amisulpride (BioDeep_00000397563)
natural product
代谢物信息卡片
amisulpride
化学式: C17H27N3O4S (369.17221820000003)
中文名称: 阿米舒必利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(N(CC1)CC)CNC(C2=CC(=C(C=C2OC)N)S(CC)(=O)=O)=O
InChI: InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AL - Benzamides
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2852
EAWAG_UCHEM_ID 2852; CONFIDENCE standard compound
CONFIDENCE standard compound; INTERNAL_ID 2142
Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
同义名列表
2 个代谢物同义名
数据库引用编号
48 个数据库交叉引用编号
- ChEBI: CHEBI:64045
- KEGGdrug: D07310
- PubChem: 2159
- DrugBank: DB06288
- ChEMBL: CHEMBL243712
- MeSH: Amisulpride
- CAS: 71675-85-9
- CAS: 71675-85-9, 81342-13-4 (HCl)
- MoNA: WA001178
- MoNA: WA001177
- MoNA: WA001176
- MoNA: WA001175
- MoNA: WA001174
- MoNA: FiehnHILIC002590
- MoNA: FiehnHILIC001760
- MoNA: FiehnHILIC000184
- MoNA: CCMSLIB00000078080
- MoNA: EA285264
- MoNA: EA285260
- MoNA: EA285259
- MoNA: EA285258
- MoNA: EA285256
- MoNA: EA285255
- MoNA: EA285254
- MoNA: EA285253
- MoNA: EA285252
- MoNA: EA285251
- MoNA: EA285214
- MoNA: EA285213
- MoNA: EA285212
- MoNA: EA285211
- MoNA: EA285210
- MoNA: EA285209
- MoNA: EA285208
- MoNA: EA285207
- MoNA: EA285206
- MoNA: EA285205
- MoNA: EA285204
- MoNA: EA285203
- MoNA: EA285202
- MoNA: EA285201
- MoNA: AU214205
- MoNA: AU214204
- MoNA: AU214203
- MoNA: AU214202
- MoNA: AU214201
- RefMet: Amisulpride
- medchemexpress: HY-14545
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jingda Cai, Li Li, Tiannan Shao, Mengxi Sun, Weiyan Wang, Peng Xie, Xiaoyi Wang, Ye Yang, Yujun Long, Dongyu Kang, Jingmei Xiao, Yuhan Su, Xingjie Peng, Yuyan Huang, Menghui Gao, Qiongqiong Wu, Chuhan Song, Furu Liu, Ping Shao, Jianjun Ou, Yidong Shen, Jing Huang, Renrong Wu. Relapse in patients with schizophrenia and amisulpride-induced hyperprolactinemia or olanzapine-induced metabolic disturbance after switching to other antipsychotics.
Psychiatry research.
2023 Mar; 322(?):115138. doi:
10.1016/j.psychres.2023.115138. [PMID: 36871411] - Hae-Jung Yang, Seung-Gon Kim, Eun Hyun Seo, Hyung-Jun Yoon. Amisulpride withdrawal akathisia responding to aripiprazole with propranolol in first-onset psychosis: a case report.
BMC psychiatry.
2022 01; 22(1):74. doi:
10.1186/s12888-022-03721-9. [PMID: 35093063] - Bozhi Yuan, Mei Yuan. Changes of Mental State and Serum Prolactin Levels in Patients with Schizophrenia and Depression after Receiving the Combination Therapy of Amisulpride and Chloroprothixol Tablets.
Computational and mathematical methods in medicine.
2022; 2022(?):6580030. doi:
10.1155/2022/6580030. [PMID: 35242209] - Jinchi Zheng, Zeya Lin, Chih-Yuan Ko, Jian-Hua Xu, Yichuan Lin, Jinyi Wang. Analysis of Gut Microbiota in Patients with Exacerbated Symptoms of Schizophrenia following Therapy with Amisulpride: A Pilot Study.
Behavioural neurology.
2022; 2022(?):4262094. doi:
10.1155/2022/4262094. [PMID: 35287288] - Kankan Qu, Feng Wang, Zhiqiang Du, Shushan Wang, Zhongdong Zhang, Yuan Shen. A novel and sensitive method for determination of amisulpride in human plasma by two-dimensional liquid chromatography.
Biomedical chromatography : BMC.
2021 Oct; 35(10):e5149. doi:
10.1002/bmc.5149. [PMID: 33928659] - Daniel A Hussar. New Drugs 2021, Part 2.
Nursing.
2021 Oct; 51(10):18-29. doi:
10.1097/01.nurse.0000791756.56705.dd. [PMID: 34580258] - Dnyandev Gadhave, Shrikant Tupe, Amol Tagalpallewar, Bapi Gorain, Hira Choudhury, Chandrakant Kokare. Nose-to-brain delivery of amisulpride-loaded lipid-based poloxamer-gellan gum nanoemulgel: In vitro and in vivo pharmacological studies.
