tiapride (BioDeep_00000397798)
代谢物信息卡片
tiapride
化学式: C15H24N2O4S (328.14567040000003)
中文名称: 泰必利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCN=C(c1cc(ccc1OC)S(=O)(=O)C)O
InChI: InChI=1S/C15H24N2O4S/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18)
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AL - Benzamides
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
CONFIDENCE standard compound; INTERNAL_ID 2278
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3028
同义名列表
1 个代谢物同义名
数据库引用编号
33 个数据库交叉引用编号
- ChEBI: CHEBI:94666
- KEGGdrug: D08590
- PubChem: 5467
- Metlin: METLIN44330
- DrugBank: DB13025
- ChEMBL: CHEMBL84158
- MeSH: Tiapride Hydrochloride
- CAS: 51012-32-9
- MoNA: WA002162
- MoNA: WA002161
- MoNA: WA002160
- MoNA: WA002159
- MoNA: WA002158
- MoNA: WA002157
- MoNA: AU227806
- MoNA: AU227805
- MoNA: AU227804
- MoNA: AU227803
- MoNA: AU227802
- MoNA: AU227801
- MoNA: EQ302856
- MoNA: EQ302855
- MoNA: EQ302854
- MoNA: EQ302853
- MoNA: EQ302852
- MoNA: EQ302851
- MoNA: EQ302806
- MoNA: EQ302805
- MoNA: EQ302804
- MoNA: EQ302803
- MoNA: EQ302802
- MoNA: EQ302801
- RefMet: Tiapride
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xue Wu, Zhong Wang, Xing Liao, Yong-Yan Wang. [Three oral Chinese patent medicines for children with tic disorder: a rapid health technology assessment].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jul; 48(14):3965-3976. doi:
10.19540/j.cnki.cjcmm.20230330.502. [PMID: 37475087] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Stefanie Fekete, K Egberts, T Preissler, C Wewetzer, C Mehler-Wex, M Romanos, M Gerlach. Estimation of a preliminary therapeutic reference range for children and adolescents with tic disorders treated with tiapride.
European journal of clinical pharmacology.
2021 Feb; 77(2):163-170. doi:
10.1007/s00228-020-03000-0. [PMID: 32986159] - Long Hongyan, Zhang Mengjiao, Wang Chunyan, Huang Yaruo. Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2/STAT3 and NF-κB pathways.
Environmental toxicology.
2019 Oct; 34(10):1114-1120. doi:
10.1002/tox.22813. [PMID: 31231976] - Hongyan Long, Chunyan Wang, Jie Ruan, Mengjiao Zhang, Yaruo Huang. Gastrodin attenuates neuroinflammation in DOI-induce Tourette syndrome in rats.
Journal of biochemical and molecular toxicology.
2019 May; 33(5):e22302. doi:
10.1002/jbt.22302. [PMID: 30790395] - Biao Zhang, Hong-Yan Long, Jin-Chun Zhang. [Effects of Jing'an Oral Liquid on the central neurotransmitter of multiple tics children].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2012 Jul; 32(7):926-9. doi:
". [PMID: 23019949] - Jose R Eguibar, Ma del Carmen Cortes, Manuel Lara-Lozano, Diana M Mendiola. Dopaminergic D2-like agonists produce yawning in the myelin mutant taiep and Sprague-Dawley rats.
Pharmacology, biochemistry, and behavior.
2012 Jul; 102(1):118-23. doi:
10.1016/j.pbb.2012.03.020. [PMID: 22497991] - Judith Matz, Daniela L Krause, Sandra Dehning, Michael Riedel, Rudolf Gruber, Markus J Schwarz, Norbert Müller. Altered monocyte activation markers in Tourette's syndrome: a case-control study.
BMC psychiatry.
