clenbuterol (BioDeep_00000397475)
代谢物信息卡片
化学式: C12H18Cl2N2O (276.0796118)
中文名称: 克伦特罗, (S)-(+)-瘦肉精
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O
InChI: InChI=1S/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3592
CONFIDENCE standard compound; INTERNAL_ID 1099
同义名列表
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:174690
- KEGGdrug: D07713
- PubChem: 2783
- Metlin: METLIN85074
- DrugBank: DB01407
- ChEMBL: CHEMBL49080
- MeSH: Clenbuterol
- CAS: 37148-27-9
- CAS: 50499-60-0
- MoNA: WA001313
- MoNA: WA001312
- MoNA: WA001311
- MoNA: WA001310
- MoNA: WA001309
- MoNA: WA001308
- MoNA: EQ359209
- MoNA: EQ359208
- MoNA: EQ359207
- MoNA: EQ359206
- MoNA: EQ359205
- MoNA: EQ359204
- MoNA: EQ359203
- MoNA: EQ359202
- MoNA: EQ359201
- MoNA: AU109901
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Chien-Jen Wang, Huei-Ju Liu, Tzu-Chieh Chou, Ching-Chun Lin, Wen-Harn Pan, Pau-Chung Chen, Jing-Fang Hsu. Simultaneous determination of eight β-adrenergic agonists in human urine by an isotope dilution-online clean-up system coupled with liquid chromatography-tandem mass spectrometry.
Chemosphere.
2022 Aug; 301(?):134778. doi:
10.1016/j.chemosphere.2022.134778
. [PMID: 35504472] - Shoji Tanaka, Naotoshi Sugimoto, Takako Ohno-Shosaku, Sachiko Madokoro, Pleiades Tiharu Inaoka, Toshiaki Yamazaki. Effects of long-term treatment with dietary theobromine on rat skeletal muscles.
Molecular biology reports.
2022 May; 49(5):3965-3973. doi:
10.1007/s11033-022-07248-w
. [PMID: 35226259] - Pamela Waller, Izabela Lomnicka, Cam Lucas, Sara Johnson, Levent Dirikolu. The medication violations in racehorses at Louisiana racetracks from 2016 to 2020.
Veterinary medicine and science.
2022 03; 8(2):553-560. doi:
10.1002/vms3.724
. [PMID: 34989156] - Jaroslawna Meister, Derek B J Bone, Jonas R Knudsen, Luiz F Barella, Thomas J Velenosi, Dmitry Akhmedov, Regina J Lee, Amanda H Cohen, Oksana Gavrilova, Yinghong Cui, Gerard Karsenty, Min Chen, Lee S Weinstein, Maximilian Kleinert, Rebecca Berdeaux, Thomas E Jensen, Erik A Richter, Jürgen Wess. Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells.
Nature communications.
2022 01; 13(1):22. doi:
10.1038/s41467-021-27540-w
. [PMID: 35013148] - Jaroslawna Meister, Derek B J Bone, Jonas R Knudsen, Luiz F Barella, Liu Liu, Regina Lee, Oksana Gavrilova, Min Chen, Lee S Weinstein, Maximilian Kleinert, Thomas E Jensen, Jürgen Wess. In vivo metabolic effects after acute activation of skeletal muscle Gs signaling.
Molecular metabolism.
2022 01; 55(?):101415. doi:
10.1016/j.molmet.2021.101415
. [PMID: 34883278] - Wenhua Zhang, Deng Hong, Meikang Lei, Xiaoli Hu, Jianbo Hou, Wen Xie, Dunming Xu, Xionghai Yi, You Li. [Separation and determination of clenbuterol enantiomers by ultra-performance convergence chromatography].
Se pu = Chinese journal of chromatography.
2021 Dec; 39(12):1347-1354. doi:
10.3724/sp.j.1123.2021.06045
. [PMID: 34812007] - Xiang Li, Yangguang Li, Pai Yu, Yanbin Tong, Bang-Ce Ye. A high sensitivity electrochemical sensor based on a dual-template molecularly imprinted polymer for simultaneous determination of clenbuterol hydrochloride and ractopamine.
The Analyst.
2021 Oct; 146(20):6323-6332. doi:
10.1039/d1an01413g
. [PMID: 34554156] - Andrew K Evans, Heui Hye Park, Nay Lui Saw, Kratika Singhal, Gaku Ogawa, Ryan D Leib, Mehrdad Shamloo. Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.
Neurobiology of aging.
2021 10; 106(?):241-256. doi:
10.1016/j.neurobiolaging.2021.06.012
. [PMID: 34320462] - Takaaki Higashihara, Hiroshi Nishi, Koji Takemura, Hiroshi Watanabe, Toru Maruyama, Reiko Inagi, Tetsuhiro Tanaka, Masaomi Nangaku. β2-adrenergic receptor agonist counteracts skeletal muscle atrophy and oxidative stress in uremic mice.
Scientific reports.
