Darunavir (BioDeep_00000397567)

   


代谢物信息卡片


(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)(4-aminobenzene)sulfonamido]-1-phenylbutan-2-yl]carbamate

化学式: C27H37N3O7S (547.2352092000001)
中文名称: 地瑞拉韦
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2COC3C2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N
InChI: InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1

描述信息

J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AE - Protease inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D000084762 - Viral Protease Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
COVID info from DrugBank, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C97366 - HIV Protease Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2179
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3016

同义名列表

3 个代谢物同义名

Darunavir; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)(4-aminobenzene)sulfonamido]-1-phenylbutan-2-yl]carbamate; AIDS073035;Darunavirum [INN-latin];TMC-114;TMC114;UIC-94017



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chloe Orkin, Jean-Michel Molina, Pedro Cahn, Johannes Lombaard, Khuanchai Supparatpinyo, Sushma Kumar, Havilland Campbell, Hong Wan, Valerie Teal, Zhi Jin Xu, Ernest Asante-Appiah, Peter Sklar, Hedy Teppler, Rima Lahoulou. Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials. The lancet. HIV. 2024 Feb; 11(2):e75-e85. doi: 10.1016/s2352-3018(23)00258-8. [PMID: 38141637]
  • Francesca Alberton, Laura Galli, Riccardo Lolatto, Caterina Candela, Nicola Gianotti, Matteo Chiurlo, Martina Ranzenigo, Martina Strano, Alessia Uglietti, Antonella Castagna. Outcome of Darunavir-Cobicistat-Based Regimens in HIV-Infected People Who Have Experienced Virological Failure. Drug design, development and therapy. 2024; 18(?):1153-1163. doi: 10.2147/dddt.s443775. [PMID: 38618279]
  • Amedeo De Nicolò, Andrea Calcagno, Ilaria Motta, Elisa De Vivo, Antonio D'Avolio, Giovanni Di Perri, Lubbe Wiesner, Isma-Eel Ebrahim, Gary Maartens, Catherine Orrell, Helen McIlleron. The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study. Antimicrobial agents and chemotherapy. 2022 06; 66(6):e0013622. doi: 10.1128/aac.00136-22. [PMID: 35583344]
  • Ruxandra-Cristina Marin, Adrian Streinu-Cercel, Lavinia Cristina Moleriu, Simona Gabriela Bungau. Analysis of virological response to therapy and resistance profile in treatment-experienced and naive HIV-1 infected Romanian patients receiving regimens containing darunavir boosted with ritonavir or cobicistat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113077. doi: 10.1016/j.biopha.2022.113077. [PMID: 35658217]
  • Nicholas I Paton, Joseph Musaazi, Cissy Kityo, Stephen Walimbwa, Anne Hoppe, Apolo Balyegisawa, Jesca Asienzo, Arvind Kaimal, Grace Mirembe, Abbas Lugemwa, Gilbert Ategeka, Margaret Borok, Henry Mugerwa, Abraham Siika, Eva Laker A Odongpiny, Barbara Castelnuovo, Agnes Kiragga, Andrew Kambugu. Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial. The lancet. HIV. 2022 06; 9(6):e381-e393. doi: 10.1016/s2352-3018(22)00092-3. [PMID: 35460601]
  • Katy Moore, Nilay Thakkar, Mindy Magee, Heather Sevinsky, Blisse Vakkalagadda, Susan Lubin, Cyril Llamoso, Peter Ackerman. Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants. Antimicrobial agents and chemotherapy. 2022 04; 66(4):e0225121. doi: 10.1128/aac.02251-21. [PMID: 35315687]
