PERYLENE (BioDeep_00000398144)
Main id: BioDeep_00000012893
代谢物信息卡片
PERYLENE
化学式: C20H12 (252.0939)
中文名称: 苝
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC2=C3C(=C1)C4=CC=CC5=C4C(=CC=C5)C3=CC=C2
InChI: InChI=1S/C20H12/c1-5-13-6-2-11-17-18-12-4-8-14-7-3-10-16(20(14)18)15(9-1)19(13)17/h1-12H
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:29861
- KEGG: C19497
- PubChem: 9142
- ChEMBL: CHEMBL4296691
- MeSH: Perylene
- CAS: 69736-15-8
- CAS: 198-55-0
- MoNA: MSJ00035
- PubChem: 124490169
- KNApSAcK: 29861
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Zhuanying Bao, Yunni Chen, Zhibin Zhang, Huilin Yang, Riming Yan, Du Zhu. Heat stress-induced NO enhanced perylenequinone biosynthesis of Shiraia sp. via calcium signaling pathway.
Applied microbiology and biotechnology.
2024 May; 108(1):317. doi:
10.1007/s00253-024-13142-1. [PMID: 38700737] - Xin Liu, Xiao-Ying He, Bo-Long Liu, Ping-Shun Song. [Determination of 13 chemical components of Epimedii Folium in pharmacopoeia by UPLC method combined with quantitative analysis of multicomponents by single-marker].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Feb; 49(4):981-988. doi:
10.19540/j.cnki.cjcmm.20231115.103. [PMID: 38621905] - Henriqueta Louro, Ariane Vettorazzi, Adela López de Cerain, Anastasia Spyropoulou, Anita Solhaug, Anne Straumfors, Anne-Cathrin Behr, Birgit Mertens, Bojana Žegura, Christiane Kruse Fæste, Dieynaba Ndiaye, Eliana Spilioti, Elisabeth Varga, Estelle Dubreil, Eszter Borsos, Francesco Crudo, Gunnar Sundstøl Eriksen, Igor Snapkow, Jérôme Henri, Julie Sanders, Kyriaki Machera, Laurent Gaté, Ludovic Le Hegarat, Matjaž Novak, Nicola M Smith, Solveig Krapf, Sonja Hager, Valérie Fessard, Yvonne Kohl, Maria João Silva, Hubert Dirven, Jessica Dietrich, Doris Marko. Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.
Archives of toxicology.
2024 Feb; 98(2):425-469. doi:
10.1007/s00204-023-03636-8. [PMID: 38147116] - Hongxiao Xie, Zhiqiang Xie, Fei Luan, Jiuseng Zeng, Xiumeng Zhang, Li Chen, Nan Zeng, Rong Liu. Potential therapeutic effects of Chinese herbal medicine in postpartum depression: Mechanisms and future directions.
Journal of ethnopharmacology.
2024 Jan; 324(?):117785. doi:
10.1016/j.jep.2024.117785. [PMID: 38262525] - Vanessa Fabienne Abegg, Miljenko Valentin Panajatovic, Riccardo Vincenzo Mancuso, Julien Arthur Allard, Urs Duthaler, Alex Odermatt, Stephan Krähenbühl, Jamal Bouitbir. Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells.
Toxicology letters.
2024 Jan; 393(?):1-13. doi:
10.1016/j.toxlet.2024.01.008. [PMID: 38219807] - Igor E Mikhnovets, Jiří Holoubek, Irina S Panina, Jan Kotouček, Daniil A Gvozdev, Stepan P Chumakov, Maxim S Krasilnikov, Mikhail Y Zhitlov, Evgeny L Gulyak, Alexey A Chistov, Timofei D Nikitin, Vladimir A Korshun, Roman G Efremov, Vera A Alferova, Daniel Růžek, Luděk Eyer, Alexey V Ustinov. Alkyl Derivatives of Perylene Photosensitizing Antivirals: Towards Understanding the Influence of Lipophilicity.
International journal of molecular sciences.
2023 Nov; 24(22):. doi:
10.3390/ijms242216483. [PMID: 38003673] - Wen Hao Shen, Lu Lu Zhou, Xin Ping Li, Rui Peng Cong, Qun Yan Huang, Li Ping Zheng, Jian Wen Wang. Bamboo polysaccharides elicit hypocrellin A biosynthesis of a bambusicolous fungus Shiraia sp. S9.
World journal of microbiology & biotechnology.
2023 Oct; 39(12):341. doi:
10.1007/s11274-023-03789-9. [PMID: 37828354] - Viktória Pevná, Ľuboš Zauška, Anass Benziane, György Vámosi, Vladimír Girman, Monika Miklóšová, Vladimír Zeleňák, Veronika Huntošová, Miroslav Almáši. Effective transport of aggregated hypericin encapsulated in SBA-15 nanoporous silica particles for photodynamic therapy of cancer cells.
Journal of photochemistry and photobiology. B, Biology.
2023 Oct; 247(?):112785. doi:
10.1016/j.jphotobiol.2023.112785. [PMID: 37714000] - Zhaolei Peng, Jing Lu, Kai Liu, Long Xie, Yulin Wang, Chunyan Cai, Dejun Yang, Jingjing Xi, Chunmei Yan, Xiaofang Li, Mingyi Shi. Hypericin as a promising natural bioactive naphthodianthrone: A review of its pharmacology, pharmacokinetics, toxicity, and safety.
Phytotherapy research : PTR.
2023 Sep; ?(?):. doi:
10.1002/ptr.8011. [PMID: 37690821] - Flávia Amanda Pedroso de Morais, Rodolfo Bento Balbinot, Amanda Beatriz Kawano Bakoshi, Danielle Lazarin-Bidoia, Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Gonçalves, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Wilker Caetano, Celso Vataru Nakamura. Advanced theranostic nanoplatforms for hypericin delivery in the cancer treatment.
