Imatinib (BioDeep_00000397882)

   


代谢物信息卡片


4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-methanesulfonate-benzamide

化学式: C29H31N7O (493.2589956)
中文名称: 伊马替尼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
InChI: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01E - Protein kinase inhibitors > L01EA - Bcr-abl tyrosine kinase inhibitors
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
COVID info from Guide to PHARMACOLOGY, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C164037 - PDGFR-targeting Agent
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C163999 - cKIT-targeting Agent
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C159198 - c-KIT Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C155700 - BCR-ABL Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D000970 - Antineoplastic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2742
INTERNAL_ID 2742; CONFIDENCE standard compound
CONFIDENCE standard compound; INTERNAL_ID 8521
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3633

同义名列表

2 个代谢物同义名

Imatinib; 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-methanesulfonate-benzamide



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhen-Yu Xiong, Yao-Jia Shen, Shi-Zhong Zhang, Hong-Hu Zhu. A review of immunotargeted therapy for Philadelphia chromosome positive acute lymphoblastic leukaemia: making progress in chemotherapy-free regimens. Hematology (Amsterdam, Netherlands). 2024 Dec; 29(1):2335856. doi: 10.1080/16078454.2024.2335856. [PMID: 38581291]
  • Jing Zhao, Dongming Yan, Yue Li, Xiaoqing Xu, Fengling Li, Shuang Zhang, Jingyi Jin, Furong Qiu. Simultaneous determination of 11 oral targeted antineoplastic drugs and 2 active metabolites by LC-MS/MS in human plasma and its application to therapeutic drug monitoring in cancer patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024 Apr; 1237(?):124100. doi: 10.1016/j.jchromb.2024.124100. [PMID: 38547701]
  • Xuechao Liu, Jing Yu, Yi Li, Hailei Shi, Xuelong Jiao, Xiaodong Liu, Dong Guo, Zequn Li, Yulong Tian, Fan Dai, Zhaojian Niu, Yanbing Zhou. Deciphering the tumor immune microenvironment of imatinib-resistance in advanced gastrointestinal stromal tumors at single-cell resolution. Cell death & disease. 2024 Mar; 15(3):190. doi: 10.1038/s41419-024-06571-3. [PMID: 38443340]
  • Da-Qian Chen, Yuhao Xie, Lu-Qi Cao, Joshua S Fleishman, Yang Chen, Tiesong Wu, Dong-Hua Yang. The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2024 Mar; 73(?):101062. doi: 10.1016/j.drup.2024.101062. [PMID: 38330827]
  • Jingting Feng, Yuhan Jiang, Sihan Liu, Linge Deng, Yanni Lv, Nanzheng Chen, Shengli Han. KIT-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography-mass spectrometry for anti-GIST compound screening from Evodia rutaecarpa. Analytical and bioanalytical chemistry. 2024 Jan; ?(?):. doi: 10.1007/s00216-024-05148-5. [PMID: 38231254]
  • Cih-En Huang, Kuan-Der Lee, Jung-Jung Chang, Huey-En Tzeng, Shih-Hao Huang, Lennex Hsueh-Lin Yu, Min-Chi Chen. Association of Nilotinib With Cardiovascular Diseases in Patients With Chronic Myelogenous Leukemia: A National Population-Based Cohort Study. The oncologist. 2024 Jan; 29(1):e81-e89. doi: 10.1093/oncolo/oyad225. [PMID: 37561957]