International journal of pharmaceutics.
2021 Sep; 607(?):121050. doi:
10.1016/j.ijpharm.2021.121050. [PMID: 34454028] - Fengli Sun, Fang Yu, Zhihan Gao, Zhibin Ren, Weidong Jin. Study on the relationship among dose, concentration and clinical response in Chinese schizophrenic patients treated with Amisulpride.
Asian journal of psychiatry.
2021 Aug; 62(?):102694. doi:
10.1016/j.ajp.2021.102694. [PMID: 34052710] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Fenglin Wang, Sandong Yang, Xinying Zhou, Jiao Feng, Tao Tang, Tong Li. [Integrated multi-column two-dimensional liquid chromatographic system for determination of amisulpride in serum].
Se pu = Chinese journal of chromatography.
2021 Feb; 39(2):197-202. doi:
10.3724/sp.j.1123.2020.07035. [PMID: 34227352] - Shanqing Huang, Lu Li, Zhanzhang Wang, Tao Xiao, Xiaolin Li, Shujing Liu, Ming Zhang, Haoyang Lu, Yuguan Wen, Dewei Shang. Modeling and Simulation for Individualized Therapy of Amisulpride in Chinese Patients with Schizophrenia: Focus on Interindividual Variability, Therapeutic Reference Range and the Laboratory Alert Level.
Drug design, development and therapy.
2021; 15(?):3903-3913. doi:
10.2147/dddt.s327506. [PMID: 34548782] - Erik Johnsen, Rune A Kroken, Else-Marie Løberg, Maria Rettenbacher, Inge Joa, Tor Ketil Larsen, Solveig Klæbo Reitan, Berit Walla, Renata Alisauskiene, Liss Gøril Anda, Christoffer Bartz-Johannessen, Jan Øystein Berle, Jill Bjarke, Farivar Fathian, Kenneth Hugdahl, Eirik Kjelby, Igne Sinkeviciute, Silje Skrede, Lena Stabell, Vidar M Steen, W Wolfgang Fleischhacker. Amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial.
The lancet. Psychiatry.
2020 11; 7(11):945-954. doi:
10.1016/s2215-0366(20)30341-2. [PMID: 33069317] - Binbin Chen, Chen Wang, Xiangzhen Xu, Haiyan Lyu, Chunling Ma, Gang Cheng. Risk of Prolonged Corrected QT Interval With Amisulpride Therapy for Renal Function Management in Patients With Schizophrenia.
Journal of clinical psychopharmacology.
2020 Sep; 40(5):482-486. doi:
10.1097/jcp.0000000000001257. [PMID: 32826486] - Eleftheria Kopelli, Myrto Samara, Antonios Siargkas, Antonis Goulas, Georgios Papazisis, Michail Chourdakis. The role of cannabidiol oil in schizophrenia treatment. a systematic review and meta-analysis.
Psychiatry research.
2020 09; 291(?):113246. doi:
10.1016/j.psychres.2020.113246. [PMID: 32599446] - Noha N Atia, Mostafa A Marzouq, Ahmed I Hassan, Walid E Eltoukhi. A rapid FTIR spectroscopic assay for quantitative determination of Memantine hydrochloride and Amisulpride in human plasma and pharmaceutical formulations.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Aug; 236(?):118377. doi:
10.1016/j.saa.2020.118377. [PMID: 32330826] - Lin Li, Lu Li, De-Wei Shang, Yu-Guan Wen, Yu-Ping Ning. A systematic review and combined meta-analysis of concentration of oral amisulpride.
British journal of clinical pharmacology.
2020 04; 86(4):668-678. doi:
10.1111/bcp.14246. [PMID: 32090363] - Noha N Atia, Mostafa A Marzouq, Ahmed I Hassan, Walid E Eltoukhi. A new spectrofluorimetric assay for quantification of Amisulpride and Memantine hydrochloride in real human plasma sample and pharmaceutical formulations via Hantzsch reaction.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Jan; 224(?):117388. doi:
10.1016/j.saa.2019.117388. [PMID: 31357052] - Gayathri Nair Sekhar, Alice L Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa B Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves, Sarah Ann Thomas. Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer's disease.
Fluids and barriers of the CNS.
2019 Dec; 16(1):38. doi:
10.1186/s12987-019-0158-1. [PMID: 31842924] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Noha N Atia, Mostafa A Marzouq, Ahmed I Hassan, Walid E Eltoukhi. A new sensitive approach for spectrofluorimetric assay of Milnacipran and Amisulpride in real plasma and pharmaceutical preparations via complexation with Eosin Y dye.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 May; 214(?):399-406. doi:
10.1016/j.saa.2019.02.071. [PMID: 30802797] - Signe W Düring, Mette Ø Nielsen, Nikolaj Bak, Birte Y Glenthøj, Bjørn H Ebdrup. Sexual dysfunction and hyperprolactinemia in schizophrenia before and after six weeks of D2/3 receptor blockade - An exploratory study.
