Strema (BioDeep_00000397430)
PANOMIX_OTCML-2023 Chemicals and Drugs
代谢物信息卡片
(R)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
化学式: C20H24N2O2 (324.18376839999996)
中文名称: 表奎宁定
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 34.48%
分子结构信息
SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20+/m0/s1
描述信息
Quinine Sulfate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
48 个代谢物同义名
(R)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2R,4S,5R)-5-ETHENYL-1-AZABICYCLO[2.2.2]OCTAN-2-YL](6-METHOXYQUINOLIN-4-YL)METHANOL; CINCHONAN-9-OL, 6-METHOXY-, (9R)-; Epiquinidine, analytical standard; Cinchonan-9-al, 6-methoxy-, (9R)-; (9R)-6-Methoxycinchonan-9-ol; LOUPRKONTZGTKE-AFHBHXEDSA-N; Hydrochloride, Quinine; Quinine Hydrochloride; Bisulfate, Quinine; Sulphate, Quinine; Quinine bisulfate; EPIQUINIDINE [MI]; Spectrum5_001184; Spectrum4_000988; Quinine sulphate; Spectrum2_001308; Spectrum3_000666; Sulfate, Quinine; Quinine Sulfate; Quinine Lafran; 9-Epiquinidine; .beta.-Quinine; DivK1c_000134; KBio3_001551; KBio2_001392; Quinine-Odan; KBio2_003960; KBio1_000134; Epiquinidine; KBio2_006528; Epichinidin; IDI1_000134; Quinoctal; Quinbisan; Quinbisul; Biquinate; Legatrim; Surquina; Quinimax; Quindan; Quinsul; Quinine; Quinson; Myoquin; Quinamm; Strema; ICQ-12
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 94175
- ChEMBL: CHEMBL576997
- MeSH: Quinine
- ChemIDplus: 0000572598
- CAS: 572-59-8
- medchemexpress: HY-W048510
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Muhammad Irfan Waris, Yanyuan Lei, Guojun Qi, Ziying Guan, Abdul Rashied, Jie Chen, Lihua Lyu. The temporal-spatial expression and functional analysis of three gustatory receptor genes in Solenopsis invicta using sweet and bitter compounds.
Insect science.
2024 Apr; 31(2):448-468. doi:
10.1111/1744-7917.13301. [PMID: 38010036] - Cécile Ficko, Pierre-Louis Conan. [Malaria in 2022: clinical and therapeutic aspects].
Medecine tropicale et sante internationale.
2023 06; 3(2):. doi:
10.48327/mtsi.v3i2.2023.378. [PMID: 37525671] - Louis H Miller, Jesus Rojas-Jaimes, Leanne M Low, Gilberto Corbellini. What Historical Records Teach Us about the Discovery of Quinine.
The American journal of tropical medicine and hygiene.
2023 01; 108(1):7-11. doi:
10.4269/ajtmh.22-0404. [PMID: 36410328] - Ning Wen, Ping-Shun Song, Lin Ni, Juan Chen. Tannic acid-aminopropyltriethoxysilane co-deposition modified polymer membrane for α-glucosidase immobilization.
Journal of chromatography. A.
2022 Nov; 1683(?):463550. doi:
10.1016/j.chroma.2022.463550. [PMID: 36219969] - Parker Elijah Joshua, Junaidu Yahaya, Daniel Emmanuel Ekpo, Joyce Oloaigbe Ogidigo, Arome Solomon Odiba, Rita Onyekachukwu Asomadu, Samson Ayodeji Oka, Olasupo Stephen Adeniyi. Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats.
BMC immunology.
2022 10; 23(1):50. doi:
10.1186/s12865-022-00519-y. [PMID: 36261807] - M G Semedo, A L Pereira, J R Pita. Cinchona bark and quinine in the Portuguese official pharmacopoeias (1794-2001).
Die Pharmazie.
2022 09; 77(7):278-285. doi:
10.1691/ph.2022.2034. [PMID: 36199186] - Ryuta Asaumi, Ken-Ichi Nunoya, Yoshiyuki Yamaura, Kunal S Taskar, Yuichi Sugiyama. Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney.
CPT: pharmacometrics & systems pharmacology.
2022 07; 11(7):919-933. doi:
10.1002/psp4.12807. [PMID: 35570332] - Rajinder Bhardwaj, Julie L Collins, Joseph Stringfellow, Jennifer Madonia, Matt S Anderson, Jeri-Anne Finley, David A Stock, Vladimir Coric, Robert Croop, Richard Bertz. P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects.
Clinical pharmacology in drug development.