2021 04; 11(1):9130. doi:
10.1038/s41598-021-88438-7
. [PMID: 33911115] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Michele Protti, Paolo M Sberna, Roccaldo Sardella, Tomaž Vovk, Laura Mercolini, Roberto Mandrioli. VAMS and StAGE as innovative tools for the enantioselective determination of clenbuterol in urine by LC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2021 Feb; 195(?):113873. doi:
10.1016/j.jpba.2020.113873
. [PMID: 33422835] - Atsushi Hashizume, Kenneth H Fischbeck, Maria Pennuto, Pietro Fratta, Masahisa Katsuno. Disease mechanism, biomarker and therapeutics for spinal and bulbar muscular atrophy (SBMA).
Journal of neurology, neurosurgery, and psychiatry.
2020 10; 91(10):1085-1091. doi:
10.1136/jnnp-2020-322949
. [PMID: 32934110] - Sara Amalie Solheim, Søren Jessen, Jakob Mørkeberg, Mario Thevis, Yvette Dehnes, Kasper Eibye, Morten Hostrup, Nikolai Baastrup Nordsborg. Single-dose administration of clenbuterol is detectable in dried blood spots.
Drug testing and analysis.
2020 Sep; 12(9):1366-1372. doi:
10.1002/dta.2872
. [PMID: 32495983] - Jun Yang, Brian Balog, Kangli Deng, Brett Hanzlicek, Anna Rietsch, Mei Kuang, Shinji Hatakeyama, Estelle Lach-Trifilieff, Hui Zhu, Margot S Damaser. Therapeutic potential of muscle growth promoters in a stress urinary incontinence model.
American journal of physiology. Renal physiology.
2020 09; 319(3):F436-F446. doi:
10.1152/ajprenal.00122.2020
. [PMID: 32686522] - Anastasia Kalinovich, Nodi Dehvari, Alice Åslund, Sten van Beek, Carina Halleskog, Jessica Olsen, Elisabete Forsberg, Evelyn Zacharewicz, Gert Schaart, Mia Rinde, Anna Sandström, Roger Berlin, Claes-Göran Östenson, Joris Hoeks, Tore Bengtsson. Treatment with a β-2-adrenoceptor agonist stimulates glucose uptake in skeletal muscle and improves glucose homeostasis, insulin resistance and hepatic steatosis in mice with diet-induced obesity.
Diabetologia.
2020 08; 63(8):1603-1615. doi:
10.1007/s00125-020-05171-y
. [PMID: 32472192] - Qian Wu, Qing Song, Xinxin Wang, Li Yao, Jianguo Xu, Jianfeng Lu, Guodong Liu, Wei Chen. Simultaneous Detection of Multiple β-Adrenergic Agonists with 2-Directional Lateral Flow Strip Platform.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2020 Jun; 36(6):653-658. doi:
10.2116/analsci.19p218
. [PMID: 31656246] - Genye He, Linghui Sheng, Jianli Zhang, Yun Wu, Xuxiao Zhao, Youxuan Xu, Jianghai Lu. Enantiomeric analysis of clenbuterol in Chinese people by LC-MS/MS to distinguish doping abuse from meat contamination.
Bioanalysis.
2020 Jun; 12(11):783-790. doi:
10.4155/bio-2020-0003
. [PMID: 32441534] - Yanan Yuan, Hailiang Nie, Junfa Yin, Yehong Han, Yunkai Lv, Hongyuan Yan. Selective extraction and detection of β-agonists in swine urine for monitoring illegal use in livestock breeding.
Food chemistry.
2020 May; 313(?):126155. doi:
10.1016/j.foodchem.2019.126155
. [PMID: 31945701] - L Dufayet, C Gorgiard, F Vayssette, J P Barbet, G Hoizey, B Ludes. Death of an apprentice bodybuilder following 2,4-dinitrophenol and clenbuterol intake.
International journal of legal medicine.
2020 May; 134(3):1003-1006. doi:
10.1007/s00414-020-02268-2
. [PMID: 32125503] - Søren Jessen, Sara A Solheim, Glenn A Jacobson, Kasper Eibye, Jens Bangsbo, Nikolai B Nordsborg, Morten Hostrup. Beta2 -adrenergic agonist clenbuterol increases energy expenditure and fat oxidation, and induces mTOR phosphorylation in skeletal muscle of young healthy men.
Drug testing and analysis.
2020 May; 12(5):610-618. doi:
10.1002/dta.2755
. [PMID: 31887249] - Benjamín Velasco-Bejarano, Jahir Bautista, Martha E Rodríguez, Raquel López-Arellano, Roberto Arreguín-Espinosa, Ricardo Velasco Carrillo. Quantification and Stereochemical Composition of R-(-) and S-(+)-Clenbuterol Enantiomers in Bovine Urine by Liquid Chromatography-Tandem Mass Spectrometry.
Journal of analytical toxicology.
2020 Apr; 44(3):237-244. doi:
10.1093/jat/bkz087
. [PMID: 31681961] - Andrew A Tester, Sheena Logan, Louisa Pollock, Allison McKie. Clenbuterol: a new toxic substance in paediatrics.
BMJ case reports.
