Garcinia lactone (BioDeep_00000396944)

   

PANOMIX_OTCML-2023


代谢物信息卡片


HYDROXYCITRIC ACID LACTONE (CONSTITUENT OF GARCINIA CAMBOGIA AND GARCINIA INDICA) [DSC]

化学式: C6H6O7 (190.0114)
中文名称: 藤黄内酯, （-）-羟基柠檬酸内酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 90.16%

分子结构信息

SMILES: C1C(=O)OC(C1(C(=O)O)O)C(=O)O
InChI: InChI=1S/C6H6O7/c7-2-1-6(12,5(10)11)3(13-2)4(8)9/h3,12H,1H2,(H,8,9)(H,10,11)/t3-,6+/m1/s1

描述信息

(+)-garcinia acid is a butan-4-olide and a hydroxy carboxylic acid. It has a role as a metabolite.
Hydroxycitric acid lactone is a natural product found in Garcinia gummi-gutta and Garcinia cowa with data available.
See also: Garcinia gummi-gutta fruit (part of).
A natural product found in Garcinia cambogia.
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].

同义名列表

18 个代谢物同义名

HYDROXYCITRIC ACID LACTONE (CONSTITUENT OF GARCINIA CAMBOGIA AND GARCINIA INDICA) [DSC]; HYDROXYCITRIC ACID LACTONE (CONSTITUENT OF GARCINIA CAMBOGIA AND GARCINIA INDICA); (2S,3S)-3-hydroxy-5-oxo-2,3,4,5-tetrahydrofuran-2,3-dicarboxylic acid; (2S,3S)-3-Hydroxy-5-oxotetrahydrofuran-2,3-dicarboxylic acid; (2S,3S)-3-Hydroxy-5-oxotetrahydrofuran-2,3-dicarboxylicacid; D-Erythro-pentaric acid, 3-c-carboxy-2-deoxy-, 1,4-lactone; 3-C-Carboxy-2-deoxy-d-erythro-pentaric acid 1,4-lactone; (2S,3S)-3-HYDROXY-5-OXOOXOLANE-2,3-DICARBOXYLIC ACID; (+)-Garcinia acid, analytical standard; Hydroxycitric acid lactone,(-)-(p); Hydroxycitric acid lactone [MI]; (-)-Hydroxycitric acid lactone; Hydroxycitric acid lactone; (+)-Garcinia acid; Garcinia lactone; UNII-7X481546MI; 7X481546MI; (-)-Hydroxycitric acid lactone



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Carlotta Granchi. ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism. European journal of medicinal chemistry. 2018 Sep; 157(?):1276-1291. doi: 10.1016/j.ejmech.2018.09.001. [PMID: 30195238]