SP-G Iia (BioDeep_00000396379)
Main id: BioDeep_00000272998
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C28H32O13 (576.1842822)
中文名称: 鬼臼毒素-4-O-葡萄糖苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)OC6C(C(C(C(O6)CO)O)O)O
InChI: InChI=1S/C28H32O13/c1-34-17-4-11(5-18(35-2)26(17)36-3)20-12-6-15-16(39-10-38-15)7-13(12)25(14-9-37-27(33)21(14)20)41-28-24(32)23(31)22(30)19(8-29)40-28/h4-7,14,19-25,28-32H,8-10H2,1-3H3/t14-,19+,20+,21-,22+,23-,24+,25-,28-/m0/s1
描述信息
Podophyllotoxin glucoside is a natural product found in Callitris drummondii, Libocedrus chevalieri, and other organisms with data available.
Physiologically active prostaglandins found in many tissues and organs. They are potent pressor substances and have many other physiological activities.
Podophyllotoxin glucoside is a?podophyllotoxin derivative, has anti-tumor effects[1].
Podophyllotoxin glucoside is a?podophyllotoxin derivative, has anti-tumor effects[1].
同义名列表
16 个代谢物同义名
(5R,5aR,8aR,9R)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one; Furo(3,4:6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-(beta-D-glucopyranosyloxy)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-; 9-(beta-D-glucopyranosyloxy)-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo(3,4:6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one (5R-(5alpha,5abeta,8aalpha,9alpha))-; 4,6-O-Benzylide-beta-D-glucopyranosidepodophyllotoxin; Podophyllotoxin-beta-D-benzylidene glucoside; Podophyllotoxin, 3-beta-D-glucopyranoside; Podophyllotoxin, beta-D-glucopyranoside; Podophyllotoxin beta-D-glucoside; Podophyllotoxin-beta-D-glucoside; podophyllotoxin-4-o-glucoside; Podophyllotoxin 4-O-glucoside; Podophyllotoxin β-D-glucoside; Podophyllotoxin glucoside; prostaglandins B; SP-G Iia; PGB
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 161177
- MeSH: Prostaglandins B
- ChemIDplus: 0016481542
- CAS: 16481-54-2
- medchemexpress: HY-N1977
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lieke C J van den Berk, Bas J H Jansen, Stuart Snowden, Kim G C Siebers-Vermeulen, Christian Gilissen, Gesine Kögler, Carl G Figdor, Craig E Wheelock, Ruurd Torensma. Cord blood mesenchymal stem cells suppress DC-T Cell proliferation via prostaglandin B2.
Stem cells and development.
2014 Jul; 23(14):1582-93. doi:
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Bioorganic & medicinal chemistry letters.
2011 Jun; 21(12):3794-7. doi:
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Archives of pharmacal research.
2010 Sep; 33(9):1325-9. doi:
10.1007/s12272-010-0905-y. [PMID: 20945130] - Joanna M Little, Mika Kurkela, Julia Sonka, Sirkku Jäntti, Raimo Ketola, Stacie Bratton, Moshe Finel, Anna Radominska-Pandya. Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases.
Journal of lipid research.
2004 Sep; 45(9):1694-703. doi:
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The Journal of biological chemistry.
2003 Jul; 278(28):25376-85. doi:
10.1074/jbc.m301233200. [PMID: 12734199] - K Büyükgüzel, H Tunaz, S M Putnam, D Stanley. Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta.
Insect biochemistry and molecular biology.
2002 Apr; 32(4):435-43. doi:
10.1016/s0965-1748(01)00121-7. [PMID: 11886778] - Jinsheng Yang, Charles E Petersen, Chung-Eun Ha, Nadhipuram V Bhagavan. Structural insights into human serum albumin-mediated prostaglandin catalysis.
Protein science : a publication of the Protein Society.
2002 Mar; 11(3):538-45. doi:
10.1110/ps.28702. [PMID: 11847277] - N Cattan, D Mary, A Peleraux, B Mari, C Aussel, B Rossi. Prostaglandin B(2) delivers a co-stimulatory signal leading to T cell activation.
European cytokine network.
2000 Jun; 11(2):293-9. doi:
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European journal of biochemistry.
2000 Feb; 267(4):1117-24. doi:
10.1046/j.1432-1327.2000.01109.x. [PMID: 10672021] - S Watanabe, T Kobayashi, H Okuyama. Absence of relation between the expression of cyclooxygenase isoforms and the synthesis of prostaglandin E2 in resident and thioglycollate-elicited macrophages in rats.
