moclobemide (BioDeep_00000397750)

   

natural product


代谢物信息卡片


moclobemide

化学式: C13H17ClN2O2 (268.0978492)
中文名称: 吗氯贝胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1C=CC(=CC=1)Cl)(=O)NCCN2CCOCC2
InChI: InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AG - Monoamine oxidase a inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
CONFIDENCE standard compound; INTERNAL_ID 2279
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2675

同义名列表

1 个代谢物同义名

moclobemide



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • F K Główka, T W Hermann, D Danielak, M Zabel, J Hermann. Bioavailability of moclobemide from two formulation tablets in healthy humans. Die Pharmazie. 2019 02; 74(2):97-100. doi: 10.1691/ph.2019.8819. [PMID: 30782258]
  • Shiyang Zhou, Guangying Chen, Gangliang Huang. Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase. Bioorganic & medicinal chemistry. 2018 09; 26(17):4863-4870. doi: 10.1016/j.bmc.2018.08.024. [PMID: 30143367]
  • Karolina Bogatko, Ewa Poleszak, Aleksandra Szopa, Elżbieta Wyska, Piotr Wlaź, Katarzyna Świąder, Aleksandra Wlaź, Urszula Doboszewska, Karol Rojek, Anna Serefko. The influence of selective A1 and A2A receptor antagonists on the antidepressant-like activity of moclobemide, venlafaxine and bupropion in mice. The Journal of pharmacy and pharmacology. 2018 Sep; 70(9):1200-1208. doi: 10.1111/jphp.12954. [PMID: 29943503]
  • Andrea E Steuer, Martina I Boxler, Lorena Stock, Thomas Kraemer. Inhibition potential of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites on the in vitro monoamine oxidase (MAO)-catalyzed deamination of the neurotransmitters serotonin and dopamine. Toxicology letters. 2016 Jan; 243(?):48-55. doi: 10.1016/j.toxlet.2015.12.001. [PMID: 26721607]
  • Alina Plenis, Natalia Rekowska, Tomasz Bączek. Column Selection for Biomedical Analysis Supported by Column Classification Based on Four Test Parameters. International journal of molecular sciences. 2016 Jan; 17(1):. doi: 10.3390/ijms17010136. [PMID: 26805819]
  • Ewa Poleszak, Aleksandra Szopa, Elżbieta Wyska, Sylwia Wośko, Anna Serefko, Aleksandra Wlaź, Mateusz Pieróg, Andrzej Wróbel, Piotr Wlaź. The influence of caffeine on the activity of moclobemide, venlafaxine, bupropion and milnacipran in the forced swim test in mice. Life sciences. 2015 Sep; 136(?):13-8. doi: 10.1016/j.lfs.2015.06.008. [PMID: 26135623]
  • Shagufta Khan, Ghulam Abbas, Fahad Shabbir Ahmed, Attaur Rahman, Ahsana Dar. Effect of dichloromethane fraction of Areca catechu nut on monoamines associated behaviors and tyramine pressor sensitivity in rodents. Pakistan journal of pharmaceutical sciences. 2014 Mar; 27(2):303-7. doi: . [PMID: 24577919]
  • Alina Plenis, Ilona Olędzka, Tomasz Bączek. Classification of LC columns based on the QSRR method and selectivity toward moclobemide and its metabolites. Journal of pharmaceutical and biomedical analysis. 2013 May; 78-79(?):161-9. doi: 10.1016/j.jpba.2013.02.020. [PMID: 23499915]
  • Urmila M Aswar, Padmaja P Kalshetti, Suhas M Shelke, Sharad H Bhosale, Subhash L Bodhankar. Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats. Asian Pacific journal of tropical biomedicine. 2012 Dec; 2(12):992-8. doi: 10.1016/s2221-1691(13)60012-x. [PMID: 23593581]
  • Pertti J Neuvonen. Towards safer and more predictable drug treatment--reflections from studies of the First BCPT Prize awardee. Basic & clinical pharmacology & toxicology. 2012 Mar; 110(3):207-18. doi: 10.1111/j.1742-7843.2012.00858.x. [PMID: 22348413]
  • María del Mar Ramírez Fernández, Sarah M R Wille, Nele Samyn. Quantitative method validation for the analysis of 27 antidepressants and metabolites in plasma with ultraperformance liquid chromatography-tandem mass spectrometry. Therapeutic drug monitoring. 2012 Feb; 34(1):11-24. doi: 10.1097/ftd.0b013e31823bf0fd. [PMID: 22210095]