2022 07; 11(7):889-897. doi:
10.1002/cpdd.1088. [PMID: 35304977] - Nourhan M Abd El-Aziz, Ibrahim Khalifa, Amira M G Darwish, Ahmed N Badr, Huda Aljumayi, El-Sayed Hafez, Mohamed G Shehata. Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092662. [PMID: 35566014] - Tatsuya Kokawa, Hiroyuki Yamamoto, Mitsuaki Itoh, Akira Shimane, Hiroya Kawai, Tomofumi Takaya. Fever-Related Ventricular Fibrillation - Potential Adverse Effect of SARS-CoV-2 Vaccination in Patients With Brugada Syndrome.
Circulation journal : official journal of the Japanese Circulation Society.
2022 Feb; 86(3):474. doi:
10.1253/circj.cj-21-0750. [PMID: 34615807] - Xiuliang Dai, Xiangjiao Yi, Yufeng Wang, Wei Xia, Jianguo Tao, Jun Wu, Dengshun Miao, Li Chen. PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice.
Frontiers in endocrinology.
2022; 13(?):781404. doi:
10.3389/fendo.2022.781404. [PMID: 35340329] - Alexander Burashnikov, Hector Barajas-Martinez, Robert Cox, Mark A Demitrack, Michael J Fossler, Michael Kramer, Robert B Kleiman, Peter Kowey, Charles Antzelevitch. Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk.
Heart rhythm.
2021 12; 18(12):2177-2186. doi:
10.1016/j.hrthm.2021.08.028. [PMID: 34481984] - Yong-Jia Chen, Kun-Yuan Ma, Sha-Sha Du, Zhi-Jun Zhang, Tian-Lin Wu, Yu Sun, Ying-Qian Liu, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, Chen Tang. Antifungal Exploration of Quinoline Derivatives against Phytopathogenic Fungi Inspired by Quinine Alkaloids.
Journal of agricultural and food chemistry.
2021 Oct; 69(41):12156-12170. doi:
10.1021/acs.jafc.1c05677. [PMID: 34623798] - Daniel M Gelfman. Reflections on quinine and its importance in dermatology today.
Clinics in dermatology.
2021 Sep; 39(5):900-903. doi:
10.1016/j.clindermatol.2021.08.017. [PMID: 34785019] - M G Semedo, A L Pereira, J R Pita. The influence of German science on Cinchona and quinine research in Portugal in the second half of the 19th century.
Die Pharmazie.
2021 08; 76(8):396-402. doi:
10.1691/ph.2021.1050. [PMID: 34412740] - J V Joviano-Santos, A Santos-Miranda, E A Neri, M H Fonseca-Alaniz, J E Krieger, A C Pereira, D Roman-Campos. SCN5A compound heterozygosity mutation in Brugada syndrome: Functional consequences and the implication for pharmacological treatment.
Life sciences.
2021 Aug; 278(?):119646. doi:
10.1016/j.lfs.2021.119646. [PMID: 34048814] - Inoussa Sanané, Judith Legrand, Christine Dillmann, Frédéric Marion-Poll. High-Throughput Feeding Bioassay for Lepidoptera Larvae.
Journal of chemical ecology.
2021 Jul; 47(7):642-652. doi:
10.1007/s10886-021-01290-x. [PMID: 34331170] - M Schneider, F Dron, E Cuinet, F Woehrlé. Comparative pharmacokinetic profile of cimicoxib in dogs and cats after IV administration.
Veterinary journal (London, England : 1997).
2021 Apr; 270(?):105625. doi:
10.1016/j.tvjl.2021.105625. [PMID: 33641805] - Francesco Trenti, Kotaro Yamamoto, Benke Hong, Christian Paetz, Yoko Nakamura, Sarah E O'Connor. Early and Late Steps of Quinine Biosynthesis.
Organic letters.
2021 03; 23(5):1793-1797. doi:
10.1021/acs.orglett.1c00206. [PMID: 33625237] - Federico Noto, Sandra Recuero, Julián Valencia, Beatrice Saporito, Domenico Robbe, Sergi Bonet, Augusto Carluccio, Marc Yeste. Inhibition of Potassium Channels Affects the Ability of Pig Spermatozoa to Elicit Capacitation and Trigger the Acrosome Exocytosis Induced by Progesterone.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041992. [PMID: 33671466] - Tianjiao Lin, Jingyu Song, Xinting Pan, Youdong Wan, Ziqian Wu, Shaoyan Lv, Liangyu Mi, Yunyun Wang, Fei Tian. Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Feb; 27(?):e927968. doi:
10.12659/msm.927968. [PMID: 33582700] - Mutaib M Mashraqi, Navaneet Chaturvedi, Qamre Alam, Saleh Alshamrani, Mosa M Bahnass, Khurshid Ahmad, Amany I Alqosaibi, Mashael M Alnamshan, Syed Sayeed Ahmad, Mirza Masroor Ali Beg, Abha Mishra, Sibhghatulla Shaikh, Syed Mohd Danish Rizvi. Biocomputational Prediction Approach Targeting FimH by Natural SGLT2 Inhibitors: A Possible Way to Overcome the Uropathogenic Effect of SGLT2 Inhibitor Drugs.