Prostaglandins & other lipid mediators.
1998 May; 56(1):7-18. doi:
10.1016/s0090-6980(98)00039-2. [PMID: 9674017] - T Hishinuma, H Nakamura, K Itoh, Y Ohyama, M Ishibashi, M Mizugaki. Microdetermination of the prostaglandin B1 in human plasma by gas chromatography/selected ion monitoring using [18O]prostaglandin B1 as an internal standard.
Prostaglandins.
1995 Apr; 49(4):239-46. doi:
10.1016/0090-6980(95)00016-4. [PMID: 7667505] - W S Powell, F Gravelle, S Gravel. Phorbol myristate acetate stimulates the formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human neutrophils by activating NADPH oxidase.
The Journal of biological chemistry.
1994 Oct; 269(41):25373-80. doi:
. [PMID: 7929234] - Y Park, T M Devlin, D P Jones. Protective effect of the dimer of 16,16-diMePGB1 against KCN-induced mitochondrial failure in hepatocytes.
The American journal of physiology.
1992 Aug; 263(2 Pt 1):C405-11. doi:
10.1152/ajpcell.1992.263.2.c405. [PMID: 1514587] - A Sakamoto, R Ogawa. [ESR study of free radical formation during ischemia-reperfusion injury in the rat brain and the protective effect of a new antioxidant].
Masui. The Japanese journal of anesthesiology.
1992 Apr; 41(4):595-602. doi:
". [PMID: 1315880] - S T Ohnishi, A Sakamoto, T Ohnishi, R Ogawa. Inhibition of lipid peroxidation by prostaglandin oligomeric derivatives.
Prostaglandins, leukotrienes, and essential fatty acids.
1992 Mar; 45(3):217-21. doi:
10.1016/0952-3278(92)90116-z. [PMID: 1317035] - S T Ohnishi, T Ohnishi. Biologically significant physico-chemical properties of antioxidative prostaglandin derivatives.
Arzneimittel-Forschung.
1991 Dec; 41(12):1201-5. doi:
. [PMID: 1667725] - A Sakamoto, S T Ohnishi, T Ohnishi, R Ogawa. Protective effect of a new anti-oxidant on the rat brain exposed to ischemia-reperfusion injury: inhibition of free radical formation and lipid peroxidation.
Free radical biology & medicine.
1991; 11(4):385-91. doi:
10.1016/0891-5849(91)90155-v. [PMID: 1665837] - L O Eriksson, B Larsson, H Hedlund, K E Andersson. Prostaglandin E2 binding sites in human renal tissue: characterization and localization by radioligand binding and autoradiography.
Acta physiologica Scandinavica.
1990 Jul; 139(3):393-404. doi:
10.1111/j.1748-1716.1990.tb08940.x. [PMID: 2173350] - E P Brass, M J Garrity. Structural specificity for prostaglandin effects on hepatocyte glycogenolysis.
The Biochemical journal.
1990 Apr; 267(1):59-62. doi:
10.1042/bj2670059. [PMID: 2158311] - R Franson, R Raghupathi, M Fry, J Saal, B Vishwanath, S S Ghosh, M D Rosenthal. Inhibition of human phospholipases A2 by cis-unsaturated fatty acids and oligomers of prostaglandin B1.
Advances in experimental medicine and biology.
1990; 279(?):219-30. doi:
10.1007/978-1-4613-0651-1_15. [PMID: 2129000] - M D Rosenthal, R C Franson. Oligomers of prostaglandin B1 inhibit arachidonic acid mobilization in human neutrophils and endothelial cells.
Biochimica et biophysica acta.
1989 Dec; 1006(3):278-86. doi:
10.1016/0005-2760(89)90014-3. [PMID: 2557075] - R C Franson, M D Rosenthal. Oligomers of prostaglandin B1 inhibit in vitro phospholipase A2 activity.
Biochimica et biophysica acta.
1989 Dec; 1006(3):272-7. doi:
10.1016/0005-2760(89)90013-1. [PMID: 2597672] - S Narasimhulu, E M Brown. Interaction of PGBx and peroxides with cytochrome c and inhibition of lipid peroxidation.
Archives of biochemistry and biophysics.
