Strictosamide (BioDeep_00000396297)

Main id: BioDeep_00000003755

 

natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


(1S,18S,19R,20S)-19-ethenyl-18-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15-pentaen-14-one

化学式: C26H30N2O8 (498.200206)
中文名称: 异长春花苷内酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CC1C2CC3C4=C(CCN3C(=O)C2=COC1OC5C(C(C(C(O5)CO)O)O)O)C6=CC=CC=C6N4
InChI: InChI=1S/C26H30N2O8/c1-2-12-15-9-18-20-14(13-5-3-4-6-17(13)27-20)7-8-28(18)24(33)16(15)11-34-25(12)36-26-23(32)22(31)21(30)19(10-29)35-26/h2-6,11-12,15,18-19,21-23,25-27,29-32H,1,7-10H2/t12-,15+,18+,19-,21-,22+,23-,25+,26+/m1/s1

描述信息

Strictosamide is a member of beta-carbolines.
Strictosamide is a natural product found in Amsonia orientalis, Ophiorrhiza pumila, and other organisms with data available.
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
Annotation level-3
Strictosamide has important effects on inflammation and inflammatory pain. Strictosamide possesses antiplasmodial and antifungal activities[1].
Strictosamide has important effects on inflammation and inflammatory pain. Strictosamide possesses antiplasmodial and antifungal activities[1].

同义名列表

5 个代谢物同义名

(1S,18S,19R,20S)-19-ethenyl-18-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15-pentaen-14-one; 5H-Indolo[2,3-a]pyrano[3,4-g]quinolizin-5-one, 1-ethenyl-2-(beta-D-glucopyranosyloxy)-1,2,7,8,13,13b,14,14a-octahydro-, (1R,2S,13bS,14aS)-; 3-epi-Vincosamide; Isovincoside lactam; Strictosidine lactam; Strictosamide; Strictosamide



