Hysco (BioDeep_00000397393)

PANOMIX_OTCML-2023 Chemicals and Drugs

代谢物信息卡片

BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, (1.ALPHA.,2.BETA.,4.BETA.,5.ALPHA.,7.BETA.)-9-METHYL-3-OXA-9-AZATRICYCLO(3.3.1.02,4)NON-7-YL ESTER, HYDROBROMIDE, HYDRATE (1:1:3), (.ALPHA.S)-

化学式: C17H21NO4.BrH.3H2O (437.10490380000005)
中文名称: (-)-东莨菪碱氢溴酸盐三水合物, 东莨菪碱氢溴酸盐三水合物, 氢溴酸菪胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4.O.O.O.Br
InChI: 1H

描述信息

Scopolamine hydrobromide trihydrate appears as white orthorhombic sphenoidal crystals from water. pH of 0.05 molar solution: 5.85. (NTP, 1992)
Scopolamine hydrobromide trihydrate is a hydrate that is the trihydrate form of scopolamine hydrobromide. It has a role as a mydriatic agent, a muscarinic antagonist, an anaesthesia adjuvant, an antispasmodic drug and an antiemetic. It contains a scopolamine hydrobromide (anhydrous).
Scopolamine Hydrobromide is the hydrobromide salt form of scopolamine, a tropane alkaloid derived from plants of the nightshade family (Solanaceae), specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties. Structurally similar to acetylcholine, scopolamine antagonizes acetylcholine activity mediated by muscarinic receptors located on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. The agent is used to cause mydriasis, cycloplegia, to control the secretion of saliva and gastric acid, to slow gut motility, and prevent vomiting.
An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Its many uses include an anesthetic premedication, the treatment of URINARY INCONTINENCE and MOTION SICKNESS, an antispasmodic, and a mydriatic and cycloplegic.
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
C78283 - Agent Affecting Organs of Special Senses > C29706 - Mydriatic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents

同义名列表

59 个代谢物同义名

BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, (1.ALPHA.,2.BETA.,4.BETA.,5.ALPHA.,7.BETA.)-9-METHYL-3-OXA-9-AZATRICYCLO(3.3.1.02,4)NON-7-YL ESTER, HYDROBROMIDE, HYDRATE (1:1:3), (.ALPHA.S)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo(3.3.1.0(sup 2,4))non-7-yl ester, hydrobromide, trihydrate, (alphaS)-; Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(sup 2,4))non-7-yl ester, hydrobromide, trihydrate, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-; Benzeneacetic acid, alpha-(hydroxymethyl)-, (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, hydrobromide, trihydrate, (alphaS)-; (1R,2R,4S,5S,7s,9s)-7-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane bromide--water (1/3); (1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate hydrobromide--water (1/3); (S)-(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 3-hydroxy-2-phenylpropanoate hydrobromide trihydrate; 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, 6-beta,7-beta-epoxy-, (-)-tropate (ester), hydrobromide, trihydrate; 6.BETA.,7.BETA.-EPOXY-1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-OL (-)-TROPATE (ESTER) HYDROBROMIDE TRIHYDRATE; 6beta,7beta-Epoxy-1alphaH,5alphaH-tropan-3alpha-ol (-)-tropate (ester) hydrobromide trihydrate; Scopolamine hydrobromide, United States Pharmacopeia (USP) Reference Standard; (-)-Scopolamine hydrobromide trihydrate, >=98\\% (HPLC), powder; Scopolamine hydrobromide, meets USP testing specifications; HYOSCINE HYDROBROMIDE TRIHYDRATE [WHO-DD]; SCOPOLAMINE HYDROBROMIDE [USP MONOGRAPH]; SCOPOLAMINE HYDROBROMIDE TRIHYDRATE [MI]; (-)-Scopolamine hydrobromide trihydrate; SCOPOLAMINE HYDROBROMIDE HYDRATE [JAN]; SCOPOLAMINE HYDROBROMIDE, TRIHYDRATE; HYOSCINE HYDROBROMIDE [EP MONOGRAPH]; Scopolamine hydrobromide trihydrate; Scopalamine hydrobromide trihydrate; Scopolamine hydrobromide [USP:JAN]; scopolammonium bromide trihydrate; SCOPOLAMINE HYDROBROMIDE [USP-RS]; SCOPOLAMINUM HYDROBROMIDUM [HPUS]; Hyoscine hydrobromide trihydrate; SCOPOLAMINE HYDROBROMIDE [VANDF]; scopolaminium bromide trihydrate; Scopolamine hydrobromide hydrate; HYOSCINE HYDROBROMIDE [VANDF]; HYOSCINE HYDROBROMIDE [MART.]; Scopolamine hbr, trihydrate; LACQPOBCQQPVIT-SEYKEWMNSA-N; Scopolaminum hydrobromidum; Scopolamine HBr trihydrate; Scopolamine hydrobromide; Hyoscine hydrobromide; Scopolamine Cooper; Scopolamine HBr; Isopto Hyoscine; Transderm-Scop; Transderm Scop; Scopoderm TTS; Travacalm HO; Tox21_200867; Tox21_111179; HYOSCINE HBr; Transderm V; Scopolamine; Boro Scopol; Boro-Scopol; Transderm-V; Scoburen; Vorigeno; Hyoscine; Scopace; Kwells; Hysco

