Edoxudine (BioDeep_00000398608)

   

Chemicals and Drugs Antibiotics


代谢物信息卡片


5-Ethyl-2-deoxyuridine

化学式: C11H16N2O5 (256.1059166)
中文名称: 乙去氧尿啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
InChI: InChI=1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)

描述信息

D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C29575 - DNA Polymerase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.339
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.333
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.334
Edoxudine is an antiviral drug, is an analog of thymidine, shows effectiveness against herpes simplex virus.

同义名列表

3 个代谢物同义名

Edoxudine; 5-Ethyl-2-deoxyuridine; EUDR



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J Kralovánszky, C Katona, A Jeney, E Pandi, P Noordhuis, V Erdélyi-Tóth, L Otvös, P Kovács, C L Van der Wilt, G J Peters. 5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil. Journal of cancer research and clinical oncology. 1999 Dec; 125(12):675-84. doi: 10.1007/s004320050333. [PMID: 10592100]
  • A M Cheraghali, R Kumar, L Wang, E E Knaus, L I Wiebe. Synthesis, biotransformation, pharmacokinetics, and antiviral properties of 5-ethyl-5-halo-6-methoxy-5,6-dihydro-2'-deoxyuridine diastereomers. Biochemical pharmacology. 1994 Apr; 47(9):1615-25. doi: 10.1016/0006-2952(94)90540-1. [PMID: 8185676]
  • J M Joly, W M Williams. High-performance liquid chromatographic analysis of 5-ethylpyrimidines and 5-methylpyrimidines in plasma. Journal of chromatography. 1991 Feb; 563(2):392-9. doi: 10.1016/0378-4347(91)80047-g. [PMID: 1878072]
  • E De Clercq, B Rosenwirth. Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2'-deoxyuridine, against herpes simplex virus. Antimicrobial agents and chemotherapy. 1985 Aug; 28(2):246-51. doi: 10.1128/aac.28.2.246. [PMID: 3010841]
  • R Kaul, B Hempel. [Isolation and identification of metabolites of 5-ethyl-2'-deoxyuridine from rat urine]. Arzneimittel-Forschung. 1985; 35(7):1055-7. doi: NULL. [PMID: 4052140]
  • Y W Lee, J B Giziewicz, E E Knaus, L I Wiebe. Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VII. [2-14C]-5-ethyl-1-(2'-deoxy-beta-D-ribofuranosyl)uracil. The International journal of applied radiation and isotopes. 1984 Nov; 35(11):1063-6. doi: 10.1016/0020-708x(84)90011-5. [PMID: 6335492]
  • J Reefschläger, G Herrmann, D Bärwolff, B Schwarz, D Cech, P Langen. Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines. Antiviral research. 1983 Sep; 3(3):175-87. doi: 10.1016/0166-3542(83)90024-4. [PMID: 6316849]
  • R Kaul, G Kiefer, S Erhardt, B Hempel. 2-14C-1-(2'-deoxy-beta-D-ribofuranosyl)-5-ethyluracil: synthesis and biotransformation in rats. Journal of pharmaceutical sciences. 1980 May; 69(5):531-4. doi: 10.1002/jps.2600690514. [PMID: 7381737]
  • N K Ayisi, V S Gupta, J B Meldrum, A K Taneja, L A Babiuk. Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2. Antimicrobial agents and chemotherapy. 1980 Apr; 17(4):558-66. doi: 10.1128/aac.17.4.558. [PMID: 6249191]
  • E De Clercq, J Descamps, P De Somer, P J Barr, A S Jones, R T Walker. (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. Proceedings of the National Academy of Sciences of the United States of America. 1979 Jun; 76(6):2947-51. doi: 10.1073/pnas.76.6.2947. [PMID: 223163]
  • E De Clercq, J Descamps, D Shugar. 5-Propyl-2'-deoxyuridine: a specific anti-herpes agent. Antimicrobial agents and chemotherapy. 1978 Mar; 13(3):545-7. doi: 10.1128/aac.13.3.545. [PMID: 233730]
  • O O Barriga. Depression of cell-mediated immunity following inoculation of Trichinella spiralis extract in the mouse. Immunology. 1978 Jan; 34(1):167-73. doi: NULL. [PMID: 23994]
  • T Kulikowski, D Shugar. 13-Alkylpyrimidine nucleosides. Preparation and properties of 5-ethyl-2'-deoxycytidine and related nucleosides. Journal of medicinal chemistry. 1974 Mar; 17(3):269-73. doi: 10.1021/jm00249a003. [PMID: 4359544]