Psychiatry research.
2019 04; 274(?):58-65. doi:
10.1016/j.psychres.2019.02.017. [PMID: 30780063] - Abd El-Halim I El Assasy, Niha F Younes, Amal I A Makhlouf. Enhanced Oral Absorption of Amisulpride Via a Nanostructured Lipid Carrier-Based Capsules: Development, Optimization Applying the Desirability Function Approach and In Vivo Pharmacokinetic Study.
AAPS PharmSciTech.
2019 Jan; 20(2):82. doi:
10.1208/s12249-018-1283-x. [PMID: 30652198] - Prajapati Jagruti B, Sawant Krutika K, Bhramanand Dubey. Oral Bioavailability Enhancement of Amisulpride: Complexation and its Pharmacokinetics and Pharmacodynamics Evaluations.
Drug metabolism letters.
2019; 13(2):132-144. doi:
10.2174/1872312813666191018152226. [PMID: 31975684] - Marwa H Shukr, Omar A Ahmed Farid. Amisulpride-CD-Loaded Liposomes: Optimization and In Vivo Evaluation.
AAPS PharmSciTech.
2018 Aug; 19(6):2658-2671. doi:
10.1208/s12249-018-1079-z. [PMID: 29943282] - Si-Si Cao, Yan-Xia Ma, Ping-Fei Fang, Hua-Lin Cai, Yang Deng, Zhen-Yan Hou, Ying Chen, Miao Yan, Bi-Kui Zhang. Pharmacokinetics and relative bioavailability of a generic amisulpride tablet in healthy Chinese volunteers
.
International journal of clinical pharmacology and therapeutics.
2017 Oct; 55(10):825-831. doi:
10.5414/cp203000. [PMID: 28793958] - Teng Wang, Yajun Zheng, Xiaoting Wang, Daniel E Austin, Zhiping Zhang. Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray.
Analytical chemistry.
2017 08; 89(15):7988-7995. doi:
10.1021/acs.analchem.7b01296. [PMID: 28686424] - Piotr Skrobecki, Anna Chmielińska, Piotr Bonarek, Piotr Stepien, Anna Wisniewska-Becker, Marta Dziedzicka-Wasylewska, Agnieszka Polit. Sulpiride, Amisulpride, Thioridazine, and Olanzapine: Interaction with Model Membranes. Thermodynamic and Structural Aspects.
ACS chemical neuroscience.
2017 07; 8(7):1543-1553. doi:
10.1021/acschemneuro.7b00057. [PMID: 28375612] - Li-Juan Gao, Hua-Gui Guo, Zhen-Tao Liang, Xiao-Xiao Zhong, Jin-Cai Zhu, Yu Yang. [Aripiprazole for drug-induced sexual dysfunction in schizophrenic males].
Zhonghua nan ke xue = National journal of andrology.
2017 Jul; 23(7):615-619. doi:
NULL. [PMID: 29723454] - Danielle S Fisher, Chad Beyer, Gerrit van Schalkwyk, Soraya Seedat, Robert J Flanagan. Measurement of Clozapine, Norclozapine, and Amisulpride in Plasma and in Oral Fluid Obtained Using 2 Different Sampling Systems.
Therapeutic drug monitoring.
2017 04; 39(2):109-117. doi:
10.1097/ftd.0000000000000377. [PMID: 28125503] - Jörg Täubel, Georg Ferber, Gabriel Fox, Sara Fernandes, Ulrike Lorch, A John Camm. Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects.
British journal of clinical pharmacology.
2017 02; 83(2):339-348. doi:
10.1111/bcp.13128. [PMID: 27618796] - Alper Bas, Gozde Gultekin, Said Incir, Tuba Ocek Bas, Murat Emul, Alaatin Duran. Level of serum thioredoxin and correlation with neurocognitive functions in patients with schizophrenia using clozapine and other atypical antipsychotics.
Psychiatry research.
2017 Jan; 247(?):84-89. doi:
10.1016/j.psychres.2016.11.021. [PMID: 27871032] - Sean J OʼHalloran, Antonia Wong, David A Joyce. A Liquid Chromatography-Tandem Mass Spectrometry Method for Quantifying Amisulpride in Human Plasma and Breast Milk, Applied to Measuring Drug Transfer to a Fully Breast-Fed Neonate.
Therapeutic drug monitoring.