数据库引用编号

10 个数据库交叉引用编号

ChEBI: CHEBI:61272
PubChem: 20055509
ChEMBL: CHEMBL4546350
ChEMBL: CHEMBL2251240
ChEMBL: CHEMBL4065982
MeSH: Scopolamine
ChemIDplus: 0006533682
CAS: 6533-68-2
CAS: 114-49-8
medchemexpress: HY-W010892

分类词条

生物碱

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Ban Chen, Shuangshuang Liu, Xican Li, Rongxin Cai, Chunhou Li, Yuchen Hu, Jiangtao Su, Tongxun Lei. Database-aided ultrahigh-performance liquid chromatography Q-Exactive-Orbitrap tandem mass spectrometry putatively identifies 16 unexpected compounds and three anticounterfeiting pharmacopoeia quality markers for Perillae Fructus. Rapid communications in mass spectrometry : RCM. 2024 Jul; 38(13):e9762. doi: 10.1002/rcm.9762. [PMID: 38693787]
Yi-Ju Lee, Chang-Mao Lin, Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang, Li-Sung Hsu. Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis. Environmental toxicology. 2024 May; 39(5):3198-3210. doi: 10.1002/tox.24175. [PMID: 38351887]
Yuqin Gou, Yanming Jing, Jiaxin Song, Mohammad Mahmoud Nagdy, Chao Peng, Lingjiang Zeng, Min Chen, Xiaozhong Lan, Zun Lai Lai Htun, Zhihua Liao, Yan Li. A novel bHLH gene responsive to low nitrogen positively regulates the biosynthesis of medicinal tropane alkaloids in Atropa belladonna. International journal of biological macromolecules. 2024 May; 266(Pt 1):131012. doi: 10.1016/j.ijbiomac.2024.131012. [PMID: 38522709]
Reza Babanzadeh, Seyed Yaser Vafaei, Davood Ahmadi Moghadam, Alireza Komaki, Mojdeh Mohammadi. Quercetin-loaded nanoemulsions prevent Scopolamine-induced neurotoxicity in male rats. Physiology & behavior. 2024 Apr; 277(?):114494. doi: 10.1016/j.physbeh.2024.114494. [PMID: 38360390]
Maria Lazarova, Elina Tsvetanova, Almira Georgieva, Miroslava Stefanova, Diamara Uzunova, Petko Denev, Valya Vassileva, Krasimira Tasheva. Extracts of Sideritis scardica and Clinopodium vulgare Alleviate Cognitive Impairments in Scopolamine-Induced Rat Dementia. International journal of molecular sciences. 2024 Feb; 25(3):. doi: 10.3390/ijms25031840. [PMID: 38339117]
Rui-Dan Hu, Wen-Li Zhu, Wei-Yao Lin, Yu-Hui Qiu, Guang-Liang Wu, Xiao-Ying Ding, Zhen-Kun Yang, Qian Feng, Rong-Rong Zhang, Li-Jun Qiao, Ye-Feng Cai, Shi-Jie Zhang. Ethanol extract of Evodia lepta Merr. ameliorates cognitive impairment through inhibiting NLRP3 inflammasome in scopolamine-treated mice. Aging. 2024 Jan; 16(?):. doi: 10.18632/aging.205486. [PMID: 38284892]
Haojie Ni, Muqiu Liu, Mindie Cao, Lingyu Zhang, Yijing Zhao, Lang Yi, Yanwu Li, Liang Liu, Peixun Wang, Qun Du, Hua Zhou, Yan Dong. Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4/NF-κB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer's disease mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 171(?):116190. doi: 10.1016/j.biopha.2024.116190. [PMID: 38278026]
Shuyao Ruan, Jiaqi Li, Hang Ruan, Qing Xia, Xiaolin Hou, Zhi Wang, Teng Guo, Chunyun Zhu, Nianping Feng, Yongtai Zhang. Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment. Journal of controlled release : official journal of the Controlled Release Society. 2024 Jan; 366(?):712-731. doi: 10.1016/j.jconrel.2024.01.013. [PMID: 38219911]
