GarcinoicAcid (BioDeep_00000397317)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(2E,6E,10E)-13-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydrochromen-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid

化学式: C27H38O4 (426.2769948)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=CC(=C2O[C@@](C)(CCC=12)CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C(O)=O)\C)C)O
InChI: InChI=1S/C27H38O4/c1-19(11-7-13-21(3)26(29)30)9-6-10-20(2)12-8-15-27(5)16-14-23-18-24(28)17-22(4)25(23)31-27/h9,12-13,17-18,28H,6-8,10-11,14-16H2,1-5H3,(H,29,30)/b19-9+,20-12+,21-13+/t27-/m1/s1

描述信息

(2e,6e,10e)-13-[(2r)-6-hydroxy-2,8-dimethyl-3,4-dihydrochromen-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid is a tocotrienol.
GarcinoicAcid is a natural product found in Garcinia kola with data available.

同义名列表

8 个代谢物同义名

(2E,6E,10E)-13-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydrochromen-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid; (6-hydroxy-2R,8-dimethyl-3,4-dihydrochromen-2-yl)-2,6,10-trimethyltrideca-2E,6E,10E-trienoic acid; Garcinoic acid, >=90\\% (LC/MS-ELSD); trans-delta-Tocotrienoloic acid; tocotrienoloic acid; Garcinoic acid; GarcinoicAcid; NQD



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Olumayokun A Olajide, Victoria U Iwuanyanwu, Izabela Lepiarz-Raba, Alaa A Al-Hindawi, Mutalib A Aderogba, Hazel L Sharp, Robert J Nash. Garcinia kola and garcinoic acid suppress SARS-CoV-2 spike glycoprotein S1-induced hyper-inflammation in human PBMCs through inhibition of NF-κB activation. Phytotherapy research : PTR. 2021 Dec; 35(12):6963-6973. doi: 10.1002/ptr.7315. [PMID: 34697842]
  • Konstantin Neukirch, Khaled Alsabil, Chau-Phi Dinh, Rossella Bilancia, Martin Raasch, Alexia Ville, Ida Cerqua, Guillaume Viault, Dimitri Bréard, Simona Pace, Veronika Temml, Elena Brunner, Paul M Jordan, Marta C Marques, Konstantin Loeser, André Gollowitzer, Stephan Permann, Jana Gerstmeier, Stefan Lorkowski, Hermann Stuppner, Ulrike Garscha, Tiago Rodrigues, Gonçalo J L Bernardes, Daniela Schuster, Denis Séraphin, Pascal Richomme, Antonietta Rossi, Alexander S Mosig, Fiorentina Roviezzo, Oliver Werz, Jean-Jacques Helesbeux, Andreas Koeberle. Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation. Journal of medicinal chemistry. 2021 08; 64(15):11496-11526. doi: 10.1021/acs.jmedchem.1c00806. [PMID: 34279935]
  • Chau Phi Dinh, Alexia Ville, Konstantin Neukirch, Guillaume Viault, Veronika Temml, Andreas Koeberle, Oliver Werz, Daniela Schuster, Hermann Stuppner, Pascal Richomme, Jean-Jacques Helesbeux, Denis Séraphin. Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. European journal of medicinal chemistry. 2020 Sep; 202(?):112518. doi: 10.1016/j.ejmech.2020.112518. [PMID: 32668380]
  • Yusuke Hioki, Siaw Onwona-Agyeman, Yuya Kakumu, Hiroyuki Hattori, Kosei Yamauchi, Tohru Mitsunaga. Garcinoic Acids and a Benzophenone Derivative from the Seeds of Garcinia kola and Their Antibacterial Activities against Oral Bacterial Pathogenic Organisms. Journal of natural products. 2020 07; 83(7):2087-2092. doi: 10.1021/acs.jnatprod.9b01045. [PMID: 32644811]
  • Maria Wallert, Julia Bauer, Stefan Kluge, Lisa Schmölz, Yung-Chih Chen, Melanie Ziegler, Amy K Searle, Alexander Maxones, Martin Schubert, Maria Thürmer, Helmut Pein, Andreas Koeberle, Oliver Werz, Marc Birringer, Karlheinz Peter, Stefan Lorkowski. The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response. Redox biology. 2019 06; 24(?):101166. doi: 10.1016/j.redox.2019.101166. [PMID: 30897408]
  • Khaled Alsabil, Sorphon Suor-Cherer, Andreas Koeberle, Guillaume Viault, Alexis Lavaud, Veronika Temml, Birgit Waltenberger, Daniela Schuster, Marc Litaudon, Stefan Lorkowski, René de Vaumas, Jean-Jacques Helesbeux, David Guilet, Hermann Stuppner, Oliver Werz, Denis Seraphin, Pascal Richomme. Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors. Planta medica. 2016 Jul; 82(11-12):1110-6. doi: 10.1055/s-0042-108739. [PMID: 27286327]
  • Francesco Mazzini, Michele Betti, Thomas Netscher, Francesco Galli, Piero Salvadori. Configuration of the vitamin E analogue garcinoic acid extracted from Garcinia Kola seeds. Chirality. 2009 May; 21(5):519-24. doi: 10.1002/chir.20630. [PMID: 18655162]
  • R Braithwaite, S Montgomery, S Dawling. Nortriptyline in depressed patients with high plasma levels. II. Clinical pharmacology and therapeutics. 1978 Mar; 23(3):303-8. doi: 10.1002/cpt1978233303. [PMID: 627136]