NMH-Pro (BioDeep_00000397439)

 

Secondary id: BioDeep_00000242517

PANOMIX_OTCML-2023


代谢物信息卡片


(2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid

化学式: C6H11NO3 (145.0738896)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 38.33%

分子结构信息

SMILES: CN1CC(CC1C(=O)O)O
InChI: InChI=1S/C6H11NO3/c1-7-3-4(8)2-5(7)6(9)10/h4-5,8H,2-3H2,1H3,(H,9,10)/t4-,5+/m1/s1

描述信息

(R)-4-hydroxy-1-methyl-L-proline is an L-proline derivative that is trans-4-hydroxy-L-proline in which the amino hydrogen has been replaced by a methyl group. It has a role as a plant metabolite and an anti-HIV-1 agent. It is a L-proline derivative and a pyrrolidine alkaloid. It is functionally related to a trans-4-hydroxy-L-proline.
An L-proline derivative that is trans-4-hydroxy-L-proline in which the amino hydrogen has been replaced by a methyl group.
4-Hydroxyhygric acid is a compound isolated from leaves of five species of the leguminous tropical tree Copuiferq. 4-Hydroxyhygric acid is the inhibitor of larval development of the seed-feeding bruchid beetle Callosobruchus maculatus and to have significant feeding deterrence of the leaf-feeding lepidopteran Spodoprera littoralis[1].

同义名列表

19 个代谢物同义名

(2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid; (2S, 4R)-1-methyl-4-hydroxy-2-pyrrolidinecarboxylic acid; (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid; (2S,4R)-4-hydroxy-1-methylpyrrolidine-2-carboxylic acid; trans -N-Methyl-4 -hydroxy-L-proline; trans -N-Methyl-4-hydroxy-L-proline; N-methyl-trans-4-hydroxy-L-proline; trans-N-Methyl-4-hydroxy-L-proline; (4R)-4-Hydroxy-1-methyl-L-proline; (R)-4-hydroxy-N-methyl-L-proline; (R)-4-hydroxy-1-methyl-L-proline; (R)-4-hydroxy-N-methylproline; (R)-4-hydroxy-1-methylproline; FMIPNAUMSPFTHK-UHNVWZDZSA-N; trans-4-hydroxy-L-proline; 4-Hydroxyhygrinic acid; 4-Hydroxyhygric acid; N-Me-Hyp-OH; NMH-Pro



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shengdi Hu, Wenliang He, Guoyao Wu. Hydroxyproline in animal metabolism, nutrition, and cell signaling. Amino acids. 2022 Apr; 54(4):513-528. doi: 10.1007/s00726-021-03056-x. [PMID: 34342708]
  • Sebastian Kwiatkowski, Maria Bozko, Michal Zarod, Apolonia Witecka, Kubra Kocdemir, Adam K Jagielski, Jakub Drozak. Recharacterization of the mammalian cytosolic type 2 (R)-β-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104). The Journal of biological chemistry. 2022 03; 298(3):101708. doi: 10.1016/j.jbc.2022.101708. [PMID: 35150746]
  • Renren Bai, Chuansheng Yao, Zhichao Zhong, Jiamin Ge, Ziqiang Bai, Xiangyang Ye, Tian Xie, Yuanyuan Xie. Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation. European journal of medicinal chemistry. 2021 Mar; 213(?):113165. doi: 10.1016/j.ejmech.2021.113165. [PMID: 33454546]
  • Pedro Everson Alexandre de Aquino, Jéssica Rabelo Bezerra, Tyciane de Souza Nascimento, Juliete Tavares, Ítalo Rosal Lustosa, Adriano José Maia Chaves Filho, Melina Mottin, Danielle Macêdo Gaspar, Geanne Matos de Andrade, Kelly Rose Tavares Neves, Giuseppe Biagini, Edilberto Rocha Silveira, Glauce Socorro de Barros Viana. A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice. International journal of molecular sciences. 2020 Jun; 21(11):. doi: 10.3390/ijms21114188. [PMID: 32545390]
  • Bah Moustapha, Gutiérrez-Avella Dora Marina, Fuentes-Ordaz Raúl, Castañeda-Moreno Raquel, Martínez Mahinda. Chemical constituents of the Mexican mistletoe (Psittacanthus calyculatus). Molecules (Basel, Switzerland). 2011 Nov; 16(11):9397-403. doi: 10.3390/molecules16119397. [PMID: 22071447]
  • Aman Dekebo, Takehiro Kashiwagi, Shin-ich Tebayashi, Chul-Sa Kim. Nitrogenous ovipositional deterrents in the leaves of sweet pepper (Capsicum annuum) at the mature stage against the leafminer, Liriomyza trifolii (Burgess). Bioscience, biotechnology, and biochemistry. 2007 Feb; 71(2):421-6. doi: 10.1271/bbb.60482. [PMID: 17284863]
  • Tammo Winkler. Comments on 'Piperidone derivative from Dalbergia sympathetica'. Magnetic resonance in chemistry : MRC. 2006 May; 44(5):571-2. doi: 10.1002/mrc.1783. [PMID: 16425210]
  • Mitsue Haraguchi, Silvana L Gorniak, Kyoko Ikeda, Yasuhiro Minami, Atsushi Kato, Alison A Watson, Robert J Nash, Russell J Molyneux, Naoki Asano. Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae). Journal of agricultural and food chemistry. 2003 Aug; 51(17):4995-5000. doi: 10.1021/jf0341722. [PMID: 12903959]
  • B R Thumma, B P Naidu, A Chandra, D F Cameron, L M Bahnisch, C Liu. Identification of causal relationships among traits related to drought resistance in Stylosanthes scabra using QTL analysis. Journal of experimental botany. 2001 Feb; 52(355):203-14. doi: . [PMID: 11283164]