flunitrazepam (BioDeep_00000397510)
代谢物信息卡片
flunitrazepam
化学式: C16H12FN3O3 (313.0862654)
中文名称: 氟硝西泮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)[N+](=O)[O-])C3=CC=CC=C3F
InChI: InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3
描述信息
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3681
CONFIDENCE standard compound; INTERNAL_ID 1595
同义名列表
1 个代谢物同义名
数据库引用编号
29 个数据库交叉引用编号
- ChEBI: CHEBI:31622
- KEGGdrug: D01230
- PubChem: 3380
- Metlin: METLIN85044
- DrugBank: DB01544
- ChEMBL: CHEMBL13280
- MeSH: Flunitrazepam
- CAS: 1622-62-4
- MoNA: WA001291
- MoNA: WA001290
- MoNA: WA001289
- MoNA: WA001288
- MoNA: WA001287
- MoNA: WA001286
- MoNA: FiehnHILIC001941
- MoNA: FiehnHILIC000359
- MoNA: EQ368109
- MoNA: EQ368108
- MoNA: EQ368107
- MoNA: EQ368106
- MoNA: EQ368105
- MoNA: EQ368104
- MoNA: EQ368103
- MoNA: EQ368102
- MoNA: EQ368101
- MoNA: AU159505
- MoNA: AU159504
- MoNA: AU159503
- MoNA: AU159502
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anna Carfora, Carlo Pietro Campobasso, Paola Cassandro, Raffaella Petrella, Renata Borriello. Long-Term Detection in Hair of Zolpidem, Oxazepam and Flunitrazepam in a Case of Drug-Facilitated Sexual Assault.
Journal of analytical toxicology.
2022 Feb; 46(1):e16-e20. doi:
10.1093/jat/bkaa174. [PMID: 33180140] - Misato Ota, Hao Ni, Yasuhito Maki, Daiki Kato, Shohei Moriguchi, Shuto Nakayama, Yuki Oiwa, Kan'ichiro Ishiuchi, Toshiaki Makino. Binding activity of Valeriana fauriei root extract on GABAA receptor flunitrazepam sites and distribution of its active ingredients in the brain of mice - A comparison with that of V. officinalis root.
Journal of ethnopharmacology.
2021 Oct; 278(?):114262. doi:
10.1016/j.jep.2021.114262. [PMID: 34116188] - David Tolulope Oluwole, Roland Eghoghosoa Akhigbe, Ayodeji Folorunsho Ajayi. Rohypnol-induced sexual dysfunction is via suppression of hypothalamic-pituitary-testicular axis: An experimental study in rats.
Andrologia.
2021 Mar; 53(2):e13931. doi:
10.1111/and.13931. [PMID: 33378084] - Xenia Simeone, Filip Koniuszewski, Markus Müllegger, Andreas Smetka, Friederike Steudle, Roshan Puthenkalam, Margot Ernst, Petra Scholze. A Benzodiazepine Ligand with Improved GABAA Receptor α5-Subunit Selectivity Driven by Interactions with Loop C.
Molecular pharmacology.
2021 01; 99(1):39-48. doi:
10.1124/molpharm.120.000067. [PMID: 33268553] - Hong Joon Ahn, Won Joon Jeong, Kwan Jae Kim, Sun Cheun Kim, Dong Woo Kim, Hye Jin Chang, Chang Shin Kang, Se Kwang Oh, Sung Uk Cho, Jin Hong Min, Yong Chul Cho, Jung Soo Park, Seung Ryu, Yeon Ho You, Jing Woong Lee, Min Su Kim. Serial plasma and urine measurements of a patient with acute intoxication of zolpidem and flunitrazepam resulting in QT prolongation and ventricular tachycardia.
Clinical toxicology (Philadelphia, Pa.).
2020 06; 58(6):501-503. doi:
10.1080/15563650.2019.1663206. [PMID: 31512527] - Ali Y Benkherouf, Nora Logrén, Tamara Somborac, Maaria Kortesniemi, Sanna L Soini, Baoru Yang, Outi M H Salo-Ahen, Oskar Laaksonen, Mikko Uusi-Oukari. Hops compounds modulatory effects and 6-prenylnaringenin dual mode of action on GABAA receptors.
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Clinica chimica acta; international journal of clinical chemistry.
2019 Dec; 499(?):81-86. doi:
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2019 Aug; 54(8):704-715. doi:
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Talanta.