2016 08; 38(4):493-8. doi:
10.1097/ftd.0000000000000300. [PMID: 27027463] - Chun-Yen Chen, Yi-Wei Yeh, Shin-Chang Kuo, Pei-Shen Ho, Chih-Sung Liang, Che-Hung Yen, Ru-Band Lu, San-Yuan Huang. Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment.
Psychoneuroendocrinology.
2016 Mar; 65(?):67-75. doi:
10.1016/j.psyneuen.2015.12.003. [PMID: 26724569] - Mucahit Avcil, Mucahit Kapçı, Irfan Yavaşoğlu, Burçak Kantekin, Mahmut Akpek. Simultaneous Use of Intravenous Lipid Emulsion and Plasma Exchange Therapies in Multiple Drug Toxicity.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre.
2016; 25(6):577-579. doi:
10.1159/000449250. [PMID: 27548660] - Ying Liang, Yun-Ai Su, Zhen-Guo Zhao, Nan Gao, Ji-Zhong Huang, Mao-Qin Tang, Ke-Qing Li, Fu-De Yang, Xin Yu, Tian-Mei Si. Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia.
Journal of clinical psychopharmacology.
2015 Oct; 35(5):583-6. doi:
10.1097/jcp.0000000000000379. [PMID: 26270200] - Coraline D Metzger, Maike Wiegers, Martin Walter, Birgit Abler, Heiko Graf. Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects.
The international journal of neuropsychopharmacology.
2015 Jul; 19(2):. doi:
10.1093/ijnp/pyv080. [PMID: 26209860] - Keumhan Noh, Yoo-Jeong Jang, Kwang-il Kwon, Eunyoung Kim, Tae Cheon Jeong, Hwi-yeol Yun, Wonku Kang. Quantitative determination of amisulpride in rat plasma by HPLC-MS/MS.
Archives of pharmacal research.
2015 Jan; 38(1):63-7. doi:
10.1007/s12272-014-0361-1. [PMID: 24619919] - Joao N Dos Santos Pereira, Sina Tadjerpisheh, Manar Abu Abed, Ali R Saadatmand, Babette Weksler, Ignacio A Romero, Pierre-Olivier Couraud, Jürgen Brockmöller, Mladen V Tzvetkov. The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family.
The AAPS journal.
2014 Nov; 16(6):1247-58. doi:
10.1208/s12248-014-9649-9. [PMID: 25155823] - Yoo-Jung Jang, Tae Cheon Jeong, Keumhan Noh, In-Whan Baek, Kwang-il Kwon, Eunyoung Kim, Young-Ran Yoon, Wonku Kang. Prandial effect on the systemic exposure of amisulpride.
Archives of pharmacal research.
2014 Oct; 37(10):1325-8. doi:
10.1007/s12272-014-0331-7. [PMID: 24469600] - Danielle S Fisher, Suzanne J Partridge, Simon A Handley, Robert J Flanagan. Stability of some atypical antipsychotics in human plasma, haemolysed whole blood, oral fluid, human serum and calf serum.
Forensic science international.
2013 Jun; 229(1-3):151-6. doi:
10.1016/j.forsciint.2013.03.021. [PMID: 23570966] - Danielle S Fisher, Suzanne J Partridge, Simon A Handley, Lewis Couchman, Phillip E Morgan, Robert J Flanagan. LC-MS/MS of some atypical antipsychotics in human plasma, serum, oral fluid and haemolysed whole blood.
Forensic science international.
2013 Jun; 229(1-3):145-50. doi:
10.1016/j.forsciint.2013.02.010. [PMID: 23477803] - M A Birch, L Couchman, S Pietromartire, T Karna, C Paton, R McAllister, A Marsh, R J Flanagan. False-positive buprenorphine by CEDIA in patients prescribed amisulpride or sulpiride.
Journal of analytical toxicology.
2013 May; 37(4):233-6. doi:
10.1093/jat/bkt016. [PMID: 23471956] - Marie Bicikova, Martin Hill, Daniela Ripova, Pavel Mohr, Richard Hampl. Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia.
The Journal of steroid biochemistry and molecular biology.
2013 Jan; 133(?):77-83. doi:
10.1016/j.jsbmb.2012.08.009. [PMID: 22944140] - David N Osser, Mohsen Jalali Roudsari, Theo Manschreck. The psychopharmacology algorithm project at the Harvard South Shore Program: an update on schizophrenia.
Harvard review of psychiatry.
2013 Jan; 21(1):18-40. doi:
10.1097/hrp.0b013e31827fd915. [PMID: 23656760] - Sally V J Bowskill, Maxine X Patel, Simon A Handley, Robert J Flanagan. Plasma amisulpride in relation to prescribed dose, clozapine augmentation, and other factors: data from a therapeutic drug monitoring service, 2002-2010.
Human psychopharmacology.