  • Alice-Andrée Mariaggi, Rebecca Bauer, Caroline Charre, Elise Gardiennet, Vincent Meiffredy, Faiza Ajana, Karine Lacombe, Gilles Pialoux, Eric Cua, Christine Rouzioux, Laurence Meyer, Antoine Cheret, Véronique Avettand-Fenoel. HIV-1-RNA and total HIV-1-DNA loads in the genital compartment in men receiving dolutegravir- versus darunavir-based combined ART (cART) regimens during primary HIV infection. The Journal of antimicrobial chemotherapy. 2022 02; 77(3):735-739. doi: 10.1093/jac/dkab427. [PMID: 35195692]
  • Tippawan Siritientong, Daylia Thet, Janthima Methaneethorn, Nattawut Leelakanok. Pharmacokinetic Outcomes of the Interactions of Antiretroviral Agents with Food and Supplements: A Systematic Review and Meta-Analysis. Nutrients. 2022 Jan; 14(3):. doi: 10.3390/nu14030520. [PMID: 35276881]
  • Alaka Sahoo, Shasank S Swain, Biswaranjan Paital, Maitreyee Panda. Combinatorial approach of vitamin C derivative and anti-HIV drug-darunavir against SARS-CoV-2. Frontiers in bioscience (Landmark edition). 2022 01; 27(1):10. doi: 10.31083/j.fbl2701010. [PMID: 35090315]
  • Eman Zeyad I Elmekaty, Rim Alibrahim, Rania Hassanin, Sitelbanat Eltaib, Ahmed Elsayed, Fatima Rustom, Mohamed Izham Mohamed Ibrahim, Mohammed Abu Khattab, Hussam Al Soub, Muna Al Maslamani, Abdullatif Al-Khal. Darunavir-cobicistat versus lopinavir-ritonavir in the treatment of COVID-19 infection (DOLCI): A multicenter observational study. PloS one. 2022; 17(5):e0267884. doi: 10.1371/journal.pone.0267884. [PMID: 35507606]
  • Malte Monin, Tim Kümmerle, Jochen Schneider, Christiane Cordes, Hans Heiken, Hans-Jürgen Stellbrink, Ivanka Krznaric, Stefan Scholten, Björn Jensen, Heiko Jessen, Wilfried Obst, Petra Spornraft-Ragaller, Pavel Khaykin, Annamaria Balogh, Eva Wolf, Helen Bidner, Christoph D Spinner, Christoph Boesecke. Switching to a NRTI-free 2 drug regimen (2DR) -a sub-analysis of the 48 weeks DUALIS study on metabolic and renal changes. HIV research & clinical practice. 2021 12; 23(1):15-21. doi: . [PMID: 35234092]
  • Engie Salama, Lucas Hill, Nimish Patel, Brookie M Best, Jeremiah D Momper. Brief Report: Pharmacokinetics of Bictegravir and Tenofovir in Combination With Darunavir/Cobicistat in Treatment-Experienced Persons With HIV. Journal of acquired immune deficiency syndromes (1999). 2021 12; 88(4):389-392. doi: 10.1097/qai.0000000000002765. [PMID: 34285156]
  • Tiziana Latronico, Federica Rizzi, Annamaria Panniello, Valentino Laquintana, Ilaria Arduino, Nunzio Denora, Elisabetta Fanizza, Serafina Milella, Claudio M Mastroianni, Marinella Striccoli, Maria Lucia Curri, Grazia M Liuzzi, Nicoletta Depalo. Luminescent PLGA Nanoparticles for Delivery of Darunavir to the Brain and Inhibition of Matrix Metalloproteinase-9, a Relevant Therapeutic Target of HIV-Associated Neurological Disorders. ACS chemical neuroscience. 2021 11; 12(22):4286-4301. doi: 10.1021/acschemneuro.1c00436. [PMID: 34726377]
  • Camilla Ingrid Hatleberg, Lene Ryom, Caroline Sabin. Cardiovascular risks associated with protease inhibitors for the treatment of HIV. Expert opinion on drug safety. 2021 Nov; 20(11):1351-1366. doi: 10.1080/14740338.2021.1935863. [PMID: 34047238]
