Broxuridine (BioDeep_00000398623)
代谢物信息卡片
5-Bromo-2-deoxyuridine
化学式: C9H11BrN2O5 (305.9851296)
中文名称: 5-溴-2-脱氧尿苷(BUdR)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)Br)CO)O
InChI: InChI=1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent
D009676 - Noxae > D000963 - Antimetabolites
D011838 - Radiation-Sensitizing Agents
D000970 - Antineoplastic Agents
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.233
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.226
5-BrdU (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA. 5-BrdU is commonly used in the detection of proliferating cells.
同义名列表
6 个代谢物同义名
5-Bromo-2-deoxyuridine; Broxuridine; BrdU; 5-Bromo-2'-deoxyuridine; BUdR; 5-BrdU
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:472552
- KEGGdrug: D01763
- PubChem: 6035
- DrugBank: DB12028
- ChEMBL: CHEMBL222280
- MeSH: Bromodeoxyuridine
- CAS: 59-14-3
- MoNA: BML80463
- MoNA: BML80461
- MoNA: BML80460
- MoNA: BML01443
- medchemexpress: HY-15910
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ishita Saha, Sourav Ghosh, Shubham Roy, Tarakdas Basu, Parimal Karmakar. Facile process ofHibiscusmucilage polymer formulation usingHibiscus rosa-sinensisleaves to treat second-degree burn and excision wounds.
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Journal of ethnopharmacology.
2024 Jan; 319(Pt 1):117081. doi:
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Biological research.
2023 Dec; 56(1):65. doi:
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2023 Nov; ?(?):117400. doi:
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European journal of pharmacology.
2023 Sep; 957(?):176041. doi:
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2022 May; 59(5):3254-3279. doi:
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Stem cells and development.
2022 04; 31(7-8):195-206. doi:
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2022 Feb; 157(2):239-250. doi:
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Pharmacology.
2022; 107(5-6):317-329. doi:
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Nutrients.
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The Analyst.
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Journal of dairy science.
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Journal of neuroscience research.
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2016 Dec; 22(12):932-940. doi:
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Planta medica.
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Autoimmunity.
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Brain research.
2015 Jul; 1614(?):28-37. doi:
10.1016/j.brainres.2015.04.013. [PMID: 25896936] - Takehito Suzuki, Hideo Fukuoka, Setsuo Ushikoshi, Reiichiro Sato, Hidetoshi Morita, Tatsuya Takizawa. Protective effect of aqueous extracts from Rhizopus oryzae on liver injury induced by carbon tetrachloride in rats.
Animal science journal = Nihon chikusan Gakkaiho.
2015 May; 86(5):532-40. doi:
10.1111/asj.12328. [PMID: 25496319] - Katsumasa Muneoka, Makiko Kuwagata, Tetsuo Ogawa, Seiji Shioda. Mother/offspring co-administration of the traditional herbal remedy yokukansan during the nursing period influences grooming and cerebellar serotonin levels in a rat model of neurodevelopmental disorders.
Cerebellum (London, England).
2015 Apr; 14(2):86-96. doi:
10.1007/s12311-014-0611-2. [PMID: 25315739] - Anna Lewinska, Justyna Siwak, Iwona Rzeszutek, Maciej Wnuk. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.
Toxicology in vitro : an international journal published in association with BIBRA.
2015 Apr; 29(3):417-25. doi:
10.1016/j.tiv.2014.12.005. [PMID: 25499067] - Xiaohui Zhang, Ruiqi Gao, Depeng Li, Hongyan Yin, Juling Zhang, Hongyu Cao, Xuefang Zheng. Study on Interaction between 5-Bromo-4-thio-2'-deoxyuridine and human serum albumin by spectroscopy and molecular docking.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Feb; 136 Pt C(?):1775-81. doi:
10.1016/j.saa.2014.10.081. [PMID: 25467669] - Isabelle Buisson, Ronan Le Bouffant, Mélinée Futel, Jean-François Riou, Muriel Umbhauer. Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development.
Developmental biology.
2015 Jan; 397(2):175-90. doi:
10.1016/j.ydbio.2014.10.022. [PMID: 25446030] - Michael Schmid, Claus Steinlein. Chromosome Banding in Amphibia. XXXII. The Genus Xenopus (Anura, Pipidae).
Cytogenetic and genome research.
2015; 145(3-4):201-17. doi:
10.1159/000433481. [PMID: 26112092] - Ronald W Irwin, Christine M Solinsky, Carlos M Loya, Francesco G Salituro, Kathleen E Rodgers, Gerhard Bauer, Michael A Rogawski, Roberta Diaz Brinton. Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.
PloS one.
