norsertraline (BioDeep_00000397503)

   


代谢物信息卡片


Cis-(+/-)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine

化学式: C16H15Cl2N (291.058149)
中文名称: 舍曲林盐酸盐
谱图信息: 最多检出来源 Homo sapiens(urine) 75%

分子结构信息

SMILES: C1CC(C2=CC=CC=C2C1C3=CC(=C(C=C3)Cl)Cl)N
InChI: InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2

描述信息

CONFIDENCE standard compound; EAWAG_UCHEM_ID 3623
CONFIDENCE standard compound; INTERNAL_ID 1566

同义名列表

3 个代谢物同义名

norsertraline; Cis-(+/-)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine; Desmethylsertraline



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ewelina Dziurkowska, Marek Wesolowski. Sertraline - isolation methods and quantitation in biological material. Psychiatria polska. 2018 Dec; 52(6):997-1012. doi: 10.12740/pp/85788. [PMID: 30659562]
  • Danielle Krout, Meghan Rodriquez, Stephen A Brose, Mikhail Y Golovko, L Keith Henry, Brent J Thompson. Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms. ACS chemical neuroscience. 2017 05; 8(5):1011-1018. doi: 10.1021/acschemneuro.6b00343. [PMID: 27959497]
  • Bikram Subedi, Bowen Du, C Kevin Chambliss, Jan Koschorreck, Heinz Rüdel, Markus Quack, Bryan W Brooks, Sascha Usenko. Occurrence of pharmaceuticals and personal care products in German fish tissue: a national study. Environmental science & technology. 2012 Aug; 46(16):9047-54. doi: 10.1021/es301359t. [PMID: 22779714]
  • Mohamed I Walash, Fathallah F Belal, Nahed M El-Enany, Heba Elmansi. Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids. Chemistry Central journal. 2011 Oct; 5(1):61. doi: 10.1186/1752-153x-5-61. [PMID: 21996025]
  • Margareta Reis, Ann-Charlotte Akerblad, Lisa Ekselius, Lars von Knorring. Partial compliance as determined from plasma levels of sertraline and its metabolite in depressed patients in primary care. Journal of clinical psychopharmacology. 2010 Dec; 30(6):746-8. doi: 10.1097/jcp.0b013e3181fc2cf1. [PMID: 21057244]
  • Sarah M R Wille, Els A De Letter, Michel H A Piette, Lien K Van Overschelde, Carlos H Van Peteghem, Willy E Lambert. Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry. International journal of legal medicine. 2009 Nov; 123(6):451-8. doi: 10.1007/s00414-008-0287-6. [PMID: 18839201]
  • Bhavin N Patel, Naveen Sharma, Mallika Sanyal, Pranav S Shrivastav. Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jan; 877(3):221-9. doi: 10.1016/j.jchromb.2008.12.008. [PMID: 19109078]
  • Reiji Yoshimura, Wakako Umene-Nakano, Nobuhisa Ueda, Atsuko Ikenouchi-Sugita, Hikaru Hori, Jun Nakamura. Addition of risperidone to sertraline improves sertraline-resistant refractory depression without influencing plasma concentrations of sertraline and desmethylsertraline. Human psychopharmacology. 2008 Dec; 23(8):707-13. doi: 10.1002/hup.979. [PMID: 18803170]
  • Marlene P Freeman, Paul E Nolan, Melinda F Davis, Marietta Anthony, Karen Fried, Martha Fankhauser, Raymond L Woosley, Francisco Moreno. Pharmacokinetics of sertraline across pregnancy and postpartum. Journal of clinical psychopharmacology. 2008 Dec; 28(6):646-53. doi: 10.1097/jcp.0b013e31818d2048. [PMID: 19011433]
  • I Rudberg, M Hermann, H Refsum, E Molden. Serum concentrations of sertraline and N-desmethyl sertraline in relation to CYP2C19 genotype in psychiatric patients. European journal of clinical pharmacology. 2008 Dec; 64(12):1181-8. doi: 10.1007/s00228-008-0533-3. [PMID: 18677622]
  • A Lajeunesse, C Gagnon, S Sauvé. Determination of basic antidepressants and their N-desmethyl metabolites in raw sewage and wastewater using solid-phase extraction and liquid chromatography-tandem mass spectrometry. Analytical chemistry. 2008 Jul; 80(14):5325-33. doi: 10.1021/ac800162q. [PMID: 18553982]
