Clematichinenoside AR (BioDeep_00000396685)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Clematichinenoside AR

化学式: C82H134O43 (1806.8298414)
中文名称: 灵仙新苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3C(OC(C(C3O)O)OC4COC(C(C4O)O)OC5C(C(OC(C5O)OC6C(C(COC6OC7CCC8(C(C7(C)C)CCC9(C8CC=C1C9(CCC2(C1CC(CC2)(C)C)C(=O)OC1C(C(C(C(O1)COC1C(C(C(C(O1)CO)OC1C(C(C(C(O1)C)O)O)O)O)O)O)O)O)C)C)C)O)O)C)O)CO)O)O)O)O)O)O
InChI: InChI=1S/C82H134O43/c1-28-42(86)49(93)56(100)67(112-28)109-25-36-46(90)51(95)58(102)72(118-36)122-64-35(23-84)116-71(61(105)54(64)98)117-38-27-111-69(55(99)48(38)92)123-65-44(88)30(3)114-74(62(65)106)124-66-45(89)33(85)24-108-75(66)120-41-14-15-79(8)39(78(41,6)7)13-16-81(10)40(79)12-11-31-32-21-77(4,5)17-19-82(32,20-18-80(31,81)9)76(107)125-73-59(103)52(96)47(91)37(119-73)26-110-68-60(104)53(97)63(34(22-83)115-68)121-70-57(101)50(94)43(87)29(2)113-70/h11,28-30,32-75,83-106H,12-27H2,1-10H3/t28-,29-,30-,32-,33-,34+,35+,36+,37+,38+,39-,40+,41-,42-,43-,44-,45-,46+,47+,48+,49+,50+,51-,52-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,68+,69-,70-,71-,72-,73-,74-,75-,79-,80+,81+,82-/m0/s1

描述信息

Clematichinenoside AR is a natural product found in Clematis chinensis with data available.

同义名列表

1 个代谢物同义名

Clematichinenoside AR



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiao Wang, Dexi Zhou, Wanwan Zhou, Jian Liu, Qiuyun Xue, Yurong Huang, Chenglong Cheng, Yuting Wang, Jun Chang, Peng Wang, Chenggui Miao. Clematichinenoside AR inhibits the pathology of rheumatoid arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis. International immunopharmacology. 2022 Dec; 113(Pt A):109376. doi: 10.1016/j.intimp.2022.109376. [PMID: 36279670]
  • Xin-Nan Wang, Wen-Rui Xia, Jian-Qun Liu, Fang-Yuan Sun, Zhu-Jun Zhong, Li-Fang Liu, Gui-Zhong Xin. Targeting tryptophan metabolism reveals Clematichinenoside AR alleviates triptolide-induced hepatotoxicity. Journal of pharmaceutical and biomedical analysis. 2022 Jan; 208(?):114461. doi: 10.1016/j.jpba.2021.114461. [PMID: 34775190]
  • Yajing Diao. Clematichinenoside AR Alleviates Foam Cell Formation and the Inflammatory Response in Ox-LDL-Induced RAW264.7 Cells by Activating Autophagy. Inflammation. 2021 Apr; 44(2):758-768. doi: 10.1007/s10753-020-01375-x. [PMID: 33151398]
  • Xue Song, Jing Li, Yan Wang, Changmin Zhou, Zhichao Zhang, Mengdi Shen, Ping Xiang, Xiaofeng Zhang, Hao Zhao, Liang Yu, Lugen Zuo, Jianguo Hu. Clematichinenoside AR ameliorated spontaneous colitis in Il-10-/- mice associated with improving the intestinal barrier function and abnormal immune responses. Life sciences. 2019 Dec; 239(?):117021. doi: 10.1016/j.lfs.2019.117021. [PMID: 31678552]
  • Ying Xiong, Yan Ma, Nandani Darshika Kodithuwakku, Weirong Fang, Lifang Liu, Fengwen Li, Yahui Hu, Yunman Li. Protective effects of Clematichinenoside AR against inflammation and cytotoxicity induced by human tumor necrosis factor-α. International immunopharmacology. 2019 Oct; 75(?):105563. doi: 10.1016/j.intimp.2019.04.010. [PMID: 31408840]
  • Rui Li, Lin-Xiu Guo, Yi Li, Wen-Qi Chang, Jian-Qun Liu, Li-Fang Liu, Gui-Zhong Xin. Dose-response characteristics of Clematis triterpenoid saponins and clematichinenoside AR in rheumatoid arthritis rats by liquid chromatography/mass spectrometry-based serum and urine metabolomics. Journal of pharmaceutical and biomedical analysis. 2017 Mar; 136(?):81-91. doi: 10.1016/j.jpba.2016.12.037. [PMID: 28064091]
  • Ying Xiong, Yan Ma, Wang Han, Nandani Darshika Kodithuwakku, Li-Fang Liu, Feng-Wen Li, Wei-Rong Fang, Yun-Man Li. Clematichinenoside AR induces immunosuppression involving Treg cells in Peyer׳s patches of rats with adjuvant induced arthritis. Journal of ethnopharmacology. 2014 Sep; 155(2):1306-14. doi: 10.1016/j.jep.2014.07.028. [PMID: 25063305]
  • Yoshihiro Mimaki, Akihito Yokosuka, Mari Hamanaka, Chiseko Sakuma, Takao Yamori, Yutaka Sashida. Triterpene saponins from the roots of Clematis chinensis. Journal of natural products. 2004 Sep; 67(9):1511-6. doi: 10.1021/np040088k. [PMID: 15387651]