Clobazam (BioDeep_00000397512)
代谢物信息卡片
Clobazam
化学式: C16H13ClN2O2 (300.0665508)
中文名称: 氧异安定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: Clc(c3)cc(c(c3)2)N(C(=O)CC(=O)N(C)2)c(c1)cccc1
InChI: InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3593
CONFIDENCE standard compound; INTERNAL_ID 1598
同义名列表
1 个代谢物同义名
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:31413
- KEGGdrug: D01253
- PubChem: 2789
- Metlin: METLIN1863
- DrugBank: DB00349
- ChEMBL: CHEMBL70418
- MeSH: Clobazam
- CAS: 22316-47-8
- MoNA: WA001307
- MoNA: WA001306
- MoNA: WA001305
- MoNA: WA001304
- MoNA: WA001303
- MoNA: WA001302
- MoNA: FiehnHILIC000266
- MoNA: EQ359309
- MoNA: EQ359308
- MoNA: EQ359307
- MoNA: EQ359306
- MoNA: EQ359305
- MoNA: EQ359304
- MoNA: EQ359303
- MoNA: EQ359302
- MoNA: EQ359301
- MoNA: AU159806
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rima Nabbout, Alexis Arzimanoglou, Stéphane Auvin, Patrick Berquin, Archana Desurkar, Douglas Fuller, Charlotte Nortvedt, Patrizia Pulitano, Anna Rosati, Victor Soto, Vicente Villanueva, J Helen Cross. Retrospective chart review study of use of cannabidiol (CBD) independent of concomitant clobazam use in patients with Lennox-Gastaut syndrome or Dravet syndrome.
Seizure.
2023 May; 110(?):78-85. doi:
10.1016/j.seizure.2023.05.003. [PMID: 37331197] - Adam Strzelczyk, Susanne Schubert-Bast. A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication.
CNS drugs.
2022 03; 36(3):217-237. doi:
10.1007/s40263-022-00898-1. [PMID: 35156171] - J J García-Peñas, A Gil Nagel-Rein, R Sánchez-Carpintero, V Villanueva-Haba. Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
Revista de neurologia.
2021 09; 73(S01):S1-S8. doi:
10.33588/rn.73s01.2021250. [PMID: 34486101] - Marta Karaźniewicz-Łada, Anna K Główka, Aniceta A Mikulska, Franciszek K Główka. Pharmacokinetic Drug-Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients.
International journal of molecular sciences.
2021 Sep; 22(17):. doi:
10.3390/ijms22179582. [PMID: 34502487] - Boudewijn Gunning, Maria Mazurkiewicz-Bełdzińska, Richard F M Chin, Hari Bhathal, Charlotte Nortvedt, Eduardo Dunayevich, Daniel Checketts. Cannabidiol in conjunction with clobazam: analysis of four randomized controlled trials.
Acta neurologica Scandinavica.
2021 Feb; 143(2):154-163. doi:
10.1111/ane.13351. [PMID: 32969022] - Kevan E VanLandingham, Julie Crockett, Lesley Taylor, Gilmour Morrison. A Phase 2, Double-Blind, Placebo-Controlled Trial to Investigate Potential Drug-Drug Interactions Between Cannabidiol and Clobazam.
Journal of clinical pharmacology.
2020 10; 60(10):1304-1313. doi:
10.1002/jcph.1634. [PMID: 32652616] - Alain Matthey, Youssef Daali, François Curtin, Antoine Poncet, Jules Desmeules, Marie Besson. GABAergic modulation of secondary hyperalgesia: A randomized controlled 4-way crossover trial with the α2-subunit preferring GABA positive allosteric modulator, N-desmethyl-clobazam in healthy volunteers.
European journal of pain (London, England).
2020 07; 24(6):1094-1106. doi:
10.1002/ejp.1554. [PMID: 32171038] - Meir Bialer, Emilio Perucca. Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials.
Epilepsia.
2020 06; 61(6):1082-1089. doi:
10.1111/epi.16542. [PMID: 32452568] - Yoshiaki Yamamoto, Yukitoshi Takahashi, Hiroko Ikeda, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Impact of CYP2C19 Phenotypes on Clinical Efficacy of Stiripentol in Japanese Patients With Dravet Syndrome.
Therapeutic drug monitoring.
2020 04; 42(2):302-308. doi:
10.1097/ftd.0000000000000676. [PMID: 31318844] - Bhuvanachandra Pasupuleti, Vamshikrishna Gone, Ravali Baddam, Raj Kumar Venisetty, Om Prakash Prasad. Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study.