Journal of photochemistry and photobiology. B, Biology.
2023 Sep; 247(?):112782. doi:
10.1016/j.jphotobiol.2023.112782. [PMID: 37660488] - Viktória Pevná, Ľuboš Zauška, Miroslav Almáši, Andrej Hovan, Gregor Bánó, Mariana Máčajová, Boris Bilčík, Vladimír Zeleňák, Veronika Huntošová. Redistribution of hydrophobic hypericin from nanoporous particles of SBA-15 silica in vitro, in cells and in vivo.
International journal of pharmaceutics.
2023 Jul; 643(?):123288. doi:
10.1016/j.ijpharm.2023.123288. [PMID: 37532008] - Li Wanying, Mariami T Okromelidze, Andrés Alexis Ramírez-Coronel, Angelina O Zekiy, Rasha Fadhel Obaid, Zanko Hassan Jawhar, Gamal A Gabr, Mais Mazin Al-Hamdani, Sokaina Issa Kadhim, Yasser Fakri Mustafa, Moslem Lari Najafi, Mohammad Miri. The association of in-utero exposure to polycyclic aromatic hydrocarbons and umbilical liver enzymes.
The Science of the total environment.
2023 May; 889(?):164220. doi:
10.1016/j.scitotenv.2023.164220. [PMID: 37211114] - Alexey A Chistov, Stepan P Chumakov, Igor E Mikhnovets, Timofei D Nikitin, Nikita A Slesarchuk, Victoria I Uvarova, Anna A Rubekina, Yulia V Nikolaeva, Eugene V Radchenko, Evgeny V Khvatov, Alexey A Orlov, Vasilisa S Frolenko, Maksim V Sukhorukov, Ekaterina S Kolpakova, Elena Y Shustova, Anastasiya V Galochkina, Philipp P Streshnev, Eugene M Osipov, Ksenia A Sapozhnikova, Andrey V Moiseenko, Vladimir A Brylev, Gleb V Proskurin, Yuri S Dokukin, Sergey V Kutyakov, Andrey V Aralov, Vladimir A Korshun, Sergei V Strelkov, Vladimir A Palyulin, Aydar A Ishmukhametov, Evgeny A Shirshin, Dmitry I Osolodkin, Anna A Shtro, Liubov I Kozlovskaya, Vera A Alferova, Alexey V Ustinov. 5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro.
Antiviral research.
2023 01; 209(?):105508. doi:
10.1016/j.antiviral.2022.105508. [PMID: 36581049] - Kang Cao, Yan Zhang, Qian Yao, Yanjuan Peng, Qu Pan, Qiuxia Jiao, Ke Ren, Fenghui Sun, Qian Zhang, Ran Guo, Jiali Zhang, Tian Chen. Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral replication.
Journal of ethnopharmacology.
2022 Oct; 296(?):115524. doi:
10.1016/j.jep.2022.115524. [PMID: 35811028] - Rui Xu, Xin Ping Li, Xiang Zhang, Wen Hao Shen, Chun Yan Min, Jian Wen Wang. Contrasting regulation of live Bacillus cereus No.1 and its volatiles on Shiraia perylenequinone production.
Microbial cell factories.
2022 Aug; 21(1):172. doi:
10.1186/s12934-022-01897-z. [PMID: 35999640] - Heba Abd-El-Azim, Ismaiel A Tekko, Ahlam Ali, Alyaa Ramadan, Noha Nafee, Nawal Khalafallah, Taifur Rahman, William Mcdaid, Rania G Aly, Lalitkumar K Vora, Steven J Bell, Fiona Furlong, Helen O McCarthy, Ryan F Donnelly. Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer.
Journal of controlled release : official journal of the Controlled Release Society.
2022 08; 348(?):849-869. doi:
10.1016/j.jconrel.2022.06.027. [PMID: 35728715] - Xia Zhu, Yiyi Chen, Xinyao Tang, Dongxia Wang, Yeqiu Miao, Jing Zhang, Ruirui Li, Lishi Zhang, Jinyao Chen. General toxicity and genotoxicity of altertoxin I: A novel 28-day multiendpoint assessment in male Sprague-Dawley rats.
Journal of applied toxicology : JAT.
2022 Aug; 42(8):1310-1322. doi:
10.1002/jat.4297. [PMID: 35128692] - Jia Gao, Max Wenderoth, Maria Doppler, Rainer Schuhmacher, Doris Marko, Reinhard Fischer. Fungal Melanin Biosynthesis Pathway as Source for Fungal Toxins.
mBio.
2022 06; 13(3):e0021922. doi:
10.1128/mbio.00219-22. [PMID: 35475649] - Lu Zheng, Hua Wang, Peng Zuo, Yueling Liu, Huiying Xu, Bang-Ce Ye. Rapid On-Chip Isolation of Cancer-Associated Exosomes and Combined Analysis of Exosomes and Exosomal Proteins.
Analytical chemistry.
2022 05; 94(21):7703-7712. doi:
10.1021/acs.analchem.2c01187. [PMID: 35575685] - Meiling Liu, Yan Zhang, Zhenbo Yuan, Liushen Lu, Xuanzhong Liu, Xiaonan Zhu, Lingling Wang, Changmei Liu, Yijian Rao. Cercosporin-bioinspired photoinactivation of harmful cyanobacteria under natural sunlight via bifunctional mechanisms.
Water research.
