alfuzosin (BioDeep_00000397860)
代谢物信息卡片
N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide, hydrochloride
化学式: C19H27N5O4 (389.2062942)
中文名称: 阿夫唑嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CCCNC(=O)C1CCCO1)c1nc2cc(c(cc2c(N)n1)OC)OC
InChI: InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)
描述信息
G - Genito urinary system and sex hormones > G04 - Urologicals > G04C - Drugs used in benign prostatic hypertrophy > G04CA - Alpha-adrenoreceptor antagonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D000089162 - Genitourinary Agents > D064804 - Urological Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3350
Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH)[1][2].
同义名列表
数据库引用编号
33 个数据库交叉引用编号
- ChEBI: CHEBI:51141
- KEGGdrug: D07124
- PubChem: 2092
- Metlin: METLIN858
- Metlin: METLIN45581
- DrugBank: DB00346
- ChEMBL: CHEMBL709
- CAS: 1100050-87-0
- CAS: 81403-80-7
- MoNA: FiehnHILIC002581
- MoNA: FiehnHILIC001748
- MoNA: FiehnHILIC001058
- MoNA: FiehnHILIC000171
- MoNA: EQ335059
- MoNA: EQ335058
- MoNA: EQ335057
- MoNA: EQ335056
- MoNA: EQ335055
- MoNA: EQ335054
- MoNA: EQ335053
- MoNA: EQ335052
- MoNA: EQ335051
- MoNA: EQ335009
- MoNA: EQ335008
- MoNA: EQ335007
- MoNA: EQ335006
- MoNA: EQ335005
- MoNA: EQ335004
- MoNA: EQ335003
- MoNA: EQ335002
- MoNA: EQ335001
- RefMet: Alfuzosin
- medchemexpress: HY-B0192
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice.
Life sciences.
2023 Mar; 317(?):121491. doi:
10.1016/j.lfs.2023.121491. [PMID: 36758669] - Mina Wadie, Hoda M Marzouk, Mamdouh R Rezk, Ezzat M Abdel-Moety, Mahmoud A Tantawy. A sensing platform of molecular imprinted polymer-based polyaniline/carbon paste electrodes for simultaneous potentiometric determination of alfuzosin and solifenacin in binary co-formulation and spiked plasma.
Analytica chimica acta.
2022 Apr; 1200(?):339599. doi:
10.1016/j.aca.2022.339599. [PMID: 35256148] - Heba Samir Elama, Shereen M Shalan, Yasser El-Shabrawy, Manal I Eid, Abdallah M Zeid. Utilization of a micellar matrix for simultaneous spectrofluorimetric estimation of alfuzosin hydrochloride and vardenafil hydrochloride.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Feb; 266(?):120420. doi:
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2007 Nov; 62(11):830-5. doi:
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2007 May; 14(5):412-5. doi:
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Dialogues in clinical neuroscience.
2007; 9(1):29-45. doi:
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Journal of neurology, neurosurgery, and psychiatry.
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The American journal of geriatric pharmacotherapy.
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Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica.
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Scandinavian journal of urology and nephrology.
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World journal of urology.
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