  • Chih-Cheng Lai, Chien-Ming Chao, Po-Ren Hsueh. Clinical efficacy of antiviral agents against coronavirus disease 2019: A systematic review of randomized controlled trials. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2021 Oct; 54(5):767-775. doi: 10.1016/j.jmii.2021.05.011. [PMID: 34253490]
  • Paolo Manganotti, Giulia Bellavita, Valentina Tommasini, Laura D Acunto, Martina Fabris, Laura Cecotti, Giovanni Furlanis, Arianna Sartori, Lucia Bonzi, Alex Buoite Stella, Valentina Pesavento. Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID-19 neuropathy patients. Journal of medical virology. 2021 Sep; 93(9):5432-5437. doi: 10.1002/jmv.27061. [PMID: 33951196]
  • Luigi Cavanna, Gabriele Cremona, Chiara Citterio, Camilla Di Nunzio, Monica Muroni, Anna Maria Andena, Evelina Cattadori, Mirella Gubbelini, Lara Muroni, Roberta Schiavo, Massimo Nolli, Mauro Codeluppi, Pietro Maniscalco, Guido Pedrazzini. COVID-19 Outbreak in Italy: Report on the First 124 Consecutive Patients Treated at Home. The Tohoku journal of experimental medicine. 2021 09; 255(1):61-69. doi: 10.1620/tjem.255.61. [PMID: 34588347]
  • Ninad S Chaudhary, Tobias Kind, Amanda L Willig, Michael S Saag, Sadeep Shrestha, Nicholas Funderburg, Howard W Wiener, E Turner Overton, Marguerite R Irvin. Changes in lipidomic profile by anti-retroviral treatment regimen: An ACTG 5257 ancillary study. Medicine. 2021 Jul; 100(30):e26588. doi: 10.1097/md.0000000000026588. [PMID: 34397689]
  • Jeremiah D Momper, Jiajia Wang, Alice Stek, David E Shapiro, Gwendolyn B Scott, Mary E Paul, Irma L Febo, Sandra Burchett, Elizabeth Smith, Nahida Chakhtoura, Kayla Denson, Kittipong Rungruengthanakit, Kathleen George, Derek Z Yang, Edmund V Capparelli, Mark Mirochnick, Brookie M Best. Pharmacokinetics of darunavir and cobicistat in pregnant and postpartum women with HIV. AIDS (London, England). 2021 07; 35(8):1191-1199. doi: 10.1097/qad.0000000000002857. [PMID: 34076612]
  • Oliver Ackaert, David McDougall, Carlos Pérez-Ruixo, Juan Jose Pérez-Ruixo, John Jezorwski, Herta M Crauwels. Population Pharmacokinetic Analysis of Darunavir and Tenofovir Alafenamide in HIV-1-Infected Patients on the Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Single-Tablet Regimen (AMBER and EMERALD Studies). The AAPS journal. 2021 06; 23(4):82. doi: 10.1208/s12248-021-00607-8. [PMID: 34100149]
  • Dario Cattaneo, Mario Corbellino, Valeria Cozzi, Marta Fusi, Cristina Gervasoni. Comment on 'Comparative Population Pharmacokinetics of Darunavir in SARS-CoV-2 Patients vs. HIV Patients: The Role of Interleukin-6'. Clinical pharmacokinetics. 2021 06; 60(6):829-831. doi: 10.1007/s40262-021-00992-5. [PMID: 33864625]
  • Pier Giorgio Cojutti, Angela Londero, Paola Della Siega, Filippo Givone, Martina Fabris, Jessica Biasizzo, Carlo Tascini, Federico Pea. Authors' Reply to Cattaneo et al.: 'Comment on: Comparative Population Pharmacokinetics of Darunavir in SARS-CoV-2 Patients vs. HIV Patients: The Role of Interleukin6'. Clinical pharmacokinetics. 2021 06; 60(6):833-834. doi: 10.1007/s40262-021-00996-1. [PMID: 33864624]