2022 May; 215(?):118242. doi:
10.1016/j.watres.2022.118242. [PMID: 35259559] - Larissa Mendes de Souza, Fernanda Diniz de Sousa, Roberta Cristina Ribeiro Cruz, Denise Crispim Tavares, Pollyanna Francielli de Oliveira. Hypericin, a medicinal compound from St. John's Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells.
Drug and chemical toxicology.
2022 May; 45(3):1302-1307. doi:
10.1080/01480545.2020.1822389. [PMID: 33050761] - Xuejia Zhai, Yan Chen, Xuemei Han, Ying Zhu, Xixuan Li, Yu Zhang, Yongning Lu. The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism.
International immunopharmacology.
2022 Apr; 105(?):108560. doi:
10.1016/j.intimp.2022.108560. [PMID: 35101848] - Esra Saçıcı, Erdem Yesilada. Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species.
Phytochemical analysis : PCA.
2022 Apr; 33(3):355-364. doi:
10.1002/pca.3093. [PMID: 34734668] - Yunni Chen, Chenglong Xu, Huilin Yang, Zhenying Liu, Zhibin Zhang, Riming Yan, Du Zhu. L-Arginine enhanced perylenequinone production in the endophytic fungus Shiraia sp. Slf14(w) via NO signaling pathway.
Applied microbiology and biotechnology.
2022 Apr; 106(7):2619-2636. doi:
10.1007/s00253-022-11877-3. [PMID: 35291023] - Mojtaba Khaksarian, Mahmoud Bahmani, Morovat Taherikalani, Behnam Ashrafi, Mahmoud Rafieian-Kopaei, Naser Abbasi. Biosynthesis of titanium dioxide nanoparticles using Hypericum perforatum and Origanum vulgare extracts and their main components, hypericin and carvacrol as promising antibacterial agents.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 04; 42(2):167-175. doi:
10.19852/j.cnki.jtcm.2022.02.002. [PMID: 35473336] - Pietro Delcanale, Eleonora Uriati, Matteo Mariangeli, Andrea Mussini, Ana Moreno, Davide Lelli, Luigi Cavanna, Paolo Bianchini, Alberto Diaspro, Stefania Abbruzzetti, Cristiano Viappiani. The Interaction of Hypericin with SARS-CoV-2 Reveals a Multimodal Antiviral Activity.
ACS applied materials & interfaces.
2022 Mar; 14(12):14025-14032. doi:
10.1021/acsami.1c22439. [PMID: 35302731] - Xinwei Li, Zikang Yang, Jiqing Bian, Mingyang Fu, Yan Zhang, Nan Jiang, Yanjun Qiao, Hua Chen, Baoxiang Gao. Fluorescent probes based on multifunctional encapsulated perylene diimide dyes for imaging of lipid droplets in live cells.
The Analyst.
2022 Mar; 147(7):1410-1416. doi:
10.1039/d2an00100d. [PMID: 35244127] - Yang Sun, Chen Liang, Lihua Zheng, Lei Liu, Zhijin Li, Guang Yang, Yuxin Li. Anti-fatigue effect of hypericin in a chronic forced exercise mouse model.
Journal of ethnopharmacology.
2022 Feb; 284(?):114767. doi:
10.1016/j.jep.2021.114767. [PMID: 34710555] - Jingxian Li, Mengyu Luo, Can Jin, Penghui Zhang, Hongfen Yang, Ren Cai, Weihong Tan. Plasmon-Enhanced Electrochemiluminescence of PTP-Decorated Eu MOF-Based Pt-Tipped Au Bimetallic Nanorods for the Lincomycin Assay.
ACS applied materials & interfaces.
2022 Jan; 14(1):383-389. doi:
10.1021/acsami.1c21528. [PMID: 34978181] - Dalong Wang, Tingting Zhao, Shan Zhao, Jing Chen, Tongyi Dou, Guangbo Ge, Changyuan Wang, Huijun Sun, Kexin Liu, Qiang Meng, Jingjing Wu. Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination.
Current drug metabolism.
2022; 23(1):38-44. doi:
10.2174/1389200223666220202093303. [PMID: 35114918] - Zhiqiang Zhang, Dan Li, Yiming Cao, Yupeng Wang, Feixia Wang, Feng Zhang, Shizhong Zheng. Biodegradable Hypocrellin B nanoparticles coated with neutrophil membranes for hepatocellular carcinoma photodynamics therapy effectively via JUNB/ROS signaling.
International immunopharmacology.
2021 Oct; 99(?):107624. doi:
10.1016/j.intimp.2021.107624. [PMID: 34343939] - Borivoj Adnadjevic, Biljana Koturevic, Jelena Jovanovic. Isothermal kinetics of ethanolic extraction of total hypericin from pre-extracted Hypericum perforatum flowers.
Phytochemical analysis : PCA.
2021 Sep; 32(5):757-766. doi:
10.1002/pca.3021. [PMID: 33319396] - Fangjing Mo, Jiang Guo, Min Chen, Hui Meng, Yingzi Fu. Gold Nanoparticles Photosensitization towards 3,4,9,10-Perylenetetracarboxylic Dianhydride Integrated with a Dual-Particle Three-Dimensional DNA Roller: A General 'ON-OFF-ON' Photoelectric Plasmon-Enhanced Biosensor.
Analytical chemistry.
2021 08; 93(31):10947-10954. doi:
10.1021/acs.analchem.1c01816. [PMID: 34319699] - Oksana Sytar, Konstantia Kotta, Dimitrios Valasiadis, Anatoliy Kosyan, Marian Brestic, Venetia Koidou, Eleftheria Papadopoulou, Maria Kroustalaki, Christina Emmanouilidou, Alexandros Pashalidis, Ilias Avdikos, Zoe Hilioti. The Effects of Photosensitizing Dyes Fagopyrin and Hypericin on Planktonic Growth and Multicellular Life in Budding Yeast.