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

74 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qi Geng, Bin Liu, Danping Fan, Zhiwen Cao, Li Li, Peipei Lu, Lin Lin, Lan Yan, Yibai Xiong, Xiaojuan He, Jun Lu, Peng Chen, Cheng Lu. Strictosamide ameliorates LPS-induced acute lung injury by targeting ERK2 and mediating NF-κB signaling pathway. Journal of ethnopharmacology. 2024 Mar; 322(?):117593. doi: 10.1016/j.jep.2023.117593. [PMID: 38113987]
  • Nassifatou Koko Tittikpina, Kumar Katragunta, Bharathi Avula, Zulfiqar Ali, Ikhlas A Khan. Strategy for the quality control of herbal preparations made of Sarcocephalus latifolius: Development and validation of a UHPLC-PDA method for quantification of angustoline and strictosamide and chemical profiling using LC-QToF. Phytochemical analysis : PCA. 2023 Jan; 34(1):105-126. doi: 10.1002/pca.3183. [PMID: 36281909]
  • Weerasak Songoen, Julia Brunmair, Florian Traxler, Viktoria Chiara Wieser, Witthawat Phanchai, Wanchai Pluempanupat, Lothar Brecker, Johann Schinnerl. Yellow Twig (Nauclea orientalis) from Thailand: Strictosamide as the Key Alkaloid of This Plant Species. Molecules (Basel, Switzerland). 2022 Aug; 27(16):. doi: 10.3390/molecules27165176. [PMID: 36014416]
  • Segun A Aderibigbe, Sunday O Idowu, Ajibola A Olaniyi, Colin W Wright, Amos A Fatokun. Bioactivity and cytotoxicity profiling of vincosamide and strictosamide, anthelmintic epimers from Sarcocephalus latifolius (Smith) Bruce leaf. Journal of ethnopharmacology. 2021 Jan; 265(?):113142. doi: 10.1016/j.jep.2020.113142. [PMID: 32697959]
  • Andreas Berger, Elias Tanuhadi, Lothar Brecker, Johann Schinnerl, Karin Valant-Vetschera. Chemodiversity of tryptamine-derived alkaloids in six Costa Rican Palicourea species (Rubiaceae-Palicoureeae). Phytochemistry. 2017 Nov; 143(?):124-131. doi: 10.1016/j.phytochem.2017.07.016. [PMID: 28806604]
  • DongYu Li, JiaQuan Chen, JiQing Ye, XiaoTing Zhai, Jie Song, CuiHua Jiang, Jing Wang, Hao Zhang, XiaoBin Jia, FenXia Zhu. Anti-inflammatory effect of the six compounds isolated from Nauclea officinalis Pierrc ex Pitard, and molecular mechanism of strictosamide via suppressing the NF-κB and MAPK signaling pathway in LPS-induced RAW 264.7 macrophages. Journal of ethnopharmacology. 2017 Jan; 196(?):66-74. doi: 10.1016/j.jep.2016.12.007. [PMID: 27989509]
  • Zan Li, Zhaoliang Li, Yunwei Lin, Zhaoqing Meng, Gang Ding, Liang Cao, Na Li, Wenjun Liu, Wei Xiao, Xiaoming Wu, Jinyi Xu. Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities. Chemical biology & drug design. 2015 Oct; 86(4):523-30. doi: 10.1111/cbdd.12515. [PMID: 25589048]
  • Ashish Kumar, Somenath Roy Chowdhury, Kumar Kalyan Jatte, Tulika Chakrabarti, Hemanta K Majumder, Tarun Jha, Sibabrata Mukhopadhyay. Anthocephaline, a new indole alkaloid and cadambine, a potent inhibitor of DNA topoisomerase IB of Leishmania donovani (LdTOP1LS), isolated from Anthocephalus cadamba. Natural product communications. 2015 Feb; 10(2):297-9. doi: . [PMID: 25920266]
  • Na Li, Liang Cao, Yue Cheng, Zhao-Qing Meng, Zhao-Hui Tang, Wen-Jun Liu, Zhen-Zhong Wang, Gang Ding, Wei Xiao. In vivo anti-inflammatory and analgesic activities of strictosamide from Nauclea officinalis. Pharmaceutical biology. 2014 Nov; 52(11):1445-50. doi: 10.3109/13880209.2014.895910. [PMID: 25026342]
  • Hanlin Pu, Hua Jiang, Rongrong Chen. Combined multispectroscopic and molecular docking investigation on the interaction between strictosamide and human serum albumin. Luminescence : the journal of biological and chemical luminescence. 2013 Jul; 28(4):482-9. doi: 10.1002/bio.2480. [PMID: 23339149]
  • Fen-Xia Zhu, Jing-Jing Wang, Jie Song, Shu-Min Ding, Xiao-Bin Jia. [Chemical constituents of Nauclea officinalis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Feb; 48(2):276-80. doi: . [PMID: 23672026]
  • Kahunu Mesia, Lutete Tona, Ma Miezi Mampunza, Nsengi Ntamabyaliro, Tsobo Muanda, Tamfum Muyembe, Kanyanga Cimanga, Jozef Totté, Tony Mets, Luc Pieters, Arnold J Vlietinck. Antimalarial efficacy of a quantified extract of Nauclea pobeguinii stem bark in human adult volunteers with diagnosed uncomplicated falciparum malaria. Part 1: a clinical phase IIA trial. Planta medica. 2012 Feb; 78(3):211-8. doi: 10.1055/s-0031-1280359. [PMID: 22095262]
  • Chen Dai, Wei Xiao, Yan Liang, Lin Xie, Guangji Wang, Gang Ding, Zhaoqing Meng, Juan Zhang, Tianye Guan, An Kang, Xiao Zheng, Tong Xie, Chunzhu Li, Qijin Zhao, Wenjun Liu, Li Zhao, Jia Xu. Validated liquid chromatography mass spectrometry method for quantitative determination of strictosamide in dog plasma and its application to pharmacokinetic study. Biomedical chromatography : BMC. 2011 Dec; 25(12):1338-42. doi: 10.1002/bmc.1606. [PMID: 21387351]
  • Dawen Xie, Yonghui Li, Li Zhao, Gang Ding, Shaowei Yuan, Jia Xu, Huarong Zhu, Wei Xiao. [Study on chemical constituents from leaves of Naudea officinalis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Apr; 36(8):1037-9. doi: . [PMID: 21809580]
  • Long Fan, Chun-Lin Fan, Ying Wang, Xiao-Qi Zhang, Qing-Wen Zhang, Jun-Qing Zhang, Wen-Cai Ye. [Alkaloids from the leaves of Nauclea officinalis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Jun; 45(6):747-51. doi: . [PMID: 20939184]
  • M F Candeias, P Abreu, A Pereira, J Cruz-Morais. Effects of strictosamide on mouse brain and kidney Na+, K+-ATPase and Mg2+-ATPase activities. Journal of ethnopharmacology. 2009 Jan; 121(1):117-22. doi: 10.1016/j.jep.2008.08.032. [PMID: 18992802]
  • Yasuyo Yamazaki, Hiroshi Sudo, Mami Yamazaki, Norio Aimi, Kazuki Saito. Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compounds. Plant & cell physiology. 2003 Apr; 44(4):395-403. doi: 10.1093/pcp/pcg051. [PMID: 12721380]