Molecules (Basel, Switzerland).
2021 Jan; 26(3):. doi:
10.3390/molecules26030582. [PMID: 33499241] - A G Tolkushin, E A Luchinin, M E Kholovnya-Voloskova, A A Zavyalov. [History of aminoquinoline preparations: from cinchona bark to chloroquine and hydroxychloroquinon].
Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny.
2020 Oct; 28(Special Issue):1118-1122. doi:
10.32687/0869-866x-2020-28-s2-1118-1122. [PMID: 33219768] - Dong Ye, Anna Harder, Zhizhou Fang, Manuel Weinheimer, Loic Laplanche, Mario Mezler. Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
Pharmaceutical research.
2020 Sep; 37(10):194. doi:
10.1007/s11095-020-02895-9. [PMID: 32918191] - Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Drug metabolism and pharmacokinetics.
2020 Aug; 35(4):389-396. doi:
10.1016/j.dmpk.2020.05.004. [PMID: 32690433] - Victoria V Golovchenko, Shinen Naranmandakh, Jamsranjav Ganbaatar, Artur Yu Prilepskii, Gennady L Burygin, Alexander O Chizhov, Alexander S Shashkov. Structural investigation and comparative cytotoxic activity of water-soluble polysaccharides from fruit bodies of the medicinal fungus quinine conk.
Phytochemistry.
2020 Jul; 175(?):112313. doi:
10.1016/j.phytochem.2020.112313. [PMID: 32353551] - Mauricio A García, Danae Contreras, Pablo M González. Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability.
Pharmaceutical research.
2020 Jun; 37(7):121. doi:
10.1007/s11095-020-02824-w. [PMID: 32514792] - Nataly Allasi Canales, Tobias Nikolaj Gress Hansen, Claus Cornett, Kim Walker, Felix Driver, Alexandre Antonelli, Carla Maldonado, Mark Nesbitt, Christopher J Barnes, Nina Rønsted. Historical chemical annotations of Cinchona bark collections are comparable to results from current day high-pressure liquid chromatography technologies.
Journal of ethnopharmacology.
2020 Mar; 249(?):112375. doi:
10.1016/j.jep.2019.112375. [PMID: 31698039] - Hans Friedrich Stabenau, Changyu Shen, Larisa G Tereshchenko, Jonathan W Waks. Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil.
Heart rhythm.
2020 03; 17(3):460-467. doi:
10.1016/j.hrthm.2019.09.017. [PMID: 31539628] - Zhiping Che, Jinming Yang, Di Sun, Yuee Tian, Shengming Liu, Xiaomin Lin, Jia Jiang, Genqiang Chen. Combinatorial Synthesis of Novel 9R-Acyloxyquinine Derivatives as Insecticidal Agents.
Combinatorial chemistry & high throughput screening.
2020; 23(2):111-118. doi:
10.2174/1386207323666200120112714. [PMID: 31958039] - Hong Shen, Ming Yao, Michael Sinz, Punit Marathe, A David Rodrigues, Mingshe Zhu. Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Molecular pharmaceutics.
2019 09; 16(9):4065-4076. doi:
10.1021/acs.molpharmaceut.9b00472. [PMID: 31335150] - Jay W Mason, David G Strauss, Martino Vaglio, Fabio Badilini. Correction of the QRS duration for heart rate.
Journal of electrocardiology.
2019 May; 54(?):1-4. doi:
10.1016/j.jelectrocard.2019.02.005. [PMID: 30782546] - Kai Wu, Yi Yao, Fang Chen, Mingxing Xu, Guangquan Lu, Tingting Jiang, Ziyu Liu, Weixing Du, Fang Li, Rugui Li, Huabing Tan, Jian Li. Analysis of Plasmodium falciparum Na+/H+ exchanger (pfnhe1) polymorphisms among imported African malaria parasites isolated in Wuhan, Central China.
BMC infectious diseases.
2019 Apr; 19(1):354. doi:
10.1186/s12879-019-3921-7. [PMID: 31035938] - Shoji Maehara, Andria Agusta, Yoshimi Tokunaga, Hirotaka Shibuya, Toshiyuki Hata. Endophyte composition and Cinchona alkaloid production abilities of Cinchona ledgeriana cultivated in Japan.
Journal of natural medicines.