Ismaheel Akinwale Adeniyi, Peace Oluwafolakemi Oregbesan, Adegboyega Adesanya, Mujeedat Adebukola Olubori, Gbenga Stanley Olayinka, Abayomi Mayowa Ajayi, Samuel Adetunji Onasanwo. Olax subscorpioidea prevented scopolamine-induced memory impairment through the prevention of oxido-inflammatory damage and modulation of cholinergic transmission. Journal of ethnopharmacology. 2024 Jan; 318(Pt B):116995. doi: 10.1016/j.jep.2023.116995. [PMID: 37541399]
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang. Ameliorative effect of scopolamine-induced cognitive dysfunction by Fufangmuniziqi formula: The roles of alkaloids, saponins, and flavonoids. Journal of ethnopharmacology. 2024 Jan; 318(Pt A):116792. doi: 10.1016/j.jep.2023.116792. [PMID: 37356745]
Maria I Lazarova, Elina R Tsvetanova, Almira P Georgieva, Miroslava O Stefanova, Diamara N Uzunova, Petko N Denev, Krasimira N Tasheva. Marrubium vulgare Extract Improves Spatial Working Memory and Oxidative Stress Damage in Scopolamine-Treated Rats. Journal of Alzheimer's disease : JAD. 2024; 99(s1):S157-S169. doi: 10.3233/jad-231011. [PMID: 38489175]
Veronica Amoah, Paul Atawuchugi, Yakubu Jibira, Augustine Tandoh, Paul Poku Sampene Ossei, George Sam, George Ainooson. Lantana camara leaf extract ameliorates memory deficit and the neuroinflammation associated with scopolamine-induced Alzheimer's-like cognitive impairment in zebrafish and mice. Pharmaceutical biology. 2023 Dec; 61(1):825-838. doi: 10.1080/13880209.2023.2209130. [PMID: 37212299]
Xiajing Xu, Yutong Song, Man Jiang, Meihan Liu, Xuanmeng Zhang, Dongmei Wang, Yingni Pan, Shumeng Ren, Xiaoqiu Liu. Screening of the Active Substances for the Assessment of Walnut Kernel in the Treatment of Scopolamine-Induced AD Animals. Molecular nutrition & food research. 2023 Nov; ?(?):e2200816. doi: 10.1002/mnfr.202200816. [PMID: 38018298]
Qiumei Zhang, Yujiao Li, Bei Fan, Fengzhong Wang, Zhi Li, Alberto Carlos Pires Dias, Xinmin Liu, Qiong Wang. Dendrobium nobile Lindl ameliorates learning and memory deficits in scopolamine-treated mice. Journal of ethnopharmacology. 2023 Nov; 324(?):117416. doi: 10.1016/j.jep.2023.117416. [PMID: 37981114]
Sung Bae Kim, Hyun Yeoul Ryu, Woo Nam, So Min Lee, Mi Ran Jang, Youn Gil Kwak, Gyoo Il Kang, Kyung Seok Song, Jae Won Lee. The Neuroprotective Effects of Dendropanax morbifera Water Extract on Scopolamine-Induced Memory Impairment in Mice. International journal of molecular sciences. 2023 Nov; 24(22):. doi: 10.3390/ijms242216444. [PMID: 38003650]
Mahalingam Jeyakumar, Devasahayam Jaya Balan, Chandramohan Kiruthiga, Sakthivel Jafni, Kasi Pandima Devi. α-bisabolol β-d-fucopyranoside (ABFP) ameliorates scopolamine-induced memory deficits through cholinesterase inhibition and attenuation of oxidative stress in zebrafish (Danio rerio). Journal of biochemical and molecular toxicology. 2023 Nov; ?(?):e23580. doi: 10.1002/jbt.23580. [PMID: 37961937]