2020 Mar; 13(3):. doi:
10.1136/bcr-2019-233180
. [PMID: 32169984] - Yu Li, Yaofeng Zhou, Xirui Chen, Xiaolin Huang, Yonghua Xiong. Comparison of three sample addition methods in competitive and sandwich colloidal gold immunochromatographic assay.
Analytica chimica acta.
2020 Jan; 1094(?):90-98. doi:
10.1016/j.aca.2019.09.079
. [PMID: 31761051] - Yu Ge, Mingren Qu, Lanjiao Xu, Xiaoqiang Wang, Junping Xin, Xiaoning Liao, Meifa Li, Mingfang Li, Yangping Wen. Phosphorene nanocomposite with high environmental stability and antifouling capability for simultaneous sensing of clenbuterol and ractopamine.
Mikrochimica acta.
2019 11; 186(12):836. doi:
10.1007/s00604-019-3908-5
. [PMID: 31758341] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Mengjun Wang, Mengde Zhu, Yu Wang, Zichun Fan, Shining Wu, Xiaobo Zhang, Zhiwei Tong. In situ Preparation of HNbMoO6/C Nanocomposite for Sensitive Detection of Clenbuterol.
Applied biochemistry and biotechnology.
2019 Nov; 189(3):960-971. doi:
10.1007/s12010-019-03054-6
. [PMID: 31152354] - Yang Cong, Hang Dong, Xiaoyuan Wei, Liqian Zhang, Jingkun Bai, Jingliang Wu, Johnny X Huang, Zhiqin Gao, Hiroshi Ueda, Jinhua Dong. A novel murine antibody and an open sandwich immunoassay for the detection of clenbuterol.
Ecotoxicology and environmental safety.
2019 Oct; 182(?):109473. doi:
10.1016/j.ecoenv.2019.109473
. [PMID: 31398783] - Sabrina Lehmann, Andreas Thomas, Karl-Heinz Schiwy-Bochat, Hans Geyer, Mario Thevis, Frank Glenewinkel, Markus Alexander Rothschild, Hilke Andresen-Streichert, Martin Juebner. Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone).
Forensic science international.
2019 Oct; 303(?):109925. doi:
10.1016/j.forsciint.2019.109925
. [PMID: 31499423] - Pascal Kintz, Laurie Gheddar, Alice Ameline, Véronique Dumestre-Toulet, Marion Verschoore, Julien Comte, Jean-Sébastien Raul. Complete Post-mortem Investigations in a Death Involving Clenbuterol After Long-term Abuse.
Journal of analytical toxicology.
2019 Sep; 43(8):660-665. doi:
10.1093/jat/bkz058
. [PMID: 31436794] - Hernández Mariana Dolores, Alma Villaseñor, Olmos Sofia Piña, Crisóforo Mercado Márquez, Benjamín Velasco Bejarano, María Eugenia Gonsebatt Bonaparte, Raquel López-Arellano. Evaluation of R- (-) and S- (+) Clenbuterol enantiomers during a doping cycle or continuous ingestion of contaminated meat using chiral liquid chromatography by LC-TQ-MS.
Drug testing and analysis.
2019 Aug; 11(8):1238-1247. doi:
10.1002/dta.2612
. [PMID: 31069953] - Jia Liu, Chaohua Tang, Ruijun Long, Kai Zhang, Yunsheng Han, Qingyu Zhao, Hongliang Wang, Fuzhong Zhao, Qingshi Meng, Junmin Zhang. The use of hair as a long-term indicator of low-dose β2 agonist treatments in cattle: Implications for growth-promoting purposes monitoring.
Drug testing and analysis.
2019 Jun; 11(6):745-751. doi:
10.1002/dta.2551
. [PMID: 30474322] - Zhen Huang, Zhijuan Xiong, Yuan Chen, Song Hu, Weihua Lai. Sensitive and Matrix-Tolerant Lateral Flow Immunoassay Based on Fluorescent Magnetic Nanobeads for the Detection of Clenbuterol in Swine Urine.
Journal of agricultural and food chemistry.
2019 Mar; 67(10):3028-3036. doi:
10.1021/acs.jafc.8b06449
. [PMID: 30793901] - Yuyang Zeng, Demei Liang, Pimiao Zheng, Tao Peng, Shujuan Sun, Ghulam Mujtaba Mari, Haiyang Jiang. Immunochromatographic fluorometric determination of clenbuterol with enhanced sensitivity.
Mikrochimica acta.
2019 03; 186(4):225. doi:
10.1007/s00604-019-3326-8
. [PMID: 30848375] - Tao Peng, Jianyi Wang, Sijun Zhao, Yuyang Zeng, Pimiao Zheng, Demei Liang, Ghulam Mujtaba Mari, Haiyang Jiang. Highly luminescent green-emitting Au nanocluster-based multiplex lateral flow immunoassay for ultrasensitive detection of clenbuterol and ractopamine.
Analytica chimica acta.
2018 Dec; 1040(?):143-149. doi:
10.1016/j.aca.2018.08.014
. [PMID: 30327104] - Yu Ge, María Belén Camarada, Lanjiao Xu, Mingren Qu, Huan Liang, Erlong Zhao, Mingfang Li, Yangping Wen. A highly stable black phosphorene nanocomposite for voltammetric detection of clenbuterol.