2015; 10(6):e0128313. doi:
10.1371/journal.pone.0128313. [PMID: 26039057] - Jianwen Wang, Guiting Lin, Amjad Alwaal, Xiaoyu Zhang, Guifang Wang, Xingyuan Jia, Lia Banie, Jacqueline Villalta, Ching-Shwun Lin, Tom F Lue. Kinetics of Label Retaining Cells in the Developing Rat Kidneys.
PloS one.
2015; 10(12):e0144734. doi:
10.1371/journal.pone.0144734. [PMID: 26650841] - Santanu Panda, Sonu Bisht, Dhruba Malakar, Ashok K Mohanty, Jai K Kaushik. In vitro culture of functionally active buffalo hepatocytes isolated by using a simplified manual perfusion method.
PloS one.
2015; 10(3):e0118841. doi:
10.1371/journal.pone.0118841. [PMID: 25790478] - Sun-Young Kong, Min-Hye Park, Mina Lee, Jae-Ouk Kim, Ha-Rim Lee, Byung Woo Han, Clive N Svendsen, Sang Hyun Sung, Hyun-Jung Kim. Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells.
PloS one.
2015; 10(2):e0118188. doi:
10.1371/journal.pone.0118188. [PMID: 25706719] - Germana Freire Rocha Caldas, Alisson Rodrigo da Silva Oliveira, Alice Valença Araújo, Simone Sette Lopes Lafayette, Giwellington Silva Albuquerque, Jacinto da Costa Silva-Neto, João Henrique Costa-Silva, Fabiano Ferreira, José Galberto Martins da Costa, Almir Gonçalves Wanderley. Gastroprotective Mechanisms of the Monoterpene 1,8-Cineole (Eucalyptol).
PloS one.
2015; 10(8):e0134558. doi:
10.1371/journal.pone.0134558. [PMID: 26244547] - Lei-Miao Yin, Ying Wei, Wen-Qian Wang, Yu Wang, Yu-Dong Xu, Yong-Qing Yang. Simultaneous application of BrdU and WST-1 measurements for detection of the proliferation and viability of airway smooth muscle cells.
Biological research.
2014 Dec; 47(?):75. doi:
10.1186/0717-6287-47-75. [PMID: 25723317] - Anna Matiašová, Juraj Sevc, Jaromír Mikeš, Rastislav Jendželovský, Zuzana Daxnerová, Peter Fedoročko. Flow cytometric determination of 5-bromo-2'-deoxyuridine pharmacokinetics in blood serum after intraperitoneal administration to rats and mice.
Histochemistry and cell biology.
2014 Dec; 142(6):703-12. doi:
10.1007/s00418-014-1253-7. [PMID: 25059651] - Hea-Jin Jung, Angelica Tatar, Yiping Tu, Chika Nobumori, Shao H Yang, Chris N Goulbourne, Harald Herrmann, Loren G Fong, Stephen G Young. An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin.
Molecular and cellular biology.
2014 Dec; 34(24):4534-44. doi:
10.1128/mcb.00997-14. [PMID: 25312645] - Chizuru Utsugi, Sadaharu Miyazono, Kazumi Osada, Mitsuyoshi Matsuda, Makoto Kashiwayanagi. Impaired mastication reduced newly generated neurons at the accessory olfactory bulb and pheromonal responses in mice.
Archives of oral biology.
2014 Dec; 59(12):1272-8. doi:
10.1016/j.archoralbio.2014.07.018. [PMID: 25150532] - Ning Su, Samuel X Shi, Xiaodong Zhu, Aimee Borazanci, Fu-Dong Shi, Yan Gan. Interleukin-7 expression and its effect on natural killer cells in patients with multiple sclerosis.
Journal of neuroimmunology.
2014 Nov; 276(1-2):180-6. doi:
10.1016/j.jneuroim.2014.08.618. [PMID: 25218211] - Takao Mukuda, Yuka Koyama, Sawako Hamasaki, Toshiyuki Kaidoh, Yasuo Furukawa. Systemic angiotensin II and exercise-induced neurogenesis in adult rat hippocampus.
Brain research.
2014 Nov; 1588(?):92-103. doi:
10.1016/j.brainres.2014.09.019. [PMID: 25223907] - Chandrav De, Dongmei Liu, Bo Zheng, Uma S Singh, Satish Chavre, Catherine White, Robert D Arnold, Fred K Hagen, Chung K Chu, Jennifer F Moffat. β-l-1-[5-(E-2-bromovinyl)-2-(hydroxymethyl)-1,3-(dioxolan-4-yl)] uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism.
Antiviral research.
