Rolitetracycline (BioDeep_00000398455)

   


代谢物信息卡片


(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(pyrrolidin-1-ylmethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

化学式: C27H33N3O8 (527.2267538000001)
中文名称: 花青素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCN5CCCC5)N(C)C)O
InChI: InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,28,31-32,36-38H,4-5,9-12H2,1-3H3/b25-19-/t14?,15?,20-,26+,27-/m0/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

2 个代谢物同义名

Rolitetracycline; (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(pyrrolidin-1-ylmethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tossapon Wongtangprasert, Wirongrong Natakuathung, Umaporn Pimpitak, Anumart Buakeaw, Tanapat Palaga, Kittinan Komolpis, Nanthika Khongchareonporn. Production of a monoclonal antibody against oxytetracycline and its application for oxytetracycline residue detection in shrimp. Journal of Zhejiang University. Science. B. 2014 Feb; 15(2):165-72. doi: 10.1631/jzus.b1300181. [PMID: 24510709]
  • Sinjan Choudhary, Nand Kishore. Unraveling the energetics and mode of the recognition of antibiotics tetracycline and rolitetracycline by bovine serum albumin. Chemical biology & drug design. 2012 Nov; 80(5):693-705. doi: 10.1111/cbdd.12009. [PMID: 22846623]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • S T Forczek, H Uhlírová, M Gryndler, J Albrechtová, K Fuksová, M Vágner, P Schröder, M Matucha. Trichloroacetic acid in Norway spruce/soil-system. II. Distribution and degradation in the plant. Chemosphere. 2004 Jul; 56(4):327-33. doi: 10.1016/j.chemosphere.2004.01.018. [PMID: 15183994]
  • L Lashev, D Pashov, I Kanelov. Species specific pharmacokinetics of rolitetracycline. Zentralblatt fur Veterinarmedizin. Reihe A. 1995 May; 42(3):201-8. doi: 10.1111/j.1439-0442.1995.tb00371.x. [PMID: 8578898]
  • A Sedlakova, I Kollar, M Ondreĭkova, A Rynikova, V Rozdobud'kova, S Pitkova. [The effect of rolitetracycline on the level of nonesterified fatty acids, phospholipids, and triacylglycerols in ischemic damage to the myocardium]. Voprosy meditsinskoi khimii. 1993 Sep; 39(5):10-3. doi: NULL. [PMID: 8279129]
  • M Vaverka, J Petrzelová. [Penetration of antibiotics into the intervertebral disk]. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca. 1991 Mar; 58(1-2):98-103. doi: NULL. [PMID: 1872117]
  • J Neuschl. [The effect of age on pharmacokinetic parameters of oxytetracycline and rolitetracycline in rabbits]. Veterinarni medicina. 1991 Feb; 36(2):119-27. doi: NULL. [PMID: 1807022]
  • H Götz, R Böcker, C J Estler. Combined effects of high doses of rolitetracycline and testosterone on the liver of mice. Archives internationales de pharmacodynamie et de therapie. 1986 Apr; 280(2):324-8. doi: NULL. [PMID: 3718089]
  • J Wójcicki, W Słuczanowski. [Rolitetracycline pharmacokinetics in patients with chronic renal failure]. Polskie Archiwum Medycyny Wewnetrznej. 1984 Apr; 71(4):241-7. doi: NULL. [PMID: 6483645]
  • R Böcker, C J Estler, H Götz, H J Pesch. Investigation into the combined hepatotoxicity of rolitetracycline and ethinyloestradiol. Archives internationales de pharmacodynamie et de therapie. 1983 Jul; 264(1):168-76. doi: NULL. [PMID: 6625765]
  • F A Bahmer, L Anton-Lamprecht. Ultrastructural features of malignant syphilis and demonstration of Treponema pallidum. International journal of dermatology. 1983 Apr; 22(3):165-70. doi: 10.1111/j.1365-4362.1983.tb03357.x. [PMID: 6343268]
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  • R Böcker, C J Estler, S Müller, C Pfandzelter, B Spachmüller. Comparative evaluation of the effects of tetracycline, rolitetracycline and doxycycline on some blood parameters related to liver function. Arzneimittel-Forschung. 1982; 32(3):237-41. doi: NULL. [PMID: 7200783]
  • J Wójcicki, K Kardel-Mizerska, B Gawrońska-Szklarz. [Pharmacokinetics of rolitetracycline in patients with solitary kidney]. Polski tygodnik lekarski (Warsaw, Poland : 1960). 1981 Jul; 36(27):1023-5. doi: NULL. [PMID: 7301651]