Mikrochimica acta.
2018 11; 185(12):566. doi:
10.1007/s00604-018-3084-z
. [PMID: 30498860] - Turibius Simon, Muthaiah Shellaiah, Perpectual Steffi, Kien Wen Sun, Fu-Hsiang Ko. Development of extremely stable dual functionalized gold nanoparticles for effective colorimetric detection of clenbuterol and ractopamine in human urine samples.
Analytica chimica acta.
2018 Sep; 1023(?):96-104. doi:
10.1016/j.aca.2018.03.022
. [PMID: 29754612] - Warren Lee, Ali Syed A, Chiuan Yee Leow, Soo Choon Tan, Chiuan Herng Leow. Isolation and characterization of a novel anti-salbutamol chicken scFv for human doping urinalysis.
Analytical biochemistry.
2018 08; 555(?):81-93. doi:
10.1016/j.ab.2018.05.009
. [PMID: 29775561] - Dulal C Kabiraz, Kinichi Morita, Kazuhira Sakamoto, Masashi Takahashi, Toshikazu Kawaguchi. Highly sensitive detection of clenbuterol in urine sample by using surface plasmon resonance immunosensor.
Talanta.
2018 Aug; 186(?):521-526. doi:
10.1016/j.talanta.2018.04.011
. [PMID: 29784396] - Tao Peng, Jianyi Wang, Sijun Zhao, Sanlei Xie, Kai Yao, Pimiao Zheng, Sihan Wang, Yuebin Ke, Haiyang Jiang. A fluorometric clenbuterol immunoassay based on the use of organic/inorganic hybrid nanoflowers modified with gold nanoclusters and artificial antigen.
Mikrochimica acta.
2018 07; 185(8):366. doi:
10.1007/s00604-018-2889-0
. [PMID: 29982940] - Fernando X Moreira, Renata Silva, Maria B André, Paula G de Pinho, Maria L Bastos, João Ruivo, Patrícia Ruivo, Helena Carmo. Quantification of doping compounds in faecal samples from racing pigeons, by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jul; 1089(?):33-42. doi:
10.1016/j.jchromb.2018.05.004
. [PMID: 29753212] - Natalia González, Marcos Grünhut, Ivana Šrámková, Adriana G Lista, Burkhard Horstkotte, Petr Solich, Hana Sklenářová, Carolina C Acebal. Flow-batch analysis of clenbuterol based on analyte extraction on molecularly imprinted polymers coupled to an in-system chromogenic reaction. Application to human urine and milk substitute samples.
Talanta.
2018 Feb; 178(?):934-942. doi:
10.1016/j.talanta.2017.10.040
. [PMID: 29136919] - Muthaiah Shellaiah, Turibius Simon, Parthiban Venkatesan, Kien Wen Sun, Fu-Hsiang Ko, Shu-Pao Wu. Nanodiamonds conjugated to gold nanoparticles for colorimetric detection of clenbuterol and chromium(III) in urine.
Mikrochimica acta.
2017 12; 185(1):74. doi:
10.1007/s00604-017-2611-7
. [PMID: 29594526] - Benjamín Velasco-Bejarano, Jahir Bautista, Ma Olivia Noguez, Evangelina Camacho, Martha E Rodríguez, Leonardo Rodríguez. Resolution of R-(-) and S-(+)- enantiomers of clenbuterol in pharmaceutical preparations and black-market products using liquid chromatography-tandem mass spectrometry.
Drug testing and analysis.
2017 Nov; 9(11-12):1738-1743. doi:
10.1002/dta.2294
. [PMID: 28856822] - M H Blokland, E F van Tricht, L A van Ginkel, S S Sterk. Applicability of an innovative steroid-profiling method to determine synthetic growth promoter abuse in cattle.
The Journal of steroid biochemistry and molecular biology.
2017 11; 174(?):265-275. doi:
10.1016/j.jsbmb.2017.10.007
. [PMID: 29030156] - Robert B Cameron, Yuri K Peterson, Craig C Beeson, Rick G Schnellmann. Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
Scientific reports.
2017 09; 7(1):10578. doi:
10.1038/s41598-017-11030-5
. [PMID: 28874749] - Yalan Liu, Qiujun Lu, Xiaojun Hu, Haiyan Wang, Haitao Li, Youyu Zhang, Shouzhuo Yao. A Nanosensor Based on Carbon Dots for Recovered Fluorescence Detection Clenbuterol in Pork Samples.
Journal of fluorescence.
2017 Sep; 27(5):1847-1853. doi:
10.1007/s10895-017-2122-2
. [PMID: 28634884] - Ling Luo, Peijing Hu, Changqing Miao, Aiqun Ma, Tingzhong Wang. Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation.
International journal of toxicology.
2017 Jul; 36(4):314-324. doi:
10.1177/1091581817710786
. [PMID: 28535735] - Fan Feng, Jianwu Zheng, Peng Qin, Tao Han, Dayun Zhao. A novel quartz crystal microbalance sensor array based on molecular imprinted polymers for simultaneous detection of clenbuterol and its metabolites.