2019 Mar; 73(2):431-438. doi:
10.1007/s11418-018-1273-z. [PMID: 30552602] - Jinrong Li, Christian H Lemon. Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2019 02; 39(9):1631-1648. doi:
10.1523/jneurosci.2000-18.2018. [PMID: 30606758] - Shinsaku Yoshitomi, Yukitoshi Takahashi, Tokito Yamaguchi, Taikan Oboshi, Asako Horino, Hiroko Ikeda, Katsumi Imai, Tohru Okanishi, Mitsuko Nakashima, Hirotomo Saitsu, Naomichi Matsumoto, Jun Yoshimoto, Takako Fujita, Atsushi Ishii, Shinichi Hirose, Yushi Inoue. Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations.
Epileptic disorders : international epilepsy journal with videotape.
2019 Feb; 21(1):48-54. doi:
10.1684/epd.2019.1026. [PMID: 30782581] - Ana Leonor Pardo Campos Godoy, Natália Valadares de Moraes, Jhohann Richard de Lima Benzi, Vera Lucia Lanchote. Changes in tramadol enantioselective pharmacokinetics and metabolism in rats with experimental diabetes treated or not with insulin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Feb; 128(?):97-102. doi:
10.1016/j.ejps.2018.11.032. [PMID: 30502451] - Kenta Watanabe, Tadashi Tsubouchi, Toru Yamada, Eiichi Hinoi, Izuru Miyawaki. Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors.
The Journal of toxicological sciences.
2019; 44(7):441-457. doi:
10.2131/jts.44.441. [PMID: 31270301] - Qiong Wang, Haiyun Wang, Youyan Zhong, Qiang Zhang. Drug-Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats.
Drug design, development and therapy.
2019; 13(?):4207-4213. doi:
10.2147/dddt.s226948. [PMID: 31849452] - Stephy George, Margarita Taburyanskaya, Vicky Lewis. Probable drug-drug interaction between dabigatran and quinidine resulting in thrombin time rebound despite multiple idarucizumab doses.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2019 Jan; 30(1):42-46. doi:
10.1097/mbc.0000000000000782. [PMID: 30431448] - Ashish Dogra, Shipra Bhatt, Asmita Magotra, Anjna Sharma, Pankul Kotwal, Abhishek Gour, Priya Wazir, Gurdarshan Singh, Utpal Nandi. Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: A possible risk for long-term use.
Phytotherapy research : PTR.
2018 Oct; 32(10):1967-1974. doi:
10.1002/ptr.6123. [PMID: 29806225] - Adele Murauer, Markus Ganzera. Quantitative determination of major alkaloids in Cinchona bark by Supercritical Fluid Chromatography.
Journal of chromatography. A.
2018 Jun; 1554(?):117-122. doi:
10.1016/j.chroma.2018.04.038. [PMID: 29699870] - Juan G Ripoll, Mahrukh S Rizvi, Rebecca L King, Craig E Daniels. Severe Babesia microti infection presenting as multiorgan failure in an immunocompetent host.
BMJ case reports.
2018 May; 2018(?):. doi:
10.1136/bcr-2018-224647. [PMID: 29848533] - Sonia Goineau, Vincent Castagné. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers.
Journal of pharmacological and toxicological methods.
2018 Mar; 90(?):58-66. doi:
10.1016/j.vascn.2017.12.003. [PMID: 29274391] - Graziela Scheuer Gomes, Tamara Ramos Maciel, Eduarda Martini Piegas, Luana Roberta Michels, Letícia Marques Colomé, Rodrigo José Freddo, Daiana Silva de Ávila, Andre Gundel, Sandra Elisa Haas. Optimization of Curcuma Oil/Quinine-Loaded Nanocapsules for Malaria Treatment.
AAPS PharmSciTech.
2018 Feb; 19(2):551-564. doi:
10.1208/s12249-017-0854-6. [PMID: 28875471] - Ryutaro Matsui, Ryutaro Hattori, Youhei Usami, Masumi Koyama, Yuki Hirayama, Emi Matsuba, Yukiya Hashimoto. Functional characteristics of a renal H+/lipophilic cation antiport system in porcine LLC-PK1 cells and rats.
Drug metabolism and pharmacokinetics.
2018 Feb; 33(1):96-102. doi:
10.1016/j.dmpk.2017.11.313. [PMID: 29338932] - Saul A Mullen, Patrick W Carney, Annie Roten, Michael Ching, Paul A Lightfoot, Leonid Churilov, Umesh Nair, Melody Li, Samuel F Berkovic, Steven Petrou, Ingrid E Scheffer. Precision therapy for epilepsy due to KCNT1 mutations: A randomized trial of oral quinidine.
Neurology.
2018 01; 90(1):e67-e72. doi:
10.1212/wnl.0000000000004769. [PMID: 29196578] - Khan Muhammad Baloch, Khan Usmanghani, Ejaz Mohiuddin, Tasneem Qureshi, Muhammad Daniyal, Muhammad Ibrar Shinwari. A randomized, control and comparative study of polyherbal formulation use for Malaria (Plasmodium falciparum).