Current drug metabolism.
2020; 21(2):126-131. doi:
10.2174/1389200221666200218121050. [PMID: 32067615] - Astghik Mikayelyan, Armine Aleksanyan, Mariam Sargsyan, Arpine Gevorgyan, Hasmik Zakaryan, Armen Harutyunyan, Lusine Zhamharyan, Yeghig Armoudjian, Tigran Margaryan. Protein precipitation method for determination of clobazam and N-desmethylclobazam in human plasma by LC-MS/MS.
Biomedical chromatography : BMC.
2020 Jan; 34(1):e4710. doi:
10.1002/bmc.4710. [PMID: 31630425] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Lyndsey L Anderson, Nathan L Absalom, Sarah V Abelev, Ivan K Low, Peter T Doohan, Lewis J Martin, Mary Chebib, Iain S McGregor, Jonathon C Arnold. Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions.
Epilepsia.
2019 11; 60(11):2224-2234. doi:
10.1111/epi.16355. [PMID: 31625159] - Pavel Klein, Dwain Tolbert, Barry E Gidal. Drug-drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures.
Epilepsy & behavior : E&B.
2019 10; 99(?):106459. doi:
10.1016/j.yebeh.2019.106459. [PMID: 31519475] - David Boels, Stéphanie Chhun, Géraldine Meyer, Bénédicte Lelièvre, Vincent Souday. Clinical consequences related to a defective elimination of clobazam caused by homozygous mutated CYP2C19 allele.
Clinical toxicology (Philadelphia, Pa.).
2019 Aug; 57(8):743-747. doi:
10.1080/15563650.2018.1550198. [PMID: 30696292] - Dwain Tolbert, Frank Larsen. A Comprehensive Overview of the Clinical Pharmacokinetics of Clobazam.
Journal of clinical pharmacology.
2019 01; 59(1):7-19. doi:
10.1002/jcph.1313. [PMID: 30285275] - Sophie Peigné, Stéphanie Chhun, Michel Tod, Elisabeth Rey, Christelle Rodrigues, Catherine Chiron, Gérard Pons, Vincent Jullien. Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy.
Clinical pharmacokinetics.
2018 06; 57(6):739-748. doi:
10.1007/s40262-017-0592-7. [PMID: 28819726] - Szu-Ying Chen, Wen-Chi Chen, Sarah Y Chang. Cyclodextrin-assisted dispersive liquid-liquid microextraction for the preconcentration of carbamazepine and clobazam with subsequent sweeping micellar electrokinetic chromatography.
Journal of separation science.
2018 Apr; 41(8):1871-1879. doi:
10.1002/jssc.201701096. [PMID: 29330897] - Giulia S Porcari, Cary Fu, Emily D Doll, Emma G Carter, Robert P Carson. Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center.
Epilepsy & behavior : E&B.
2018 03; 80(?):240-246. doi:
10.1016/j.yebeh.2018.01.026. [PMID: 29429908] - Yoshiaki Yamamoto, Naotaka Usui, Takuji Nishida, Miho Mori, Yukitoshi Takahashi, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Influence of Renal Function on Pharmacokinetics of Antiepileptic Drugs Metabolized by CYP3A4 in a Patient With Renal Impairment.
Therapeutic drug monitoring.
2018 02; 40(1):144-147. doi:
10.1097/ftd.0000000000000461. [PMID: 29095797] - Dwain Tolbert, Judy Gordon, Stuart Harris, Mark Walzer, Ihor Bekersky, Susan Reid. A Thorough QT/QTc Study of Clobazam in Healthy Volunteers.
Clinical therapeutics.
2017 Oct; 39(10):2073-2086. doi:
10.1016/j.clinthera.2017.08.020. [PMID: 28958437] - Monica Puligheddu, Miriam Melis, Giuliano Pillolla, Giulia Milioli, Liborio Parrino, Giovanni Mario Terzano, Sonia Aroni, Claudia Sagheddu, Francesco Marrosu, Marco Pistis, Anna Lisa Muntoni. Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy.
Epilepsia.
2017 10; 58(10):1762-1770. doi:
10.1111/epi.13863. [PMID: 28766701] - Tyler E Gaston, E Martina Bebin, Gary R Cutter, Yuliang Liu, Jerzy P Szaflarski. Interactions between cannabidiol and commonly used antiepileptic drugs.