  • Xiangfei Sun, Qiang Zhang, Xiaohan Lin, Ping Shu, Xiaodong Gao, Kuntang Shen. Imatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination. Cell death & disease. 2023 12; 14(12):839. doi: 10.1038/s41419-023-06300-2. [PMID: 38110356]
  • Yehai An, Qian Zhang, Yu Chen, Fei Xia, Yin-Kwan Wong, Hengkai He, Mingjing Hao, Jiahang Tian, Xiaoyong Zhang, Piao Luo, Jigang Wang. Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria-Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1. Advanced biology. 2023 Dec; ?(?):e2300538. doi: 10.1002/adbi.202300538. [PMID: 38105424]
  • Markus Fischer, Meike Luck, Max Werle, Alexander Vogel, Mohammad Bashawat, Kai Ludwig, Holger A Scheidt, Peter Müller. The small-molecule kinase inhibitor ceritinib, unlike imatinib, causes a significant disturbance of lipid membrane integrity: A combined experimental and MD study. Chemistry and physics of lipids. 2023 11; 257(?):105351. doi: 10.1016/j.chemphyslip.2023.105351. [PMID: 37863350]
  • Huimin Feng, Yue Fu, Zelong Cui, Minran Zhou, Lu Zhang, Zhenxing Gao, Sai Ma, Chunyan Chen. Histone demethylase PHF8 facilitates the development of chronic myeloid leukaemia by directly targeting BCR::ABL1. British journal of haematology. 2023 09; 202(6):1178-1191. doi: 10.1111/bjh.18983. [PMID: 37469124]
  • Victoria O Oyanna, Kenisha Y Garcia-Torres, Baron J Bechtold, Katherine D Lynch, M Ridge Call, Miklós Horváth, Preston K Manwill, Tyler N Graf, Nadja B Cech, Nicholas H Oberlies, Mary F Paine, John D Clarke. Goldenseal-mediated inhibition of intestinal uptake transporters decreases metformin systemic exposure in mice. Drug metabolism and disposition: the biological fate of chemicals. 2023 Aug; ?(?):. doi: 10.1124/dmd.123.001360. [PMID: 37562957]
  • Szymon Macioszek, Danuta Dudzik, Margot Biesemans, Agnieszka Wozniak, Patrick Schöffski, Michal J Markuszewski. A multiplatform metabolomics approach for comprehensive analysis of GIST xenografts with various KIT mutations. The Analyst. 2023 Aug; 148(16):3883-3891. doi: 10.1039/d3an00599b. [PMID: 37458061]
  • Guiping Huang, Zhao Yin, Xiuyuan Wang, Ziqi Wen, Rui Su, Chuting Li, Yanjun Liu, Juhua Yang, Haiyan Hu, Hong Nie, Xiaobin Zeng, Jia Fei. System analysis of Huang-Lian-Jie-Du-Tang and their key active ingredients for overcoming CML resistance by suppression of leukemia stem cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 117(?):154918. doi: 10.1016/j.phymed.2023.154918. [PMID: 37329755]
  • Jingyang Su, Jinhua Lu, Jialin Zhang, Menglei Wang, Jiang Yan, Shengyou Lin. A meta-analysis of the efficacy and toxicity of tyrosine kinase inhibitors in treating patients with different types of thyroid cancer: how to choose drugs appropriately?. Current opinion in oncology. 2023 03; 35(2):132-144. doi: 10.1097/cco.0000000000000924. [PMID: 36721897]
  • Yan-Fang Song, Li Luo, Peng-Chong Shi, Zhao-Zhong Li, Tai-Gang Zhang, Ying-Ping Cao, Xian-Jin Zhu. [Effect of Cyr61 on Imatinib Resistance in Chronic Myeloid Leukemia and Its Mechanism]. Zhongguo shi yan xue ye xue za zhi. 2023 Feb; 31(1):1-7. doi: 10.19746/j.cnki.issn.1009-2137.2023.01.001. [PMID: 36765469]
  • Yan Chen, Rui Zhang, Dandan Mi, Qiuju Wang, Tingwenli Huang, Xinwei Dong, Hongwei Zhang, Hongtao Xiao, Sanjun Shi. SPK1/S1P axis confers gastrointestinal stromal tumors (GISTs) resistance of imatinib. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2023 01; 26(1):26-43. doi: 10.1007/s10120-022-01332-7. [PMID: 35999321]