Farimah Moazzam, Ashrafalsadat Hatamian-Zarmi, Bahman Ebrahimi Hosseinzadeh, Fariba Khodagholi, Meisam Rooki, Fatemehsadat Rashidi. Preparation and characterization of brain-targeted polymeric nanocarriers (Frankincense-PMBN-lactoferrin) and in-vivo evaluation on an Alzheimer's disease-like rat model induced by scopolamine. Brain research. 2023 Oct; ?(?):148622. doi: 10.1016/j.brainres.2023.148622. [PMID: 37832760]
Rohit Malik, Sunishtha Kalra, Pooja, Govind Singh, Meenu, Vinod Gahlot, Anjali Kajal, Rimpy. Antioxidative and neuroprotective potential of Acorus calamus linn. and Cordia dichotoma G. Forst. In Alzheimer's type dementia in rodent. Brain research. 2023 Oct; 1822(?):148616. doi: 10.1016/j.brainres.2023.148616. [PMID: 37793605]
Baile Ning, Zhifang Wang, Jiangshan He, Qian Wu, Qiyue Deng, Qing Yang, Jing Gao, Wen Fu, Ying Deng, Bingxin Wu, Xichang Huang, Jilin Mei, Fan Jiang, Wenbin Fu. The rapid antidepressant effect of acupuncture on two animal models of depression by inhibiting M1-Ach receptors regulates synaptic plasticity in the prefrontal cortex. Brain research. 2023 Sep; 1822(?):148609. doi: 10.1016/j.brainres.2023.148609. [PMID: 37783259]
Fanying Deng, Fuxia Zhao, Wenhui Wang, Shiqi Liu, Yan Wang. Serum lipidomics reveal the mechanism of memory disorder improvement by Qifu decoction. Analytical methods : advancing methods and applications. 2023 Sep; ?(?):. doi: 10.1039/d3ay00899a. [PMID: 37668283]
Hira Afshan, Humera Khatoon, Aisha Aziz, Mariam Arefa, Sheikh Abdul Khaliq, Nausheen Alam. Memory and cognition enhancing effects of combination of Melissa officinalis and Panax ginseng. Pakistan journal of pharmaceutical sciences. 2023 Sep; 36(5(Special)):1609-1618. doi: ". [PMID: 38008959]
Qi Xie, Xianrun Hu, Xiang Zhao, Zedong Xiang, Qianping Chen, Zhejun Xie, Hanxue Wang, Yonglin Zhao, Xuemei Cheng, Changhong Wang. Effects and mechanism of extracts rich in phenylpropanoids-polyacetylenes and polysaccharides from Codonopsis Radix on improving scopolamine-induced memory impairment of mice. Journal of ethnopharmacology. 2023 Aug; 319(Pt 1):117106. doi: 10.1016/j.jep.2023.117106. [PMID: 37652198]
Xiajing Xu, Yong Ding, Meihan Liu, Xuanmeng Zhang, Dongmei Wang, Yingni Pan, Shumeng Ren, Xiaoqiu Liu. Neuroprotective mechanisms of defatted walnut powder against scopolamine-induced Alzheimer's disease in mice revealed through metabolomics and proteomics analyses. Journal of ethnopharmacology. 2023 Aug; 319(Pt 1):117107. doi: 10.1016/j.jep.2023.117107. [PMID: 37652196]
Rafia Ferdous, Md Badrul Islam, Md Yusuf Al-Amin, Anik Kumar Dey, Md Omar Ali Mondal, Md Nurul Islam, Ahm Khurshid Alam, Aziz Abdur Rahman, Md Golam Sadik. Anticholinesterase and antioxidant activity of Drynaria quercifolia and its ameliorative effect in scopolamine-induced memory impairment in mice. Journal of ethnopharmacology. 2023 Aug; ?(?):117095. doi: 10.1016/j.jep.2023.117095. [PMID: 37634747]
Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Roua A Alsubki, Kaynat Sajid, Sana Shoukat, Kotb A Attia, Sajid Fiaz, Shaukat Ali, Itoh Kimiko, Ghulam Muhammad Ali. Synergistic neuroprotection by phytocompounds of Bacopa monnieri in scopolamine-induced Alzheimer's disease mice model. Molecular biology reports. 2023 Aug; ?(?):. doi: 10.1007/s11033-023-08674-0. [PMID: 37535247]
Lizeth M Zavala-Ocampo, Perla Y López-Camacho, Eva Aguirre-Hernández, René Cárdenas-Vázquez, Herlinda Bonilla-Jaime, Gustavo Basurto-Islas. Neuroprotective effects of Petiveria alliacea on scopolamine-induced learning and memory impairment mouse model. Journal of ethnopharmacology. 2023 Jul; 318(Pt A):116881. doi: 10.1016/j.jep.2023.116881. [PMID: 37460029]
Swati Pant, Mohan Gupta, Tulika Anthwal, Monika Chauhan, Sumitra Nain. Neuroprotective effects of novel pyrrolidine-2-one derivatives on scopolamine-induced cognitive impairment in mice: Behavioral and biochemical analysis. Pharmacology, biochemistry, and behavior. 2023 Jul; ?(?):173602. doi: 10.1016/j.pbb.2023.173602. [PMID: 37453560]
Umesh Chandra Dash, Sandeep Kumar Swain, Atala Bihari Jena, Jagnehswar Dandapat, Atish Kumar Sahoo. The ameliorative effect of Piper trioicum in attenuating cognitive deficit in scopolamine induced neurotoxicity in experimental rats. Journal of ethnopharmacology. 2023 Jul; ?(?):116911. doi: 10.1016/j.jep.2023.116911. [PMID: 37451488]
Mater H Mahnashi, Muhammad Ashraf, Abdulaziz Hassan Alhasaniah, Hammad Ullah, Alam Zeb, Mehreen Ghufran, Shah Fahad, Muhammad Ayaz, Maria Daglia. Polyphenol-enriched Desmodium elegans DC. ameliorate scopolamine-induced amnesia in animal model of Alzheimer's disease: In Vitro, In Vivo and In Silico approaches. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 165(?):115144. doi: 10.1016/j.biopha.2023.115144. [PMID: 37437376]
Rengasamy Balakrishnan, Yon-Suk Kim, Ga-Won Kim, Woo-Jung Kim, Sun-Mee Hong, Choong-Gon Kim, Dong-Kug Choi. Standardized extract of Glehnia Littoralis abrogates memory impairment and neuroinflammation by regulation of CREB/BDNF and NF-κB/MAPK signaling in scopolamine-induced amnesic mice model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 165(?):115106. doi: 10.1016/j.biopha.2023.115106. [PMID: 37421783]
Ismail O Ishola, Taiwo Grace Olubodun-Obadun, Abisola Sekinat Akinwande, Olufunmilayo Olaide Adeyemi. Cajanus cajan (L) Millsp. seed extract ameliorates scopolamine-induced amnesia through increase in antioxidant defense mechanisms and cholinergic neurotransmission. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2023 Jun; 38(1):91-99. doi: 10.54548/njps.v38i1.13. [PMID: 38243363]
Rifat Jahan, Mohammad Yousaf, Hamayun Khan, Shahid Ali Shah, Abdul Aziz Khan, Nousheen Bibi, Fatima Javed, Musarrat Ijaz, Arif Ali, Dong-Qing Wei. Zinc Ortho Methyl Carbonodithioate Improved Pre and Post-Synapse Memory Impairment via SIRT1/p-JNK Pathway against Scopolamine in Adult Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023 Jun; ?(?):. doi: 10.1007/s11481-023-10067-w. [PMID: 37261605]
Juan M Minoia, María E Villanueva, Guillermo J Copello, Julián Rodríguez Talou, Alejandra B Cardillo. Recycling of hyoscyamine 6β-hydroxylase for the in vitro production of anisodamine and scopolamine. Applied microbiology and biotechnology. 2023 Apr; ?(?):. doi: 10.1007/s00253-023-12537-w. [PMID: 37099059]