1985 Dec; 243(2):461-9. doi:
10.1016/0003-9861(85)90523-5. [PMID: 3002276] - J D Watkins, J Jarabak. The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney.
Prostaglandins.
1985 Aug; 30(2):335-49. doi:
10.1016/0090-6980(85)90196-0. [PMID: 3901124] - C Y Ching, N Ching, D S Seto, Y Hokama. Relationships of prostaglandin levels and natural killer (NK) cell cytotoxicity of mononuclear cells in cord blood.
Journal of medicine.
1984; 15(3):233-6. doi:
NULL. [PMID: 6597256] - K Matsumoto, K Saito, H Fukuda. Centrally specific and GABA-insensitive inhibition of benzodiazepine binding by prostaglandins (A1, A2 and B2).
Journal of pharmacobio-dynamics.
1983 Oct; 6(10):784-6. doi:
10.1248/bpb1978.6.784. [PMID: 6319659] - M H Wiley, K R Feingold, C Grunfeld, V Quesney-Huneeus, J M Wu. Evidence for cAMP-independent inhibition of S-phase DNA synthesis by prostaglandins.
The Journal of biological chemistry.
1983 Jan; 258(1):491-6. doi:
. [PMID: 6294110] - Y Hokama, L Yokochi, M A Abad, L Shigemura, L H Kimura, C Okano, S C Chou. Presence of prostaglandins (PGs) in Tetrahymena pyriformis, GL and the effect of aspirin.
Research communications in chemical pathology and pharmacology.
1982 Oct; 38(1):169-72. doi:
". [PMID: 6815741] - S Ivanković, S Ivković, V Molnar. [Prostaglandins in the plasma of patients with chronic renal diseases treated with hemodialysis].
Lijecnicki vjesnik.
1982 Jul; 104(7-8):280-2. doi:
NULL. [PMID: 6958953] - H W Shmukler, E Soffer, M G Zawryt, E Polis, W Feely, S F Kwong, F W Cope. Mechanism of polymeric prostaglandin PGBx for in vitro stabilization of rat liver mitochondrial oxidative phosphorylation.
Physiological chemistry and physics.
1982; 14(5):445-69. doi:
NULL. [PMID: 7186641] - J D Sraer, L Moulonguet-Doleris, F Delarue, J Sraer, R Ardaillou. Prostaglandin synthesis by glomeruli isolated from rats with glycerol-induced acute renal failure.
Circulation research.
1981 Sep; 49(3):775-83. doi:
10.1161/01.res.49.3.775. [PMID: 7020977] - C D Dunn. Prostaglandins and erythropoiesis: structure/action relationships and identification of the prostaglandin responsive cells.
Blut.
1981 May; 42(5):307-14. doi:
10.1007/bf00996847. [PMID: 7236897] - P R Harvey, L H Kimura, C Cripps, Y Hokama. Distribution of prostaglandins B, E and F series in plasma of cancer patients.
Journal of medicine.
1981; 12(6):427-32. doi:
NULL. [PMID: 6948071] - H W Shmukler, M G Zawryt, E Soffer, W Feely, E Polis. Interaction of bovine serum albumin with PGBx (polymeric 15-keto-prostaglandin B1).
Physiological chemistry and physics.
1981; 13(3):241-50. doi:
NULL. [PMID: 7301945] - C J Kirkpatrick. The effects of prostaglandin A1 and prostaglandin B1 on the differentiation of cartilage in the chick embryo.
Cell and tissue research.
1980; 210(1):111-20. doi:
10.1007/bf00232147. [PMID: 7407857] - E W Gold, P R Edgar. The effect of physiological levels of non-esterified fatty acids on the radioimmunoassay of prostaglandins.
Prostaglandins.
1978 Dec; 16(6):945-52. doi:
10.1016/0090-6980(78)90110-7. [PMID: 748981] - V A Skrinska, A Butkus. Analysis of A, B, E, and F prostaglandins as pentafluorobenzyl esters by electron-capture gas-liquid chromatography.
Prostaglandins.
1978 Oct; 16(4):571-82. doi:
10.1016/0090-6980(78)90187-9. [PMID: 725087] - E W Gold, O D Fox, S Weissfeld, P H Curtiss. Corticosteroid-induced avascular necrosis: an experimental study in rabbits.
Clinical orthopaedics and related research.
1978 Sep; ?(135):272-80. doi:
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1977 Sep; 83(9):693-9. doi:
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