Bexarotene (BioDeep_00000397850)

natural product

代谢物信息卡片

4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid

化学式: C24H28O2 (348.2089188)
中文名称: 4-[1-(3,5,5,8,8-五甲基-5,6,7,8-四氢萘)-乙烯基]-苯甲酸, 蓓萨罗丁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C12=C(C=C(C(=C1)C)C(C3=CC=C(C=C3)C(=O)O)=C)C(CCC2(C)C)(C)C
InChI: InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XF - Retinoids for cancer treatment
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
D000970 - Antineoplastic Agents
CONFIDENCE standard compound; INTERNAL_ID 501; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6073; ORIGINAL_PRECURSOR_SCAN_NO 6071
CONFIDENCE standard compound; INTERNAL_ID 501; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6096; ORIGINAL_PRECURSOR_SCAN_NO 6094
CONFIDENCE standard compound; INTERNAL_ID 501; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6097; ORIGINAL_PRECURSOR_SCAN_NO 6096
CONFIDENCE standard compound; INTERNAL_ID 501; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6100; ORIGINAL_PRECURSOR_SCAN_NO 6095
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3295

同义名列表

3 个代谢物同义名

4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid; Bexarotene; 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid

数据库引用编号

24 个数据库交叉引用编号

ChEBI: CHEBI:50859
KEGGdrug: D03106
PubChem: 82146
Metlin: METLIN85360
DrugBank: DB00307
ChEMBL: CHEMBL1023
MeSH: Bexarotene
CAS: 153559-49-0
CAS: 166175-31-1
MoNA: LU050154
MoNA: LU050153
MoNA: LU050152
MoNA: LU050151
MoNA: CCMSLIB00000078433
MoNA: EQ329554
MoNA: EQ329553
MoNA: EQ329552
MoNA: EQ329551
MoNA: EQ329506
MoNA: EQ329505
MoNA: EQ329504
MoNA: EQ329503
MoNA: EQ329502
MoNA: EQ329501