  • J Wójcicki, B Gawrońska-Szklarz, T Kardel-Mizerska, W Górnik. Effect of unilateral nephrectomy on the pharmacokinetics of rolitetracycline in rabbits. Arzneimittel-Forschung. 1981; 31(9):1456-8. doi: NULL. [PMID: 7197954]
  • C J Estler, R Böcker. Age dependency of rolitetracycline-induced hepatic steatosis. Developmental pharmacology and therapeutics. 1981; 3(4):189-96. doi: 10.1159/000457442. [PMID: 7344877]
  • C J Estler, R Böcker. Role of sex and age in the tetracycline-induced hepatic steatosis. I. Comparative study on the effect of rolitetracycline on some parameters of hepatic lipid metabolism in male and female mice. Toxicology and applied pharmacology. 1980 Jul; 54(3):508-13. doi: 10.1016/0041-008x(80)90178-7. [PMID: 7394802]
  • K Moorthi, F Becker, K Wiederholt, E Buchartz. [Random comparative study of polyvinylpyrrolidone-doxycycline and N-pyrrolidinomethyltetracycline with determinations in serum, bile, gallbladder wall, peritoneum and abdominal muscle]. Die Medizinische Welt. 1980 Jun; 31(25):963-5. doi: NULL. [PMID: 6448331]
  • R Böcker, C J Estler. A high pressure liquid chromatographic method for the determination of tetracyclines in blood and organs of experimental animals. Arzneimittel-Forschung. 1979; 29(11):1690-3. doi: NULL. [PMID: 543876]
  • R Böcker, C J Estler. Distribution of pyrrolidinomethyl-tetracycline (rolitetracycline) and tetracycline in blood and various organs of mice measured by high pressure liquid chromatography. Arzneimittel-Forschung. 1979; 29(11):1693-5. doi: NULL. [PMID: 543877]
  • H Wacha, H Knothe. [Antibiotic concentrations of the gallbladder following cystic duct stenosis. Clinical studies and animal experiments]. Chirurgisches Forum fur experimentelle und klinische Forschung. 1978; ?(1978):177-81. doi: NULL. [PMID: 752585]
  • F Daschner. [Tetracyclines: bacteriostatic or bactericidal drugs? In vitro studies with rolitetracycline, minocycline and doxycycline (author's transl)]. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie. 1977 Dec; 239(4):527-34. doi: NULL. [PMID: 345688]
  • P Klatt, P Hajdu. Pharmacokinetic investigations on diminazene and rolitetracycline in comparison to a combination of both. The Veterinary record. 1976 Nov; 99(19):372-4. doi: 10.1136/vr.99.19.372. [PMID: 997179]
  • H Wacha, W Hartel. [Concentration of antibiotics in the human lung. Clinical studies of Reverin distribution in various pulmonary lobes]. Fortschritte der Medizin. 1975 Aug; 93(24):1094, 1096. doi: NULL. [PMID: 1225794]
  • B Kark, M Bocchi. [The behaviour of creatine phosphokinase in serum after the intramuscular injection of a Tetracyclin preparation (author's transl)]. Medizinische Klinik. 1975 Aug; 70(34):1341-4. doi: NULL. [PMID: 1160797]
  • N N Aleutskiĭ, D Ia Berger. [Study of the effect of tetracycline carboxamide derivatives on the cardiovascular and urinary systems]. Antibiotiki. 1975 May; 20(5):467-70. doi: NULL. [PMID: 131506]
  • Y Harada, T Hanabusa, B Granulation. [Toxicity test of cephalothin local application. A stimulation test. B. Granulation test (author's transl)]. The Japanese journal of antibiotics. 1975 Apr; 28(2):188-94. doi: NULL. [PMID: 1152277]
  • K Fukaya, O Kunii, K Mashimo, O Kitamoto. [Studies on the absorption and excretion of doxycycline for intravenous use (author's transl)]. The Japanese journal of antibiotics. 1975 Feb; 28(1):61-6. doi: NULL. [PMID: 1127831]
  • N N Aleutskiĭ, V V Nifontova, A Ia Sul'din. [The therapeutic effect of morphocycline, glycocycline and reverin in experimental nephritis both complicated and not complicated by infection]. Antibiotiki. 1974 Apr; 19(4):355-9. doi: NULL. [PMID: 4282566]
  • N N Aleutskiĭ, V V Nifontova. [Binding of morphocycline, glycocycline and reverin by kidney homogenates of normal rabbits and rabbits with pathological processes]. Antibiotiki. 1973 Oct; 18(10):911-5. doi: NULL. [PMID: 4762742]
  • N N Aleutskiĭ, L K Aleutskaia, V V Nifontova. [Binding of morphocycline, glycocycline and reverine by kidneys in normal rabbits and rabbits with infections, uncomplicated nephritis and nephritis associated with infections]. Antibiotiki. 1973 Mar; 18(3):241-3. doi: NULL. [PMID: 4797160]