Pakistan journal of pharmaceutical sciences.
2018 Jan; 31(1(Suppl.)):291-297. doi:
". [PMID: 29386156] - John I Glendinning, Joyce Tang, Ana Paula Morales Allende, Bruce P Bryant, Lisa Youngentob, Steven L Youngentob. Fetal alcohol exposure reduces responsiveness of taste nerves and trigeminal chemosensory neurons to ethanol and its flavor components.
Journal of neurophysiology.
2017 08; 118(2):1198-1209. doi:
10.1152/jn.00108.2017. [PMID: 28490641] - Olasupo Stephen Adeniyi, Olubiyi Vincent Makinde, Emmanuel Titus Friday, Samuel Babafemi Olaleye. Effects of quinine on gastric ulcer healing in Wistar rats.
Journal of complementary & integrative medicine.
2017 Jun; 14(4):. doi:
10.1515/jcim-2016-0132. [PMID: 28665790] - Subramanyam J Tantry, Shankar D Markad, Vikas Shinde, Jyothi Bhat, Gayathri Balakrishnan, Amit K Gupta, Anisha Ambady, Anandkumar Raichurkar, Chaitanyakumar Kedari, Sreevalli Sharma, Naina V Mudugal, Ashwini Narayan, C N Naveen Kumar, Robert Nanduri, Sowmya Bharath, Jitendar Reddy, Vijender Panduga, K R Prabhakar, Karthikeyan Kandaswamy, Ramanatha Saralaya, Parvinder Kaur, Neela Dinesh, Supreeth Guptha, Kirsty Rich, David Murray, Helen Plant, Marian Preston, Helen Ashton, Darren Plant, Jarrod Walsh, Peter Alcock, Kathryn Naylor, Matthew Collier, James Whiteaker, Robert E McLaughlin, Meenakshi Mallya, Manoranjan Panda, Suresh Rudrapatna, Vasanthi Ramachandran, Radha Shandil, Vasan K Sambandamurthy, Khisi Mdluli, Christopher B Cooper, Harvey Rubin, Takahiro Yano, Pravin Iyer, Shridhar Narayanan, Stefan Kavanagh, Kakoli Mukherjee, V Balasubramanian, Vinayak P Hosagrahara, Suresh Solapure, Sudha Ravishankar, Shahul Hameed P. Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.
Journal of medicinal chemistry.
2017 02; 60(4):1379-1399. doi:
10.1021/acs.jmedchem.6b01358. [PMID: 28075132] - Zhou Meng, Harma Ellens, Joe Bentz. Extrapolation of Elementary Rate Constants of P-glycoprotein-Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells.
Drug metabolism and disposition: the biological fate of chemicals.
2017 02; 45(2):190-197. doi:
10.1124/dmd.116.072140. [PMID: 27856526] - G Gachelin, P Garner, E Ferroni, U Tröhler, I Chalmers. Evaluating Cinchona bark and quinine for treating and preventing malaria.
Journal of the Royal Society of Medicine.
2017 Feb; 110(2):73-82. doi:
10.1177/0141076816688411. [PMID: 28169590] - Ricardo P Garay, George T Grossberg. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type.
Expert opinion on investigational drugs.
2017 Jan; 26(1):121-132. doi:
10.1080/13543784.2017.1267726. [PMID: 27936965] - G Gachelin, P Garner, E Ferroni, U Tröhler, I Chalmers. Evaluating Cinchona bark and quinine for treating and preventing malaria.
Journal of the Royal Society of Medicine.
2017 Jan; 110(1):31-40. doi:
10.1177/0141076816681421. [PMID: 28106483] - Rao Mukkavilli, Gajanan Jadhav, Subrahmanyam Vangala. Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines.
Current pharmaceutical biotechnology.
2017; 18(14):1151-1158. doi:
10.2174/1389201019666180308091855. [PMID: 29521222] - Valerie B Duffy, Shristi Rawal, Jeeha Park, Mark H Brand, Mastaneh Sharafi, Bradley W Bolling. Characterizing and improving the sensory and hedonic responses to polyphenol-rich aronia berry juice.
Appetite.
2016 12; 107(?):116-125. doi:
10.1016/j.appet.2016.07.026. [PMID: 27457970] - Miki Fukao, Eri Kondo, Hiroki Nishino, Ryutaro Hattori, Asuka Horie, Yukiya Hashimoto. Presence of an H+/Quinidine Antiport System in Madin-Darby Canine Kidney Cells.
European journal of drug metabolism and pharmacokinetics.
2016 Dec; 41(6):819-824. doi:
10.1007/s13318-015-0314-1. [PMID: 26628429] - Suneetha Achanti, Raja Rajeswari Katta. High-throughput liquid chromatography tandem mass spectrometry method for simultaneous determination of fampridine, paroxetine, and quinidine in rat plasma: Application to in vivo perfusion study.