  • Sarah M R Wille, Paul Van Hee, Hugo M Neels, Carlos H Van Peteghem, Willy E Lambert. Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma. Journal of chromatography. A. 2007 Dec; 1176(1-2):236-45. doi: 10.1016/j.chroma.2007.10.096. [PMID: 18022628]
  • Alessandro Musenga, Ernst Kenndler, Laura Mercolini, Mario Amore, Salvatore Fanali, Maria Augusta Raggi. Determination of sertraline and N-desmethylsertraline in human plasma by CE with LIF detection. Electrophoresis. 2007 Jun; 28(11):1823-31. doi: 10.1002/elps.200600591. [PMID: 17450537]
  • Roberto Mandrioli, Maria Addolorata Saracino, Silvia Ferrari, Domenico Berardi, Ernst Kenndler, Maria Augusta Raggi. HPLC analysis of the second-generation antidepressant sertraline and its main metabolite N-desmethylsertraline in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 May; 836(1-2):116-9. doi: 10.1016/j.jchromb.2006.03.026. [PMID: 16581317]
  • Sarah M R Wille, Kristof E Maudens, Carlos H Van Peteghem, Willy E E Lambert. Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis. Journal of chromatography. A. 2005 Dec; 1098(1-2):19-29. doi: 10.1016/j.chroma.2005.08.059. [PMID: 16314157]
  • Victor L Serebruany, Raymond F Suckow, Thomas B Cooper, Christopher M O'Connor, Alex I Malinin, K Ranga R Krishnan, Louis T van Zyl, Vladimir Lekht, Alexander H Glassman. Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. The American journal of psychiatry. 2005 Jun; 162(6):1165-70. doi: 10.1176/appi.ajp.162.6.1165. [PMID: 15932816]
  • Margareta Reis, Anna Aberg-Wistedt, Hans Agren, Ann-Charlotte Akerblad, Finn Bengtsson. Compliance with SSRI medication during 6 months of treatment for major depression: an evaluation by determination of repeated serum drug concentrations. Journal of affective disorders. 2004 Nov; 82(3):443-6. doi: 10.1016/j.jad.2004.02.003. [PMID: 15555696]
  • Jonathan Rampono, Stephen Proud, L Peter Hackett, Judith H Kristensen, Kenneth F Ilett. A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate. The international journal of neuropsychopharmacology. 2004 Sep; 7(3):329-34. doi: 10.1017/s1461145704004286. [PMID: 15035694]
  • Margareta Reis, Anna Aberg-Wistedt, Hans Agren, Peter Höglund, Ann-Charlotte Akerblad, Finn Bengtsson. Serum disposition of sertraline, N-desmethylsertraline and paroxetine: a pharmacokinetic evaluation of repeated drug concentration measurements during 6 months of treatment for major depression. Human psychopharmacology. 2004 Jul; 19(5):283-91. doi: 10.1002/hup.599. [PMID: 15252820]
  • Ann-Charlotte Akerblad, Finn Bengtsson, Lisa Ekselius, Lars von Knorring. Effects of an educational compliance enhancement programme and therapeutic drug monitoring on treatment adherence in depressed patients managed by general practitioners. International clinical psychopharmacology. 2003 Nov; 18(6):347-54. doi: 10.1097/00004850-200311000-00006. [PMID: 14571155]
  • Zachary N Stowe, Amy L Hostetter, Michael J Owens, James C Ritchie, Kevan Sternberg, Lee S Cohen, Charles B Nemeroff. The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations. The Journal of clinical psychiatry. 2003 Jan; 64(1):73-80. doi: 10.4088/jcp.v64n0114. [PMID: 12590627]
  • P T Pollak, S D Mukherjee, A D Fraser. Sertraline-induced hypoglycemia. The Annals of pharmacotherapy. 2001 Nov; 35(11):1371-4. doi: 10.1345/aph.1z431. [PMID: 11724085]
  • N Epperson, K A Czarkowski, D Ward-O'Brien, E Weiss, R Gueorguieva, P Jatlow, G M Anderson. Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs. The American journal of psychiatry. 2001 Oct; 158(10):1631-7. doi: 10.1176/appi.ajp.158.10.1631. [PMID: 11578995]
  • J H Wang, Z Q Liu, W Wang, X P Chen, Y Shu, N He, H H Zhou. Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19. Clinical pharmacology and therapeutics. 2001 Jul; 70(1):42-7. doi: 10.1067/mcp.2001.116513. [PMID: 11452243]