Molecules (Basel, Switzerland).
2021 Aug; 26(16):. doi:
10.3390/molecules26164708. [PMID: 34443298] - Masroor Hossain, G J Blanchard. Ceramide-mediation of diffusion in supported lipid bilayers.
Chemistry and physics of lipids.
2021 08; 238(?):105090. doi:
10.1016/j.chemphyslip.2021.105090. [PMID: 33971138] - Marija Zivanovic, Zhi-Yuan Chen. In Vitro Screening of Various Bacterially Produced Double-Stranded RNAs for Silencing Cercospora cf. flagellaris Target Genes and Suppressing Cercosporin Production.
Phytopathology.
2021 Jul; 111(7):1228-1237. doi:
10.1094/phyto-09-20-0409-r. [PMID: 33289403] - Siukan Law, Chuiman Lo, Jie Han, Albert Wingnang Leung, Chuanshan Xu. Antimicrobial photodynamic therapy with hypocrellin B against SARS-CoV-2 infection?.
Photodiagnosis and photodynamic therapy.
2021 06; 34(?):102297. doi:
10.1016/j.pdpdt.2021.102297. [PMID: 33892181] - Tingan Zhou, Shiyu Yu, Yifan Hu, Yan Zhang, Yuechen Song, Jieyu Chu, Changmei Liu, Yijian Rao. Enhanced cercosporin production by co-culturing Cercospora sp. JNU001 with leaf-spot-disease-related endophytic bacteria.
Microbial cell factories.
2021 May; 20(1):100. doi:
10.1186/s12934-021-01587-2. [PMID: 33992112] - Eleni Pitsillou, Julia Liang, Katherine Ververis, Andrew Hung, Tom C Karagiannis. Interaction of small molecules with the SARS-CoV-2 papain-like protease: In silico studies and in vitro validation of protease activity inhibition using an enzymatic inhibition assay.
Journal of molecular graphics & modelling.
2021 05; 104(?):107851. doi:
10.1016/j.jmgm.2021.107851. [PMID: 33556646] - Hongyan Su, Jie Li, Sijin Chen, Ping Sun, Hua Xing, Delong Yang, Xiaona Zhang, Mengfei Li, Jianhe Wei. Physiological and Transcriptomic Analysis Provide Insight into Low Temperature Enhancing Hypericin Biosynthesis in Hypericum perforatum.
Molecules (Basel, Switzerland).
2021 Apr; 26(8):. doi:
10.3390/molecules26082294. [PMID: 33921038] - Yue Li, Shuncong Wang, Xiao Jiang, Xiaoxiong Wang, Xiang Zhou, Liangrong Wan, Haitao Zhao, Zhaoli Zhou, LingJie Gao, Gang Huang, Yicheng Ni, Xiaoyan He. Preparation and validation of cyclodextrin-based excipients for radioiodinated hypericin applied in a targeted cancer radiotherapy.
International journal of pharmaceutics.
2021 Apr; 599(?):120393. doi:
10.1016/j.ijpharm.2021.120393. [PMID: 33639227] - Hongjing Dong, Xue Yao, Lanping Guo, Shuai Yu, Wenjuan Duan, Wei Liu, Xiao Wang. Purification of hypocrellins from Shiraia bambusicola by coordinated high-speed countercurrent chromatography using cupric chloride as a complexing agent.
Journal of separation science.
2021 Apr; 44(7):1383-1390. doi:
10.1002/jssc.202001133. [PMID: 33471412] - Xiaoxv Dong, Yawen Zeng, Zhiqin Zhang, Jing Fu, Longtai You, Yuanyuan He, Yang Hao, Zili Gu, Zhenfeng Yu, Changhai Qu, Xingbin Yin, Jian Ni, Luis J Cruz. Hypericin-mediated photodynamic therapy for the treatment of cancer: a review.
The Journal of pharmacy and pharmacology.
2021 Mar; 73(4):425-436. doi:
10.1093/jpp/rgaa018. [PMID: 33793828] - Flávia Amanda Pedroso de Morais, Renato Sonchini Gonçalves, Katieli Souza Campanholi, Bruna Martins de França, Otávio Augusto Capeloto, Danielle Lazarin-Bidoia, Rodolfo Bento Balbinot, Celso Vataru Nakamura, Luis Carlos Malacarne, Wilker Caetano, Noboru Hioka. Photophysical characterization of Hypericin-loaded in micellar, liposomal and copolymer-lipid nanostructures based F127 and DPPC liposomes.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Mar; 248(?):119173. doi:
10.1016/j.saa.2020.119173. [PMID: 33316657] - Wei Zhou, Jiaze Hou, Yongxin Li, Huipeng Zhou, Hui Huang, Ling Zhang, Muhammad Azhar Hayat Nawaz, Cong Yu. Protein discrimination based on DNA induced perylene probe self-assembly.
Talanta.
2021 Mar; 224(?):121897. doi:
10.1016/j.talanta.2020.121897. [PMID: 33379104] - Malaika K Ebert, Lorena I Rangel, Rebecca E Spanner, Demetris Taliadoros, Xiaoyun Wang, Timothy L Friesen, Ronnie de Jonge, Jonathan D Neubauer, Gary A Secor, Bart P H J Thomma, Eva H Stukenbrock, Melvin D Bolton. Identification and characterization of Cercospora beticola necrosis-inducing effector CbNip1.
Molecular plant pathology.
2021 03; 22(3):301-316. doi:
10.1111/mpp.13026. [PMID: 33369055] - Katerina Makarova, Joanna J Sajkowska-Kozielewicz, Katarzyna Zawada, Ewa Olchowik-Grabarek, Michał Aleksander Ciach, Krzysztof Gogolewski, Natalia Dobros, Paulina Ciechowicz, Hélène Freichels, Anna Gambin. Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John's wort's (Hypericum perforatum L.) flowers.