2012 Sep; 27(5):507-13. doi:
10.1002/hup.2256. [PMID: 22996618] - Ulrich Schmitt, Katrin M Kirschbaum, Birk Poller, Manisha Kusch-Poddar, Jürgen Drewe, Christoph Hiemke, Heike Gutmann. In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes.
Pharmacology, biochemistry, and behavior.
2012 Aug; 102(2):312-20. doi:
10.1016/j.pbb.2012.04.002. [PMID: 22525746] - Hyun-Ghang Jeong, Moon-Soo Lee, Hwa-Young Lee, Young-Hoon Ko, Changsu Han, Sook-Haeng Joe. Changes in sexual function and gonadal axis hormones after switching to aripiprazole in male schizophrenia patients: a prospective pilot study.
International clinical psychopharmacology.
2012 Jul; 27(4):177-83. doi:
10.1097/yic.0b013e328351c8c4. [PMID: 22407277] - Katharina Wulff, Derk-Jan Dijk, Benita Middleton, Russell G Foster, Eileen M Joyce. Sleep and circadian rhythm disruption in schizophrenia.
The British journal of psychiatry : the journal of mental science.
2012 Apr; 200(4):308-16. doi:
10.1192/bjp.bp.111.096321. [PMID: 22194182] - Anna Dietrich-Muszalska, Bogdan Kontek, Beata Olas, Jolanta Rabe-Jabłońska. Epicatechin inhibits human plasma lipid peroxidation caused by haloperidol in vitro.
Neurochemical research.
2012 Mar; 37(3):557-62. doi:
10.1007/s11064-011-0642-8. [PMID: 22076501] - Bun-Hee Lee, Seung-Gul Kang, Tae-Woo Kim, Heon-Jeong Lee, Ho-Kyoung Yoon, Young-Min Park. Hyperprolactinemia induced by low-dosage amisulpride in Korean psychiatric patients.
Psychiatry and clinical neurosciences.
2012 Feb; 66(1):69-73. doi:
10.1111/j.1440-1819.2011.02296.x. [PMID: 22250612] - Manuel Maria de Carvalho, Carlos Góis. [Hyperprolactinemia in mentally ill patients].
Acta medica portuguesa.
2011 Nov; 24(6):1005-12. doi:
. [PMID: 22713195] - Stefano Espinoza, Ali Salahpour, Bernard Masri, Tatyana D Sotnikova, Mirko Messa, Larry S Barak, Marc G Caron, Raul R Gainetdinov. Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.
Molecular pharmacology.
2011 Sep; 80(3):416-25. doi:
10.1124/mol.111.073304. [PMID: 21670104] - Tim Moons, Mariska de Roo, Stephan Claes, Geert Dom. Relationship between P-glycoprotein and second-generation antipsychotics.
Pharmacogenomics.
2011 Aug; 12(8):1193-211. doi:
10.2217/pgs.11.55. [PMID: 21843066] - L Couchman, P E Morgan, R J Flanagan. Basic drug analysis by strong cation-exchange liquid chromatography-tandem mass spectrometry: simultaneous analysis of amisulpride, and of metamfetamine and amfetamine in serum/plasma.
Biomedical chromatography : BMC.
2011 Aug; 25(8):867-72. doi:
10.1002/bmc.1530. [PMID: 21058410] - Anna Dietrich-Muszalska, Beata Olas, Bogdan Kontek, Jolanta Rabe-Jabłońska. Beta-glucan from Saccharomyces cerevisiae reduces plasma lipid peroxidation induced by haloperidol.
International journal of biological macromolecules.
2011 Jul; 49(1):113-6. doi:
10.1016/j.ijbiomac.2011.03.007. [PMID: 21421004] - Ramakotaiah Mogili, Kanchanamala Kanala, Balasekhara Reddy Challa, Babu Rao Chandu, Chandrasekhar Kottapalli Bannoth. Development and validation of amisulpride in human plasma by HPLC coupled with tandem mass spectrometry and its application to a pharmacokinetic study.
Scientia pharmaceutica.
2011 Jul; 79(3):583-99. doi:
10.3797/scipharm.1105-12. [PMID: 21886905] - Peter Malik, Georg Kemmler, Martina Hummer, Anita Riecher-Roessler, René S Kahn, W Wolfgang Fleischhacker. Sexual dysfunction in first-episode schizophrenia patients: results from European First Episode Schizophrenia Trial.
Journal of clinical psychopharmacology.
2011 Jun; 31(3):274-80. doi:
10.1097/jcp.0b013e3182199bcc. [PMID: 21508850] - Marija Bošković, Tomaž Vovk, Blanka Kores Plesničar, Iztok Grabnar. Oxidative stress in schizophrenia.
Current neuropharmacology.