  • Yujian Yang, Qiuchun Yu, Lean Hu, Botao Dai, Ruxi Qi, Yu Chang, Qingwen Zhang, Zhang Zhang, Yingjun Li, Xumu Zhang. Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia. European journal of medicinal chemistry. 2022 Dec; 244(?):114731. doi: 10.1016/j.ejmech.2022.114731. [PMID: 36242991]
  • Jiangzhao Zhang, Min Zhang, Yan Liang, Min Liu, Zhiping Huang. Downregulation of Smad4 expression confers chemoresistance against imatinib mesylate to chronic myeloid leukemia K562 cells. Hematology (Amsterdam, Netherlands). 2022 Dec; 27(1):43-52. doi: 10.1080/16078454.2021.2010331. [PMID: 34957936]
  • Yong Huang, Chunyan Yuan, Qiwei Liu, Lingying Wang. KIF23 promotes autophagy-induced imatinib resistance in chronic myeloid leukaemia through activating Wnt/β-catenin pathway. Clinical and experimental pharmacology & physiology. 2022 12; 49(12):1334-1341. doi: 10.1111/1440-1681.13718. [PMID: 36066385]
  • Fangfang Cai, Bibao Li, Jiang Li, Yong Ding, Dandan Xu, Fei Huang. Myricetin is effective and selective in inhibiting imatinib-resistant chronic myeloid leukemia stem and differentiated cells through targeting eIF4E. Anti-cancer drugs. 2022 Nov; ?(?):. doi: 10.1097/cad.0000000000001421. [PMID: 36730418]
  • Wen Liu, Xiaoying Zhu, Ling Tang, Na Shen, Fanjun Cheng, Ping Zou, Yong You, Guolin Yuan, Qing Li, Xiaojian Zhu. ACSL1 promotes imatinib-induced chronic myeloid leukemia cell senescence by regulating SIRT1/p53/p21 pathway. Scientific reports. 2022 10; 12(1):17990. doi: 10.1038/s41598-022-21009-6. [PMID: 36289272]
  • Amruta Gorajiya, Anita Lalwani. Leveraging the Exploratory and Predictive Capabilities of Design of Experiments in Development of Intraarticular Injection of Imatinib Mesylate Containing Lipospheres. AAPS PharmSciTech. 2022 Oct; 23(7):275. doi: 10.1208/s12249-022-02431-5. [PMID: 36207604]
  • Bharati Shriyan, Parsshava Mehta, Anand Patil, Shraddha Jadhav, Sharath Kumar, Apeksha S Puri, Ravina Govalkar, Manjunath Nookala Krishnamurthy, Sachin Punatar, Anant Gokarn, Navin Khattry, Vikram Gota. Role of ADME gene polymorphisms on imatinib disposition: results from a population pharmacokinetic study in chronic myeloid leukaemia. European journal of clinical pharmacology. 2022 Aug; 78(8):1321-1330. doi: 10.1007/s00228-022-03345-8. [PMID: 35652931]
  • Valentin García-Gutiérrez, Massimo Breccia, Elias Jabbour, Michael Mauro, Jorge E Cortes. A clinician perspective on the treatment of chronic myeloid leukemia in the chronic phase. Journal of hematology & oncology. 2022 Jul; 15(1):90. doi: 10.1186/s13045-022-01309-0. [PMID: 35818053]
  • Xinran Chen, Liying Du, Mingfeng Liu. Development, validation, and application of an UPLC-MS/MS method for vancomycin, norvancomycin, methotrexate, paclitaxel, and imatinib analysis in human plasma. Annals of clinical biochemistry. 2022 07; 59(4):253-263. doi: 10.1177/00045632221077183. [PMID: 35209719]
  • Weina Ma, Man Zhu, Bo Wang, Zhengyan Gong, Xia Du, Tianfeng Yang, Xianpeng Shi, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang, Yanhong Ji, Yang Wang, Song Li, Yanmin Zhang. Vandetanib drives growth arrest and promotes sensitivity to imatinib in chronic myeloid leukemia by targeting ephrin type-B receptor 4. Molecular oncology. 2022 07; 16(14):2747-2765. doi: 10.1002/1878-0261.13270. [PMID: 35689424]