2018 Jan; 176(?):293-298. doi:
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2013 May; 147(2):412-8. doi:
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2012 Dec; 33(4):293-6. doi:
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The Analyst.
2010 Oct; 135(10):2737-42. doi:
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Trauma, violence & abuse.
2008 Jul; 9(3):178-88. doi:
10.1177/1524838008320221. [PMID: 18541699] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Yves Denizot, Alexandre Leguyader, Elisabeth Cornu, Marc Laskar, Isabelle Orsel, Christelle Vincent, Nathalie Nathan. Alterations in plasma soluble vascular endothelial growth factor receptor-1 (sFlt-1) concentrations during coronary artery bypass graft surgery: relationships with post-operative complications.
Journal of cardiothoracic surgery.
2008 Apr; 3(?):16. doi:
10.1186/1749-8090-3-16. [PMID: 18423019] - Subrat Kumar Bhattamisra, Vinay Kumar Khanna, Ashok Kumar Agrawal, Paras Nath Singh, Sushil Kumar Singh. Antidepressant activity of standardised extract of Marsilea minuta Linn.
Journal of ethnopharmacology.
2008 Apr; 117(1):51-7. doi:
10.1016/j.jep.2008.01.012. [PMID: 18299179] - Marc Deveaux, Marjorie Chèze, Gilbert Pépin. The role of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to test blood and urine samples for the toxicological investigation of drug-facilitated crimes.
Therapeutic drug monitoring.
2008 Apr; 30(2):225-8. doi:
10.1097/ftd.0b013e3181676186. [PMID: 18367985] - Kei Zaitsu, Akihiro Miki, Munehiro Katagi, Hitoshi Tsuchihashi. Long-term stability of various drugs and metabolites in urine, and preventive measures against their decomposition with special attention to filtration sterilization.
Forensic science international.
2008 Jan; 174(2-3):189-96. doi:
10.1016/j.forsciint.2007.04.224. [PMID: 17555899] - Sergio Abanades, Magi Farré, Diego Barral, Marta Torrens, Neus Closas, Klaus Langohr, Antoni Pastor, Rafael de la Torre. Relative abuse liability of gamma-hydroxybutyric acid, flunitrazepam, and ethanol in club drug users.
Journal of clinical psychopharmacology.
2007 Dec; 27(6):625-38. doi:
10.1097/jcp.0b013e31815a2542. [PMID: 18004131] - Anita Holmgren, Per Holmgren, Fredrik C Kugelberg, A Wayne Jones, Johan Ahlner. Predominance of illicit drugs and poly-drug use among drug-impaired drivers in Sweden.
Traffic injury prevention.
2007 Dec; 8(4):361-7. doi:
10.1080/15389580701329344. [PMID: 17994489] - A S Reece. Psychosocial and treatment correlates of opiate free success in a clinical review of a naltrexone implant program.
Substance abuse treatment, prevention, and policy.
2007 Nov; 2(?):35. doi:
10.1186/1747-597x-2-35. [PMID: 18036213] - Matthew P Juhascik, Adam Negrusz, Diana Faugno, Linda Ledray, Pam Greene, Alice Lindner, Barbara Haner, R E Gaensslen. An estimate of the proportion of drug-facilitation of sexual assault in four U.S. localities.
Journal of forensic sciences.
2007 Nov; 52(6):1396-400. doi:
10.1111/j.1556-4029.2007.00583.x. [PMID: 18093069] - Yves Denizot, Alexandre Leguyader, Elisabeth Cornu, Marc Laskar, Isabelle Orsel, Christelle Vincent, Nathalie Nathan. Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1) during coronary artery bypass surgery.
Journal of cardiothoracic surgery.
2007 Sep; 2(?):38. doi:
10.1186/1749-8090-2-38. [PMID: 17888151] - Andrew Pike, Susan M Cook, Alan P Watt, Paul Scott-Stevens, Thomas W Rosahl, Ruth M McKernan, Luanda J Pym, Alec Guiblin, Christopher Moyes, Bindi Sohal, John R Atack. Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.
Biopharmaceutics & drug disposition.
2007 Sep; 28(6):275-82. doi:
10.1002/bdd.553. [PMID: 17570124] - Jaime M Monti, S R Pandi-Perumal. Eszopiclone: its use in the treatment of insomnia.
Neuropsychiatric disease and treatment.
2007 Aug; 3(4):441-53. doi:
NULL. [PMID: 19300573] - Xuejing Li, David R Serwanski, Celia P Miralles, Ben A Bahr, Angel L De Blas. Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex.
