Gardenin (BioDeep_00000397186)

Main id: BioDeep_00000266163

 

PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 5-hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)-

化学式: C21H22O9 (418.1263762)
中文名称: 栀子(黄)素A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(OC)=C(OC)C2OC(C3C=C(OC)C(OC)=C(OC)C=3)=CC(=O)C=2C(O)=C1OC
InChI: InChI=1S/C21H22O9/c1-24-13-7-10(8-14(25-2)17(13)26-3)12-9-11(22)15-16(23)19(27-4)21(29-6)20(28-5)18(15)30-12/h7-9,23H,1-6H3

描述信息

Gardenin A is a natural product found in Gardenia resinifera, Tamarix dioica, and Murraya paniculata with data available.

同义名列表

23 个代谢物同义名

4H-1-Benzopyran-4-one, 5-hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)-; 4H-1-Benzopyran-4-one,5-hydroxy-6,7,8- trimethoxy-2-(3,4,5-trimethoxyphenyl)-; 5-Hydroxy-6,7,8-trimethoxy-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one; 5-hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one; 5-hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one; 4H-1-Benzopyran-4-one,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)-; 5-hydroxy-6,7,8,3,4,5-hexamethoxyflavone; 5-Hydroxy-3,4,5,6,7,8-hexamethoxyflavone; 3,4,5,6,7,8-Hexamethoxy-5-hydroxyflavone; 5-Hydroxy-6,7,8,3,4,5-Hexamethoxyflaone; Flavone,4,5,6,7,8-hexamethoxy-; MQBFFYQCZCKSBX-UHFFFAOYSA-N; 5OH3456,7,8-hexMeO-Flavone; gardenin a, AldrichCPR; GARDENIN A [MI]; UNII-24J0W87Z43; MEGxp0_001882; Gardenin (1); NCI60_042113; ACon1_000048; 24J0W87Z43; Gardenin A; Gardenin



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wyatt Hack, Noah Gladen-Kolarsky, Swarnali Chatterjee, Qiaoli Liang, Urmila Maitra, Lukasz Ciesla, Nora E Gray. Gardenin A treatment attenuates inflammatory markers, synuclein pathology and deficits in tyrosine hydroxylase expression and improves cognitive and motor function in A53T-α-syn mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116370. doi: 10.1016/j.biopha.2024.116370. [PMID: 38458012]
  • Erenius Toppo, S Sylvester Darvin, S Esakkimuthu, A Stalin, K Balakrishna, K Sivasankaran, P Pandikumar, S Ignacimuthu, N A Al-Dhabi. Antihyperlipidemic and hepatoprotective effects of Gardenin A in cellular and high fat diet fed rodent models. Chemico-biological interactions. 2017 May; 269(?):9-17. doi: 10.1016/j.cbi.2017.03.013. [PMID: 28351695]
  • Yearam Jung, Soon Young Shin, Yeonjoong Yong, Hyeryoung Jung, Seunghyun Ahn, Young Han Lee, Yoongho Lim. Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships. Chemical biology & drug design. 2015 May; 85(5):574-85. doi: 10.1111/cbdd.12445. [PMID: 25298094]
  • Jiayu Zhang, Fang Wang, Wei Cai, Qian Zhang, Ying Liu, Yun Li, Rongrong Liu, Guangshang Cao. Identification of metabolites of gardenin A in rats by combination of high-performance liquid chromatography with linear ion trap-Orbitrap mass spectrometer based on multiple data processing techniques. Biomedical chromatography : BMC. 2015 Mar; 29(3):379-87. doi: 10.1002/bmc.3287. [PMID: 25041995]
  • Shiming Li, Min-Hsiung Pan, Ching-Shu Lai, Chih-Yu Lo, Slavik Dushenkov, Chi-Tang Ho. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorganic & medicinal chemistry. 2007 May; 15(10):3381-9. doi: 10.1016/j.bmc.2007.03.021. [PMID: 17391969]
  • R S Zand, D J Jenkins, E P Diamandis. Steroid hormone activity of flavonoids and related compounds. Breast cancer research and treatment. 2000 Jul; 62(1):35-49. doi: 10.1023/a:1006422302173. [PMID: 10989984]