  • Guilherme A Behr, José C F Moreira, Benicio N Frey. Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder. Oxidative medicine and cellular longevity. 2012; 2012(?):609421. doi: 10.1155/2012/609421. [PMID: 22693652]
  • Julia Sacher, Sylvain Houle, Jun Parkes, Pablo Rusjan, Sandra Sagrati, Alan A Wilson, Jeffrey H Meyer. Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study. Journal of psychiatry & neuroscience : JPN. 2011 Nov; 36(6):375-82. doi: 10.1503/jpn.100117. [PMID: 21463543]
  • Mohamed I Walash, Fathallah F Belal, Nahed M El-Enany, Heba Elmansi. Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids. Chemistry Central journal. 2011 Oct; 5(1):61. doi: 10.1186/1752-153x-5-61. [PMID: 21996025]
  • Charles V Vorhees, LaRonda R Morford, Devon L Graham, Matthew R Skelton, Michael T Williams. Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug. Behavioral and brain functions : BBF. 2011 Oct; 7(?):41. doi: 10.1186/1744-9081-7-41. [PMID: 21974752]
  • Milena Araújo Tonon, Valquíria A P Jabor, Pierina Sueli Bonato. Enantioselective analysis of zopiclone and its metabolites in plasma by liquid chromatography/tandem mass spectrometry. Analytical and bioanalytical chemistry. 2011 Jul; 400(10):3517-25. doi: 10.1007/s00216-011-5033-0. [PMID: 21547427]
  • Eva Choong, Serge Rudaz, Astrid Kottelat, Sophie Haldemann, Davy Guillarme, Jean-Luc Veuthey, Chin B Eap. Quantification of 4 antidepressants and a metabolite by LC-MS for therapeutic drug monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jun; 879(19):1544-50. doi: 10.1016/j.jchromb.2011.03.049. [PMID: 21524943]
  • Toni-Lee Sterley, Fleur M Howells, Vivienne A Russell. Effects of early life trauma are dependent on genetic predisposition: a rat study. Behavioral and brain functions : BBF. 2011 May; 7(?):11. doi: 10.1186/1744-9081-7-11. [PMID: 21548935]
  • Anita Rakic Ignjatovic, Branislava Miljkovic, Dejan Todorovic, Ivana Timotijevic, Milena Pokrajac. Evaluation of single-point sampling strategies for the estimation of moclobemide exposure in depressive patients. Journal of clinical pharmacology. 2011 May; 51(5):661-71. doi: 10.1177/0091270010372105. [PMID: 20495135]
  • Tomi Rantamäki, Liisa Vesa, Hanna Antila, Antonio Di Lieto, Päivi Tammela, Angelika Schmitt, Klaus-Peter Lesch, Maribel Rios, Eero Castrén. Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PloS one. 2011; 6(6):e20567. doi: 10.1371/journal.pone.0020567. [PMID: 21666748]
  • Julio Licinio, Ma-Li Wong. Pharmacogenomics of antidepressant treatment effects. Dialogues in clinical neuroscience. 2011; 13(1):63-71. doi: NULL. [PMID: 21485747]
  • Alice F Viana, Izaque S Maciel, Emerson M Motta, Paulo C Leal, Luiz Pianowski, Maria M Campos, João B Calixto. Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):120820. doi: 10.1093/ecam/nep144. [PMID: 19815648]
  • Luc Dupuis, Odile Spreux-Varoquaux, Gilbert Bensimon, Philippe Jullien, Lucette Lacomblez, François Salachas, Gaëlle Bruneteau, Pierre-François Pradat, Jean-Philippe Loeffler, Vincent Meininger. Platelet serotonin level predicts survival in amyotrophic lateral sclerosis. PloS one. 2010 Oct; 5(10):e13346. doi: 10.1371/journal.pone.0013346. [PMID: 20967129]
  • Samina Bano, Mehnaz Gitay, Iffat Ara, Abdulla Badawy. Acute effects of serotonergic antidepressants on tryptophan metabolism and corticosterone levels in rats. Pakistan journal of pharmaceutical sciences. 2010 Jul; 23(3):266-72. doi: . [PMID: 20566438]
  • Chia-Wei Hung, Ying-Jay Liou, Shao-Wei Lu, Ling-Ming Tseng, Chung-Lan Kao, Shih-Jen Chen, Shih-Hwa Chiou, Charn-Jung Chang. Stem cell-based neuroprotective and neurorestorative strategies. International journal of molecular sciences. 2010 May; 11(5):2039-55. doi: 10.3390/ijms11052039. [PMID: 20559500]