  • V L Serebruany, P A Gurbel, C M O'Connor. Platelet inhibition by sertraline and N-desmethylsertraline: a possible missing link between depression, coronary events, and mortality benefits of selective serotonin reuptake inhibitors. Pharmacological research. 2001 May; 43(5):453-62. doi: 10.1006/phrs.2001.0817. [PMID: 11394937]
  • A J Lee, W K Chan, A F Harralson, J Buffum, B C Bui. The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study. Clinical therapeutics. 1999 Nov; 21(11):1890-9. doi: 10.1016/s0149-2918(00)86737-5. [PMID: 10890261]
  • S Allard, S M Sainati, B F Roth-Schechter. Coadministration of short-term zolpidem with sertraline in healthy women. Journal of clinical pharmacology. 1999 Feb; 39(2):184-91. doi: 10.1177/00912709922007624. [PMID: 11563412]
  • K L Wisner, J M Perel, J Blumer. Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs. The American journal of psychiatry. 1998 May; 155(5):690-2. doi: 10.1176/ajp.155.5.690. [PMID: 9585724]
  • J H Kristensen, K F Ilett, L J Dusci, L P Hackett, P Yapp, R E Wojnar-Horton, M J Roberts, M Paech. Distribution and excretion of sertraline and N-desmethylsertraline in human milk. British journal of clinical pharmacology. 1998 May; 45(5):453-7. doi: 10.1046/j.1365-2125.1998.00705.x. [PMID: 9643617]
  • G T Vatassery, L A Holden, D K Hazel, M W Dysken. Analysis of sertraline and desmethylsertraline in human plasma and red blood cells. Clinical biochemistry. 1997 Oct; 30(7):565-8. doi: 10.1016/s0009-9120(97)00101-x. [PMID: 9399026]
  • Z N Stowe, M J Owens, J C Landry, C D Kilts, T Ely, A Llewellyn, C B Nemeroff. Sertraline and desmethylsertraline in human breast milk and nursing infants. The American journal of psychiatry. 1997 Sep; 154(9):1255-60. doi: 10.1176/ajp.154.9.1255. [PMID: 9286185]
  • O K Mammen, J M Perel, G Rudolph, J P Foglia, S B Wheeler. Sertraline and norsertraline levels in three breastfed infants. The Journal of clinical psychiatry. 1997 Mar; 58(3):100-3. doi: 10.4088/jcp.v58n0302. [PMID: 9108810]
  • R A Ronfeld, L M Tremaine, K D Wilner. Pharmacokinetics of sertraline and its N-demethyl metabolite in elderly and young male and female volunteers. Clinical pharmacokinetics. 1997; 32 Suppl 1(?):22-30. doi: 10.2165/00003088-199700321-00004. [PMID: 9068932]
  • J Patel, E P Spencer, R J Flanagan. HPLC of sertraline and norsertraline in plasma or serum. Biomedical chromatography : BMC. 1996 Nov; 10(6):351-4. doi: 10.1002/(sici)1099-0801(199611)10:6<351::aid-bmc620>3.0.co;2-o. [PMID: 8949919]
  • B J Ring, S N Binkley, L Roskos, S A Wrighton. Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro. The Journal of pharmacology and experimental therapeutics. 1995 Dec; 275(3):1131-5. doi: . [PMID: 8531073]
  • B Levine, A J Jenkins, J E Smialek. Distribution of sertraline in postmortem cases. Journal of analytical toxicology. 1994 Sep; 18(5):272-4. doi: 10.1093/jat/18.5.272. [PMID: 7990446]
  • D Rogowsky, M Marr, G Long, C Moore. Determination of sertraline and desmethylsertraline in human serum using copolymeric bonded-phase extraction, liquid chromatography and gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical applications. 1994 Apr; 655(1):138-41. doi: 10.1016/0378-4347(94)00112-x. [PMID: 8061822]
  • M E Reith, C T Fischette. Sertraline and cocaine-induced locomotion in mice. II. Chronic studies. Psychopharmacology. 1991; 103(3):306-13. doi: 10.1007/bf02244283. [PMID: 2057536]
  • M E Reith, H L Wiener, C T Fischette. Sertraline and cocaine-induced locomotion in mice. I. Acute studies. Psychopharmacology. 1991; 103(3):297-305. doi: 10.1007/bf02244282. [PMID: 2057535]