Yuman Xie, Li Liu, Junzuo Zheng, Kun Shi, Wenqi Ai, Xuesong Zhang, Ping Wang, Zhou Lan, Lvyi Chen. Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma ameliorate scopolamine-induced cognitive impairment by regulating the cholinergic and synaptic associated proteins. Journal of ethnopharmacology. 2023 Mar; 311(?):116400. doi: 10.1016/j.jep.2023.116400. [PMID: 37003402]
Seung-Eun Lee, Saetbyeol Park, Gwi Yeong Jang, Jeonghoon Lee, Minho Moon, Yun-Jeong Ji, Ji Wook Jung, Yunkwon Nam, Soo Jung Shin, Yunji Lee, Jehun Choi, Dong Hwi Kim. Extract of Aster koraiensis Nakai Leaf Ameliorates Memory Dysfunction via Anti-inflammatory Action. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065765. [PMID: 36982837]
Fangyuan Zhang, Fei Qiu, Junlan Zeng, Zhichao Xu, Yueli Tang, Tengfei Zhao, Yuqin Gou, Fei Su, Shiyi Wang, Xiuli Sun, Zheyong Xue, Weixing Wang, Chunxian Yang, Lingjiang Zeng, Xiaozhong Lan, Min Chen, Junhui Zhou, Zhihua Liao. Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family. Nature communications. 2023 Mar; 14(1):1446. doi: 10.1038/s41467-023-37133-4. [PMID: 36922496]
Maria I Lazarova, Lyubka P Tancheva, Krasimira N Tasheva, Petko N Denev, Diamara N Uzunova, Miroslava O Stefanova, Elina R Tsvetanova, Almira P Georgieva, Reni E Kalfin. Effects of Sideritis scardica Extract on Scopolamine-Induced Learning and Memory Impairment in Mice. Journal of Alzheimer's disease : JAD. 2023 Mar; ?(?):. doi: 10.3233/jad-230017. [PMID: 36872784]
Khushboo Govind Faldu, Snehal Sanjay Patel, Jigna Samir Shah. Celastrus paniculatus oil ameliorates NF-KB mediated neuroinflammation and synaptic plasticity in the scopolamine-induced cognitive impairment rat model. Metabolic brain disease. 2023 Feb; ?(?):. doi: 10.1007/s11011-023-01186-7. [PMID: 36809523]
Binod Timalsina, Md Nazmul Haque, Ho Jin Choi, Raju Dash, Il Soo Moon. Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model. Phytotherapy research : PTR. 2023 Feb; ?(?):. doi: 10.1002/ptr.7777. [PMID: 36808768]
Yogesh Chand Yadav, Satyanarayan Pattnaik. Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect. Drug development and industrial pharmacy. 2023 Feb; 49(2):240-247. doi: 10.1080/03639045.2023.2201625. [PMID: 37032647]
Monique de Nijs, Colin Crews, Folke Dorgelo, Susan MacDonald, Patrick P J Mulder. Emerging Issues on Tropane Alkaloid Contamination of Food in Europe. Toxins. 2023 Jan; 15(2):. doi: 10.3390/toxins15020098. [PMID: 36828413]
Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A Alananzeh, Mohd Nizam Mordi. Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies. Journal of ethnopharmacology. 2023 Jan; 300(?):115753. doi: 10.1016/j.jep.2022.115753. [PMID: 36162546]
Sakshi Tyagi, Ajit Kumar Thakur. Neuropharmacological Study on Capsaicin in Scopolamine-injected Mice. Current Alzheimer research. 2023; 20(9):660-676. doi: 10.2174/0115672050286225231230130613. [PMID: 38213170]
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