  • Tianming Dai, Min Wang, Pengzhen Wang, Libing Dai, Renke Dai, Qingqi Meng. Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. Die Pharmazie. 2021 05; 76(5):195-201. doi: 10.1691/ph.2021.01005. [PMID: 33964992]
  • Rujipas Sirijatuphat, Yupin Suputtamongkol, Nasikarn Angkasekwinai, Navin Horthongkham, Methee Chayakulkeeree, Pinyo Rattanaumpawan, Pornpan Koomanachai, Susan Assanasen, Yong Rongrungruang, Nitipatana Chierakul, Ranistha Ratanarat, Anupop Jitmuang, Walaiporn Wangchinda, Wannee Kantakamalakul. Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital. BMC infectious diseases. 2021 Apr; 21(1):382. doi: 10.1186/s12879-021-06081-z. [PMID: 33902480]
  • Mizuki Kobayashi, Miria Chinen, Atsushi Hirano, Tsunefusa Hayashida, Koji Watanabe, Junichi Masuda. Successful treatment by doravirine with cobicistat-boosted darunavir for end-stage renal failure under chronic haemodialysis. The Journal of antimicrobial chemotherapy. 2021 04; 76(5):1370-1372. doi: 10.1093/jac/dkab001. [PMID: 33491079]
  • Jovana Milic, Alessio Novella, Marianna Meschiari, Marianna Menozzi, Antonella Santoro, Andrea Bedini, Gianluca Cuomo, Erica Franceschini, Margherita Digaetano, Federica Carli, Giacomo Ciusa, Sara Volpi, Erica Bacca, Giacomo Franceschi, Dina Yaacoub, Carlotta Rogati, Marco Tutone, Giulia Burastero, Matteo Faltoni, Vittorio Iadisernia, Giovanni Dolci, Andrea Cossarizza, Cristina Mussini, Luca Pasina, Giovanni Guaraldi. Darunavir/Cobicistat Is Associated with Negative Outcomes in HIV-Negative Patients with Severe COVID-19 Pneumonia. AIDS research and human retroviruses. 2021 04; 37(4):283-291. doi: 10.1089/aid.2020.0305. [PMID: 33619997]
  • Yi Zheng, Gabrielle Lui, Sana Boujaafar, Radia Aboura, Naïm Bouazza, Frantz Foissac, Jean-Marc Treluyer, Sihem Benaboud, Déborah Hirt, Inès Gana. Development of a simple and rapid method to determine the unbound fraction of dolutegravir, raltegravir and darunavir in human plasma using ultrafiltration and LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2021 Mar; 196(?):113923. doi: 10.1016/j.jpba.2021.113923. [PMID: 33571728]
  • R N Dallocchio, A Dessì, A De Vito, G Delogu, P A Serra, G Madeddu. Early combination treatment with existing HIV antivirals: an effective treatment for COVID-19?. European review for medical and pharmacological sciences. 2021 Mar; 25(5):2435-2448. doi: 10.26355/eurrev_202103_25285. [PMID: 33755983]
  • Ashraf A Aly, Alaa A Hassan, Asmaa H Mohamed, Esraa M Osman, Stefan Bräse, Martin Nieger, Mahmoud A A Ibrahim, Sara M Mostafa. Synthesis of 3,3'-methylenebis(4-hydroxyquinolin-2(1H)-ones) of prospective anti-COVID-19 drugs. Molecular diversity. 2021 Feb; 25(1):461-471. doi: 10.1007/s11030-020-10140-z. [PMID: 32926254]
  • Etienne Meriglier, Claire Rivoisy, Mojgan Hessamfar, Noelle Bernard, Ines Aureau, Joelle Lapoirie, Anne Contis, Frédéric Sacher, Benjamin Sacristan, Marin Lahouati, Stéphane Pedeboscq, Marie-Anne Vandenhende, Stéphane Bouchet, Fabrice Bonnet. Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection. The Journal of antimicrobial chemotherapy. 2021 01; 76(2):482-486. doi: 10.1093/jac/dkaa441. [PMID: 33221868]