2012 May; 12(?):29. doi:
10.1186/1471-244x-12-29. [PMID: 22471395] - Milan Nobilis, Zuzana Vybíralová, Barbora Szotáková, Květa Sládková, Martin Kuneš, Zbyněk Svoboda. High-performance liquid chromatographic determination of tiapride and its phase I metabolite in blood plasma using tandem UV photodiode-array and fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Dec; 879(32):3845-52. doi:
10.1016/j.jchromb.2011.10.032. [PMID: 22100559] - Su-Hyun Jo, So-Young Lee. Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2010 Oct; 14(5):305-10. doi:
10.4196/kjpp.2010.14.5.305. [PMID: 21165329] - Naoki Hiroi, Aya Yoshihara, Mariko Sue, Gen Yoshino, Mariko Higa. Central adrenal insufficiency and diabetes insipidus misdiagnosed as severe depression.
Clinical medicine insights. Case reports.
2010; 3(?):55-8. doi:
10.4137/ccrep.s5812. [PMID: 21769255] - Jin-Hee Park, Yoo-Sin Park, Si-Youn Rhim, Hyun-Jin Kim, Ok-Hwa Jhee, Yun-Sik Lee, Min-Ho Lee, Leslie M Shaw, Ju-Seop Kang. Rapid quantification of levosulpiride in human plasma using RP-HPLC-MS/MS for pharmacokinetic and bioequivalence study.
Biomedical chromatography : BMC.
2009 Dec; 23(12):1350-6. doi:
10.1002/bmc.1260. [PMID: 19488984] - Ding Yang, Chen Yu, Shuijun Li, Gangyi Liu, Youli Lu, Yiping Wang. Liquid chromatography/tandem mass spectrometry for the determination of changrolin in rat plasma: application to a bioavailability study.
Journal of pharmaceutical and biomedical analysis.
2009 Sep; 50(2):189-93. doi:
10.1016/j.jpba.2009.04.010. [PMID: 19467818] - Ma Soledad García, Joaquín A Ortuño, Ma Isabel Albero, Mustafa Salem Abuherba. Development of membrane selective electrode for determination of the antipsychotic sulpiride in pharmaceuticals and urine.
Sensors (Basel, Switzerland).
2009; 9(6):4309-22. doi:
10.3390/s90604309. [PMID: 22408528] - Vincent Ioos, Vincent Das, Eric Maury, Jean-Luc Baudel, Jérôme Guéchot, Bertrand Guidet, Georges Offenstadt. A thyrotoxicosis outbreak due to dietary pills in Paris.
Therapeutics and clinical risk management.
2008 Dec; 4(6):1375-9. doi:
10.2147/tcrm.s4110. [PMID: 19337445] - Gerald Rehor, Meinhard Eiler, Andreas Conca. [D3 agonism: an augmentative treatment in tardive dyskinesia? A case report].
Psychiatrische Praxis.
2008 Nov; 35(8):404-5. doi:
10.1055/s-2008-1067380. [PMID: 18504692] - Inako Okamoto, Kumiko Ohkubo, Hironobu Kawashima, Hiroshi Ideguchi, Junko Ono. [Case of enzyme-linked immunoglobulin with persistent elevation of lactate dehydrogenase activity in serum by administration of an anti-psychotic drug].
Rinsho byori. The Japanese journal of clinical pathology.
2008 Aug; 56(8):671-7. doi:
NULL. [PMID: 18800622] - Fadia H Metwally, Mohammad Abdelkawy, Nada S Abdelwahab. Stability-indicating methods for determination of tiapride in pure form, pharmaceutical preparation, and human plasma.
Journal of AOAC International.
2007 Nov; 90(6):1554-65. doi:
NULL. [PMID: 18193732] - M H Al-Zubaidy, F K Mohammad. Metoclopramide protection of diazinon-induced toxicosis in chickens.
Journal of veterinary science.