Scientific reports.
2021 02; 11(1):3989. doi:
10.1038/s41598-021-83409-4. [PMID: 33597594] - S Jafarirad, M Kosari-Nasab, R Mohammadpour Tavana, S Mahjouri, R Ebadollahi. Impacts of manganese bio-based nanocomposites on phytochemical classification, growth and physiological responses of Hypericum perforatum L. shoot cultures.
Ecotoxicology and environmental safety.
2021 Feb; 209(?):111841. doi:
10.1016/j.ecoenv.2020.111841. [PMID: 33387772] - Ning Zhao, Yingying Yu, Yunxia Yue, Mingzhu Dou, Bingjing Guo, Shuzhen Yan, Shuanglin Chen. Nitric oxide regulates perylenequinones biosynthesis in Shiraia bambusicola S4201 induced by hydrogen peroxide.
Scientific reports.
2021 01; 11(1):2365. doi:
10.1038/s41598-021-81990-2. [PMID: 33504905] - Wenli Jiao, Mengxue Xu, Rujun Zhou, Yiwei Fu, Zibo Li, Caiyun Xue. Genomic analysis of Elsinoë arachidis reveals its potential pathogenic mechanism and the biosynthesis pathway of elsinochrome toxin.
PloS one.
2021; 16(12):e0261487. doi:
10.1371/journal.pone.0261487. [PMID: 34914789] - Hamid Zaferani Arani, Maedeh Olya, Asra Sadat Mirahmadi, Hossein Saleki, Hesam Adin Atashi, Hadi Zare Marzouni, Mohammad Hoseinian, Mohammad Amin Javidi, Amirhossein Zabolian. Hypericin induces apoptosis in K562 cells via downregulation of Myc and Mdm2.
Journal of cancer research and therapeutics.
2021 Jan; 17(1):242-247. doi:
10.4103/jcrt.jcrt_826_19. [PMID: 33723162] - Ali Ranjbar Jafarabadi, Mehdi Dashtbozorg, Eva Raudonytė-Svirbutavičienė, Alireza Riyahi Bakhtiari. Biomonitoring of perylene in symbiotic reef and non-reef building corals and species-specific responses in the Kharg and Larak coral reefs (Persian Gulf, Iran): Bioaccumulation and source identification.
Environmental pollution (Barking, Essex : 1987).
2020 Dec; 267(?):115476. doi:
10.1016/j.envpol.2020.115476. [PMID: 32891049] - Junghyun Cho, Changjoon Keum, Sang-Guk Lee, Sang-Yup Lee. Aggregation-driven fluorescence quenching of imidazole-functionalized perylene diimide for urea sensing.
The Analyst.
2020 Nov; 145(22):7312-7319. doi:
10.1039/d0an01252a. [PMID: 32902520] - Paride Rizzo, Lothar Altschmied, Beena M Ravindran, Twan Rutten, John C D'Auria. The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum Perforatum L., One of the Largest Medicinal Crops in Europe.
Genes.
2020 10; 11(10):. doi:
10.3390/genes11101210. [PMID: 33081197] - Francesco Crudo, Georg Aichinger, Jovana Mihajlovic, Luca Dellafiora, Elisabeth Varga, Hannes Puntscher, Benedikt Warth, Chiara Dall'Asta, David Berry, Doris Marko. Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro.
Archives of toxicology.
2020 10; 94(10):3541-3552. doi:
10.1007/s00204-020-02831-1. [PMID: 32623606] - Alice Romeo, Federico Iacovelli, Mattia Falconi. Targeting the SARS-CoV-2 spike glycoprotein prefusion conformation: virtual screening and molecular dynamics simulations applied to the identification of potential fusion inhibitors.
Virus research.
2020 09; 286(?):198068. doi:
10.1016/j.virusres.2020.198068. [PMID: 32565126] - Bharadwaj Revuru, Miroslava Bálintová, Jana Henzelyová, Eva Čellárová, Souvik Kusari. MALDI-HRMS Imaging Maps the Localization of Skyrin, the Precursor of Hypericin, and Pathway Intermediates in Leaves of Hypericum Species.
Molecules (Basel, Switzerland).
2020 Aug; 25(17):. doi:
10.3390/molecules25173964. [PMID: 32878122] - Mária Macejová, Veronika Sačková, Petra Hradická, Rastislav Jendželovský, Vlasta Demečková, Peter Fedoročko. Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Aug; 66(?):104860. doi:
10.1016/j.tiv.2020.104860. [PMID: 32298799] - Farahnaz Tavakoli, Mohammad Rafieiolhossaini, Rudabeh Ravash, Morteza Ebrahimi. Subject: UV-B radiation and low temperature promoted hypericin biosynthesis in adventitious root culture of Hypericum perforatum.
Plant signaling & behavior.
2020 07; 15(7):1764184. doi:
10.1080/15592324.2020.1764184. [PMID: 32419579] - Nikita A Slesarchuk, Evgeny V Khvatov, Alexey A Chistov, Gleb V Proskurin, Timofei D Nikitin, Anastasiya I Lazarevich, Angelina A Ulanovskaya, Egor A Ulashchik, Alexey A Orlov, Artjom V Jegorov, Alexey V Ustinov, Anton P Tyurin, Vadim V Shmanai, Aydar A Ishmukhametov, Vladimir A Korshun, Dmitry I Osolodkin, Liubov I Kozlovskaya, Andrey V Aralov. Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction.
Bioorganic & medicinal chemistry letters.
