • V A Florio, E M Ross. Regulation of the catalytic component of adenylate cyclase. Potentiative interaction of stimulatory ligands and 2',5'-dideoxyadenosine. Molecular pharmacology. 1983 Sep; 24(2):195-202. doi: NULL. [PMID: 6310361]
  • K C Agarwal, F X Russo, R E Parks. Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula). Thrombosis and haemostasis. 1982 Oct; 48(2):162-5. doi: . [PMID: 6983740]
  • N Vogt, A Englhardt. [Different forms of hyperlipoproteinemia in diabetics (author's transl)]. Medizinische Klinik. 1975 Nov; 70(46):1871-7. doi: NULL. [PMID: 171548]