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Akimasa Sanagawa, Tomoaki Hayakawa, Emi Nishida, Aya Yamamoto, Kyoko Ikumi, Yukari Mori, Yuji Hotta, Kazunori Kimura, Yoko Furukawa-Hibi, Akimichi Morita. Impact of body mass index on the severity of bexarotene-associated hypertriglyceridemia: A post hoc analysis of an open-labeled clinical study of combined bexarotene and phototherapy in Japanese patients with cutaneous T-cell lymphoma. The Journal of dermatology. 2023 Jul; 50(7):917-926. doi: 10.1111/1346-8138.16801. [PMID: 37041679]
Ken-Ichi Nakashima, Marina Okamura, Imari Matsumoto, Nanae Kameda, Tomoe Tsuboi, Eiji Yamaguchi, Akichika Itoh, Makoto Inoue. Regulation of adipogenesis through retinoid X receptor and/or peroxisome proliferator-activated receptor by designed lignans based on natural products in 3T3-L1 cells. Journal of natural medicines. 2023 Mar; 77(2):315-326. doi: 10.1007/s11418-022-01674-7. [PMID: 36607539]
Venkatram R Atigadda, Mahendra P Kashyap, Zhengrong Yang, Debasish Chattopadhyay, Nathalia Melo, Rajesh Sinha, Olga V Belyaeva, Chu-Fang Chou, Pi-Ling Chang, Natalia Y Kedishvili, Clinton J Grubbs, Matthew B Renfrow, Donald D Muccio, Craig A Elmets, Mohammad Athar. Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers. Journal of medicinal chemistry. 2022 11; 65(21):14409-14423. doi: 10.1021/acs.jmedchem.2c00735. [PMID: 36318154]
Huimei Fu, Lijuan Chu, He Jiao, Longyi Lin, Youping Liu, Guoliang Chen, Libo Zou, Xin Wang, Xin Di. A highly sensitive and rapid LC-MS/MS method for quantification of bexarotene in mouse plasma and brain tissue: Application to mice pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jan; 1189(?):123025. doi: 10.1016/j.jchromb.2021.123025. [PMID: 34840083]
Charles M Bowen, Lewins Walter, Ester Borras, Wenhui Wu, Zuhal Ozcan, Kyle Chang, Prashant V Bommi, Melissa W Taggart, Selvi Thirumurthi, Patrick M Lynch, Laura Reyes-Uribe, Paul A Scheet, Krishna M Sinha, Eduardo Vilar. Combination of Sulindac and Bexarotene for Prevention of Intestinal Carcinogenesis in Familial Adenomatous Polyposis. Cancer prevention research (Philadelphia, Pa.). 2021 09; 14(9):851-862. doi: 10.1158/1940-6207.capr-20-0496. [PMID: 34266857]
Jessica A Moerland, Di Zhang, Lyndsey A Reich, Sarah Carapellucci, Beth Lockwood, Ana S Leal, Teresa Krieger-Burke, Bilal Aleiwi, Edmund Ellsworth, Karen T Liby. The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer. Scientific reports. 2020 12; 10(1):22244. doi: 10.1038/s41598-020-79260-8. [PMID: 33335263]
Shuofeng Yuan, Jasper F W Chan, Kenn K H Chik, Chris C Y Chan, Jessica O L Tsang, Ronghui Liang, Jianli Cao, Kaiming Tang, Lin-Lei Chen, Kun Wen, Jian-Piao Cai, Zi-Wei Ye, Gang Lu, Hin Chu, Dong-Yan Jin, Kwok-Yung Yuen. Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system. Pharmacological research. 2020 09; 159(?):104960. doi: 10.1016/j.phrs.2020.104960. [PMID: 32473310]
Yasuhiro Ishihara, Hikaru Sakurai, Ami Oguro, Mayumi Tsuji, Christoph F A Vogel, Takeshi Yamazaki. Retinoid X receptor-mediated neuroprotection via CYP19 upregulation and subsequent increases in estradiol synthesis. The Journal of steroid biochemistry and molecular biology. 2019 10; 193(?):105421. doi: 10.1016/j.jsbmb.2019.105421. [PMID: 31265900]
Elham Fanaee-Danesh, Chaitanya Chakravarthi Gali, Jelena Tadic, Martina Zandl-Lang, Alexandra Carmen Kober, Vicente Roca Agujetas, Cristina de Dios, Carmen Tam-Amersdorfer, Anika Stracke, Nicole Maria Albrecher, Anil Paul Chirackal Manavalan, Marielies Reiter, Yidan Sun, Anna Colell, Frank Madeo, Ernst Malle, Ute Panzenboeck. Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells. Biochimica et biophysica acta. Molecular basis of disease. 2019 09; 1865(9):2224-2245. doi: 10.1016/j.bbadis.2019.04.019. [PMID: 31055081]
Yuta Takamura, Manami Takahashi, Midori Nishii, Osamu Shibahara, Masaki Watanabe, Michiko Fujihara, Hiroki Kakuta. 3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity. Bioorganic & medicinal chemistry letters. 2019 08; 29(15):1891-1894. doi: 10.1016/j.bmcl.2019.05.050. [PMID: 31160175]