2020 05; 30(10):127100. doi:
10.1016/j.bmcl.2020.127100. [PMID: 32199731] - Tanzir Ahmed, Sander van den Driesche, Jayesh Arun Bafna, Martin Oellers, Roland Hemmler, Karsten Gall, Richard Wagner, Mathias Winterhalter, Michael J Vellekoop. Rapid lipid bilayer membrane formation on Parylene coated apertures to perform ion channel analyses.
Biomedical microdevices.
2020 04; 22(2):32. doi:
10.1007/s10544-020-0473-y. [PMID: 32355998] - Shuo Wang, Qi Zhang, Shaojin Chen, Kun-Peng Wang, Zhi-Qiang Hu. A diazabenzoperylene derivative as ratiometric fluorescent probe for cysteine with super large Stokes shift.
Analytical and bioanalytical chemistry.
2020 Apr; 412(11):2687-2696. doi:
10.1007/s00216-020-02500-3. [PMID: 32072211] - Chen Liang, Yan Li, Miao Bai, Yanxin Huang, Hang Yang, Lei Liu, Shuyue Wang, Chunlei Yu, Zhenbo Song, Yongli Bao, Jingwen Yi, Luguo Sun, Yuxin Li. Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo.
Pharmacological research.
2020 03; 153(?):104657. doi:
10.1016/j.phrs.2020.104657. [PMID: 31982488] - Xianzhen Song, Xinrong Shao, Li Dai, Dawei Fan, Xiang Ren, Xiaojun Sun, Chuannan Luo, Qin Wei. Triple Amplification of 3,4,9,10-Perylenetetracarboxylic Acid by Co2+-Based Metal-Organic Frameworks and Silver-Cysteine and Its Potential Application for Ultrasensitive Assay of Procalcitonin.
ACS applied materials & interfaces.
2020 Feb; 12(8):9098-9106. doi:
10.1021/acsami.9b23248. [PMID: 31990177] - Kapil Kumar, Sandeep Kaur, Satwinderjeet Kaur, Gaurav Bhargava, Subodh Kumar, Prabhpreet Singh. Self-assembled nanofibers of perylene diimide for the detection of hypochlorite in water, bio-fluids and solid-state: exogenous and endogenous bioimaging of hypochlorite in cells.
Journal of materials chemistry. B.
2020 01; 8(1):125-135. doi:
10.1039/c9tb01902b. [PMID: 31777906] - Josielle Santos Rezende, Marija Zivanovic, Maria Izabel Costa de Novaes, Zhi-Yuan Chen. The AVR4 effector is involved in cercosporin biosynthesis and likely affects the virulence of Cercospora cf. flagellaris on soybean.
Molecular plant pathology.
2020 01; 21(1):53-65. doi:
10.1111/mpp.12879. [PMID: 31642594] - Xin-Yao Liu, Li Fan, Jian Gao, Xiao-Ye Shen, Cheng-Lin Hou. Global identification of alternative splicing in Shiraia bambusicola and analysis of its regulation in hypocrellin biosynthesis.
Applied microbiology and biotechnology.
2020 Jan; 104(1):211-223. doi:
10.1007/s00253-019-10189-3. [PMID: 31768612] - Elizabeth Thomas, Sonia Herrero, Hayde Eng, Nafisa Gomaa, Jeff Gillikin, Roslyn Noar, Aydin Beseli, Margaret E Daub. Engineering Cercospora disease resistance via expression of Cercospora nicotianae cercosporin-resistance genes and silencing of cercosporin production in tobacco.
PloS one.
2020; 15(3):e0230362. doi:
10.1371/journal.pone.0230362. [PMID: 32176712] - Kapil Kumar, Sandeep Kaur, Satwinderjeet Kaur, Gaurav Bhargava, Subodh Kumar, Prabhpreet Singh. Perylene diimide-Cu2+ based fluorescent nanoparticles for the detection of spermine in clinical and food samples: a step toward the development of a diagnostic kit as a POCT tool for spermine.
Journal of materials chemistry. B.
2019 12; 7(45):7218-7227. doi:
10.1039/c9tb02039j. [PMID: 31663586] - Chuangli Zhang, Jiasheng Wu, Weimin Liu, Xiuli Zheng, Pengfei Wang. Natural-Origin Hypocrellin-HSA Assembly for Highly Efficient NIR Light-Responsive Phototheranostics against Hypoxic Tumors.
ACS applied materials & interfaces.
2019 Dec; 11(48):44989-44998. doi:
10.1021/acsami.9b18345. [PMID: 31755268] - Nikola Plenagl, Lili Duse, Benjamin Sebastian Seitz, Nathalie Goergen, Shashank Reddy Pinnapireddy, Jarmila Jedelska, Jana Brüßler, Udo Bakowsky. Photodynamic therapy - hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity.
Drug delivery.
2019 Dec; 26(1):23-33. doi:
10.1080/10717544.2018.1531954. [PMID: 30691327] - Matthew Ryan Smith, Collynn F Woeller, Karan Uppal, Thomas H Thatcher, Douglas I Walker, Philip K Hopke, Patricia Rohrbeck, Timothy M Mallon, Pamela L Krahl, Mark J Utell, Young-Mi Go, Dean P Jones. Associations of Benzo(ghi)perylene and Heptachlorodibenzo-p-dioxin in Serum of Service Personnel Deployed to Balad, Iraq, and Bagram, Afghanistan Correlates With Perturbed Amino Acid Metabolism in Human Lung Fibroblasts.
Journal of occupational and environmental medicine.