Journal of food and drug analysis.
2016 10; 24(4):866-875. doi:
10.1016/j.jfda.2016.03.004. [PMID: 28911626] - Charles P Taylor, Stephen F Traynelis, Joao Siffert, Laura E Pope, Rae R Matsumoto. Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use.
Pharmacology & therapeutics.
2016 08; 164(?):170-82. doi:
10.1016/j.pharmthera.2016.04.010. [PMID: 27139517] - Felicity Muth, Jacob S Francis, Anne S Leonard. Bees use the taste of pollen to determine which flowers to visit.
Biology letters.
2016 Jul; 12(7):. doi:
10.1098/rsbl.2016.0356. [PMID: 27405383] - Magdalena Bamburowicz-Klimkowska, Tadeusz Szost, Anna Małkowska, Mirosław Szutowski. QUINIDINE AND DOMPERIDONE INTERACTIONS IN THE RAT EXPERIMENTAL MODEL OF REPEATED ADMINISTRATION.
Acta poloniae pharmaceutica.
2016 07; 73(4):1057-1066. doi:
NULL. [PMID: 29648732] - Ken-Ichi Miyata, Yoshiaki Nakagawa, Yasuhisa Kimura, Kazumitsu Ueda, Miki Akamatsu. In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines.
Toxicology and applied pharmacology.
2016 May; 298(?):40-7. doi:
10.1016/j.taap.2016.03.008. [PMID: 26995013] - Shengxin Cai, April L Risinger, Shalini Nair, Jiangnan Peng, Timothy J C Anderson, Lin Du, Douglas R Powell, Susan L Mooberry, Robert H Cichewicz. Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants.
Journal of natural products.
2016 Mar; 79(3):490-8. doi:
10.1021/acs.jnatprod.5b00874. [PMID: 26722868] - Adebanjo J Adegbola, Julius O Soyinka, Babatunde A Adeagbo, Sharon I Igbinoba, Thomas I Nathaniel. Alteration of the Disposition of Quinine in Healthy Volunteers After Concurrent Ciprofloxacin Administration.
American journal of therapeutics.
2016 Mar; 23(2):e398-404. doi:
10.1097/mjt.0000000000000087. [PMID: 25406952] - Qin Ma, Jian-Guo Jiang. Functional Components from Nature-Derived Drugs for the Treatment of Rheumatoid Arthritis.
Current drug targets.
2016; 17(14):1673-1686. doi:
10.2174/1389450117666160527122233. [PMID: 27231112] - Henrik Permin, Svend Norn, Edith Kruse, Poul R Kruse. On the history of Cinchona bark in the treatment of Malaria.
Dansk medicinhistorisk arbog.
2016 ; 44(?):9-30. doi:
". [PMID: 29737660] - Li Liu, Ann C Collier, Jeanne M Link, Karen B Domino, David A Mankoff, Janet F Eary, Charles F Spiekerman, Peng Hsiao, Anand K Deo, Jashvant D Unadkat. Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Nov; 43(11):1795-804. doi:
10.1124/dmd.114.058685. [PMID: 26354948] - Johandie Gildenhuys, Chandre J Sammy, Ronel Müller, Victor A Streltsov, Tanya le Roex, David Kuter, Katherine A de Villiers. Alkoxide coordination of iron(III) protoporphyrin IX by antimalarial quinoline methanols: a key interaction observed in the solid-state and solution.
Dalton transactions (Cambridge, England : 2003).
2015 Oct; 44(38):16767-77. doi:
10.1039/c5dt02671g. [PMID: 26335948] - Jose Vicente, Jacob Simlund, Lars Johannesen, Frida Sundh, Jeffry Florian, Martin Ugander, Galen S Wagner, Raymond L Woosley, David G Strauss. Investigation of potential mechanisms of sex differences in quinidine-induced torsade de pointes risk.
Journal of electrocardiology.
2015 Jul; 48(4):533-8. doi:
10.1016/j.jelectrocard.2015.03.011. [PMID: 25796102] - Jianguo Sun, Ying Peng, Hui Wu, Xueyuan Zhang, Yunxi Zhong, Yanan Xiao, Fengyi Zhang, Huanhuan Qi, Lili Shang, Jianping Zhu, Yue Sun, Ke Liu, Jinghan Liu, Jiye A, Rodney J Y Ho, Guangji Wang. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms.
Drug metabolism and disposition: the biological fate of chemicals.
2015 May; 43(5):713-24. doi:
10.1124/dmd.114.060905. [PMID: 25681130] - Jose Vicente, Lars Johannesen, Jay W Mason, William J Crumb, Esther Pueyo, Norman Stockbridge, David G Strauss. Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil.
Journal of the American Heart Association.