2007 Sep; 8(3):249-54. doi:
10.4142/jvs.2007.8.3.249. [PMID: 17679771] - Fadia Hussein Metwally. Membrane sensors for the selective determination of tiapride in presence of its degradation products.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2007 Aug; 127(8):1267-73. doi:
10.1248/yakushi.127.1267. [PMID: 17666880] - Jianguo Li, Fengjuan Zhao, Huangxian Ju. Simultaneous electrochemiluminescence determination of sulpiride and tiapride by capillary electrophoresis with cyclodextrin additives.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 May; 835(1-2):84-9. doi:
10.1016/j.jchromb.2006.03.017. [PMID: 16569516] - G A Petroianu, M Y Hasan, S M Nurulain, K Arafat, M Shafiullah, R Sheen. Tiapride pre-treatment in acute exposure to paraoxon: comparison of effects of administration at different points-in-time in rats.
Molecular and cellular biochemistry.
2006 Apr; 285(1-2):79-86. doi:
10.1007/s11010-005-9057-7. [PMID: 16479322] - A B Skorniakov, R A Kalekin, D S Lazarian. [Identification of haloperidol and tiapride in the urine with thin layer chromatography].
Sudebno-meditsinskaia ekspertiza.
2006 Mar; 49(2):37-9. doi:
NULL. [PMID: 16826845] - G A Petroianu, M Y Hasan, K Arafat, S M Nurulain, A Schmitt. Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride.
Journal of applied toxicology : JAT.
2005 Nov; 25(6):562-7. doi:
10.1002/jat.1097. [PMID: 16193528] - G A Petroianu, A Schmitt, K Arafat, M Y Hasan. Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): in vitro effect of tiapride.
International journal of toxicology.
2005 Mar; 24(2):79-86. doi:
10.1080/10915810590921360. [PMID: 16036766] - Koh Iwasaki, Takuma Satoh-Nakagawa, Masahiro Maruyama, Yasutake Monma, Miyako Nemoto, Naoki Tomita, Haruko Tanji, Hironori Fujiwara, Takashi Seki, Masahiko Fujii, Hiroyuki Arai, Hidetada Sasaki. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients.
The Journal of clinical psychiatry.
2005 Feb; 66(2):248-52. doi:
10.4088/jcp.v66n0214. [PMID: 15705012] - In Bok Paek, Ya Moon, Hye Young Ji, Hui-Hyun Kim, Hye Won Lee, Yong-Bok Lee, Hye Suk Lee. Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of levosulpiride in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Oct; 809(2):345-50. doi:
10.1016/j.jchromb.2004.07.005. [PMID: 15315786] - Ya Moon, In Bok Paek, Hui-Hyun Kim, Hye Young Ji, Hye Won Lee, Hyoung-Geun Park, Hye Suk Lee. Determination of tiapride in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Archives of pharmacal research.
2004 Sep; 27(9):901-5. doi:
10.1007/bf02975840. [PMID: 15473657] - Nathalie Bock, Gunther H Moll, Maike Wicker, Jürgen Pilz, Eckart Rüther, Tobias Banaschewski, Gerald Huether, Aribert Rothenberger. Early administration of tiapride to young rats without long-lasting changes in the development of the dopaminergic system.
Pharmacopsychiatry.
2004 Jul; 37(4):163-7. doi:
10.1055/s-2004-827171. [PMID: 15467972] - Nicole Kotzailias, Josef Finsterer, Susanne Aull, Hans-Georg Eichler, Barbara Pratscher, Bernd Jilma. Influence of tiapride on platelet counts in healthy volunteers and patients with movement disorders.
Progress in neuro-psychopharmacology & biological psychiatry.
2003 Jun; 27(4):595-9. doi:
10.1016/s0278-5846(03)00046-0. [PMID: 12787844] - Ryoko Chiba, Ayako Ogasawara, Teppei Kubo, Hiroyuki Yamazaki, Masuo Umino, Yoichi Ishizuka. Direct determination of benzamides in serum by column-switching high-performance liquid chromatography.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2003 May; 19(5):785-9. doi:
10.2116/analsci.19.785. [PMID: 12769385] - T Norman, E Chiu, R H James, M S Gregory. Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease.
European journal of clinical pharmacology.
1987; 32(6):583-6. doi:
10.1007/bf02455992. [PMID: 2958291]