  • Sven Armbrust, Werner Nikischin, Gertrud Rochholz, Cornelia Franzelius, Andreas Bielstein, Hans-Heiner Kramer. Hypothermia in a combined intoxication with doxepin and moclobemide in an adolescent. Forensic science international. 2010 Feb; 195(1-3):e1-3. doi: 10.1016/j.forsciint.2009.10.017. [PMID: 20074878]
  • Anthony W Fox. Subcutaneous sumatriptan pharmacokinetics: delimiting the monoamine oxidase inhibitor effect. Headache. 2010 Feb; 50(2):249-55. doi: 10.1111/j.1526-4610.2009.01568.x. [PMID: 19925626]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Johannes Kornhuber, Lothar Terfloth, Stefan Bleich, Jens Wiltfang, Rainer Rupprecht. Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors. European journal of medicinal chemistry. 2009 Jun; 44(6):2667-72. doi: 10.1016/j.ejmech.2008.12.003. [PMID: 19144451]
  • Wilfried Dimpfel. Rat electropharmacograms of the flavonoids rutin and quercetin in comparison to those of moclobemide and clinically used reference drugs suggest antidepressive and/or neuroprotective action. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2009 Apr; 16(4):287-94. doi: 10.1016/j.phymed.2009.02.005. [PMID: 19303757]
  • Margareta Reis, Trond Aamo, Olav Spigset, Johan Ahlner. Serum concentrations of antidepressant drugs in a naturalistic setting: compilation based on a large therapeutic drug monitoring database. Therapeutic drug monitoring. 2009 Feb; 31(1):42-56. doi: 10.1097/ftd.0b013e31819114ea. [PMID: 19077925]
  • Anita Rakic Ignjatovic, Branislava Miljkovic, Dejan Todorovic, Ivana Timotijevic, Milena Pokrajac. Moclobemide monotherapy vs. combined therapy with valproic acid or carbamazepine in depressive patients: a pharmacokinetic interaction study. British journal of clinical pharmacology. 2009 Feb; 67(2):199-208. doi: 10.1111/j.1365-2125.2008.03326.x. [PMID: 19076986]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • P R Martin-Du, P Baumann. [Sexual dysfunctions induced by antidepressants and antipsychotics]. Revue medicale suisse. 2008 Mar; 4(150):758-62. doi: . [PMID: 18476641]
  • Alina Plenis, Aleksandra Chmielewska, Lucyna Konieczna, Henryk Lamparczyk. A validated high-performance liquid chromatographic method for the determination of moclobemide and its two metabolites in human plasma and application to pharmacokinetic studies. Biomedical chromatography : BMC. 2007 Sep; 21(9):958-66. doi: 10.1002/bmc.840. [PMID: 17450597]
  • Wen-Huang Peng, Kuan-Lin Lo, Yi-Hsuen Lee, Tai-Huang Hung, Ying-Chih Lin. Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life sciences. 2007 Aug; 81(11):933-8. doi: 10.1016/j.lfs.2007.08.003. [PMID: 17804020]
  • Miran Brvar, Dusan Stajer, Gordana Kozelj, Josko Osredkar, Martin Mozina, Matjaz Bunc. Urinary serotonin level is associated with serotonin syndrome after moclobemide, sertraline, and citalopram overdose. Clinical toxicology (Philadelphia, Pa.). 2007 Jun; 45(5):458-60. doi: 10.1080/15563650601118101. [PMID: 17503244]
  • Anita Rakic, Branislava Miljkovic, Milena Pokrajac, Katarina Vucicevic. High-performance liquid chromatographic method for the determination of moclobemide and its two major metabolites in human plasma. Journal of pharmaceutical and biomedical analysis. 2007 Mar; 43(4):1416-22. doi: 10.1016/j.jpba.2006.10.032. [PMID: 17141442]
  • H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Oct; 843(1):100-13. doi: 10.1016/j.jchromb.2006.05.031. [PMID: 16798119]
  • Ashwin A Patkar, C-U Pae, Prakash S Masand. Transdermal selegiline: the new generation of monoamine oxidase inhibitors. CNS spectrums. 2006 May; 11(5):363-75. doi: 10.1017/s1092852900014498. [PMID: 16641841]