2014 Oct; 110(?):10-9. doi:
10.1016/j.antiviral.2014.07.007. [PMID: 25051026] - Weilun Sun, Tilly Wilhelmina Aalders, Egbert Oosterwijk. Identification of potential bladder progenitor cells in the trigone.
Developmental biology.
2014 Sep; 393(1):84-92. doi:
10.1016/j.ydbio.2014.06.018. [PMID: 24992712] - Simona Infantino, Sarah A Jones, Jennifer A Walker, Mhairi J Maxwell, Amanda Light, Kristy O'Donnell, Evelyn Tsantikos, Victor Peperzak, Toby Phesse, Matthias Ernst, Fabienne Mackay, Margaret L Hibbs, Kirsten A Fairfax, David M Tarlinton. The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice.
Science signaling.
2014 Aug; 7(338):ra77. doi:
10.1126/scisignal.2005105. [PMID: 25118329] - Ying Xu, Guo-jing Dai, Qian Liu, Xiao-ping Ma, Li Li, Wei-heng Chen, Na Lin. Effect of Ermiao Recipe with medicinal guide Angelicae Pubescentis Radix on promoting the homing of bone marrow stem cells to treat cartilage damage in osteoarthritis rats.
Chinese journal of integrative medicine.
2014 Aug; 20(8):600-9. doi:
10.1007/s11655-014-1761-2. [PMID: 25087604] - Eyal Shteyer, Ami Ben Ya'acov, Lidia Zolotaryova, Avital Sinai, Yoav Lichtenstein, Orit Pappo, Olga Kryukov, Tsiona Elkayam, Smadar Cohen, Yaron Ilan. Reduced liver cell death using an alginate scaffold bandage: a novel approach for liver reconstruction after extended partial hepatectomy.
Acta biomaterialia.
2014 Jul; 10(7):3209-16. doi:
10.1016/j.actbio.2014.02.047. [PMID: 24607858] - Yinan Wang, Deepta Bhattacharya. Adjuvant-specific regulation of long-term antibody responses by ZBTB20.
The Journal of experimental medicine.
2014 May; 211(5):841-56. doi:
10.1084/jem.20131821. [PMID: 24711582] - Stéphane Chevrier, Dianne Emslie, Wei Shi, Tobias Kratina, Cameron Wellard, Alexander Karnowski, Erdem Erikci, Gordon K Smyth, Kamal Chowdhury, David Tarlinton, Lynn M Corcoran. The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity.
The Journal of experimental medicine.
2014 May; 211(5):827-40. doi:
10.1084/jem.20131831. [PMID: 24711583] - Xiao-Jing Wang, Tao Sun, Liang Kong, Zhen-Hua Shang, Kun-Qi Yang, Qing-Yu Zhang, Fang-Miao Jing, Lun Dong, Xu-Feng Xu, Jia-Xin Liu, Hua Xin, Zhe-Yu Chen. Gypenosides pre-treatment protects the brain against cerebral ischemia and increases neural stem cells/progenitors in the subventricular zone.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2014 Apr; 33(?):49-56. doi:
10.1016/j.ijdevneu.2013.12.001. [PMID: 24334222] - Jose Cordoba-Chacon, Manuel D Gahete, Naveen K Pokala, David Geldermann, Maria Alba, Roberto Salvatori, Raul M Luque, Rhonda D Kineman. Long- but not short-term adult-onset, isolated GH deficiency in male mice leads to deterioration of β-cell function, which cannot be accounted for by changes in β-cell mass.
Endocrinology.
2014 Mar; 155(3):726-35. doi:
10.1210/en.2013-1825. [PMID: 24424062] - Alexis Tapanes-Castillo, Francelethia S Shabazz, Mam Y Mboge, Katarina Vajn, Martin Oudega, Jeffery A Plunkett. Characterization of a novel primary culture system of adult zebrafish brainstem cells.
Journal of neuroscience methods.
2014 Feb; 223(?):11-9. doi:
10.1016/j.jneumeth.2013.11.022. [PMID: 24316294] - Amr S Abu Lila, Yumi Uehara, Tatsuhiro Ishida, Hiroshi Kiwada. Application of polyglycerol coating to plasmid DNA lipoplex for the evasion of the accelerated blood clearance phenomenon in nucleic acid delivery.
Journal of pharmaceutical sciences.
2014 Feb; 103(2):557-66. doi:
10.1002/jps.23823. [PMID: 24347396] - S Babic, D Jezova. Effect of phenytoin treatment on cell proliferation in the hippocampus and the heart and related neuroendocrine changes under non-stress and stress conditions.
Neurological research.
2014 Feb; 36(2):112-7. doi:
10.1179/1743132813y.0000000278. [PMID: 24172819] - Sarah E Wetzel-Strong, Manyu Li, Klara R Klein, Toshio Nishikimi, Kathleen M Caron. Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists.