  • J Winckler, W Westphal. [Specificity of calcium determination using tetracycline]. Histochemie. Histochemistry. Histochimie. 1973; 33(2):95-105. doi: 10.1007/bf00305738. [PMID: 4122856]
  • T Dimmling. [Comparative study on 3 tetracycline derivatives for intravenous administration (blood and urine levels)]. Medizinische Klinik. 1972 Dec; 67(49):1632-7. doi: NULL. [PMID: 4645394]
  • E Arrigoni, G Benzi, A Ferrara. Effect of tetracyclines and 4-epiderivatives on the ureter. British journal of pharmacology. 1972 Apr; 44(4):788-93. doi: 10.1111/j.1476-5381.1972.tb07316.x. [PMID: 4625269]
  • F Reubi. [Influence of the renal function on the pharmacokinetics of various drugs]. Arzneimittel-Forschung. 1972 Feb; 22(2):319-24. doi: NULL. [PMID: 5067483]
  • G Ia Kivman, V P Iakovlev, A V Kosolapova. [Distribution of water soluble tetracycline derivatives in the blood and organs of animals]. Antibiotiki. 1971; 16(8):722-7. doi: NULL. [PMID: 5139447]
  • I Tintoré, R Canela, E Goñalons, T Grau, F Vericat, J Colomé. [Blood and tissue levels of guaiacol sulfonate of N-(pyrrolidine-methyl) tetracycline]. Archivos del Instituto de Farmacologia Experimental (Medicina). 1971; 23(1):83-91. doi: NULL. [PMID: 5144048]
  • J Wieriks, H E Schornagel. Animal reactions to, and tolerance of, two local anesthetic-free tetracycline preparations injected by various routes. A comparison of vendarcin with rolitetracycline. Chemotherapy. 1971; 16(2):85-108. doi: 10.1159/000220717. [PMID: 5171279]
  • N N Aleutskiĭ. [On the question of the effect of tetracyclines on the content of catecholamines in the body of rabbits and rats]. Antibiotiki. 1969 Apr; 14(4):347-51. doi: NULL. [PMID: 5795745]
  • O Lochman, F Výmola, J Lochmanová. Levels of antibiotics in the serum of experimental animals immunized by antibiotics. Journal of hygiene, epidemiology, microbiology, and immunology. 1969; 13(2):235-9. doi: NULL. [PMID: 5817424]
  • E Moog, H Knothe. [Passage of various tetracyclines into human aqueous humor in dependence on their protein binding in the blood serum]. Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft. 1969; 69(?):536-9. doi: NULL. [PMID: 4982272]
  • L Nuzzolo, S Sanguigni, L Pierangeli, M Longhi. [Study on serum and urine concentrations of erythromycin succinate of pyrrolidine-methyl-tetracycline]. Archivio per le scienze mediche. 1968 Sep; 125(9):403-5. doi: NULL. [PMID: 17340794]
  • F Reubi. [Elimination and posology of pyrrolidino-methyl-tetracycline (PMT) in patients with renal insufficiency]. Journal d'urologie et de nephrologie. 1967 Apr; 73(4):306-13. doi: NULL. [PMID: 6057518]
  • F Reubi. [Blood levels, excretion and dosage of N-pyrrolidino-methyl-tetracycline (PMT, Reverin) in kidney patients]. Klinische Wochenschrift. 1967 Feb; 45(3):133-7. doi: 10.1007/bf01725068. [PMID: 5599557]
  • S Banerjee, K S Kumar, A Bandyopadhyay. Carbohydrate and lipid metabolism in animals treated with pyrrolidinomethyl tetracycline. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1966 Jul; 122(3):652-7. doi: 10.3181/00379727-122-31217. [PMID: 4958460]
  • L Blomquist, A Hanngren. Fluorescence technique applied to whole body sections for distribution studies of tetracyclines. Biochemical pharmacology. 1966 Mar; 15(3):215-9. doi: 10.1016/0006-2952(66)90292-9. [PMID: 4957916]
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  • B M LIMSON, R B GUEVARA. Efficacy of a single intravenous injection of pyrrolidinomethyltetracycline in pneumococcal pneumonia: report of 20 cases with assays of 24 hour antibiotic activity in serum. Antibiotics & chemotherapy (Northfield, Ill.). 1962 Feb; 12(?):85-90. doi: NULL. [PMID: 14465339]
  • L KIER. [Pyelophlebitis. A case treated with pyrrolidinomethyltetracycline (Reverin)]. Ugeskrift for laeger. 1961 Mar; 123(?):342-4. doi: NULL. [PMID: 13755859]
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