  • Andrew J Smith, Prashant Ruchaya, Robert Walmsley, Kathleen E Wright, Fiona C Lewis-McDougall, Jacquelyn Bond, Georgina M Ellison-Hughes. Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells. Scientific reports. 2022 Jun; 12(1):10132. doi: 10.1038/s41598-022-13203-3. [PMID: 35710779]
  • Sitong Sun, Manshu Wang, Yu Yuan, Shuo Wang, Haoran Ding, Chenrui Liang, Xiaomeng Li, Simiao Fan, Yubo Li. A new strategy for the rapid identification and validation of direct toxicity targets of psoralen-induced hepatotoxicity. Toxicology letters. 2022 Jun; 363(?):11-26. doi: 10.1016/j.toxlet.2022.05.002. [PMID: 35597499]
  • Uma Fogueri, Georgia Charkoftaki, Gavriel Roda, Stacey Tuey, Mustafa Ibrahim, Indushekhar Persaud, Michael F Wempe, Jared M Brown, Joshua M Thurman, Thomas J Anchordoquy, Melanie S Joy. An evaluation of a novel nanoformulation of imatinib mesylate in a mouse model of lupus nephritis. Drug delivery and translational research. 2022 06; 12(6):1445-1454. doi: 10.1007/s13346-021-01022-4. [PMID: 34322850]
  • Bahman Amani, Sara Zareei, Behnam Amani, Mahsa Zareei, Neda Zareei, Rouhollah Shabestan, Arash Akbarzadeh. Artesunate, imatinib, and infliximab in COVID-19: A rapid review and meta-analysis of current evidence. Immunity, inflammation and disease. 2022 06; 10(6):e628. doi: 10.1002/iid3.628. [PMID: 35634954]
  • Takahiro Sumimoto, Ryosuke Nakahara, Yosuke Suzuki, Ryota Tanaka, Natsumi Yoshida, Masao Ogata, Hiroki Itoh. Development of a Sensitive and High-Throughput Assay for Simultaneous Quantification of 5 Tyrosine Kinase Inhibitors and 2 Active Metabolites in Human Plasma Using Ultra-high Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Therapeutic drug monitoring. 2022 06; 44(3):419-429. doi: 10.1097/ftd.0000000000000922. [PMID: 34469417]
  • Weiyan Zhou, Yuhang Deng, Chao Zhang, Zhenni Liu, Jiangtao Zhang, Li Zhou, Lijun Shao, Chuanbao Zhang. Current status of therapeutic drug monitoring for methotrexate, imatinib, paclitaxel in China. Clinical biochemistry. 2022 Jun; 104(?):44-50. doi: 10.1016/j.clinbiochem.2022.03.005. [PMID: 35331753]
  • Veerandra Kumar, Priyanka Singh, Sonu Kumar Gupta, Villayat Ali, Jyotirmayee, Malkhey Verma. Alterations in cellular metabolisms after Imatinib therapy: a review. Medical oncology (Northwood, London, England). 2022 May; 39(5):95. doi: 10.1007/s12032-022-01699-8. [PMID: 35570245]
  • Shymaa M Abd Elhaleem, F Elsebaei, Sh Shalan, F Belal. Turn-off fluorescence of nitrogen and sulfur carbon quantum dots as effective fluorescent probes for determination of imatinib. Application to biological fluids. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 May; 272(?):120954. doi: 10.1016/j.saa.2022.120954. [PMID: 35151161]
  • Vikrant Palande, Tali Siegal, Rajesh Detroja, Alessandro Gorohovski, Rainer Glass, Charlotte Flueh, Andrew A Kanner, Yoseph Laviv, Sagi Har-Nof, Adva Levy-Barda, Marcela Viviana Karpuj, Marina Kurtz, Shira Perez, Dorith Raviv Shay, Milana Frenkel-Morgenstern. Detection of gene mutations and gene-gene fusions in circulating cell-free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis. Molecular oncology. 2022 05; 16(10):2098-2114. doi: 10.1002/1878-0261.13157. [PMID: 34875133]