2015 Apr; 4(4):. doi:
10.1161/jaha.114.001615. [PMID: 25870186] - Toyofumi Suzuki, Toshiro Fukami, Kazuo Tomono. Possible involvement of cationic-drug sensitive transport systems in the blood-to-brain influx and brain-to-blood efflux of amantadine across the blood-brain barrier.
Biopharmaceutics & drug disposition.
2015 Mar; 36(2):126-37. doi:
10.1002/bdd.1926. [PMID: 25410756] - Sharon I Igbinoba, Cyprian O Onyeji, Moses A Akanmu, Julius O Soyinka, Srirama Sarma V V Pullela, James M Cook, Thomas I Nathaniel. Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers.
Journal of clinical pharmacology.
2015 Mar; 55(3):348-54. doi:
10.1002/jcph.414. [PMID: 25328082] - Matthew R Durk, Jianghong Fan, Huadong Sun, Yingbo Yang, Henrianna Pang, K Sandy Pang, Inés A M de Lannoy. Vitamin D receptor activation induces P-glycoprotein and increases brain efflux of quinidine: an intracerebral microdialysis study in conscious rats.
Pharmaceutical research.
2015 Mar; 32(3):1128-40. doi:
10.1007/s11095-014-1524-y. [PMID: 25319098] - Bogna Badyra, Bartosz Lisowski, Sebastian Polak, John Kudolo, Barbara Wiśniowska. How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction.
Folia medica Cracoviensia.
2015; 55(4):5-19. doi:
. [PMID: 26867116] - Lily P H Yang, Emma D Deeks. Dextromethorphan/quinidine: a review of its use in adults with pseudobulbar affect.
Drugs.
2015 Jan; 75(1):83-90. doi:
10.1007/s40265-014-0328-z. [PMID: 25420446] - Motoya Suzuki, Hiroshi Komura, Tomonori Yoshikawa, Seiji Enya, Akemi Nagao, Hiroaki Takubo, Motohiro Kogayu. Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Nov; 44(11):1039-45. doi:
10.3109/00498254.2014.920551. [PMID: 24839994] - Gang Xie, Ka-Wing Cheng, Liqun Huang, Basil Rigas. The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent.
Biochemical pharmacology.
2014 Sep; 91(2):249-55. doi:
10.1016/j.bcp.2014.07.007. [PMID: 25044307] - Arjo Roersch van der Hoogte, Toine Pieters. Science in the service of colonial agro-industrialism: the case of cinchona cultivation in the Dutch and British East Indies, 1852-1900.
Studies in history and philosophy of biological and biomedical sciences.
2014 Sep; 47 Pt A(?):12-22. doi:
10.1016/j.shpsc.2014.05.019. [PMID: 24981994] - Laura Kervezee, Robin Hartman, Dirk-Jan van den Berg, Shinji Shimizu, Yumi Emoto-Yamamoto, Johanna H Meijer, Elizabeth C M de Lange. Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain.
The AAPS journal.
2014 Sep; 16(5):1029-37. doi:
10.1208/s12248-014-9625-4. [PMID: 24917180] - Karine Danno, Frédéric Rerolle, Sylvie de Sigalony, Aurélie Colas, Laurence Terzan, Marie-France Bordet. China rubra for side-effects of quinine: a prospective, randomised study in pregnant women with malaria in Cotonou, Benin.
Homeopathy : the journal of the Faculty of Homeopathy.
2014 Jul; 103(3):165-71. doi:
10.1016/j.homp.2014.03.002. [PMID: 24931747] - Geneviève Genest, David M P Thomson. Fixed drug eruption to quinine: a case report and review of the literature.
The journal of allergy and clinical immunology. In practice.
2014 Jul; 2(4):469-70. doi:
10.1016/j.jaip.2014.02.013. [PMID: 25017539] - Yan Liu, Mingmao Chen, Shuaihua Wang, Jingjing Lin, Lizhen Cai, Ling Song. New insight into the stereoselective interactions of quinine and quinidine, with bovine serum albumin.
Journal of molecular recognition : JMR.
2014 May; 27(5):239-49. doi:
10.1002/jmr.2355. [PMID: 24700591] - Mitesh Patel, Nanda K Mandava, Dhananjay Pal, Ashim K Mitra. Amino acid prodrug of quinidine: an approach to circumvent P-glycoprotein mediated cellular efflux.
International journal of pharmaceutics.
2014 Apr; 464(1-2):196-204. doi:
10.1016/j.ijpharm.2014.01.006. [PMID: 24440401] - Dominik Gartzke, Gert Fricker. Establishment of optimized MDCK cell lines for reliable efflux transport studies.
Journal of pharmaceutical sciences.