Qi Zhang, Sang Beom Lee, Xu Chen, Morgan E Stevenson, Jing Pan, Donghai Xiong, Yu Zhou, Mark Steven Miller, Ronald A Lubet, Yian Wang, Shama P Mirza, Ming You. Optimized Bexarotene Aerosol Formulation Inhibits Major Subtypes of Lung Cancer in Mice. Nano letters. 2019 04; 19(4):2231-2242. doi: 10.1021/acs.nanolett.8b04309. [PMID: 30873838]
Di Zhang, Ana S Leal, Sarah Carapellucci, Pritika H Shahani, Jaskaran S Bhogal, Samir Ibrahim, San Raban, Peter W Jurutka, Pamela A Marshall, Michael B Sporn, Carl E Wagner, Karen T Liby. Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention. Cancer prevention research (Philadelphia, Pa.). 2019 04; 12(4):211-224. doi: 10.1158/1940-6207.capr-18-0317. [PMID: 30760500]
Yogita Dheer, Nitin Chitranshi, Veer Gupta, Samridhi Sharma, Kanishka Pushpitha, Mojdeh Abbasi, Mehdi Mirzaei, Yuyi You, Stuart L Graham, Vivek Gupta. Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice. Experimental neurology. 2019 04; 314(?):111-125. doi: 10.1016/j.expneurol.2019.01.015. [PMID: 30703361]
Jong Bong Lee, Tae Hwan Kim, Wanshan Feng, Hyeon Gwan Choi, Atheer Zgair, Soyoung Shin, Sun Dong Yoo, Pavel Gershkovich, Beom Soo Shin. Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach. Journal of pharmaceutical sciences. 2019 02; 108(2):1047-1052. doi: 10.1016/j.xphs.2018.09.025. [PMID: 30268807]
Irene Cabello, Pedro Alia, Xavier Pintó, Cristina Muniesa, Ricardo Fernandez-de-Misa, Yerai Peñate, Mercedes Morillo, Amparo Perez-Farriols, Teresa Estrach, Rosa Izu, Fernando Gallardo, Concepción Román, Iván Cervigón, Ariadna Ortiz-Brugues, Pablo L Ortiz-Romero, Octavio Servitje. Association of APOA5 and APOC3 Genetic Polymorphisms With Severity of Hypertriglyceridemia in Patients With Cutaneous T-Cell Lymphoma Treated With Bexarotene. JAMA dermatology. 2018 12; 154(12):1424-1431. doi: 10.1001/jamadermatol.2018.3679. [PMID: 30422238]
Frits Kamp, Holger A Scheidt, Edith Winkler, Gabriele Basset, Hannes Heinel, James M Hutchison, Loren M LaPointe, Charles R Sanders, Harald Steiner, Daniel Huster. Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes. ACS chemical neuroscience. 2018 07; 9(7):1702-1713. doi: 10.1021/acschemneuro.8b00068. [PMID: 29717863]
Chu-Fang Chou, Yu-Hua Hsieh, Clinton J Grubbs, Venkatram R Atigadda, James A Mobley, Reinhard Dummer, Donald D Muccio, Isao Eto, Craig A Elmets, W Timothy Garvey, Pi-Ling Chang. The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis. Journal of dermatological science. 2018 Jun; 90(3):343-356. doi: 10.1016/j.jdermsci.2018.03.006. [PMID: 29599065]
Bahar Tunctan, Sefika P Kucukkavruk, Meryem Temiz-Resitoglu, Demet S Guden, Ayse N Sari, Seyhan Sahan-Firat. Bexarotene, a Selective RXRα Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock. Inflammation. 2018 Feb; 41(1):337-355. doi: 10.1007/s10753-017-0691-5. [PMID: 29188497]
Khalid Z Masoodi, Kurtis Eisermann, Zhenyu Yang, Javid A Dar, Laura E Pascal, Minh Nguyen, Katherine O'Malley, Erica Parrinello, Firuz G Feturi, Alex N Kenefake, Joel B Nelson, Paul A Johnston, Peter Wipf, Zhou Wang. Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone. Endocrinology. 2017 10; 158(10):3152-3161. doi: 10.1210/en.2017-00408. [PMID: 28977599]
I Cabello, O Servitje, X Corbella, I Bardés, X Pintó. Omega-3 fatty acids as adjunctive treatment for bexarotene-induced hypertriglyceridaemia in patients with cutaneous T-cell lymphoma. Clinical and experimental dermatology. 2017 Apr; 42(3):276-281. doi: 10.1111/ced.13044. [PMID: 28233333]
Pascal Heitel, Janosch Achenbach, Daniel Moser, Ewgenij Proschak, Daniel Merk. DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators. Bioorganic & medicinal chemistry letters. 2017 03; 27(5):1193-1198. doi: 10.1016/j.bmcl.2017.01.066. [PMID: 28169169]
Jong Bong Lee, Atheer Zgair, Tae Hwan Kim, Min Gi Kim, Sun Dong Yoo, Peter M Fischer, Pavel Gershkovich. Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jan; 1040(?):73-80. doi: 10.1016/j.jchromb.2016.11.024. [PMID: 27978471]
Matthew A J Duncton, Ryan B Murray, Gary Park, Rajinder Singh. Tetrazolone as an acid bioisostere: application to marketed drugs containing a carboxylic acid. Organic & biomolecular chemistry. 2016 Oct; 14(39):9343-9347. doi: 10.1039/c6ob01646d. [PMID: 27714239]