Journal of neurochemistry.
2007 Aug; 102(4):1329-45. doi:
10.1111/j.1471-4159.2007.04635.x. [PMID: 17663755] - Ming-Ren Fuh, Shi-Wei Lin, Li-Lung Chen, Tzuen-Yeuan Lin. Determination of flunitrazepam and 7-aminoflunitrazepam in human urine by on-line solid phase extraction liquid chromatography-electrospray-tandem mass spectrometry.
Talanta.
2007 Jun; 72(4):1329-35. doi:
10.1016/j.talanta.2007.01.040. [PMID: 19071765] - Hossam Ebaid, Mohamed A Dkhil, Mohamed A Danfour, Amany Tohamy, Mohamed S Gabry. Piroxicam-induced hepatic and renal histopathological changes in mice.
The Libyan journal of medicine.
2007 Jun; 2(2):82-9. doi:
10.4176/070130. [PMID: 21503258] - J Macek, J Klíma, P Ptácek. Rapid determination of omeprazole in human plasma by protein precipitation and liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):282-7. doi:
10.1016/j.jchromb.2007.01.026. [PMID: 17293174] - Danka Pericić, Dubravka Svob Strac, Maja Jazvinsćak Jembrek, Josipa Vlainić. Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Naunyn-Schmiedeberg's archives of pharmacology.
2007 May; 375(3):177-87. doi:
10.1007/s00210-007-0152-z. [PMID: 17377772] - Victoria F Samanidou, Anastasia P Pechlivanidou, Ioannis N Papadoyannis. Development of a validated HPLC method for the determination of four 1,4-benzodiazepines in human biological fluids.
Journal of separation science.
2007 Mar; 30(5):679-87. doi:
10.1002/jssc.200600365. [PMID: 17461106] - Ivano Marchi, Serge Rudaz, Maurice Selman, Jean-Luc Veuthey. Evaluation of the influence of protein precipitation prior to on-line SPE-LC-API/MS procedures using multivariate data analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jan; 845(2):244-52. doi:
10.1016/j.jchromb.2006.08.045. [PMID: 17030156] - Lutea A A de Jong, C Margot Jeronimus-Stratingh, Thomas I F H Cremers. Development of a multiplex non-radioactive receptor assay: the benzodiazepine receptor, the serotonin transporter and the beta-adrenergic receptor.
Rapid communications in mass spectrometry : RCM.
2007; 21(4):567-72. doi:
10.1002/rcm.2869. [PMID: 17245793] - Bruno Mégarbane, Xavier Declèves, Vanessa Bloch, Christophe Bardin, François Chast, Frédéric J Baud. Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships.
Critical care (London, England).
2007; 11(1):R5. doi:
10.1186/cc5150. [PMID: 17224045] - He Zhu, Beata Karolewicz, Emily Nail, Craig A Stockmeier, Katalin Szebeni, Gregory A Ordway. Normal [3H]flunitrazepam binding to GABAA receptors in the locus coeruleus in major depression and suicide.
Brain research.
2006 Dec; 1125(1):138-46. doi:
10.1016/j.brainres.2006.09.082. [PMID: 17118347] - Euguenia Bouairi, Harriet Kamendi, Xin Wang, Christopher Gorini, David Mendelowitz. Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus.
Journal of neurophysiology.
2006 Dec; 96(6):3266-72. doi:
10.1152/jn.00590.2006. [PMID: 16914614] - Franz E Dussy, Cornelia Hamberg, Thomas A Briellmann. Quantification of benzodiazepines in whole blood and serum.
International journal of legal medicine.
2006 Nov; 120(6):323-30. doi:
10.1007/s00414-005-0042-1. [PMID: 16220317] - Karsten Müssig, Elisabeth Friess, Stefan A Wudy, Klaus Mörike, Hans-Ulrich Häring, Dietrich Overkamp. Secondary adrenal failure due to long-term treatment with flunitrazepam.
Clinical endocrinology.
2006 Oct; 65(4):549-50. doi:
10.1111/j.1365-2265.2006.02622.x. [PMID: 16984251] - José G Ortiz, Nicole Rassi, Patricia M Maldonado, Silvia González-Cabrera, Igmeris Ramos. Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes.
Phytotherapy research : PTR.
2006 Sep; 20(9):794-8. doi:
10.1002/ptr.1960. [PMID: 16819753] - M C Hellión-Ibarrola, D A Ibarrola, Y Montalbetti, M L Kennedy, O Heinichen, M Campuzano, J Tortoriello, S Fernández, C Wasowski, M Marder, T C M De Lima, S Mora. The anxiolytic-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice.