2011 Jun; 9(2):301-12. doi:
10.2174/157015911795596595. [PMID: 22131939] - Jessica Deslauriers, Marilou Lefrançois, Annie Larouche, Philippe Sarret, Sylvain Grignon. Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y neuroblastoma cells.
Synapse (New York, N.Y.).
2011 Apr; 65(4):321-31. doi:
10.1002/syn.20851. [PMID: 20730801] - Stephanie Teoh, Kenneth F Ilett, L Peter Hackett, Rolland Kohan. Estimation of rac-amisulpride transfer into milk and of infant dose via milk during its use in a lactating woman with bipolar disorder and schizophrenia.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2011 Apr; 6(2):85-8. doi:
10.1089/bfm.2010.0016. [PMID: 20925494] - H Y Meltzer, B W Massey. The role of serotonin receptors in the action of atypical antipsychotic drugs.
Current opinion in pharmacology.
2011 Feb; 11(1):59-67. doi:
10.1016/j.coph.2011.02.007. [PMID: 21420906] - Pascal Bonaventure, Leah Aluisio, James Shoblock, Jamin D Boggs, Ian C Fraser, Brian Lord, Timothy W Lovenberg, Ruggero Galici. Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission.
PloS one.
2011; 6(6):e20210. doi:
10.1371/journal.pone.0020210. [PMID: 21701689] - Chih-Ken Chen, Yu-Shu Huang, Shao-Chun Ree, Cheng-Cheng Hsiao. Differential add-on effects of aripiprazole in resolving hyperprolactinemia induced by risperidone in comparison to benzamide antipsychotics.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Dec; 34(8):1495-9. doi:
10.1016/j.pnpbp.2010.08.012. [PMID: 20732372] - Kenneth F Ilett, Felice Watt, L Peter Hackett, Rolland Kohan, Stephanie Teoh. Assessment of infant dose through milk in a lactating woman taking amisulpride and desvenlafaxine for treatment-resistant depression.
Therapeutic drug monitoring.
2010 Dec; 32(6):704-7. doi:
10.1097/ftd.0b013e3181f88f70. [PMID: 20926994] - Ming-Hong Hsieh, Wei-Wen Lin, Shao-Tsu Chen, Kao-Ching Chen, Kuang-Peng Chen, Nan-Ying Chiu, Chao Huang, Ching-Jui Chang, Cheng-Hsiu Lin, Te-Jen Lai. A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting.
Annals of general psychiatry.
2010 Sep; 9(?):35. doi:
10.1186/1744-859x-9-35. [PMID: 20849577] - Susanne Englisch, Frank Enning, Martin Grosshans, Lars Marquardt, Robert Waltereit, Mathias Zink. Quetiapine combined with amisulpride in schizophrenic patients with insufficient responses to quetiapine monotherapy.
Clinical neuropharmacology.
2010 Sep; 33(5):227-9. doi:
10.1097/wnf.0b013e3181f0f013. [PMID: 20838213] - Anna Dietrich-Muszalska, Beata Olas. Inhibitory effects of polyphenol compounds on lipid peroxidation caused by antipsychotics (haloperidol and amisulpride) in human plasma in vitro.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2010 Mar; 11(2 Pt 2):276-81. doi:
10.1080/15622970902718790. [PMID: 19225991] - Emmanouil N Rizos, Athanasia Papadopoulou, Efstathios Laskos, Panagiota G Michalopoulou, Anastasia Kastania, Dimitrios Vasilopoulos, Konstantinos Katsafouros, Lefteris Lykouras. Reduced serum BDNF levels in patients with chronic schizophrenic disorder in relapse, who were treated with typical or atypical antipsychotics.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2010 Mar; 11(2 Pt 2):251-5. doi:
10.3109/15622970802182733. [PMID: 20218789] - Johann Steiner, Aye Mu Myint, Kolja Schiltz, Sabine Westphal, Hans-Gert Bernstein, Martin Walter, Matthias L Schroeter, Markus J Schwarz, Bernhard Bogerts. S100B Serum Levels in Schizophrenia Are Presumably Related to Visceral Obesity and Insulin Resistance.
Cardiovascular psychiatry and neurology.
2010; 2010(?):480707. doi:
10.1155/2010/480707. [PMID: 20631894] - Arlan L Rosenbloom. Hyperprolactinemia with antipsychotic drugs in children and adolescents.
International journal of pediatric endocrinology.
2010; 2010(?):. doi:
10.1155/2010/159402. [PMID: 20871665] - Mario F Juruena, Eduardo Pondé de Sena, Irismar Reis de Oliveira. Safety and tolerability of antipsychotics: focus on amisulpride.
Drug, healthcare and patient safety.
2010; 2(?):205-11. doi:
10.2147/dhps.s6226. [PMID: 21701632] - A Sparshatt, D Taylor, M X Patel, S Kapur. Amisulpride - dose, plasma concentration, occupancy and response: implications for therapeutic drug monitoring.