2019 12; 61 Suppl 12(?):S35-S44. doi:
10.1097/jom.0000000000001669. [PMID: 31800449] - Huijie Chen, Rui Feng, Ishfaq Muhammad, Ghulam Abbas, Yue Zhang, Yudong Ren, Xiaodan Huang, Ruili Zhang, Lei Diao, Xiurong Wang, Guangxing Li. Protective effects of hypericin against infectious bronchitis virus induced apoptosis and reactive oxygen species in chicken embryo kidney cells.
Poultry science.
2019 Dec; 98(12):6367-6377. doi:
10.3382/ps/pez465. [PMID: 31399732] - Paride Rizzo, Lothar Altschmied, Pauline Stark, Twan Rutten, André Gündel, Sarah Scharfenberg, Katrin Franke, Helmut Bäumlein, Ludger Wessjohann, Marcus Koch, Ljudmilla Borisjuk, Timothy F Sharbel. Discovery of key regulators of dark gland development and hypericin biosynthesis in St. John's Wort (Hypericum perforatum).
Plant biotechnology journal.
2019 12; 17(12):2299-2312. doi:
10.1111/pbi.13141. [PMID: 31037808] - Hang Li, Jinyu Hu, Haochen Wei, Peter S Solomon, Keith A Stubbs, Yit-Heng Chooi. Biosynthesis of a Tricyclo[6.2.2.02,7 ]dodecane System by a Berberine Bridge Enzyme-Like Aldolase.
Chemistry (Weinheim an der Bergstrasse, Germany).
2019 Nov; 25(66):15062-15066. doi:
10.1002/chem.201904360. [PMID: 31553484] - Wei Zhang, Yue Song, Shuijian He, Lei Shang, Rongna Ma, Liping Jia, Huaisheng Wang. Perylene diimide as a cathodic electrochemiluminescence luminophore for immunoassays at low potentials.
Nanoscale.
2019 Nov; 11(43):20910-20916. doi:
10.1039/c9nr06812k. [PMID: 31660563] - Ramin Tahmasebi-Boldaji, Mohammad-Sadegh Hatamipour, Morteza Khanahmadi, Pegah Sadeh, Iman Najafipour. Ultrasound-assisted packed-bed extraction of hypericin from Hypericum perforatum L. and optimization by response surface methodology.
Ultrasonics sonochemistry.
2019 Oct; 57(?):89-97. doi:
10.1016/j.ultsonch.2019.05.018. [PMID: 31208622] - R Ebadollahi, S Jafarirad, M Kosari-Nasab, S Mahjouri. Effect of explant source, perlite nanoparticles and TiO2/perlite nanocomposites on phytochemical composition of metabolites in callus cultures of Hypericum perforatum.
Scientific reports.
2019 09; 9(1):12998. doi:
10.1038/s41598-019-49504-3. [PMID: 31506546] - P S Pradeep, S Manisha, J Monica Amala Nayaki, D Sivaraman, R Selvaraj, S Seeni. Potential antioxidant and anti-inflammatory action of Hypericum hookerianum extracts in a liposome system evaluated with zebrafish embryos.
Journal of microencapsulation.
2019 Sep; 36(6):513-522. doi:
10.1080/02652048.2019.1631400. [PMID: 31190600] - Atsushi Tanaka, Zuoyue Liu, Yasuko Osakada. Synthesis of unsymmetric perylenediimide dye molecule and its photochemical properties on lipid membrane.
Bioorganic & medicinal chemistry letters.
2019 08; 29(15):1899-1903. doi:
10.1016/j.bmcl.2019.05.053. [PMID: 31175011] - Ling-Hua Wei, Tian-Ran Chen, Hong-Bo Fang, Qiang Jin, Shui-Jun Zhang, Jie Hou, Yang Yu, Tong-Yi Dou, Yun-Feng Cao, Wen-Zhi Guo, Guang-Bo Ge. Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin.
International journal of biological macromolecules.
2019 Aug; 134(?):622-630. doi:
10.1016/j.ijbiomac.2019.04.181. [PMID: 31047931] - Ulrich M Hanke, Ana L Lima-Braun, Timothy I Eglinton, Jeffrey P Donnelly, Valier Galy, Pascale Poussart, Konrad Hughen, Ann P McNichol, Li Xu, Christopher M Reddy. Significance of Perylene for Source Allocation of Terrigenous Organic Matter in Aquatic Sediments.
Environmental science & technology.
2019 Jul; 53(14):8244-8251. doi:
10.1021/acs.est.9b02344. [PMID: 31259540] - Yuri L Boteon, Joseph Attard, Amanda P C S Boteon, Lorraine Wallace, Gary Reynolds, Stefan Hubscher, Darius F Mirza, Hynek Mergental, Ricky H Bhogal, Simon C Afford. Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2019 07; 25(7):1007-1022. doi:
10.1002/lt.25439. [PMID: 30821045] - D Yonar, A Kılıç Süloğlu, G Selmanoğlu, M M Sünnetçioğlu. An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy.
BMC molecular and cell biology.
2019 06; 20(1):16. doi:
10.1186/s12860-019-0205-4. [PMID: 31221093] - Yuanyuan Yao, Tianlan Kang, Ling Jin, Zihan Liu, Zhen Zhang, Hua Xing, Ping Sun, Mengfei Li. Temperature-dependent growth and hypericin biosynthesis in Hypericum perforatum.
Plant physiology and biochemistry : PPB.
2019 Jun; 139(?):613-619. doi:
10.1016/j.plaphy.2019.04.012. [PMID: 31030029] - Paolo Bianchini, Marco Cozzolino, Michele Oneto, Luca Pesce, Francesca Pennacchietti, Massimiliano Tognolini, Carmine Giorgio, Santi Nonell, Luigi Cavanna, Pietro Delcanale, Stefania Abbruzzetti, Alberto Diaspro, Cristiano Viappiani. Hypericin-Apomyoglobin: An Enhanced Photosensitizer Complex for the Treatment of Tumor Cells.