Talanta.
2017 May; 167(?):94-102. doi:
10.1016/j.talanta.2017.02.001
. [PMID: 28340793] - Maria Kristina Parr, Marco H Blokland, Franz Liebetrau, Alexander H Schmidt, Thijs Meijer, Mijo Stanic, Dorota Kwiatkowska, Emilia Waraksa, Saskia S Sterk. Distinction of clenbuterol intake from drug or contaminated food of animal origin in a controlled administration trial - the potential of enantiomeric separation for doping control analysis.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2017 Apr; 34(4):525-535. doi:
10.1080/19440049.2016.1242169
. [PMID: 27690842] - Pengqi Guo, Zhimin Luo, Xinya Xu, Yulan Zhou, Bilin Zhang, Ruimiao Chang, Wei Du, Chun Chang, Qiang Fu. Development of molecular imprinted column-on line-two dimensional liquid chromatography for selective determination of clenbuterol residues in biological samples.
Food chemistry.
2017 Feb; 217(?):628-636. doi:
10.1016/j.foodchem.2016.09.021
. [PMID: 27664680] - Tianyi Li, Liusheng Fan, Yingfeng Wang, Xuebin Huang, Jianguo Xu, Jinxing Lu, Mei Zhang, Wei Xu. Molecularly Imprinted Membrane Electrospray Ionization for Direct Sample Analyses.
Analytical chemistry.
2017 02; 89(3):1453-1458. doi:
10.1021/acs.analchem.6b02571
. [PMID: 28035803] - Daichi Ijiri, Kanae Ishitani, Mahmoud Mohamed Hamza El-Deep, Mana Kawaguchi, Saki Shimamoto, Yoshitaka Ishimaru, Akira Ohtsuka. Single injection of clenbuterol into newly hatched chicks decreases abdominal fat pad weight in growing broiler chickens.
Animal science journal = Nihon chikusan Gakkaiho.
2016 Oct; 87(10):1298-1303. doi:
10.1111/asj.12541
. [PMID: 26707345] - Jie Cheng, Xiao-Ou Su, Shi Wang, Yiping Zhao. Highly Sensitive Detection of Clenbuterol in Animal Urine Using Immunomagnetic Bead Treatment and Surface-Enhanced Raman Spectroscopy.
Scientific reports.
2016 09; 6(?):32637. doi:
10.1038/srep32637
. [PMID: 27599754] - Heather K Knych, Linda M Harrison, Stacy J Steinmetz, Nadira Chouicha, Phil H Kass. Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses.
BMC genomics.
2016 08; 17(?):596. doi:
10.1186/s12864-016-2945-2
. [PMID: 27506674] - Saki Shimamoto, Daichi Ijiri, Kazuki Nakashima, Mana Kawaguchi, Yoshitaka Ishimaru, Airi Furukawa, Akira Ohtsuka. Clenbuterol changes phosphorylated FOXO1 localization and decreases protein degradation in the sartorius muscle of neonatal chicks.
Bioscience, biotechnology, and biochemistry.
2016 Aug; 80(8):1499-504. doi:
10.1080/09168451.2016.1158629
. [PMID: 27055887] - Guanglei Li, Yuhua Fu, Xiaosong Han, Xinyun Li, Changchun Li. Metabolomic investigation of porcine muscle and fatty tissue after Clenbuterol treatment using gas chromatography/mass spectrometry.
Journal of chromatography. A.
2016 Jul; 1456(?):242-8. doi:
10.1016/j.chroma.2016.06.017
. [PMID: 27320379] - Yongjing Liu, Miaoduo Deng, Jia Yu, Zhen Jiang, Xingjie Guo. Capillary electrophoretic enantioseparation of basic drugs using a new single-isomer cyclodextrin derivative and theoretical study of the chiral recognition mechanism.
Journal of separation science.
2016 May; 39(9):1766-75. doi:
10.1002/jssc.201501026
. [PMID: 26935589] - Wenwen Wang, Xiaoxiao Su, Hui Ouyang, Lin Wang, Zhifeng Fu. A novel immunochromatographic assay based on a time-resolved chemiluminescence strategy for the multiplexed detection of ractopamine and clenbuterol.
Analytica chimica acta.
2016 Apr; 917(?):79-84. doi:
10.1016/j.aca.2016.03.001
. [PMID: 27026603] - Fengxia Qiao, Mengge Wang. Preparation of selective magnetic dispersive solid-phase sorbent and its application for recognition clenbuterol from bovine urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Apr; 1017-1018(?):18-27. doi:
10.1016/j.jchromb.2016.02.019
. [PMID: 26937590] - Nicole M Grimmer, Renee Petzel Gimbar, Adam Bursua, Meet Patel. Rhabdomyolysis Secondary to Clenbuterol Use and Exercise.
The Journal of emergency medicine.
2016 Feb; 50(2):e71-4. doi:
10.1016/j.jemermed.2015.09.006
. [PMID: 26482831] - Ahmed M Alkhunaizi, Mohamed A ElTigani, Rola S Rabah, Samih H Nasr. Acute bile nephropathy secondary to anabolic steroids.