2014 Feb; 243(2):243-56. doi:
10.1002/dvdy.24065. [PMID: 24123312] - Alexis Koutseff, Christophe Mittelhaeuser, Karim Essabri, Johan Auwerx, Hamid Meziane. Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease?.
Brain research.
2014 Jan; 1542(?):32-40. doi:
10.1016/j.brainres.2013.10.003. [PMID: 24140109] - Rui-Hong Wang, Tyler J Lahusen, Qiang Chen, Xiaoling Xu, Lisa M Miller Jenkins, Elisabetta Leo, Haiqing Fu, Mirit Aladjem, Yves Pommier, Ettore Appella, Chu-Xia Deng. SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing.
International journal of biological sciences.
2014; 10(10):1193-202. doi:
10.7150/ijbs.11066. [PMID: 25516717] - Shuai Li, Ti Zhou, Cen Li, Zhiyu Dai, Di Che, Yachao Yao, Lei Li, Jianxing Ma, Xia Yang, Guoquan Gao. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner.
PloS one.
2014; 9(5):e97330. doi:
10.1371/journal.pone.0097330. [PMID: 24823908] - Bruna Ribeiro Carneiro, Paulo Castanho A Pernambuco Filho, Ana Paula de Sousa Mesquita, Douglas Santos da Silva, Maria Aparecida S Pinhal, Helena B Nader, Carla Cristina Lopes. Acquisition of anoikis resistance up-regulates syndecan-4 expression in endothelial cells.
PloS one.
2014; 9(12):e116001. doi:
10.1371/journal.pone.0116001. [PMID: 25549223] - J Mikeš, J Ševc, J Košuth, A Matiašová, Z Daxnerová, P Fedoročko. Flow cytometric method for estimation of 5-bromo-2´-deoxyuridine content in rat serum.
Physiological research.
2014; 63(6):763-70. doi:
10.33549/physiolres.932753. [PMID: 25157659] - Kim Bartholomeus, Daniel Jacobs-Tulleneers-Thevissen, Sun Shouyue, Krista Suenens, Peter A In't Veld, Miriam Pipeleers-Marichal, Daniel G Pipeleers, Karine Hellemans. Omentum is better site than kidney capsule for growth, differentiation, and vascularization of immature porcine β-cell implants in immunodeficient rats.
Transplantation.
2013 Dec; 96(12):1026-33. doi:
10.1097/tp.0b013e3182a6ee41. [PMID: 24056625] - Akiko Iizuka-Kogo, Tetsu Akiyama, Takao Senda. Decreased apoptosis and persistence of the common nephric duct during the development of an aberrant vesicoureteral junction in Dlg1 gene-targeted mice.
Anatomical record (Hoboken, N.J. : 2007).
2013 Dec; 296(12):1936-42. doi:
10.1002/ar.22814. [PMID: 24142560] - Andrea Dueregger, Fabian Guggenberger, Jan Barthelmes, Günther Stecher, Markus Schuh, Daniel Intelmann, Gudrun Abel, Jutta Haunschild, Helmut Klocker, Reinhold Ramoner, Natalie Sampson. Attenuation of nucleoside and anti-cancer nucleoside analog drug uptake in prostate cancer cells by Cimicifuga racemosa extract BNO-1055.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Nov; 20(14):1306-14. doi:
10.1016/j.phymed.2013.07.009. [PMID: 23972793] - L Scheideler, C Füger, C Schille, F Rupp, H-P Wendel, N Hort, H P Reichel, J Geis-Gerstorfer. Comparison of different in vitro tests for biocompatibility screening of Mg alloys.
Acta biomaterialia.
2013 Nov; 9(10):8740-5. doi:
10.1016/j.actbio.2013.02.020. [PMID: 23429234] - Zhanfeng Chen, Man Wang, Qiang Xiang, Zhenliang Sun, Rong Zhang. The lectin of Dolichos biflorus agglutinin recognises glycan epitopes on the surface of a subset of cardiac progenitor cells.
Cell biology international.
2013 Nov; 37(11):1238-45. doi:
10.1002/cbin.10162. [PMID: 23881868] - Shiang-Suo Huang, Henrich Cheng, Ching-Min Tang, Mao-Wei Nien, Yuahn-Sieh Huang, I-Huei Lee, Jiu-Haw Yin, Terry B J Kuo, Cheryl C H Yang, Shen-Kou Tsai, Ding-I Yang. Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats.
Experimental neurology.
2013 Sep; 247(?):680-8. doi:
10.1016/j.expneurol.2013.03.004. [PMID: 23499832]