Biomacromolecules.
2019 05; 20(5):2024-2033. doi:
10.1021/acs.biomac.9b00222. [PMID: 30995399] - Xing Yang, Xiaohui Niu, Zunli Mo, Ruibin Guo, Nijuan Liu, Pan Zhao, Zhenyu Liu. Perylene-functionalized graphene sheets modified with chitosan for voltammetric discrimination of tryptophan enantiomers.
Mikrochimica acta.
2019 05; 186(6):333. doi:
10.1007/s00604-019-3442-5. [PMID: 31065866] - Yan Jun Ma, Chun Xiao Sun, Jian Wen Wang. Enhanced Production of Hypocrellin A in Submerged Cultures of Shiraia bambusicola by Red Light.
Photochemistry and photobiology.
2019 05; 95(3):812-822. doi:
10.1111/php.13038. [PMID: 30338861] - Yongxin Li, Shuhan Yin, Jiaze Hou, Lianjie Meng, Mengjin Gao, Yuchu Sun, Chengzu Zhang, Sheng Bai, Jia Ren, Cong Yu. Metal coordination polymer induced perylene probe excimer fluorescence and its application in acetylcholinesterase sensing and alpha-fetoprotein immunoassay.
The Analyst.
2019 Mar; 144(6):2034-2041. doi:
10.1039/c8an02231c. [PMID: 30702092] - Magdy Kazzem, Yu-Ting Sun, Mitchell Low, Sai Wang Seto, Dennis Chang, Samiuela Lee, Harsha Suresh, Cheang S Khoo, Alan Bensoussan, Hosen Kiat. Chromatographic Analysis and Anti-Oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves.
Molecules (Basel, Switzerland).
2019 Mar; 24(6):. doi:
10.3390/molecules24061101. [PMID: 30897753] - Malaika K Ebert, Rebecca E Spanner, Ronnie de Jonge, David J Smith, Jason Holthusen, Gary A Secor, Bart P H J Thomma, Melvin D Bolton. Gene cluster conservation identifies melanin and perylenequinone biosynthesis pathways in multiple plant pathogenic fungi.
Environmental microbiology.
2019 03; 21(3):913-927. doi:
10.1111/1462-2920.14475. [PMID: 30421572] - Nelli Keksel, Hendrik Bussmann, Matthias Unger, Jürgen Drewe, Georg Boonen, Hanns Häberlein, Sebastian Franken. St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Feb; 54(?):66-76. doi:
10.1016/j.phymed.2018.06.013. [PMID: 30668384] - Eldad Yechiam, Daniel Ben-Eliezer, Nathaniel J S Ashby, Mili Bar-Shaked. The acute effect of Hypericum perforatum on short-term memory in healthy adults.
Psychopharmacology.
2019 Feb; 236(2):613-623. doi:
10.1007/s00213-018-5088-0. [PMID: 30382352] - Hannes Puntscher, Svenja Hankele, Katharina Tillmann, Eva Attakpah, Dominik Braun, Mary-Liis Kütt, Giorgia Del Favero, Georg Aichinger, Gudrun Pahlke, Harald Höger, Doris Marko, Benedikt Warth. First insights into Alternaria multi-toxin in vivo metabolism.
Toxicology letters.
2019 Feb; 301(?):168-178. doi:
10.1016/j.toxlet.2018.10.006. [PMID: 30321595] - Wei Liu, Anyi Chen, Shengkai Li, Kanfu Peng, Yaqin Chai, Ruo Yuan. Perylene Derivative/Luminol Nanocomposite as a Strong Electrochemiluminescence Emitter for Construction of an Ultrasensitive MicroRNA Biosensor.
Analytical chemistry.
2019 01; 91(2):1516-1523. doi:
10.1021/acs.analchem.8b04638. [PMID: 30567424] - Mahmoud Bahmani, Morovat Taherikalani, Mojtaba Khaksarian, Setareh Soroush, Behnam Ashrafi, Rouhollah Heydari. Phytochemical Profiles and Antibacterial Activities of Hydroalcoholic Extracts of Origanum vulgare and Hypericum perforatum and Carvacrol and Hypericin as a Promising Anti-Staphylococcus aureus.
Mini reviews in medicinal chemistry.
2019; 19(11):923-932. doi:
10.2174/1389557519666190121124317. [PMID: 30663566] - Ahmad Sobhani Najafabadi, Morteza Khanahmadi, Mortaza Ebrahimi, Kosar Moradi, Poone Behroozi, Nafiseh Noormohammadi. Effect of different quality of light on growth and production of secondary metabolites in adventitious root cultivation of Hypericum perforatum.
Plant signaling & behavior.
2019; 14(9):1640561. doi:
10.1080/15592324.2019.1640561. [PMID: 31291819] - Sheela Verjee, Olaf Kelber, Christiane Kolb, Heba Abdel-Aziz, Veronika Butterweck. Permeation characteristics of hypericin across Caco-2 monolayers in the presence of single flavonoids, defined flavonoid mixtures or Hypericum extract matrix.
The Journal of pharmacy and pharmacology.
2019 Jan; 71(1):58-69. doi:
10.1111/jphp.12717. [PMID: 28294333] - Aruna Vigneshwari, Dávid Rakk, Anikó Németh, Sándor Kocsubé, Noémi Kiss, Dezső Csupor, Tamás Papp, Biljana Škrbić, Csaba Vágvölgyi, András Szekeres. Host metabolite producing endophytic fungi isolated from Hypericum perforatum.
PloS one.
2019; 14(5):e0217060. doi:
10.1371/journal.pone.0217060. [PMID: 31112560]