Clinical nephrology.
2016 Feb; 85(2):121-6. doi:
10.5414/cn108696
. [PMID: 26587777] - Feng Qin, Bincan Yin, Lijuan Wang, Kunjie Li, Famei Li, Zhili Xiong. Quantification of trantinterol, its two metabolites and their primary conjugated metabolites in human plasma by ultra-high-performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2016 Jan; 117(?):413-8. doi:
10.1016/j.jpba.2015.09.020
. [PMID: 26448609] - Lijun Li, Chaohua Tang, Junmin Zhang, Qingyu Zhao, Kai Zhang. The Potential of Various Living Tissues for Monitoring Clenbuterol Abuse in Food-Producing Chinese Simmental Beef Cattle.
Journal of analytical toxicology.
2016 Jan; 40(1):72-7. doi:
10.1093/jat/bkv118
. [PMID: 26487642] - Jie Huang, Qi Pei, Hongyi Tan, Hong Yuan, Youli Lu, Gangyi Liu, Zhijun Huang, Guoping Yang. Pharmacokinetics of trantinterol and its metabolite in healthy elderly and young subjects.
International journal of clinical pharmacology and therapeutics.
2015 Oct; 53(10):875-82. doi:
10.5414/cp202315
. [PMID: 26308170] - Yanjuan Wang, Feng Qin, Zhili Xiong, Xiaohuan Fu, Chao Ma. An LC-MS/MS method for simultaneous determination of trantinterol and its major metabolite in rat plasma and its application to a comparative pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Sep; 1000(?):163-8. doi:
10.1016/j.jchromb.2015.07.022
. [PMID: 26245359] - Jie Huang, Youli Lu, Qian Wan, Meiwei Zhang, Qi Pei, Mengqi Zhang, Gangyi Liu, Guoping Yang. Simultaneous Determination of Trantinterol and One of Its Major Metabolites, 1-Carbonyl Trantinterol, in Human Plasma by LC-MS-MS.
Journal of chromatographic science.
2015 Sep; 53(8):1303-9. doi:
10.1093/chromsci/bmv009
. [PMID: 25689985] - Feng Qin, Lijuan Wang, Kunjie Li, Zhili Xiong, Famei Li. Simultaneous quantification of trantinterol and its metabolites in human urine by ultra performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Aug; 997(?):64-9. doi:
10.1016/j.jchromb.2015.05.007
. [PMID: 26093121] - Zhen Zhao, Ting Yao, Yuchang Qin, Xiaowei Yang, Jun Li, Junguo Li, Xu Gu. Clenbuterol Distribution and Residues in Goat Tissues After the Repeated Administration of a Growth-Promoting Dose.
Journal of analytical toxicology.
2015 Jul; 39(6):465-71. doi:
10.1093/jat/bkv038
. [PMID: 25910488] - Yuping Wu, Yanfeng Bi, Gali Bingga, Xiaowei Li, Suxia Zhang, Jiancheng Li, Hui Li, Shuangyang Ding, Xi Xia. Metabolomic analysis of swine urine treated with β2-agonists by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Journal of chromatography. A.
2015 Jun; 1400(?):74-81. doi:
10.1016/j.chroma.2015.04.050
. [PMID: 25980694] - Norbert Baume, Nicolas Jan, Caroline Emery, Béatrice Mandanis, Carine Schweizer, Sylvain Giraud, Nicolas Leuenberger, François Marclay, Raul Nicoli, Laurent Perrenoud, Neil Robinson, Jiri Dvorak, Martial Saugy. Antidoping programme and biological monitoring before and during the 2014 FIFA World Cup Brazil.
British journal of sports medicine.
2015 May; 49(9):614-22. doi:
10.1136/bjsports-2015-094762
. [PMID: 25878079] - Feng Qin, Yanjuan Wang, Lijuan Wang, Longshan Zhao, Li Pan, Maosheng Cheng, Famei Li. Determination of trantinterol enantiomers in human plasma by high-performance liquid chromatography - tandem mass spectrometry using vancomycin chiral stationary phase and solid phase extraction and stereoselective pharmacokinetic application.
Chirality.
2015 May; 27(5):327-31. doi:
10.1002/chir.22432
. [PMID: 25782043] - Manwen Yao, Yichuan Wu, Xiangyi Fang, Yucong Yang, Hongjun Liu. Spectral surface plasmon resonance imaging for the detection of clenbuterol via three-dimensional immobilization of bioprobes.
Analytical biochemistry.
2015 Apr; 475(?):40-3. doi:
10.1016/j.ab.2015.01.012
. [PMID: 25637304] - Jennifer Bishop, Brendan Heffron, Lisa Taddei, Marc Benoit, Laura Hurt, Sara Costello, Melissa Gross, Adam Negrusz. Confirmation and quantification of clenbuterol in horse urine using liquid chromatography tandem mass spectrometry triple quadrupole.
Journal of analytical toxicology.
