Kinetin riboside (BioDeep_00000398556)
natural product PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C15H17N5O5 (347.1229632)
中文名称: 激动素核苷, 动力精核苷
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 28.57%
分子结构信息
SMILES: C1=COC(=C1)CNC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O
InChI: InChI=1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1
描述信息
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D003583 - Cytokinins
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.645
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.646
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.642
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.644
Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM.
同义名列表
3 个代谢物同义名
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:95050
- PubChem: 20345
- Metlin: METLIN43508
- ChEMBL: CHEMBL411066
- CAS: 4338-47-0
- MoNA: Bruker_HCD_library000935
- MoNA: VF-NPL-QTOF008256
- MoNA: VF-NPL-QTOF008255
- MoNA: VF-NPL-QTOF008254
- MoNA: VF-NPL-QTOF008253
- MoNA: VF-NPL-QTOF008252
- MoNA: VF-NPL-QTOF008251
- MoNA: BML81538
- MoNA: BML81537
- MoNA: BML81536
- MoNA: BML81535
- MoNA: BML01863
- MoNA: BML00556
- MoNA: BML00548
- MoNA: BML00540
- MoNA: BML00531
- MoNA: BML00522
- medchemexpress: HY-101055
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Zhen Xiang, Jialin Liu, Dake Shi, Wei Chen, Jun Li, Ranlin Yan, Yufang Bi, Weiguo Hu, Zhenggang Zhu, Yingyan Yu, Zhitao Yang. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.
International journal of biological sciences.
2020; 16(13):2382-2391. doi:
10.7150/ijbs.47652. [PMID: 32760206] - Dariusz Wawrzyniak, Katarzyna Rolle, Jan Barciszewski. Biological activity of N6-furfuryladenosine.
Postepy biochemii.
2019 06; 65(2):109-117. doi:
10.18388/pb.2019_265. [PMID: 31642649] - Laura Osgerby, Yu-Chiang Lai, Peter J Thornton, Joseph Amalfitano, Cécile S Le Duff, Iqra Jabeen, Hachemi Kadri, Ageo Miccoli, James H R Tucker, Miratul M K Muqit, Youcef Mehellou. Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization.
Journal of medicinal chemistry.
2017 04; 60(8):3518-3524. doi:
10.1021/acs.jmedchem.6b01897. [PMID: 28323427] - Giulio Vistoli, Andrea Brizzolari, Elena Faioni, Cristina Razzari, Enzo Santaniello. Naturally occurring N(6)-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: an in silico evaluation of their interaction with the P2Y(12) receptor.
Bioorganic & medicinal chemistry letters.
2014 Dec; 24(24):5652-5655. doi:
10.1016/j.bmcl.2014.10.080. [PMID: 25467153] - Vishal Gupta, Manoj Kumar, Harshad Brahmbhatt, C R K Reddy, Abhiram Seth, Bhavanath Jha. Simultaneous determination of different endogenetic plant growth regulators in common green seaweeds using dispersive liquid-liquid microextraction method.
Plant physiology and biochemistry : PPB.
2011 Nov; 49(11):1259-63. doi:
10.1016/j.plaphy.2011.08.004. [PMID: 22000048] - Jirí Voller, Marek Zatloukal, René Lenobel, Karel Dolezal, Tibor Béres, Vladimír Krystof, Lukás Spíchal, Percy Niemann, Petr Dzubák, Marián Hajdúch, Miroslav Strnad. Anticancer activity of natural cytokinins: a structure-activity relationship study.
Phytochemistry.
2010 Aug; 71(11-12):1350-9. doi:
10.1016/j.phytochem.2010.04.018. [PMID: 20553699] - Jane Cheong, David Goh, Jean Wan Hong Yong, Swee Ngin Tan, Eng Shi Ong. Inhibitory effect of kinetin riboside in human heptamoa, HepG2.
Molecular bioSystems.
2009 Jan; 5(1):91-8. doi:
10.1039/b712807j. [PMID: 19081935] - S M Siddiqi, K A Jacobson, J L Esker, M E Olah, X D Ji, N Melman, K N Tiwari, J A Secrist, S W Schneller, G Cristalli. Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.
Journal of medicinal chemistry.
1995 Mar; 38(7):1174-88. doi:
10.1021/jm00007a014. [PMID: 7707320] - S Kusachi, R D Thompson, N Yamada, D T Daly, R A Olsson. Dog coronary artery adenosine receptor: structure of the N6-aryl subregion.
Journal of medicinal chemistry.
1986 Jun; 29(6):989-96. doi:
10.1021/jm00156a016. [PMID: 3012086]