  • Jinfu Peng, Mayur K Ladumor, Jashvant D Unadkat. Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model. Drug metabolism and disposition: the biological fate of chemicals. 2022 05; 50(5):613-623. doi: 10.1124/dmd.121.000733. [PMID: 35149540]
  • Joo Young Na, Ki Young Huh, Kyung-Sang Yu, Joon Young Hyon, Hye Cheong Koo, Jong Ho Lee, Ji Chang You, Jae-Yong Chung. Safety, tolerability, and pharmacokinetics of single and multiple topical ophthalmic administration of imatinib mesylate in healthy subjects. Clinical and translational science. 2022 05; 15(5):1123-1130. doi: 10.1111/cts.13226. [PMID: 35133064]
  • Noa Markovits, Daniel Kurnik, Carmel Friedrich, Itai Gueta, Hillel Halkin, Sara David, Yossi Lomnicky, Yael Topol, Amir Tirosh, Ronen Loebstein. Effects of imatinib on glycemic and lipid profiles: a retrospective cohort study. Leukemia & lymphoma. 2022 Apr; ?(?):1-9. doi: 10.1080/10428194.2022.2068003. [PMID: 35475716]
  • Romano Strobelt, Julia Adler, Nir Paran, Yfat Yahalom-Ronen, Sharon Melamed, Boaz Politi, Ziv Shulman, Dominik Schmiedel, Yosef Shaul. Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism. Scientific reports. 2022 04; 12(1):5758. doi: 10.1038/s41598-022-09664-1. [PMID: 35388061]
  • Erik Duijvelaar, Job R Schippers, Patrick J Smeele, Michiel Alexander de Raaf, Arthur L E M Vanhove, Siebe G Blok, Jos W R Twisk, Anton Vonk Noordegraaf, Frances S de Man, Harm Jan Bogaard, Jurjan Aman. Long-term clinical outcomes of COVID-19 patients treated with imatinib. The Lancet. Respiratory medicine. 2022 04; 10(4):e34-e35. doi: 10.1016/s2213-2600(22)00052-2. [PMID: 35183270]
  • Keiko Maekawa, Masahiro Yamamura, Atsushi Matsuki, Takashi Ishikawa, Toshihiro Hirai, Yoshiyuki Yamaguchi, Yoshiro Saito, Tatsuo Kanda. Impacts of SNPs on adverse events and trough concentration of imatinib in patients with gastrointestinal stromal tumors. Drug metabolism and pharmacokinetics. 2022 Apr; 43(?):100441. doi: 10.1016/j.dmpk.2021.100441. [PMID: 35144161]
  • Avinash Kumar Singh, Salman Hussain, Rayaz Ahmed, Narendra Agrawal, Dinesh Bhurani, Miloslav Klugar, Manju Sharma. Impact of imatinib treatment on renal function in chronic myeloid leukaemia patients. Nephrology (Carlton, Vic.). 2022 Apr; 27(4):318-326. doi: 10.1111/nep.14014. [PMID: 34894374]
  • Zilun Li, Meixiu Peng, Pin Chen, Chenshu Liu, Ao Hu, Yixin Zhang, Jiangyun Peng, Jiang Liu, Yihui Li, Wenxue Li, Wei Zhu, Dongxian Guan, Yang Zhang, Hongyin Chen, Jiuzhou Li, Dongxiao Fan, Kan Huang, Fen Lin, Zefeng Zhang, Zeling Guo, Hengli Luo, Xi He, Yuanyuan Zhu, Linghua Li, Bingding Huang, Weikang Cai, Lei Gu, Yutong Lu, Kai Deng, Li Yan, Sifan Chen. Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. Cell metabolism. 2022 03; 34(3):424-440.e7. doi: 10.1016/j.cmet.2022.01.008. [PMID: 35150639]
  • Jamal Bouitbir, Miljenko V Panajatovic, Stephan Krähenbühl. Mitochondrial Toxicity Associated with Imatinib and Sorafenib in Isolated Rat Heart Fibers and the Cardiomyoblast H9c2 Cell Line. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042282. [PMID: 35216404]
  • Leila Atmowihardjo, Job R Schippers, Imke H Bartelink, Pierre M Bet, Nienke van Rein, Keith Purdy, David Cavalla, Valérie Comberiati, Andrew McElroy, Sue D Snape, Harm Jan Bogaard, Leo Heunks, Nicole Juffermans, Marcus Schultz, Pieter R Tuinman, Lieuwe D J Bos, Jurjan Aman. The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19. Trials. 2022 Feb; 23(1):158. doi: 10.1186/s13063-022-06055-9. [PMID: 35172891]