2015 Mar; 39(2):130-2. doi:
10.1093/jat/bku140
. [PMID: 25505053] - Xu Jing, Bing Bai, Chenxuan Zhang, Wenying Wu, Liming Du, Hailong Liu, Guojun Yao. Rapid and sensitive determination of clenbuterol in porcine muscle and swine urine using a fluorescent probe.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2015 Feb; 136 Pt B(?):714-8. doi:
10.1016/j.saa.2014.09.086
. [PMID: 25315870] - Tingting Wang, Yantong Sun, Wenxiao Ma, Zhichao Yang, Junfeng Yang, Jingrui Liu, Hongbo Fan, Yan Yang, Jingkai Gu, John Paul Fawcett, Yingjie Guo. Trantinterol, a novel β2-adrenoceptor agonist, noncompetitively inhibits P-glycoprotein function in vitro and in vivo.
Molecular pharmaceutics.
2015 Jan; 12(1):1-9. doi:
10.1021/mp500239v
. [PMID: 25389765] - Kai Hu, Suxiang Feng, Mingxia Wu, Shuang Wang, Wenjie Zhao, Qiong Jiang, Ajuan Yu, Shusheng Zhang. Development of a V-shape bis(tetraoxacalix[2]arene[2]triazine) stationary phase for high performance liquid chromatography.
Talanta.
2014 Dec; 130(?):63-70. doi:
10.1016/j.talanta.2014.06.054
. [PMID: 25159380] - Jelka Pleadin, Ana Vulić, Svjetlana Terzić, Nada Vahčić, Ksenija Šandor, Eleonora Perak. Comparison of accumulation of clenbuterol and salbutamol residues in animal internal tissues, non-pigmented eyes and hair.
Journal of analytical toxicology.
2014 Nov; 38(9):681-5. doi:
10.1093/jat/bku081
. [PMID: 24990876] - Sheng L Deng, Shan Shan, Chao L Xu, Dao F Liu, Yong H Xiong, Hua Wei, Wei H Lai. Sample preincubation strategy for sensitive and quantitative detection of clenbuterol in swine urine using a fluorescent microsphere-based immunochromatographic assay.
Journal of food protection.
2014 Nov; 77(11):1998-2003. doi:
10.4315/0362-028x.jfp-14-086
. [PMID: 25364937] - Qin Wang, Shengrui Zhang. Studies on binding interactions between clenbuterol hydrochloride and two serum albumins by multispectroscopic approaches in vitro.
Luminescence : the journal of biological and chemical luminescence.
2014 Aug; 29(5):492-9. doi:
10.1002/bio.2574
. [PMID: 24030872] - Peng Miao, Kun Han, Haixuan Sun, Jian Yin, Jing Zhao, Bidou Wang, Yuguo Tang. Melamine functionalized silver nanoparticles as the probe for electrochemical sensing of clenbuterol.
ACS applied materials & interfaces.
2014 Jun; 6(11):8667-72. doi:
10.1021/am501473m
. [PMID: 24785124] - H K Knych, M M Mitchell, S J Steinmetz, D S McKemie. Detection, pharmacokinetics and cardiac effects following administration of clenbuterol to exercised horses.
Equine veterinary journal.
2014 May; 46(3):380-5. doi:
10.1111/evj.12118
. [PMID: 23773115] - Iori Hirosawa, Mai Ishikawa, Mio Ogino, Hiroshi Ito, Takuya Hirao, Harumi Yamada, Mariko Asahi, Hajime Kotaki, Yoshimichi Sai, Ken-Ichi Miyamoto. Enantioselective disposition of clenbuterol in rats.
Biopharmaceutics & drug disposition.
2014 May; 35(4):207-17. doi:
10.1002/bdd.1885
. [PMID: 24323748] - Yan-Qing Yao, Zi-Wei Wang, Ying-Xue Ding, Yang Yu, Wen-Xing Jiang, Xiao-Hong Liu, Zhong-Hao Zhang, Hong Cui. [Effect of Zhifei mixture combined western drugs on symptoms and signs of children with mycoplasma pneumonia].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2014 May; 34(5):522-5. doi:
"
. [PMID: 24941836] - Shuyun Bi, Bo Pang, Tianjiao Wang, Tingting Zhao, Wang Yu. Investigation on the interactions of clenbuterol to bovine serum albumin and lysozyme by molecular fluorescence technique.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014; 120(?):456-61. doi:
10.1016/j.saa.2013.09.137
. [PMID: 24211804] - Chunmei Song, Aimin Zhi, Qingtang Liu, Jifei Yang, Guochao Jia, Jahanian Shervin, Liang Tang, Xiaofei Hu, Ruiguang Deng, Chuanlai Xu, Gaiping Zhang. Rapid and sensitive detection of β-agonists using a portable fluorescence biosensor based on fluorescent nanosilica and a lateral flow test strip.
Biosensors & bioelectronics.
2013 Dec; 50(?):62-5. doi:
10.1016/j.bios.2013.06.022
. [PMID: 23835218] - Feng Qin, Xintao Wang, Lijuan Jing, Li Pan, Maosheng Cheng, Guoxiang Sun, Famei Li. Bidirectional chiral inversion of trantinterol enantiomers after separate doses to rats.