Acta psychiatrica Scandinavica.
2009 Dec; 120(6):416-28. doi:
10.1111/j.1600-0447.2009.01429.x. [PMID: 19573049] - Chris M Dodds, Luke Clark, Anja Dove, Ralf Regenthal, Frank Baumann, Ed Bullmore, Trevor W Robbins, Ulrich Müller. The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory.
Psychopharmacology.
2009 Nov; 207(1):35-45. doi:
10.1007/s00213-009-1634-0. [PMID: 19672580] - S Chabroux, E Haffen, A Penfornis. [Diabetes and second-generation (atypical) antipsychotics].
Annales d'endocrinologie.
2009 Sep; 70(4):202-10. doi:
10.1016/j.ando.2009.07.003. [PMID: 19700142] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Viktoria Simon, Ruud van Winkel, Marc De Hert. Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? A literature review.
The Journal of clinical psychiatry.
2009 Jul; 70(7):1041-50. doi:
10.4088/jcp.08r04392. [PMID: 19653979] - Matthias J Müller, F X Eich, B Regenbogen, J Sachse, S Härtter, C Hiemke. Amisulpride doses and plasma levels in different age groups of patients with schizophrenia or schizoaffective disorder.
Journal of psychopharmacology (Oxford, England).
2009 May; 23(3):278-86. doi:
10.1177/0269881108089806. [PMID: 18562411] - Ayan Das, Uttam Bhaumik, Uday S Chakrabarty, Amlan Kanti Sarkar, Animesh Ghosh, Anirbandeep Bose, Bappaditya Chatterjee, Tapan K Pal. Comparative bioavailability study of amisulpride tablets in healthy Indian volunteers.
Arzneimittel-Forschung.
2009; 59(4):166-70. doi:
10.1055/s-0031-1296381. [PMID: 19517892] - A Tschoner, J Engl, M Rettenbacher, M Edlinger, S Kaser, T Tatarczyk, M Effenberger, J R Patsch, W W Fleischhacker, C F Ebenbichler. Effects of six second generation antipsychotics on body weight and metabolism - risk assessment and results from a prospective study.
Pharmacopsychiatry.
2009 Jan; 42(1):29-34. doi:
10.1055/s-0028-1100425. [PMID: 19153944] - Linda Hanssens, Gilbert L'Italien, Jean-Yves Loze, Ronald N Marcus, Miranda Pans, Wendy Kerselaers. The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).
BMC psychiatry.
2008 Dec; 8(?):95. doi:
10.1186/1471-244x-8-95. [PMID: 19102734] - Mong-Liang Lu, Winston W Shen, Chun-Hsin Chen. Time course of the changes in antipsychotic-induced hyperprolactinemia following the switch to aripiprazole.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Dec; 32(8):1978-81. doi:
10.1016/j.pnpbp.2008.09.016. [PMID: 18848860] - Ramakrishna Nirogi, Gopinadh Bhyrapuneni, Vishwottam Kandikere, Koteshwara Mudigonda, Devender Ajjala, Ramakrishna Suraneni, K Mukkanti. Liquid chromatography tandem mass spectrometry method for the quantification of amisulpride with LLOQ of 100 pg/mL using 100 microL of plasma.
Biomedical chromatography : BMC.
2008 Dec; 22(12):1424-33. doi:
10.1002/bmc.1076. [PMID: 18655221] - J Cordes, A Sinha-Röder, K G Kahl, J Malevani, J Thuenker, C Lange-Asschenfeldt, H Hauner, M W Agelink, A Klimke. [Therapeutic options for weight management in schizophrenic patients treated with atypical antipsychotics].
Fortschritte der Neurologie-Psychiatrie.
2008 Dec; 76(12):703-14. doi:
10.1055/s-2008-1038279. [PMID: 18924059] - Béla Kiss, István Laszlovszky, Attila Horváth, Zsolt Némethy, Eva Schmidt, Gyula Bugovics, Károly Fazekas, István Gyertyán, Eva Agai-Csongor, György Domány, Zsolt Szombathelyi. Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15.
Naunyn-Schmiedeberg's archives of pharmacology.
2008 Nov; 378(5):515-28. doi:
10.1007/s00210-008-0308-5. [PMID: 18551280] - Sridhar Natesan, Greg E Reckless, Karren B L Barlow, José N Nobrega, Shitij Kapur. Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine.
Schizophrenia research.
2008 Oct; 105(1-3):224-35. doi:
10.1016/j.schres.2008.07.005. [PMID: 18710798] - E M Meisenzahl, G Schmitt, G Gründer, S Dresel, T Frodl, C la Fougère, J Scheuerecker, M Schwarz, R Boerner, J Stauss, K Hahn, H-J Möller. Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study.