L M Lin, F Peng, Y P Liu, D J Chai, R B Ning, C S Xu, J X Lin. Coadministration of VDR and RXR agonists synergistically alleviates atherosclerosis through inhibition of oxidative stress: An in vivo and in vitro study. Atherosclerosis. 2016 08; 251(?):273-281. doi: 10.1016/j.atherosclerosis.2016.06.005. [PMID: 27428295]
Jin-Chul Heo, Tae-Hoon Jung, Sungjin Lee, Hyun Young Kim, Gildon Choi, Myungeun Jung, Daeyoung Jung, Heung Kyoung Lee, Jung-Ok Lee, Ji-Hwan Park, Daehee Hwang, Ho Jun Seol, Heeyeong Cho. Effect of bexarotene on differentiation of glioblastoma multiforme compared with ATRA. Clinical & experimental metastasis. 2016 06; 33(5):417-29. doi: 10.1007/s10585-016-9786-x. [PMID: 26957434]
Beata Nowak, Agnieszka Matuszewska, Jarosław Filipiak, Anna Nikodem, Anna Merwid-Ląd, Małgorzata Pieśniewska, Lidia Fereniec-Gołębiewska, Joanna Kwiatkowska, Adam Szeląg. The influence of bexarotene, a selective agonist of the retinoid receptor X (RXR), and tazarotene, a selective agonist of the retinoid acid receptor (RAR), on bone metabolism in rats. Advances in medical sciences. 2016 Mar; 61(1):85-9. doi: 10.1016/j.advms.2015.09.001. [PMID: 26569440]
Jeffrey L Cummings, Kate Zhong, Jefferson W Kinney, Chelcie Heaney, Joanne Moll-Tudla, Abhinay Joshi, Michael Pontecorvo, Michael Devous, Anne Tang, James Bena. Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease. Alzheimer's research & therapy. 2016 Jan; 8(?):4. doi: 10.1186/s13195-016-0173-2. [PMID: 26822146]
Samata Basani, Abhimanyu Garg. Marked lowering of high-density lipoprotein cholesterol levels due to high dose bexarotene therapy. Journal of clinical lipidology. 2015 Nov; 9(6):832-836. doi: 10.1016/j.jacl.2015.08.004. [PMID: 26687705]
Amelia H Baker, James Watt, Cassie K Huang, Louis C Gerstenfeld, Jennifer J Schlezinger. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chemical research in toxicology. 2015 Jun; 28(6):1156-66. doi: 10.1021/tx500433r. [PMID: 25932594]
Makoto Inoue, Hiroki Tanabe, Ken-ichi Nakashima, Yukihiro Ishida, Hitoshi Kotani. Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene. Journal of natural products. 2014 Jul; 77(7):1670-7. doi: 10.1021/np5002016. [PMID: 24959987]
Venkatram R Atigadda, Gang Xia, Anil Desphande, LeeAnn J Boerma, Susan Lobo-Ruppert, Clinton J Grubbs, Craig D Smith, Wayne J Brouillette, Donald D Muccio. Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. Journal of medicinal chemistry. 2014 Jun; 57(12):5370-80. doi: 10.1021/jm5004792. [PMID: 24801499]
Anat Boehm-Cagan, Daniel M Michaelson. Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 May; 34(21):7293-301. doi: 10.1523/jneurosci.5198-13.2014. [PMID: 24849361]
Jacques Fantini, Coralie Di Scala, Nouara Yahi, Jean-Denis Troadec, Kevin Sadelli, Henri Chahinian, Nicolas Garmy. Bexarotene blocks calcium-permeable ion channels formed by neurotoxic Alzheimer's β-amyloid peptides. ACS chemical neuroscience. 2014 Mar; 5(3):216-24. doi: 10.1021/cn400183w. [PMID: 24383913]
Vladimir Lerner, Chanoch Miodownik, Anatoly Gibel, Pinchas Sirota, Ilan Bush, Hadi Elliot, Ruben Benatov, Michael S Ritsner. The retinoid X receptor agonist bexarotene relieves positive symptoms of schizophrenia: a 6-week, randomized, double-blind, placebo-controlled multicenter trial. The Journal of clinical psychiatry. 2013 Dec; 74(12):1224-32. doi: 10.4088/jcp.12m08160. [PMID: 24434091]
Krista McFarland, Tracy A Spalding, David Hubbard, Jian-Nong Ma, Roger Olsson, Ethan S Burstein. Low dose bexarotene treatment rescues dopamine neurons and restores behavioral function in models of Parkinson's disease. ACS chemical neuroscience. 2013 Nov; 4(11):1430-8. doi: 10.1021/cn400100f. [PMID: 24117438]
Francesco Torino, Agnese Barnabei, Rosamaria Paragliola, Roberto Baldelli, Marialuisa Appetecchia, Salvatore Maria Corsello. Thyroid dysfunction as an unintended side effect of anticancer drugs. Thyroid : official journal of the American Thyroid Association. 2013 Nov; 23(11):1345-66. doi: 10.1089/thy.2013.0241. [PMID: 23750887]