Chirality.
2013 Dec; 25(12):934-8. doi:
10.1002/chir.22236
. [PMID: 24114947] - J L Norton, K Jackson, J W Chen, R Boston, R D Nolen-Walston. Effect of clenbuterol on tracheal mucociliary transport in horses undergoing simulated long-distance transportation.
Journal of veterinary internal medicine.
2013 Nov; 27(6):1523-7. doi:
10.1111/jvim.12166
. [PMID: 24033504] - Jing Han, Hongfei Gao, Wenwen Wang, Zhenxing Wang, Zhifeng Fu. Time-resolved chemiluminescence strategy for multiplexed immunoassay of clenbuterol and ractopamine.
Biosensors & bioelectronics.
2013 Oct; 48(?):39-42. doi:
10.1016/j.bios.2013.03.033
. [PMID: 23644144] - Ming-Ling Wu, Jou-Fang Deng, Yi Chen, Wei-Lan Chu, Dong-Zong Hung, Chen-Chang Yang. Late diagnosis of an outbreak of leanness-enhancing agent-related food poisoning.
The American journal of emergency medicine.
2013 Oct; 31(10):1501-3. doi:
10.1016/j.ajem.2013.07.001
. [PMID: 23928328] - Bing Bo, Xuejun Zhu, Peng Miao, Dong Pei, Bo Jiang, Yue Lou, Yongqian Shu, Genxi Li. An electrochemical biosensor for clenbuterol detection and pharmacokinetics investigation.
Talanta.
2013 Sep; 113(?):36-40. doi:
10.1016/j.talanta.2013.03.056
. [PMID: 23708621] - Kunjie Li, Yanjuan Wang, Lili Zhang, Feng Qin, Xingjie Guo, Famei Li. Simultaneous determination of trantinterol and its metabolites in rat urine and feces by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Sep; 934(?):89-96. doi:
10.1016/j.jchromb.2013.06.033
. [PMID: 23911540] - Hongyuan Yan, Suting Liu, Mengmeng Gao, Ning Sun. Ionic liquids modified dummy molecularly imprinted microspheres as solid phase extraction materials for the determination of clenbuterol and clorprenaline in urine.
Journal of chromatography. A.
2013 Jun; 1294(?):10-6. doi:
10.1016/j.chroma.2013.04.024
. [PMID: 23659982] - L A Cudmore, T Muurlink, T Whittem, S R Bailey. Effects of oral clenbuterol on the clinical and inflammatory response to endotoxaemia in the horse.
Research in veterinary science.
2013 Jun; 94(3):682-6. doi:
10.1016/j.rvsc.2013.01.003
. [PMID: 23462621] - Raul Nicoli, Michael Petrou, Flavia Badoud, Jiri Dvorak, Martial Saugy, Norbert Baume. Quantification of clenbuterol at trace level in human urine by ultra-high pressure liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2013 May; 1292(?):142-50. doi:
10.1016/j.chroma.2012.12.008
. [PMID: 23294994] - Xiaobing Li, Man Zhou, Mamat Turson, Shen Lin, Ping Jiang, Xiangchao Dong. Preparation of clenbuterol imprinted monolithic polymer with hydrophilic outer layers by reversible addition-fragmentation chain transfer radical polymerization and its application in the clenbuterol determination from human serum by on-line solid-phase extraction/HPLC analysis.
The Analyst.
2013 May; 138(10):3066-74. doi:
10.1039/c3an36801g
. [PMID: 23586071] - Mario Thevis, Lina Geyer, Hans Geyer, Sven Guddat, Jiri Dvorak, Anthony Butch, Saskia S Sterk, Wilhelm Schänzer. Adverse analytical findings with clenbuterol among U-17 soccer players attributed to food contamination issues.
Drug testing and analysis.
2013 May; 5(5):372-6. doi:
10.1002/dta.1471
. [PMID: 23559541] - J Pleadin, A Vulić, N Perši, S Terzić, M Andrišić, I Žarković. Rapid immunoassay method for the determination of clenbuterol and salbutamol in blood.
Journal of analytical toxicology.
2013 May; 37(4):241-5. doi:
10.1093/jat/bkt017
. [PMID: 23482498] - Sheng Yang, Xin Liu, Yanyi Xing, Dapeng Zhang, Shan Wang, Xiaobing Wang, Youxuan Xu, Moutian Wu, Zhenwen He, Jian Zhao. Detection of clenbuterol at trace levels in doping analysis using different gas chromatographic-mass spectrometric techniques.
Journal of chromatographic science.
2013 May; 51(5):436-45. doi:
10.1093/chromsci/bms160
. [PMID: 23042839] - Juan C Domínguez-Romero, Juan F García-Reyes, Rubén Martínez-Romero, Esther Martínez-Lara, María L Del Moral-Leal, Antonio Molina-Díaz. Detection of main urinary metabolites of β2-agonists clenbuterol, salbutamol and terbutaline by liquid chromatography high resolution mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Apr; 923-924(?):128-35. doi:
10.1016/j.jchromb.2013.02.008
. [PMID: 23500357]