Epilepsia.
2017 09; 58(9):1586-1592. doi:
10.1111/epi.13852. [PMID: 28782097] - Toshiyuki Iwasaki, Yutaka Nonoda, Tomoya Ishida, Taira Toki, Masahiro Ishii. Correlating blood and urinary concentrations of clobazam doses in Japanese children and adolescents with intractable epilepsy.
Biomedical chromatography : BMC.
2017 Apr; 31(4):. doi:
10.1002/bmc.3848. [PMID: 27595429] - Toshihiro Jogamoto, Yoshiaki Yamamoto, Mitsumasa Fukuda, Yuka Suzuki, Katsumi Imai, Yukitoshi Takahashi, Yushi Inoue, Yoko Ohtsuka. Add-on stiripentol elevates serum valproate levels in patients with or without concomitant topiramate therapy.
Epilepsy research.
2017 02; 130(?):7-12. doi:
10.1016/j.eplepsyres.2016.12.014. [PMID: 28081475] - Jarogniew J Luszczki, Pawel Patrzylas, Miroslaw Zagaja, Marta Andres-Mach, Katarzyna Zaluska, Maria W Kondrat-Wrobel, Monika Szpringer, Jaroslaw Chmielewski, Magdalena Florek-Luszczki. Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
PloS one.
2017; 12(8):e0183873. doi:
10.1371/journal.pone.0183873. [PMID: 28859122] - Tomoya Takeuchi, Jun Natsume, Hiroyuki Kidokoro, Naoko Ishihara, Hiroyuki Yamamoto, Yoshiteru Azuma, Yuji Ito, Naoko Kurahashi, Takeshi Tsuji, Motomasa Suzuki, Kazuya Itomi, Keitaro Yamada, Hirokazu Kurahashi, Shinpei Abe, Akihisa Okumura, Koichi Maruyama, Tamiko Negoro, Kazuyoshi Watanabe, Seiji Kojima. The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
Brain & development.
2016 Sep; 38(8):723-30. doi:
10.1016/j.braindev.2016.03.004. [PMID: 27033151] - Margrete L Burns, Arton Baftiu, Mimi S Opdal, Svein I Johannessen, Cecilie Johannessen Landmark. Therapeutic Drug Monitoring of Clobazam and Its Metabolite-Impact of Age and Comedication on Pharmacokinetic Variability.
Therapeutic drug monitoring.
2016 06; 38(3):350-7. doi:
10.1097/ftd.0000000000000272. [PMID: 26751267] - Anant Dhondopant Patil. Does orally dissolving formulation of clobazam provide clinical advantage over it's standard formulation.
Indian journal of pharmacology.
2016 May; 48(3):339-40. doi:
10.4103/0253-7613.182877. [PMID: 27298514] - Sudhir Chandra Sarangi, Manjari Tripathi, Ashish Kumar Kakkar, Yogendra Kumar Gupta. Comparison of body composition in persons with epilepsy on conventional & new antiepileptic drugs.
The Indian journal of medical research.
2016 Mar; 143(3):323-30. doi:
10.4103/0971-5916.182623. [PMID: 27241646] - Dwain Tolbert, Ihor Bekersky, Hui-May Chu, Ene I Ette. An integrative population pharmacokinetics approach to the characterization of the effect of hepatic impairment on clobazam pharmacokinetics.
Journal of clinical pharmacology.
2016 Feb; 56(2):213-22. doi:
10.1002/jcph.586. [PMID: 26139309] - Vincent Jullien, Stéphanie Chhun, Elisabeth Rey, Olivier Dulac, Michel Tod, Catherine Chiron, Gérard Pons. Pharmacokinetics of clobazam and N-desmethylclobazam in children with dravet syndrome receiving concomitant stiripentol and valproic Acid.
Clinical pharmacokinetics.
2015 May; 54(5):527-36. doi:
10.1007/s40262-014-0223-5. [PMID: 25503589] - Sachiyo Hashi, Ikuko Yano, Mai Shibata, Satohiro Masuda, Masako Kinoshita, Riki Matsumoto, Akio Ikeda, Ryosuke Takahashi, Kazuo Matsubara. Effect of CYP2C19 polymorphisms on the clinical outcome of low-dose clobazam therapy in Japanese patients with epilepsy.
European journal of clinical pharmacology.