  • Theo Rein. Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development efforts. Journal of cellular biochemistry. 2022 02; 123(2):155-160. doi: 10.1002/jcb.30166. [PMID: 34668225]
  • Matthias Hoch, Julia Zack, Michelle Quinlan, Felix Huth, Sofia Forte, Stephanie Dodd, Paola Aimone, Florence Hourcade-Potelleret. Pharmacokinetics of Asciminib When Taken With Imatinib or With Food. Clinical pharmacology in drug development. 2022 02; 11(2):207-219. doi: 10.1002/cpdd.1019. [PMID: 34609077]
  • Álvaro Corral Alaejos, Aránzazu Zarzuelo Castañeda, Silvia Jiménez Cabrera, Fermín Sánchez-Guijo, María José Otero, Jonás Samuel Pérez-Blanco. External evaluation of population pharmacokinetic models of imatinib in adults diagnosed with chronic myeloid leukaemia. British journal of clinical pharmacology. 2022 02; 88(4):1913-1924. doi: 10.1111/bcp.15122. [PMID: 34705297]
  • Alejandro Morales-Ortega, Ana Isabel Farfán-Sedano, Aida Izquierdo-Martínez, Cristina Llarena-Barroso, Beatriz Jaenes-Barrios, Nieves Mesa-Plaza, María Toledano-Macías, Guillermo Soria Fernández-Llamazares, Laura Molina-Esteban, Jaime García de Tena, Santiago Prieto-Menchero, Sonia Gonzalo-Pascua, Juan Víctor San Martín-López, David Bernal-Bello. Antibody formation against SARS-CoV-2 in imatinib-treated COVID-19 patients. The Journal of infection. 2022 02; 84(2):248-288. doi: 10.1016/j.jinf.2021.08.034. [PMID: 34437930]
  • Natsumi Morita, Tomomi Ozaki, Soichiro Yokota, Hidenori Sasaki, Maho Watanabe, Koji Takahashi, Naoko Himuro, Kenji Ito, Tetsuhiko Yasuno, Katsuhisa Miyake, Aya Nawata, Toshiyuki Nakayama, Noriko Uesugi, Kosuke Masutani. Focal segmental glomerulosclerosis and concurrent glomerular microangiopathy after long-term imatinib administration. CEN case reports. 2022 02; 11(1):134-140. doi: 10.1007/s13730-021-00622-w. [PMID: 34505278]
  • Chengzhu Song, Dongning Li, Jie Zhang, Xiaoyan Zhao. Role of ferroptosis in promoting cardiotoxicity induced by Imatinib Mesylate via down-regulating Nrf2 pathways in vitro and in vivo. Toxicology and applied pharmacology. 2022 01; 435(?):115852. doi: 10.1016/j.taap.2021.115852. [PMID: 34973290]
  • Zhengdong Ai, Chong Ma, Ruiming Wan, Jingyi Yin, Guiming Li, Yan Li, Li Chen. Anticancer Activity and Molecular Mechanism of Momordica cochinchinensis Seed Extract in Chronic Myeloid Leukemia Cells. Nutrition and cancer. 2022; 74(7):2644-2656. doi: 10.1080/01635581.2021.2014904. [PMID: 34907814]
  • Marwa S Hamza, Samia A Shouman, Raafat Abdelfattah, Heba S Moussa, Mervat M Omran. Determination of the Cut-off Value for Imatinib Plasma Levels Linked to Occurrence of Bone Pain in CML Patients. Drug design, development and therapy. 2022; 16(?):1595-1604. doi: 10.2147/dddt.s365646. [PMID: 35669281]
  • Frank L van de Veerdonk, Evangelos Giamarellos-Bourboulis, Peter Pickkers, Lennie Derde, Helen Leavis, Reinout van Crevel, Job J Engel, W Joost Wiersinga, Alexander P J Vlaar, Manu Shankar-Hari, Tom van der Poll, Marc Bonten, Derek C Angus, Jos W M van der Meer, Mihai G Netea. A guide to immunotherapy for COVID-19. Nature medicine. 2022 01; 28(1):39-50. doi: 10.1038/s41591-021-01643-9. [PMID: 35064248]
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