  • Brigitte Eisensamer, Manfred Uhr, Sabrina Meyr, Gerald Gimpl, Tobias Deiml, Gerhard Rammes, Jeremy J Lambert, Walter Zieglgänsberger, Florian Holsboer, Rainer Rupprecht. Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Nov; 25(44):10198-206. doi: 10.1523/jneurosci.2460-05.2005. [PMID: 16267227]
  • Z Fisar, M Anders, E Tvrzická, B Stanková. Effect of long-term administration of antidepressants on the lipid composition of brain plasma membranes. General physiology and biophysics. 2005 Jun; 24(2):221-36. doi: . [PMID: 16118474]
  • Toshio Naka, Daryl Jones, Ian Baldwin, Nigel Fealy, Samantha Bates, Hermann Goehl, Stanislao Morgera, Hans H Neumayer, Rinaldo Bellomo. Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report. Critical care (London, England). 2005 Apr; 9(2):R90-5. doi: 10.1186/cc3034. [PMID: 15774055]
  • A Jennifer Morton, Mark J Hunt, Angela K Hodges, Paul D Lewis, Amanda J Redfern, Stephen B Dunnett, Lesley Jones. A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease. The European journal of neuroscience. 2005 Feb; 21(4):855-70. doi: 10.1111/j.1460-9568.2005.03895.x. [PMID: 15787692]
  • Janet D McEnroe, Joseph C Fleishaker. Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clinical pharmacokinetics. 2005; 44(3):237-46. doi: 10.2165/00003088-200544030-00002. [PMID: 15762767]
  • Pierre Baumann, Sven Ulrich, Gabriel Eckermann, Manfred Gerlach, Hans-Joachim Kuss, Gerd Laux, Bruno Müller-Oerlinghausen, Marie Luise Rao, Peter Riederer, Gerald Zernig, Christoph Hiemke. The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants. Dialogues in clinical neuroscience. 2005; 7(3):231-47. doi: NULL. [PMID: 16156382]
  • Hossein Amini, Badri Shahmir, Abolhassan Ahmadiani. Determination of moclobemide in human plasma by high-performance liquid chromatography with spectrophotometric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Aug; 807(2):271-5. doi: 10.1016/j.jchromb.2004.04.016. [PMID: 15203040]
  • Christian Giroud, Beat Horisberger, Chin Eap, Marc Augsburger, Annick Ménétrey, Pierre Baumann, Patrice Mangin. Death following acute poisoning by moclobemide. Forensic science international. 2004 Feb; 140(1):101-7. doi: 10.1016/j.forsciint.2003.10.021. [PMID: 15013171]
  • B Eisensamer, G Rammes, G Gimpl, M Shapa, U Ferrari, G Hapfelmeier, B Bondy, C Parsons, K Gilling, W Zieglgänsberger, F Holsboer, R Rupprecht. Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor. Molecular psychiatry. 2003 Nov; 8(12):994-1007. doi: 10.1038/sj.mp.4001314. [PMID: 14647397]
  • Geoffrey K Isbister, L P Hackett, Andrew H Dawson, Ian M Whyte, Anthony J Smith. Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity. British journal of clinical pharmacology. 2003 Oct; 56(4):441-50. doi: 10.1046/j.1365-2125.2003.01895.x. [PMID: 12968990]
  • Charlotte Duverneuil, Geoffroy Lorin de la Grandmaison, Philippe de Mazancourt, Jean-Claude Alvarez. A high-performance liquid chromatography method with photodiode-array UV detection for therapeutic drug monitoring of the nontricyclic antidepressant drugs. Therapeutic drug monitoring. 2003 Oct; 25(5):565-73. doi: 10.1097/00007691-200310000-00005. [PMID: 14508379]
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  • J Hoskins, G Shenfield, M Murray, A Gross. Characterization of moclobemide N-oxidation in human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems. 2001 Jul; 31(7):387-97. doi: 10.1080/00498250110055488. [PMID: 11531003]
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  • R Dams, T H Benijts, W E Lambert, J F Van Bocxlaer, D Van Varenbergh, C Van Peteghem, A P De Leenheer. A fatal case of serotonin syndrome after combined moclobemide-citalopram intoxication. Journal of analytical toxicology. 2001 Mar; 25(2):147-51. doi: 10.1093/jat/25.2.147. [PMID: 11300508]
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