2014 Apr; 103(4):1298-304. doi:
10.1002/jps.23901. [PMID: 24532159] - Kassoum Kayentao, Etienne A Guirou, Ogobara K Doumbo, Meera Venkatesan, Christopher V Plowe, Teresa L Parsons, Craig W Hendrix, Myaing M Nyunt. Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection.
The American journal of tropical medicine and hygiene.
2014 Mar; 90(3):530-534. doi:
10.4269/ajtmh.13-0655. [PMID: 24420779] - Xiaochun Zhu, Yuping Chen, Raju Subramanian. Comparison of information-dependent acquisition, SWATH, and MS(All) techniques in metabolite identification study employing ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Analytical chemistry.
2014 Jan; 86(2):1202-9. doi:
10.1021/ac403385y. [PMID: 24383719] - Makoto Miyazaki, Chisako Nishimura, Minori Minamida, Kazunori Iwanaga, Masawo Kakemi. Pharmacokinetic assessment of absorptive interaction of oral etoposide and morphine in rats.
Biological & pharmaceutical bulletin.
2014; 37(3):371-7. doi:
10.1248/bpb.b13-00716. [PMID: 24351551] - Linda Björkhem-Bergman, Tobias Bäckström, Hanna Nylén, Yuko Rönquist-Nii, Eva Bredberg, Tommy B Andersson, Leif Bertilsson, Ulf Diczfalusy. Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.
Drug metabolism and pharmacokinetics.
2014; 29(4):352-5. doi:
10.2133/dmpk.dmpk-13-sh-138. [PMID: 24522201] - Gary N Y Chan, Victor Saldivia, Yingbo Yang, Henrianna Pang, Inés de Lannoy, Reina Bendayan. In vivo induction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study.
Journal of neurochemistry.
2013 Nov; 127(3):342-52. doi:
10.1111/jnc.12344. [PMID: 23777437] - Adrian Martin Pohlit, Renata Braga Souza Lima, Gina Frausin, Luiz Francisco Rocha E Silva, Stefanie Costa Pinto Lopes, Carolina Borsoi Moraes, Pedro Cravo, Marcus Vinícius Guimarães Lacerda, André Machado Siqueira, Lucio H Freitas-Junior, Fabio Trindade Maranhão Costa. Amazonian plant natural products: perspectives for discovery of new antimalarial drug leads.
Molecules (Basel, Switzerland).
2013 Aug; 18(8):9219-40. doi:
10.3390/molecules18089219. [PMID: 23917112] - Kaliyaperumal Karunamoorthi, Shanmugavelu Sabesan, Kaliyaperumal Jegajeevanram, Jayaraman Vijayalakshmi. Role of traditional antimalarial plants in the battle against the global malaria burden.
Vector borne and zoonotic diseases (Larchmont, N.Y.).
2013 Aug; 13(8):521-44. doi:
10.1089/vbz.2011.0946. [PMID: 23930972] - Joost Westerhout, Jean Smeets, Meindert Danhof, Elizabeth C M de Lange. The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid.
Journal of pharmacokinetics and pharmacodynamics.
2013 Jun; 40(3):327-42. doi:
10.1007/s10928-013-9314-4. [PMID: 23539188] - Seok-Jeong Oh, Hyo-Kyung Han, Keon-Wook Kang, Young-Joo Lee, Moo-Yeol Lee. Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity.
Archives of pharmacal research.
2013 Apr; 36(4):509-16. doi:
10.1007/s12272-013-0052-3. [PMID: 23435914] - Swaroop Kumar Pandey, Hemlata Dwivedi, Sarika Singh, Waseem Ahmad Siddiqui, Renu Tripathi. Antimalarial interaction of quinine and quinidine with clarithromycin.
Parasitology.
2013 Mar; 140(3):406-13. doi:
10.1017/s003118201200176x. [PMID: 23137860] - Nilufer Rahmioglu, James Heaton, Gail Clement, Raj Gill, Gabriela Surdulescu, Karolina Zlobecka, Dylan Hodgkiss, Norman W Smith, Kourosh R Ahmadi. Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity.
European journal of drug metabolism and pharmacokinetics.
2013 Mar; 38(1):63-7. doi:
10.1007/s13318-012-0103-z. [PMID: 22945461] - Philippe Cettour-Rose, Carole Bezençon, Christian Darimont, Johannes le Coutre, Sami Damak. Quinine controls body weight gain without affecting food intake in male C57BL6 mice.
BMC physiology.
2013 Feb; 13(?):5. doi:
10.1186/1472-6793-13-5. [PMID: 23394313] - Hania Habeeb, Jill R Ripper, Alice Cohen, Patrick B Hinfey. A case of imported severe plasmodium falciparum malaria in the emergency department and the current role of exchange transfusion treatment.
The Journal of emergency medicine.
2013 Feb; 44(2):e211-5. doi:
10.1016/j.jemermed.2012.02.051. [PMID: 22609412]