  • Priyanka R Ipte, Sudipa Manna, Srikant Sahoo, Ashis Kumar Satpati. Probing the interaction of anti-HIV drug Darunavir with dsDNA and HSA using electrochemical and spectroscopic measurements. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2021; 56(13):1435-1444. doi: 10.1080/10934529.2021.2008205. [PMID: 34986753]
  • Ibrahim A Darwish, Abdulrahman A Al-Majed, Nawaf A Alsaif, Ahmed H Bakheit, Rashed N Herqash, Abdullah Alzaid. Darunavir: A comprehensive profile. Profiles of drug substances, excipients, and related methodology. 2021; 46(?):1-50. doi: 10.1016/bs.podrm.2020.07.001. [PMID: 33461696]
  • Erika Tyrberg, Arvid Edén, Jaran Eriksen, Staffan Nilsson, Carl Johan Treutiger, Anders Thalme, Åsa Mellgren, Magnus Gisslén, Lars-Magnus Andersson. Higher plasma drug levels in elderly people living with HIV treated with darunavir. PloS one. 2021; 16(2):e0246171. doi: 10.1371/journal.pone.0246171. [PMID: 33539440]
  • Luigi Moschini, Marco Loffi, Valentina Regazzoni, Giuseppe Di Tano, Elisa Gherbesi, Gian Battista Danzi. Effects on QT interval of hydroxychloroquine associated with ritonavir/darunavir or azithromycin in patients with SARS-CoV-2 infection. Heart and vessels. 2021 Jan; 36(1):115-120. doi: 10.1007/s00380-020-01671-4. [PMID: 32676695]
  • Sekhar Talluri. Molecular Docking and Virtual Screening Based Prediction of Drugs for COVID-19. Combinatorial chemistry & high throughput screening. 2021; 24(5):716-728. doi: 10.2174/1386207323666200814132149. [PMID: 32798373]
  • Son Tung Ngo, Ngoc Quynh Anh Pham, Ly Thi Le, Duc-Hung Pham, Van V Vu. Computational Determination of Potential Inhibitors of SARS-CoV-2 Main Protease. Journal of chemical information and modeling. 2020 12; 60(12):5771-5780. doi: 10.1021/acs.jcim.0c00491. [PMID: 32530282]
  • Shaojia Lu, Ning Wei, Jiajun Jiang, Lingling Wu, Jifang Sheng, Jianying Zhou, Qiang Fang, Yu Chen, Shufa Zheng, Feng Chen, Tingbo Liang, Shaohua Hu. First report of manic-like symptoms in a COVID-19 patient with no previous history of a psychiatric disorder. Journal of affective disorders. 2020 12; 277(?):337-340. doi: 10.1016/j.jad.2020.08.031. [PMID: 32858315]
  • Yong-Zheng Guo, Kai-Jin Xu, Yong-Tao Li, Jia-Dan Fu, Min Xu, Ling Yu, Ji-Fang Sheng, Biao Zhu. Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China. Journal of Zhejiang University. Science. B. 2020 Dec; 21(12):948-954. doi: 10.1631/jzus.b2000204. [PMID: 33843160]
  • Palumbo Roberto, Londrino Francesco, Cordova Emanuela, Gambardella Giorgia, Niscola Pasquale, Dominijanni Sara. Current treatment of COVID-19 in renal patients: hope or hype?. Internal and emergency medicine. 2020 11; 15(8):1389-1398. doi: 10.1007/s11739-020-02510-0. [PMID: 32986137]
  • Antonio Desai, Orazio Giuseppe Santonocito, Giuseppe Caltagirone, Maria Kogan, Federica Ghetti, Ilaria Donadoni, Francesca Porro, Victor Savevski, Dario Poretti, Michele Ciccarelli, Filippo Martinelli Boneschi, Antonio Voza. Effectiveness of Streptococcus Pneumoniae Urinary Antigen Testing in Decreasing Mortality of COVID-19 Co-Infected Patients: A Clinical Investigation. Medicina (Kaunas, Lithuania). 2020 Oct; 56(11):. doi: 10.3390/medicina56110572. [PMID: 33138045]
  • Michael Li, Walter W Chan, Stephen D Zucker. Association Between Atazanavir-Induced Hyperbilirubinemia and Cardiovascular Disease in Patients Infected with HIV. Journal of the American Heart Association. 2020 10; 9(19):e016310. doi: 10.1161/jaha.120.016310. [PMID: 32930032]