2015 Jan; 71(1):51-8. doi:
10.1007/s00228-014-1773-z. [PMID: 25323806] - Catherine Monteil-Ganiere, Jean-Michel Gaulier, Daniel Chopineaux, Lucia Barrios, Alain Pineau, Éric Dailly, Renaud Clément. Fatal anoxia due to rachacha consumption: Two cases reported.
Forensic science international.
2014 Dec; 245(?):e1-5. doi:
10.1016/j.forsciint.2014.09.010. [PMID: 25450509] - Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Masaaki Takahashi, Masahiko Nakai, Yushi Inoue, Yoshiyuki Kagawa. Impact of cytochrome P450 inducers with or without inhibitors on the serum clobazam level in patients with antiepileptic polypharmacy.
European journal of clinical pharmacology.
2014 Oct; 70(10):1203-10. doi:
10.1007/s00228-014-1719-5. [PMID: 25048408] - Junji Saruwatari, Naoki Ogusu, Masatsugu Shimomasuda, Hiroo Nakashima, Takayuki Seo, Koji Tanikawa, Yoshiyuki Tsuda, Miki Nishimura, Rie Nagata, Norio Yasui-Furukori, Sunao Kaneko, Takateru Ishitsu, Kazuko Nakagawa. Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in japanese patients with epilepsy.
Therapeutic drug monitoring.
2014 Jun; 36(3):302-9. doi:
10.1097/ftd.0000000000000015. [PMID: 24345815] - Yushi Inoue, Yoko Ohtsuka. Effectiveness of add-on stiripentol to clobazam and valproate in Japanese patients with Dravet syndrome: additional supportive evidence.
Epilepsy research.
2014 May; 108(4):725-31. doi:
10.1016/j.eplepsyres.2014.02.008. [PMID: 24630050] - Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Yukiko Mogami, Kazumi Matsuda, Masahiko Nakai, Yoshiyuki Kagawa, Yushi Inoue. Interaction between sulthiame and clobazam: sulthiame inhibits the metabolism of clobazam, possibly via an action on CYP2C19.
Epilepsy & behavior : E&B.
2014 May; 34(?):124-6. doi:
10.1016/j.yebeh.2014.03.018. [PMID: 24742983] - Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Kou Miyakawa, Shigeko Nishimura, Risa Kasai, Hiroko Ikeda, Rumiko Takayama, Yukiko Mogami, Tokito Yamaguchi, Kiyohito Terada, Kazumi Matsuda, Yushi Inoue, Yoshiyuki Kagawa. Influence of CYP2C19 polymorphism and concomitant antiepileptic drugs on serum clobazam and N-desmethyl clobazam concentrations in patients with epilepsy.
Therapeutic drug monitoring.
2013 Jun; 35(3):305-12. doi:
10.1097/ftd.0b013e318283b49a. [PMID: 23666564] - Jose de Leon, Edoardo Spina, Francisco J Diaz. Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies.
Therapeutic drug monitoring.
2013 Feb; 35(1):30-47. doi:
10.1097/ftd.0b013e31827ada88. [PMID: 23318278] - Mai Shibata, Sachiyo Hashi, Haruka Nakanishi, Satohiro Masuda, Toshiya Katsura, Ikuko Yano. Detection of 22 antiepileptic drugs by ultra-performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring.
Biomedical chromatography : BMC.
2012 Dec; 26(12):1519-28. doi:
10.1002/bmc.2726. [PMID: 22383262] - Rima Nabbout, Catherine Chiron. Stiripentol: an example of antiepileptic drug development in childhood epilepsies.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.
2012 Sep; 16 Suppl 1(?):S13-7. doi:
10.1016/j.ejpn.2012.04.009. [PMID: 22695038] - Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood.
Journal of chromatography. A.
2012 Aug; 1249(?):147-54. doi:
10.1016/j.chroma.2012.06.023. [PMID: 22749457] - Theodor W May, Rainer Boor, Thomas Mayer, Uwe Jürgens, Bernhard Rambeck, Nils Holert, Elisabeth Korn-Merker, Christian Brandt. Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication.
Therapeutic drug monitoring.
2012 Aug; 34(4):390-7. doi:
10.1097/ftd.0b013e31825dc4a6. [PMID: 22743350] - Mark Walzer, Ihor Bekersky, Robert A Blum, Dwain Tolbert. Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes.
Pharmacotherapy.
2012 Apr; 32(4):340-53. doi:
10.1002/j.1875-9114.2012.01028.x. [PMID: 22422635] - László Héja, Gabriella Nyitrai, Orsolya Kékesi, Arpád Dobolyi, Pál Szabó, Richárd Fiáth, István Ulbert, Borbála Pál-Szenthe, Miklós Palkovits, Julianna Kardos. Astrocytes convert network excitation to tonic inhibition of neurons.