Journal of ethnopharmacology.
2006 May; 105(3):400-8. doi:
10.1016/j.jep.2005.11.013. [PMID: 16386395] - Chiung-Wei Huang, Hsiu-Ping Jen, Ren-De Wang, You-Zung Hsieh. Sweeping technique combined with micellar electrokinetic chromatography for the simultaneous determination of flunitrazepam and its major metabolites.
Journal of chromatography. A.
2006 Mar; 1110(1-2):240-4. doi:
10.1016/j.chroma.2006.01.070. [PMID: 16483590] - Jeffery Hackett, Albert A Elian. Extraction and analysis of flunitrazepam/7-aminoflunitrazepam in blood and urine by LC-PDA and GC-MS using butyl SPE columns.
Forensic science international.
2006 Mar; 157(2-3):156-62. doi:
10.1016/j.forsciint.2005.03.019. [PMID: 15955650] - Pauline Saint-Martin, Yves Furet, Patrick O'Byrne, Marie Bouyssy, Gilles Paintaud, Elisabeth Autret-Leca. [Chemical submission: a literature review].
Therapie.
2006 Mar; 61(2):145-50. doi:
10.2515/therapie:2006028. [PMID: 16886708] - H L Lord, M Rajabi, S Safari, J Pawliszyn. Development of immunoaffinity solid phase microextraction probes for analysis of sub ng/mL concentrations of 7-aminoflunitrazepam in urine.
Journal of pharmaceutical and biomedical analysis.
2006 Feb; 40(3):769-80. doi:
10.1016/j.jpba.2005.10.003. [PMID: 16352414] - T Ohshima. A case of drug-facilitated sexual assault by the use of flunitrazepam.
Journal of clinical forensic medicine.
2006 Jan; 13(1):44-5. doi:
10.1016/j.jcfm.2005.05.006. [PMID: 16087387] - Peter Ondra, Katerina Zedníková, Radek Matlach. Possibilities and problems with identification and determination of "new" hypnotics.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2005 Dec; 149(2):469-72. doi:
10.5507/bp.2005.082. [PMID: 16601812] - Ilsemarie Kurzthaler, Markus Wambacher, Karl Golser, Gernot Sperner, Barbara Sperner-Unterweger, Alexander Haidekker, Marion Pavlic, Georg Kemmler, W Wolfgang Fleischhacker. Alcohol and/or benzodiazepine use: different accidents--different impacts?.
Human psychopharmacology.
2005 Dec; 20(8):583-9. doi:
10.1002/hup.736. [PMID: 16317801] - Gregory A O'Sullivan, Matthias Kneussel, Zvulun Elazar, Heinrich Betz. GABARAP is not essential for GABA receptor targeting to the synapse.
The European journal of neuroscience.
2005 Nov; 22(10):2644-8. doi:
10.1111/j.1460-9568.2005.04448.x. [PMID: 16307606] - Dong-Liang Lin, Rea-Ming Yin, Cheng-Hsing Chen, Ya-Lei Chen, Ray H Liu. Performance characteristics of 7-aminoflunitrazepam specific enzyme-linked immunosorbent assays.
Journal of analytical toxicology.
2005 Oct; 29(7):718-23. doi:
10.1093/jat/29.7.718. [PMID: 16419407] - Emiko Kurisaki, Makiko Hayashida, Makoto Nihira, Youkichi Ohno, Hirobumi Mashiko, Takaaki Okano, Shin-ichi Niwa, Kouichi Hiraiwa. Diagnostic performance of Triage for benzodiazepines: urine analysis of the dose of therapeutic cases.
Journal of analytical toxicology.
2005 Sep; 29(6):539-43. doi:
NULL. [PMID: 16168176] - Roland Baur, Urs Simmen, Martin Senn, Urs Séquin, Erwin Sigel. Novel plant substances acting as beta subunit isoform-selective positive allosteric modulators of GABAA receptors.
Molecular pharmacology.
2005 Sep; 68(3):787-92. doi:
10.1124/mol.105.011882. [PMID: 15939801] - Ritu Chadda, Leslie L Devaud. Differential effects of mild repeated restraint stress on behaviors and GABA(A) receptors in male and female rats.
Pharmacology, biochemistry, and behavior.
2005 Aug; 81(4):854-63. doi:
10.1016/j.pbb.2005.06.009. [PMID: 16039700]