  • Heba Elkateb, Lee M Tatham, Helen Cauldbeck, Edyta Niezabitowska, Andrew Owen, Steve Rannard, Tom McDonald. Optimization of the synthetic parameters of lipid polymer hybrid nanoparticles dual loaded with darunavir and ritonavir for the treatment of HIV. International journal of pharmaceutics. 2020 Oct; 588(?):119794. doi: 10.1016/j.ijpharm.2020.119794. [PMID: 32828978]
  • Teruhisa S Komatsu, Noriaki Okimoto, Yohei M Koyama, Yoshinori Hirano, Gentaro Morimoto, Yousuke Ohno, Makoto Taiji. Drug binding dynamics of the dimeric SARS-CoV-2 main protease, determined by molecular dynamics simulation. Scientific reports. 2020 10; 10(1):16986. doi: 10.1038/s41598-020-74099-5. [PMID: 33046764]
  • Emanuele Durante-Mangoni, Roberto Andini, Lorenzo Bertolino, Ferruccio Mele, Letizia Lucia Florio, Patrizia Murino, Antonio Corcione, Rosa Zampino. Early experience with remdesivir in SARS-CoV-2 pneumonia. Infection. 2020 Oct; 48(5):779-782. doi: 10.1007/s15010-020-01448-x. [PMID: 32418190]
  • Pier Giorgio Cojutti, Angela Londero, Paola Della Siega, Filippo Givone, Martina Fabris, Jessica Biasizzo, Carlo Tascini, Federico Pea. Comparative Population Pharmacokinetics of Darunavir in SARS-CoV-2 Patients vs. HIV Patients: The Role of Interleukin-6. Clinical pharmacokinetics. 2020 10; 59(10):1251-1260. doi: 10.1007/s40262-020-00933-8. [PMID: 32856282]
  • Simon Weidlich, Christoph Boesecke, Jochen Schneider, Hartwig H F Klinker, Alexander Zink, Annamaria Balogh, Eva Wolf, Helen Bidner, Christoph D Spinner. Adequate plasma levels of dolutegravir in combination with ritonavir-boosted darunavir: a pharmacokinetic subgroup analysis of the DUALIS study. The Journal of antimicrobial chemotherapy. 2020 10; 75(10):3082-3084. doi: 10.1093/jac/dkaa234. [PMID: 32634214]
  • Georg Härter, Christoph D Spinner, Julia Roider, Markus Bickel, Ivanka Krznaric, Stephan Grunwald, Farhad Schabaz, Daniel Gillor, Nils Postel, Matthias C Mueller, Markus Müller, Katja Römer, Knud Schewe, Christian Hoffmann. COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients. Infection. 2020 Oct; 48(5):681-686. doi: 10.1007/s15010-020-01438-z. [PMID: 32394344]
  • Elton Dajti, Francesco Cristini, Giacomo Tamanini, Matteo Cescon, Franco Bazzoli, Mariarosa Tamè. COVID-19 in a young liver transplant recipient: caution for drug-drug interactions. Journal of gastrointestinal and liver diseases : JGLD. 2020 09; 29(3):470. doi: 10.15403/jgld-2672. [PMID: 32830825]
  • Ibrahim A Darwish, Abdulrahman A Almehizia, Awwad A Radwan, Rashed N Herqash. Preparation and Characterization of Two Immunogens and Production of Polyclonal Antibody with High Affinity and Specificity for Darunavir. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184075. [PMID: 32906585]
  • Eun Jin Kim, Sun Ha Choi, Jae Seok Park, Yong Shik Kwon, Jaehee Lee, Yeonjae Kim, Shin Yup Lee, Eun Young Choi. Use of Darunavir-Cobicistat as a Treatment Option for Critically Ill Patients with SARS-CoV-2 Infection. Yonsei medical journal. 2020 Sep; 61(9):826-830. doi: 10.3349/ymj.2020.61.9.826. [PMID: 32882767]
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