Pharmacopsychiatry.
2008 Sep; 41(5):169-75. doi:
10.1055/s-2008-1076727. [PMID: 18763218] - Ayşen Esen-Danaci, Asli Sarandöl, Fatma Taneli, Fatma Yurtsever, Nesrin Ozlen. Effects of second generation antipsychotics on leptin and ghrelin.
Progress in neuro-psychopharmacology & biological psychiatry.
2008 Aug; 32(6):1434-8. doi:
10.1016/j.pnpbp.2008.03.015. [PMID: 18579280] - Cedric Tessier, Philippe Nuss, Galya Staneva, Claude Wolf. Modification of membrane heterogeneity by antipsychotic drugs: an X-ray diffraction comparative study.
Journal of colloid and interface science.
2008 Apr; 320(2):469-75. doi:
10.1016/j.jcis.2008.01.034. [PMID: 18279883] - Ruud van Winkel, Marc De Hert, Martien Wampers, Dominique Van Eyck, Linda Hanssens, Andre Scheen, Joseph Peuskens. Major changes in glucose metabolism, including new-onset diabetes, within 3 months after initiation of or switch to atypical antipsychotic medication in patients with schizophrenia and schizoaffective disorder.
The Journal of clinical psychiatry.
2008 Mar; 69(3):472-9. doi:
10.4088/jcp.v69n0320. [PMID: 18348593] - Luca Pani, José M Villagrán, Vassilis P Kontaxakis, Köksal Alptekin. Practical issues with amisulpride in the management of patients with schizophrenia.
Clinical drug investigation.
2008; 28(8):465-77. doi:
10.2165/00044011-200828080-00001. [PMID: 18598092] - Jaromír Svestka, Oldrich Synek, Jana Tomanová, Irena Rodáková, Andrea Cejpková. Differences in the effect of second-generation antipsychotics on prolactinaemia: six weeks open-label trial in female in-patients.
Neuro endocrinology letters.
2007 Dec; 28(6):881-8. doi:
NULL. [PMID: 18063941] - Stephen E Nicolson, Charles B Nemeroff. Ziprasidone in the treatment of mania in bipolar disorder.
Neuropsychiatric disease and treatment.
2007 Dec; 3(6):823-34. doi:
10.2147/ndt.s794. [PMID: 19300617] - Matthias J Müller, Boris Regenbogen, Sebastian Härtter, Franz X Eich, Christoph Hiemke. Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia.
Journal of psychiatric research.
2007 Oct; 41(8):673-9. doi:
10.1016/j.jpsychires.2005.10.003. [PMID: 16324716] - Niels Bergemann, Fatima Abu-Tair, Kai R Kress, Peter Parzer, Jürgen Kopitz. Increase in plasma concentration of amisulpride after addition of concomitant lithium.
Journal of clinical psychopharmacology.
2007 Oct; 27(5):546-9. doi:
10.1097/jcp.0b013e31814f4dbb. [PMID: 17873709] - Luiz Dratcu, Alistair Grandison, Gavin McKay, Adekunle Bamidele, Vinodini Vasudevan. Clozapine-resistant psychosis, smoking, and caffeine: managing the neglected effects of substances that our patients consume every day.
American journal of therapeutics.
2007 May; 14(3):314-8. doi:
10.1097/01.pap.0000249958.96498.ce. [PMID: 17515710] - A De Nayer, M De Hert, A Scheen, L Van Gaal, J Peuskens. [Conference report: Belgian consensus on metabolic problems associated with atypical antipsychotics].
L'Encephale.
2007 Mar; 33(2):197-202. doi:
10.1016/s0013-7006(07)91550-x. [PMID: 17675915] - Pierre Chue. Long-acting risperidone injection: efficacy, safety, and cost-effectiveness of the first long-acting atypical antipsychotic.
Neuropsychiatric disease and treatment.
2007 Feb; 3(1):13-39. doi:
10.2147/nedt.2007.3.1.13. [PMID: 19300536] - Thomas Paparrigopoulos, John Liappas, Elias Tzavellas, Iraklis Mourikis, Constantin Soldatos. Amisulpride-induced hyperprolactinemia is reversible following discontinuation.
Progress in neuro-psychopharmacology & biological psychiatry.
2007 Jan; 31(1):92-6. doi:
10.1016/j.pnpbp.2006.07.006. [PMID: 16938372] - Massimo C Mauri, Lucia S Volonteri, Alessandro Colasanti, Alessio Fiorentini, Ilaria F De Gaspari, Silvio R Bareggi. Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response.
Clinical pharmacokinetics.
2007; 46(5):359-88. doi:
10.2165/00003088-200746050-00001. [PMID: 17465637]