Sukhmani K Padda, Laveena Chhatwani, Lisa Zhou, Charlotte D Jacobs, Arturo Lopez-Anaya, Heather A Wakelee. Phase I and pharmacokinetic study of bexarotene in combination with gefitinib in the third-line treatment of non-small-cell lung cancer: brief report. Anti-cancer drugs. 2013 Aug; 24(7):731-5. doi: 10.1097/cad.0b013e32836100d7. [PMID: 23552470]
Rakeshwar S Guleria, Amar B Singh, Irina T Nizamutdinova, Tatiana Souslova, Amin A Mohammad, Jonathan A Kendall, Kenneth M Baker, Jing Pan. Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats. Journal of molecular and cellular cardiology. 2013 Apr; 57(?):106-18. doi: 10.1016/j.yjmcc.2013.01.017. [PMID: 23395853]
J J Scarisbrick, S Morris, R Azurdia, T Illidge, E Parry, R Graham-Brown, R Cowan, E Gallop-Evans, R Wachsmuth, M Eagle, A S Wierzbicki, H Soran, S Whittaker, E M Wain. U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphoma. The British journal of dermatology. 2013 Jan; 168(1):192-200. doi: 10.1111/bjd.12042. [PMID: 22963233]
Lian Chen, Martin Conda-Sheridan, P V Narasimha Reddy, Andrew Morrell, Eun-Jung Park, Tamara P Kondratyuk, John M Pezzuto, Richard B van Breemen, Mark Cushman. Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. Journal of medicinal chemistry. 2012 Jun; 55(12):5965-81. doi: 10.1021/jm3006806. [PMID: 22712432]
Jordi Rodon, Charlotte D Jacobs, Quincy Chu, Eric K Rowinsky, Arturo Lopez-Anaya, Chris H Takimoto, Heather A Wakelee. A phase I pharmacokinetic study of bexarotene with paclitaxel and carboplatin in patients with advanced non-small cell lung cancer (NSCLC). Cancer chemotherapy and pharmacology. 2012 Mar; 69(3):825-34. doi: 10.1007/s00280-011-1770-1. [PMID: 22057853]
Heather A Wakelee, Gary Middleton, David Dunlop, Rodryg Ramlau, Natasha Leighl, Desiree Hao, Arturo Lopez-Anaya, Petr Zatloukal, Charlotte D Jacobs. A phase I pharmacokinetic study of bexarotene with vinorelbine and cisplatin in patients with advanced non-small-cell lung cancer (NSCLC). Cancer chemotherapy and pharmacology. 2012 Mar; 69(3):815-24. doi: 10.1007/s00280-011-1771-0. [PMID: 22057854]
Heather A Wakelee, Chris H Takimoto, Arturo Lopez-Anaya, Quincy Chu, Gary Middleton, David Dunlop, Rodryg Ramlau, Natasha Leighl, Eric K Rowinsky, Desiree Hao, Petr Zatloukal, Charlotte D Jacobs, Jordi Rodon. The effect of bexarotene on atorvastatin pharmacokinetics: results from a phase I trial of bexarotene plus chemotherapy in patients with advanced non-small cell lung cancer. Cancer chemotherapy and pharmacology. 2012 Feb; 69(2):563-71. doi: 10.1007/s00280-011-1772-z. [PMID: 22057855]
Naveena B Janakiram, Altaf Mohammed, Li Qian, Chang-In Choi, Vernon E Steele, Chinthalapally V Rao. Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of Apc(Min/+) mice. Neoplasia (New York, N.Y.). 2012 Feb; 14(2):159-68. doi: 10.1593/neo.111440. [PMID: 22431924]
Iván P Uray, Jennifer M Rodenberg, Reid P Bissonnette, Powel H Brown, Michael A Mancini. Cancer-preventive rexinoid modulates neutral lipid contents of mammary epithelial cells through a peroxisome proliferator-activated receptor γ-dependent mechanism. Molecular pharmacology. 2012 Feb; 81(2):228-38. doi: 10.1124/mol.111.072967. [PMID: 22053058]
Hitoshi Kotani, Hiroki Tanabe, Hajime Mizukami, Sakae Amagaya, Makoto Inoue. A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers. Biological & pharmaceutical bulletin. 2012; 35(1):1-9. doi: 10.1248/bpb.35.1. [PMID: 22223330]
Tomomitsu Miyagaki, Makoto Sugaya. Erythrodermic cutaneous T-cell lymphoma: how to differentiate this rare disease from atopic dermatitis. Journal of dermatological science. 2011 Oct; 64(1):1-6. doi: 10.1016/j.jdermsci.2011.07.007. [PMID: 21872448]
Anne Hespel, Najet Mejdoubi-Charef, Said Yous, José Courty, Dulce Papy-Garcia, Said Charef. Interactions of bexarotene (LGD1069, Targretin) with the coagulation system. Cancer chemotherapy and pharmacology. 2011 Oct; 68(4):847-54. doi: 10.1007/s00280-010-1553-0. [PMID: 21229355]
Susan C Yanik, Amelia H Baker, Koren K Mann, Jennifer J Schlezinger. Organotins are potent activators of PPARγ and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cells. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Aug; 122(2):476-88. doi: 10.1093/toxsci/kfr140. [PMID: 21622945]
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