BMC biology.
2012 Mar; 10(?):26. doi:
10.1186/1741-7007-10-26. [PMID: 22420899] - Amilcar Falcão, Eliane Fuseau, Teresa Nunes, Luis Almeida, Patricio Soares-da-Silva. Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analyses.
CNS drugs.
2012 Jan; 26(1):79-91. doi:
10.2165/11596290-000000000-00000. [PMID: 22171585] - Izuru Miyawaki, Izumi Matsumoto, Hiroshi Horie, Hiroshi Inada, Juki Kimura, Hitoshi Funabashi, Takaki Seki. Toxicological approach for elucidation of clobazam-induced hepatomegaly in male rats.
Regulatory toxicology and pharmacology : RTP.
2011 Aug; 60(3):323-31. doi:
10.1016/j.yrtph.2011.04.009. [PMID: 21575666] - Yosuke Suzuki, Hiroki Itoh, Tomohide Abe, Fumihiro Nishimura, Yuhki Sato, Masaharu Takeyama. No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy.
The Journal of pharmacy and pharmacology.
2011 Jul; 63(7):976-81. doi:
10.1111/j.2042-7158.2011.01282.x. [PMID: 21635265] - Muhannad R M Salih, Mohd Baidi Bahari, Arwa Y Abd. Selected pharmacokinetic issues of the use of antiepileptic drugs and parenteral nutrition in critically ill patients.
Nutrition journal.
2010 Dec; 9(?):71. doi:
10.1186/1475-2891-9-71. [PMID: 21194458] - Markus Rauchenzauner, Gerhard Luef. Update on treatment of partial onset epilepsy: role of eslicarbazepine.
Neuropsychiatric disease and treatment.
2010 Nov; 6(?):723-30. doi:
10.2147/ndt.s5840. [PMID: 21127691] - Svein I Johannessen, Cecilie Johannessen Landmark. Antiepileptic drug interactions - principles and clinical implications.
Current neuropharmacology.
2010 Sep; 8(3):254-67. doi:
10.2174/157015910792246254. [PMID: 21358975] - Clare Greenaway, Neville Ratnaraj, Josemir W Sander, Philip N Patsalos. A high-performance liquid chromatography assay to monitor the new antiepileptic drug lacosamide in patients with epilepsy.
Therapeutic drug monitoring.
2010 Aug; 32(4):448-52. doi:
10.1097/ftd.0b013e3181dcc5fb. [PMID: 20386357] - Danièle Bentué-Ferrer, Olivier Tribut, Marie-Clémence Verdier, Danièle Debruyne. [Therapeutic drug monitoring of clobazam].
Therapie.
2010 May; 65(3):225-31. doi:
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Der Nervenarzt.
2010 Apr; 81(4):391-5. doi:
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PloS one.
2009 Sep; 4(9):e7153. doi:
10.1371/journal.pone.0007153. [PMID: 19777062] - Mitsuhiro Nakamura, Tomofumi Ohmori, Yoshinori Itoh, Masato Terashita, Kazuyuki Hirano. Simultaneous determination of benzodiazepines and their metabolites in human serum by liquid chromatography-tandem mass spectrometry using a high-resolution octadecyl silica column compatible with aqueous compounds.
Biomedical chromatography : BMC.
2009 Apr; 23(4):357-64. doi:
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Neuropsychiatric disease and treatment.
2009; 5(?):467-76. doi:
10.2147/ndt.s4844. [PMID: 19777068] - Kalyani Karkare, Sanjib Sinha, Shivashankar Ravishankar, Narayanappa Gayathri, T Chikkabasavaiah Yasha, Manoj K Goyal, Joy Vijayan, Ayyasamy Vanniarajan, Kumarswamy Thangaraj, Arun B Taly. Epilepsia partialis continua in mitochondrial dysfunction: Interesting phenotypic and MRI observations.
Annals of Indian Academy of Neurology.
2008 Jul; 11(3):193-6. doi:
10.4103/0972-2327.42942. [PMID: 19893669] - Arne Reimers, Eirik Skogvoll, Janne Kutschera Sund, Olav Spigset. Lamotrigine in children and adolescents: the impact of age on its serum concentrations and on the extent of drug interactions.
European journal of clinical pharmacology.
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